혈장(血漿) MHPG와 HVA 농도(濃度)의 24시간(時間) 주기성(週期性) 변화(變化)에 관한 연구(硏究)

김기웅,이정희,우종인,Kim, Ki-Woong,Lee, Jung Hie,Woo, Jong Inn 대한생물정신의학회 1995 생물정신의학 Vol.2 No.2

We invesigated whether the circadian rhythms of plasma MHPG and HVA concentrations exist in 11 healthy young adults, and analyzed the patterns of their circadian rhythms. The results were as follows : 1) The change in the mean plasma MHPG concentrations analyzed by repeated measures ANOVA was not statistically significant. Five subjects showed significant circadian rhythms of plasma MHPG concentrations of each individual, and 4 of those had the acrophases between 17PM and 24PM. 2) The change in the mean plasma HVA concentrations analyzed by repeated measures ANOVA was not statistically significant. Six subjects showed significant circadian rhythms of plasma HVA concentrations of each individual, and 4 of those had the acrophases between 21PM and 6AM. In conclusion, the circadian rhythm pattern of plasma HVA concentrations in our result is consistent with the previous study. It was suggested that plasma MHPG and HVA concentrations should be measured more frequently, and the physical activities of subjects be controlled more strictly for the following study.

도시 및 농촌 노인의 한국판 MMSE 점수에 사회인구학적 변인이 미치는 영향에 관한 연구

여형용(Hyung Yong Yeo),이강욱(Kang Yk Lee),이군희(Gun Hee Lee),주진형(Jin Hyung Jhoo),김기웅(Ki Woong Kim),이정희(Jung Hie Lee),하규섭(Kyoo Seob Ha),정도언(Do Un Jeong),김용식(Yong Sik Kim),우종인(Jong Inn Woo) 한국정신병리진단분류학회 1998 精神病理學 Vol.7 No.1

N/A N/A

월드와이드웹과 포터블 문서양식을 이용한 의학 학술지의 온라인 출판

김주한(Ju Han Kim),우종인(Jong Inn Woo),김창윤(Chang Yoon Kim),이정희(Jung Hie Lee),김창남(Chang Nam Kim),한오수(Oh Su Han) 한국정신병리진단분류학회 1997 精神病理學 Vol.6 No.1

N/A N/A

다섯 가지 시계그리기검사 채점법의 알쯔하이머병 선별 유용성 비교

서은현 ( Eun Hyun Seo ),박희형 ( Hee Hyung Park ),이동영 ( Dong Young Lee ),추일한 ( Il Han Choo ),이정희 ( Jung Hie Lee ),정세훈 ( Sae Hoon Chung ),윤종철 ( Jong Chul Youn ),김기웅 ( Ki Woong Kim ),주진형 ( Jin Hyung Jhoo ),김신 한국정신병리진단분류학회 2006 精神病理學 Vol.15 No.1

Objectives: This study aimed to compare the reliability and screening ability for Alzheimer`s disease (AD) of five scoring methods of clock drawing test(CDT). Methods: Consecutively recruited 155 probable AD patients and 155 normal control subjects participated in the study. The clock picture drawn by each subject was scored according to five CDT scoring methods, such as the CERAD, Rouleau, Sunderland, Mendez and Todd method. The inter-rater reliability was compared by calculating Pearson`s correlation coefficients. The screening ability was compared by analyzing the receiver operating characteristic(ROC) curves. Results: The five scoring methods had excellent inter-rater reliability in common. In terms of the screening ability for overall AD, there was no difference among the scoring methods. There was also no inter-method difference in screening ability for very mild AD. In contrast, as for the screening of mild to severe AD, the CERAD method showed significantly better ability than the other four methods. Conclusions: Regardless of their complexity, CDT scoring methods appears to have similar screening ability for overall AD. In screening clinically more evident AD except very mild one, however, the CERAD methods, in spite of its simplicity, can be probably applied more usefully than other CDT scoring methods.

