간세포암의 십이지장침윤에 의한 상부위장관 출혈 1 예

유태현,한광협,박성하,김형길,문영명,한재호,조상호 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.2

Recent advances in both the diagnosis and treatment of hepatocellular carcinoma have improved the prognosis and changed the clinical significance of the recently increasing distant metastases. Distant metastases found after successful treament of the primary lesions are of great clinical significance for the treatment of hepatocellular carcinoma. The duodenum is a rare site of hematogenous metastases or direct invasion from hepatocellular carcinoma. A 23 year old man was admitted with upper gastrointestinal bleeding. He had been diagnosed with hepatocellular carcinoma and treated by a left lobectomy and chemoembolization. The patient was admittted for 12 months after the treatment of the primary tumor. Endoscopic examination revealed a mass in the duodenal bulb that protruded into the lumen. He died due to massive hematemesis. We report on a rare case of hepatocellular carcinoma with duodenal invasion in a 23-year-old male patient.

5급 와동의 수복에 있어서 수종의 compomer의 미세 변연 누출에 관한 연구

오태석,박동성,유현미 大韓齒科保存學會 2000 Restorative Dentistry & Endodontics Vol.25 No.1

주파수의존 근관장 측정기가 습윤한 근관내에서 근첨을 인지하게 되는 원리에 관한 연구

오태석,유현미,박한수 大韓齒科保存學會 1998 Restorative Dentistry & Endodontics Vol.23 No.2

APEX FINDER A.F.A의 정확성에 관한 연구

오태석,유현미,양미영 大韓齒科保存學會 1998 Restorative Dentistry & Endodontics Vol.23 No.2

THE INFLUENCE OF OBTURATION TIMING AND THICKNESS OF MINERAL TRIOXIDE AGGREAGATE ON SEALING ABILITY OF CANAL WITH OPEN APEX

곽경인,박동성,유현미,오태석 대한치과보존학회 2000 Restorative Dentistry & Endodontics Vol.25 No.4

임상에서 점차 Mineral Trioxide Aggregate (MTA) 에 대한 우수성이 소개되면서, apical matrix로의 사용은 주목할 만하다 할 수 있다. 본 연구의 목적은 개방형근관에서 MTA가 apical matrix로 사용될 때의 치근단 밀폐효과를 알아보고, 근관충전의 시기와 matrix의 두께가 치근단 밀폐에 미치는 영향을 치근단 미세누출의 측면과 matrix탈락빈도의 측면에서 관찰하고자 하는 것이다. 개방형 근관을 재현하고자 45개의 발거된 단근치에 #90크기로 근단공을 형성하였고, 투명레진등을 이용하여 치근단병소를 갖는 치조골을 재현한 후, 4개의 실험 군과 1개의 대조 군으로 분류하였다. A군: 2mm두께의 MTA matrix 형성후, 열연화된 Gutta-percha와AH26 sealer를 이용하여 즉시 근관충전. B군: 2mm두께의 MTA matrix 형성후, A군과 같은 방법으로 24시간 후 근관충전. C군: 4mm 두께의 MTA matrix 형성후, A군과 같은 방법으로 즉시 근관충전. D군: 4mm두께의 MTA matrix 형성후, A군과 같은 방법으로 24시간 후 근관충전. 대조군: matrix를 사용하지 않고 열연화된 Gutta-percha와 AH26 sealer를 이용하여 근관충전하였다. Matrix의 탈락이 있는 경우 기록하고 완전수세 후 다시 시행하였다. 색소침투정도의 평가를 위해 methylene blue 에 치아를 48시간 침수시킨 후 협설로 양분하였다. 각 시편들을 고배율 현미경 관찰 후 비디오촬영 하였고, digitalized image analysing program 을 이용하여 두명의 관찰자가 누출의 정도를 평가한 후, One-way ANOVA로 통계적 유의성을 검증하여 다음과 같은 결과를 얻었다. 1. Matrix를 사용한 실험 군이 matrix를 사용하지 않은 대조 군에 비해 유의성 있게 낮은 누출을 보였다(p<0.05) . 그러나 근관충전시기와 matrix의 두께를 달리한 실험군 내에서는 누출에 유의성 있는 차이가 나타나지 않았다. 2 모든 실험군에서 gutta-percha를 이용한 근관충전의 시기에 matrix탈락 및 gutta-percha 의 압출은 발생하지 않았다.