저산소증을 동반하지 않는 만성폐쇄성폐질환 환자에서의 인지기능장애

김우진 ( Woo Jin Kim ),한선숙 ( Seon Sook Han ),박명옥 ( Myoung Ok Park ),이승준 ( Seung Joon Lee ),김성재 ( Seong Jae Kim ),이정희 ( Jung Hie Lee ) 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.62 No.5

연구배경: 저산소증을 동반한 COPD 환자에서 인지기능 장애를 보이는 것은 잘 알려져 있다. 그러나 저산소증이 없는 COPD 환자에서의 인지기능에 대해서는 논란의 여지가 있다. 또한, COPD 환자는 수면장애를 동반하는 것으로 알려져 있다. 저자들은 저산소증이 없는 COPD 환자들의 인지기능을 평가하고, 인지기능 장애를 가진 COPD 환자들에서 수면장애가 얼마나 나타나는지 알아보았다. 방법: 90% 이상의 동맥혈 산소 포화도를 가진 28명의 COPD 환자를 대상으로 연구를 시행하였으며, 환자의 평균 나이는 70.7세였다. 대조군은 건강검진을 위해 내원한 33명의 건강성인을 대상으로 하였고, 대조군의 평균 나이는 69.5세였다. 모든 환자 및 대조군은 the Korean version of the Consortium to Establish a Registry for Alzheimer``s Disease(CERAD- K)를 이용하여 신경인지기능을 평가하였다. 결과: COPD 환자군은 단어목록회상(p=0.03)과 단어목록재인(p=0.006) 항목에서 대조군과 비교하여 유의하게 낮은 점수를 보였다. 9명의 환자에서 유의미한 인지기능 장애를 가지고 있었으며, 이 중 7명의 환자에서 수면다원검사를 시행한 결과, 5명의 환자에서 시간당 5회 이상의 apnea-hypopnea index를 보였다. 7명의 환자에서 동맥혈 산소 포화도 감소 지수 및 평균 사지 운동 지수는 각각 3.6/시간과 38.6/시간이었다. 결론: 이 연구는 저산소증이 없는 COPD 환자에서 언어기억 장애를 가진다는 것을 시사하며, 이렇게 인지기능 장애를 가진 COPD 환자들이 수면장애를 동반하고 있어 이에 관한 추가연구의 필요성이 제시되었다. Background: The cognitive function is impaired in patients with hypoxemic chronic obstructive pulmonary disease (COPD). However, there are conflicting results regarding the cognitive function in patients with non-hypoxemic COPD. COPD patients also have sleep disorders. This study examined the cognitive function in non-hypoxemic COPD patients, and nocturnal sleep was assessed in COPD patients with a cognitive dysfunction. Methods: Twenty-eight COPD patients (mean age, 70.7 years) with an oxygen saturation > 90%, and 33 healthy control subjects (mean age, 69.5 years) who had visited for a routine check-up were selected. The neurocognitive tests were performed using the Korean version of the Consortium to Establish a Registry for Alzheimer`s Disease (CERAD-K) Neuropsychological Battery. Results: The scores of the word list recall test (p=0.03) and the word list recognition test (p=0.006) in the COPD group were significantly lower than those in the control group. Nine patients showed a significantly impaired cognitive function. Seven of these underwent polysomnography, which revealed apnea-hypopnea indices ≥ five per hour in five patients. The median oxygen desaturation index and median limb movement index were 3.6/h and 38.6/h, respectively. Conclusion: These results suggest that the verbal memory function is impaired in non-hypoxemic COPD patients. Six out of seven COPD patients with an impaired cognitive function had sleep disorders of sleep apnea and/or periodic limb movements during sleep. (Tuberc Respir Dis 2007; 62: 382-388)