수산화칼슘 처리된 Porphyromonas endodontalis Lipopolysaccharide가 다형핵백혈구의 IL-1과 TNF-α 생성에 미치는 영향에 관한 연구

박찬제,박동성,유현미,오태석,임성삼 大韓齒科保存學會 2002 Restorative Dentistry & Endodontics Vol.27 No.5

Bacterial lipopolysaccharide (LPS) plays a major role in stimulating the synthesis and release of the principal osteoclast-activating cytokines , namely, interleukin 1 and tumor necrosis factor-α from immune cells, Although monocytes/macrophages are the main producers of these cytokines, recent evidence has indicated that polymorphonuclear leukocytes (PMN) have the ability to release IL-1 and TNF-α. Calcium hydroxide has been shown to be an effective medicament in root canal infectionsm, reducing the microbial titre within the canal. It has been proposed that the therapeutic effect of Ca(OH)_2 may also be the result of direct inactivation of LPS. The purpose of this study was to investigate whether treatment of Porphyromanas endodonatalis LPS with calcium hydroxide alters its biological action as neasured by human PMN secretion of IL-1 and TNF-α, and it was compared with Escherichia coli LPS. P.endodonatalis ATCC 35406 was cultured in anaerobic condition, and LPS was extracted using the hot-phenol water extraction method and purified. Purchased E. coli LPS was also purified . 100 ㎍/ml of each LPS in pyrogen free water were incubated with 25mg/ml Ca(OH)_2 at 37℃ for 7 days. The supernatants were subjected to ultrafiltration. And the isolates were lyophilized and weighed. PMNs were obtained from peripheral blood by centrifugation layered over Lymphoprep. The cells were resuspended (4 × 10^6 cells/ml) in RPMI 1640 followed by treatment with various concentrations of LPS (0, 0.1, 1, 10㎍/ml) for 24 hours at 37℃ in 5% CO_2 incubator. The supernatants of cells were collected and the levels of IL-1α, IL-1β and TNF-α were measured by enzyme-linked immunosorbent assay. The results were as follows; 1. The levels of IL-1α, IL-1β, TNF-α from PMN treated with each LPS were significantly higher than those released from unstimulated PMN of the control group (p<0.05). 2. The levels of all three cytokines released from PMN stimulated with each calcium hydroxide treated LPS were significantly lower than those released from PMN stimulated with each untreated LPS (p<0.05). while they were not significantly different from those released from unstimulated PMN of the control group (p>0.05). 3. The levels of secretion or all three cytokines were affected in a dose-dependent manner in PMN stimulated with each LPS (p<0.05), but not in PMN stimulated with each calcium hydroxide treated LPS (p>0.05). 4. The levels of all three cytokines released from PMN stimulated with P.endodontalis LPS were significantly lower than those released from PMN stimulated with E. coli LPS (p<0.05).