농촌지역 거주노인의연령, 성별, 교육수준이 한국판 MMSE 점수에 미치는 영향에 관한 연구

우종인,홍진표,이정희 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.1

저자들은 사회인구학적인 변인들이 인지기능검사에 미치는 영향을 살펴보기 위하여, 경기도 연천군의 4개 읍면지역에 거주하는 65세 이상 노인 인구를 대상으로 하여 MMSE-K검사를 시행하였다. 이 검사 점수와 연령, 성별, 교육수준 등과의 상관관계를 살펴본 바, 그 결과를 다음과 같이 요약할 수 있었다. 1) 연령, 성별, 교육수준 등 사회 인구학적인 변인들에 의해 MMSE-K 점수 변이의 약 40%를 설명할 수 있을 정도로 밀접한 상관 관계를 나타내었다. 2) 교육 수준은 MMSE-K 점수와 밀접한 상관 관계(r=0.49)를 갖고 있으며 국졸 이상군의 경우 무학군에 비해 5∼6점, 국중퇴군에 비해 1-3점의 평균 점수의 차이를 보였다. 3) 남자는 여자에 비하여 MMSE-K 점수가 의미있게 높았으나 이 차이는 주로 무학 등 저학력 남녀 노인간의 차이에서 유래한 것이다. 이는 남녀간의 인지기능 점수의 차이가 생물학적인 근거에 의해 생기는 것이 아니라는 것을 말하며 저학력군에서는 남녀의 사회적인 역할의 차이가 인지기능 점수에 큰 영향을 미친다는 것을 보여준다. 4) 인지기능 검사 점수는 연령, 성별, 교육 수준 등의 사회인구학적인 변수, 특히 교육 수준에 따른 보정을 반드시 필요로 하며, 그 보정방식의 적합성은 2차적인 임상진단과정에 의해 검증될 수 있다. 결론적으로, 본 연구결과는 MMSE-K가 인지기능 장애의 선별검사로서의 제 기능을 발휘하려면 사회인구학적인 변수, 특히 교육 수준에 따른 적절한 보정을 필요로 하며, 그 보정방식의 적합성에 대한 검증이 요청됨을 보여준다. In order to observe the sociodemographic effects on Mini-Mental State Examination-Korean version(MMSE-K), MMSE-K was administered to the residents aged 65 and older in Yonchon county, Kyungki-do. Following results were found: 1) Forty percent of the variance in MMSE-K scores was accounted by educational level, age and sex. 2) Educational levels closely correlated with MMSE-K scores(r=0.49). The group of elementary school graduates and over scored higher scores of 5-6 points and 1-3 points higher in comparison to the noneducated group and the elementary school failure group, respectively. 3) Men received higher MMSE-K scores than women, especially in the noneducated group and the elementary school failure group. In conclusion, readjustments of MMSE-K scores for demographic variables, especially for educational level, are necessary in order to use the MMSE-K as a screening measure for dementia.

치매의 정신병리 평가

이정희 韓國精神病理-診斷分類學會 1997 精神病理學 Vol.6 No.1

Comprehensive informations of psychiatric history, neurological history, hisotry of substance abuse, family history of dementia or depression, and general medical history are all required for the general clinical evaluation of the patient with dementia. Both the cognitive function and non-cognitive function should be considered for the assessment of psychopathology in dementia. 1. Cognition and function related symptomatology The four major cognitive domains to which the symptoms of dementia belong are domains of memory, language, visuospatial function and executive function. The memory impairment which starts to occur in the early stage of Alzheimer's disease(AD) is not becn?e of the loss or disruption of memory, but be(ni'se of abnormality in aquisition or encoding of memory. Both explicit and implicit memory are also impaired in AD. The higher the rate of AD in the family history is, the more frequently the language impairment occurs. The main types of aphasia in AD are anomie, Wemike's, and transcortical sensory aphasia, which usually reflects the severity of dementia even in its later stage. The purposes of the neuropsychological assessment are the primary screening, comprehensive diagnostic assessment, assessment of the disease progression, and assessment the efficacy in clinical trial. 1) Primary neuropsychological screening The most accurate neuropsychological test for detecting dementia in its early stage is the delayed free recall task in the semantic memory test. Very high sensitivity and specificity were also shown in the verbal fluency test and Wisconsin card sorting test. The delayed recall test in WAIS and verbal fluency test are proposed for detecting the patient with age-associated cognitive decline. 2) Neuropsychological assessment of the progression of dementia The test instruments for globally assessing the cognitive decline in the patient with dementia are CDR, GDS, FAS, and HDS. FAST which is the part of GDS to assess the degree of functional aspect is relatively efficient test, including the description of subdividing the later stages of dementia 2. Non-cognitive or behavioral symptomatology The test instruments to assess the non-cognitive symptoms of dementia are the tests for assessing its degree such as BEHAVE-AD, and for assessing its frequency as CMAI. The noncognitive symptoms of dementia can be divided as the psychiatric symptoms and behavioral disturbances. Since the definitions of these symptoms in the corresponding factors are different each other among different tests, the methodological issue has occurred. When these tests are used for assessing the efficacy in clinical trial, the comprehensive assessment including the assessment of the caregiver burden as well as the quality of life in dementia patients should be done. As the depressive symptom is frequently accompanied by dementia, the proper assessment based on its similarity and difference is required.

癌과 憂鬱症 : 癌患者의 精神科的 側面에 대하여 Psychiatric Aspects of Cancer Patients

李靜姬 서울대학교 의과대학 정신과학교실 1983 精神醫學報 Vol.7 No.1

Imipramine이 백서의 임파구 베타 아드레날린 수용체 결합과 혈장 3-Methoxy-4-Hydroxyphenylglycol(MHPG) 농도에 미치는 영향에 관한 연구

우종인,김창윤,이정희 大韓神經精神醫學會 1993 신경정신의학 Vol.32 No.6

Objects : The levels of plasma MHPG and the beta-adrenergic receptors of the peripheral lymphocytes were investigated at various times during chronic administration of imipramine. And the relationship between these peripheral measures and the central noradrenergic activities(MHPG levels and beta-adrenergic receptor bindings in the cerebral cortex) which were measured simultaneously with this experiment were studied. The purpose of this experiment was to know whether the peripheral measures reflect the central noradrenergic activities. And also the relationship between the levels of plasma MHPG and the beta-adrenergic receptors of the peripheral lymphocytes were investigated. Method : The levels of MHPG in plasma were measured by high performance liquid chromatography with electrochemical detector(HPLC-ECD). Beta-adrenergic receptors of the peripheral lymphocytes were assayed by ³H-dihydroalprenolol(³H-DHA) ligand bindings. Results : 1) A short term administration of imipramine decreased the level of plasma MHPG while increase in plasma MHPG level was shown by long term(2 weeks) administration, both of which were statistically significant. 2) A significant increase in the number(Bmax) of lymphocyte beta-adrenergic receptors was observed after a 5 week administration but the affinity(Kd) did not change significantly. 3) A positive correlation was noted between the change in plasma MHPG level and that in beta-adrenergic receptors which was not statistically significant. 4) A positive correlation was noted between the change in plasma MHPG level and that in MHPG level in cerebral cortex, but it was not statistically significant. 5) A strong negative correlation was noted between the beta-adrenergic receptor numbers(Bmax) of cerebral cortex and that of lymphocytes, but it was not significant statistically. In summary, the possibility of plasma MHPG as a useful peripheral marker for central presynaptic noradrenergic activity was not ascertained because their parallel change was not statistically significant. Conclusions : The lymphocyte beta-adrenergic receptor was not found to be a adequate marker for central beta-adrenergic receptors. Further studies will be necessary to find the exact meaning of the change in the lymphocyte beta-adrenergic receptors and their relations with those in the central nervous system as well as with the plasma noradrenergic activity.

腦影像術을 통한 腦의 形態學的 分析 方法論 硏究

김주한,우종인,이정희 大韓神經精神醫學會 1995 신경정신의학 Vol.34 No.4

Objects : For the quantification and topographic analysis of cross-sectional brain images. Methods : The authors developed a planimetric method with boundary tracing image digitizing and pixel counting. And each axial brain image was splitted into unit sectors of equal area, using polar coordinates as the frame of reference with its origin at the center of the symmetry line of the brain image. the sectors were reconstructed on a radial coordinates so as to represent the topographic profiles of the CSF spaces. A MRI study with these methods was performed in 26 alzheimer patients(age, 72.2±7.0) according to NINCDS-ADRDA criteria and 22 normal control subjects(age, 71.5±5.4). Results : Alzheimer patients showed greater ventricular and cerebral(cortical and ventricular) atrophy than control subjects(p<0.05). In healthy volunteers, all the cerebral atrophy indices measured exhibited significant correlation with age(p<0.005), but not in Alzheimer patients. analysis of the topographic profiles of the Alzheimer and control groups demonstrated that showed accentuated dilatation in frontal and occipital horns. Conclusion : These methods could be useful in quantifying and characterizing morphologic changes in cross-sectional brain images.