장치 및 미디어 관리를 통한 네트워크 기방 백업 및 복구

복경수,강태호,윤종현,유재수 충북대학교 컴퓨터정보통신 연구소 2005 컴퓨터정보통신연구 Vol.13 No.1

저장 매체의 대용량화가 가속화되면서 대용량의 데이터를 효과적으로 백업하기 위한 요구가 증가되고 있다. 본 논문에서는 네트워크 장치 및 미디어 관리를 통해 네트워크 기반 백업 및 복구를 지원하는 백업 소프트웨어를 설계하고 구현한다. 제안하는 백업 소프트웨어는 디스크 기반 백업을 지원하기 위해 NDMP 프로토콜을 확장한다. 제안하는 백업 소프트웨어는 전체 또는 부분 백업, 수동 또는 자동백업 기능을 제공한다. 또한, 사용자에 의해 요청되는 부가적인 작업을 처리하기 위해 pre/post 스크립트 기능을 제공한다. 제안하는 백업 소프트웨어는 백업 장치 및 미디어를 효과적으로 관리하고 이를 풀(pool)이라는 논리적인 단위로 관리하는 장치 및 미디어 관리 기능을 제공한다. As the size of storage media is growing, the efficient backup for the huge capacity data are required. In this paper, we design and implement the backup software that supports network based backup and restore with management of network devices and media. The proposed backup software extends NDMP protocol for the disk to disk backup. In addition, the proposed backup software has various features such as partial or full backup, immediate or automatic backup, and so on. It supports pre/post script to process additional actions for users. It also provides devices and medium management features that efficiently manages a large number of backup devices and media, and groups devices and media management functions that are managed by logical units called pools.

모래의 입도분포가 모르터의 물성에 미치는 영향에 관한 연구

김경원,김문희,김유진,안흥난,허태경,현철 경성대학교 공학기술연구소 2010 공학기술연구지 Vol.16 No.-

Fineness Modulus is a term used as an index to the fineness of sand. It is well - known that the modulus distribution of sand plays an important role in achieving the desired properties of mortar. The maximum size of sand is also important parameter in mortar. These parameters affect workability, strength and unitweight of mortar. In tills study, different sand gradings were used to investigate effects of fineness moduli of sand for examination about the workability, strength and unit weight characteristics of cement mortar. Two kinds of sands with various size distribution and three kinds of fine aggregates with the similar particle size distribution (Sieve No.16~30, No.30~50, No.50~100) were used. Water-cement ratio (W/C) of mortar mix was kept constant for all the trial mixes with sand of different fineness modulus. Major findings of tills study are: (a) Fine sand with the similar size distribution reduces the workability and unit weight of cement mortar. (b) The compressive strength of mortar is not sensitive to sand grading variations. (c) The compressive strengths at the age of 28 days range from 32.1 to 54.1 MPa. (d) The sand with standard modulus distribution has better positive effects on the properties of the mortar.

Sinomenine, an Alkaloid Derived from Sinomenium acutum Potentiates Pentobarbital-Induced Sleep Behaviors and Non-Rapid Eye Movement (NREM) Sleep in Rodents

Yoo, Jae Hyeon,Ha, Tae-Woo,Hong, Jin Tae,Oh, Ki-Wan The Korean Society of Applied Pharmacology 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.6

Sinomenium acutum has been long used in the preparations of traditional medicine in Japan, China and Korea for the treatment of various disorders including rheumatism, fever, pulmonary diseases and mood disorders. Recently, it was reported that Sinomenium acutum, has sedative and anxiolytic effects mediated by GABA-ergic systems. These experiments were performed to investigate whether sinomenine (SIN), an alkaloid derived from Sinomenium acutum enhances pentobarbital-induced sleep via ${\gamma}$-aminobutyric acid (GABA)-ergic systems, and modulates sleep architecture in mice. Oral administration of SIN (40 mg/kg) markedly reduced spontaneous locomotor activity, similar to diazepam (a benzodiazepine agonist) in mice. SIN shortened sleep latency, and increased total sleep time in a dose-dependent manner when co-administrated with pentobarbital (42 mg/kg, i.p.). SIN also increased the number of sleeping mice and total sleep time by concomitant administration with the sub-hypnotic dosage of pentobarbital (28 mg/kg, i.p.). SIN reduced the number of sleep-wake cycles, and increased total sleep time and non-rapid eye movement (NREM) sleep. In addition, SIN also increased chloride influx in the primary cultured hypothalamic neuronal cells. Furthermore, protein overexpression of glutamic acid decarboxylase ($GAD_{65/67}$) and $GABA_A$ receptor subunits by western blot were found, being activated by SIN. In conclusion, SIN augments pentobarbital-induced sleeping behaviors through $GABA_A$-ergic systems, and increased NREM sleep. It could be a candidate for the treatment of insomnia.

Deimmunization of a bacterial therapeutic enzyme

Tae Hyeon YOO 한국생물공학회 2011 한국생물공학회 학술대회 Vol.2011 No.10