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Associations of night shift status during pregnancy with birth outcomes
Se Jin Lee(Se Jin Lee),Chorong Kim(Chorong Kim),Eun Ju Lee(Eun Ju Lee),Myoung-Nam Lim(Myoung-Nam Lim),Jeeyoung Kim(Jeeyoung Kim),Sunghun Na(Sunghun Na),Woo Jin Kim(Woo Jin Kim),Ko-CHENS study group(Ko 한국환경보건학회 2022 한국환경보건학회 학술대회 자료집 Vol.2022 No.5
Kim Hyeok,Park Soon-Jung,Park Jae-Hyun,Lee Sunghun,Park Bong Woo,Lee Soon Min,Hwang Ji-Won,Kim Jin-Ju,Kang Byeongmin,Sim Woo-Sup,Kim Hyo-Jin,Jeon Seung Hwan,Kim Dong-Bin,Jang Jinah,Cho Dong-Woo,Moon S 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Since an impaired coronary blood supply following myocardial infarction (MI) negatively affects heart function, therapeutic neovascularization is considered one of the major therapeutic strategies for cell-based cardiac repair. Here, to more effectively achieve therapeutic neovascularization in ischemic hearts, we developed a dual stem cell approach for effective vascular regeneration by utilizing two distinct types of stem cells, CD31+-endothelial cells derived from human induced pluripotent stem cells (hiPSC-ECs) and engineered human mesenchymal stem cells that continuously secrete stromal derived factor-1α (SDF-eMSCs), to simultaneously promote natal vasculogenesis and angiogenesis, two core mechanisms of neovascularization. To induce more comprehensive vascular regeneration, we intramyocardially injected hiPSC-ECs to produce de novo vessels, possibly via vasculogenesis, and a 3D cardiac patch encapsulating SDF-eMSCs (SDF-eMSC-PA) to enhance angiogenesis through prolonged secretion of paracrine factors, including SDF-1α, was implanted into the epicardium of ischemic hearts. We verified that hiPSC-ECs directly contribute to de novo vessel formation in ischemic hearts, resulting in enhanced cardiac function. In addition, the concomitant implantation of SDF1α-eMSC-PAs substantially improved the survival, retention, and vasculogenic potential of hiPSC-ECs, ultimately achieving more comprehensive neovascularization in the MI hearts. Of note, the newly formed vessels through the dual stem cell approach were significantly larger and more functional than those formed by hiPSC-ECs alone. In conclusion, these results provide compelling evidence that our strategy for effective vascular regeneration can be an effective means to treat ischemic heart disease.
김재욱(Jaeuk Kim),김성훈(Sunghun Kim),이유정(Yujung Lee),전영주(Youngju Jeon),김근호(Keunho Kim),김종열(Jongyoel Kim) 한국한의학연구원 2009 한국한의학연구원논문집 Vol.15 No.2
Recently, there have been emerging research activities in classifying the Sasang constitution objectively by machine-based methods. The concordance rate of the classification by the pulse wave features was, however, only around 50% up to now. In this paper, we introduce a novel classification algorithm that can promote the accuracy substantially at the expense of the non-classifiable subgroup as a byproduct. For instance, with the pulse wave features alone, we show that female/male subject group in their 20s can be classified into the Sasang constitution group with the concordance rate of 68.4%/65.5% for a subgroup of 57/29(31%/15%) subjects out of 184/195, by leaving the other subjects as the non-classifiable group. Next, we show that the pulse diagnosis has been used only as a supportive tool in determining one's constitution, and consequently the accuracy of the concordance ratio by the pulse wave features alone cannot exceed a finite value, which we estimate to be about 60%.
Extremely Flexible Transparent Conducting Electrodes for Organic Devices
Jung, Sunghoon,Lee, Sunghun,Song, Myungkwan,Kim, Do-Geun,You, Dae Sung,Kim, Jong-Kuk,Kim, Chang Su,Kim, Tae-Min,Kim, Kwon-Hyeon,Kim, Jang-Joo,Kang, Jae-Wook Wiley Blackwell (John Wiley Sons) 2014 Advanced Energy Materials Vol.4 No.1
<P>Extremely flexible transparent conducting electrodes are developed using a combination of metal-embedding architecture into plastic substrate and ultrathin transparent electrodes, which leads to highly transparent (optical transmittance approximate to 93% at a wavelength of 550 nm), highly conducting (sheet resistance approximate to 13 Omega square(-1)), and extremely flexible (bending radius approximate to 200 mu m) electrodes. The electrodes are used to fabricate flexible organic solar cells and organic light-emitting diodes that exhibit performance similar or superior to that of devices fabricated on glass substrates. Moreover, the flexible devices do not show degradation in their performance even after being folded with a radius of approximate to 200 mu m.</P>
Kim, Taereem,Shin, Ju-Young,Kim, Sunghun,Heo, Jun-Haeng Elsevier 2018 Journal of hydrology Vol.557 No.-
<P><B>Abstract</B></P> <P>Climate indices characterize climate systems and may identify important indicators for long-term precipitation, which are driven by climate interactions in atmosphere-ocean circulation. In this study, we investigated the climate indices that are effective indicators of long-term precipitation in South Korea, and examined their relationships based on statistical methods. Monthly total precipitation was collected from a total of 60 meteorological stations, and they were decomposed by ensemble empirical mode decomposition (EEMD) to identify the inherent oscillating patterns or cycles. Cross-correlation analysis and stepwise variable selection were employed to select the significant climate indices at each station. The climate indices that affect the monthly precipitation in South Korea were identified based on the selection frequencies of the selected indices at all stations. The NINO12 indices with four- and ten-month lags and AMO index with no lag were identified as indicators of monthly precipitation in South Korea. Moreover, they indicate meaningful physical information (e.g. periodic oscillations and long-term trend) inherent in the monthly precipitation. The NINO12 indices with four- and ten- month lags was a strong indicator representing periodic oscillations in monthly precipitation. In addition, the long-term trend of the monthly precipitation could be explained by the AMO index. A multiple linear regression model was constructed to investigate the influences of the identified climate indices on the prediction of monthly precipitation. Three identified climate indices successfully explained the monthly precipitation in the winter dry season. Compared to the monthly precipitation in coastal areas, the monthly precipitation in inland areas showed stronger correlation to the identified climate indices.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Inherent climate variability in monthly precipitation are decomposed by EEMD. </LI> <LI> Four- and ten-month lagged NINO12 indices represent the periodic oscillations. </LI> <LI> Behavior of AMO index indicates inherent long-term trend of monthly precipitation. </LI> <LI> Climate indices as predictive indicators to predict precipitation are suggested. </LI> <LI> Statistical relationships are examined by a multiple linear regression model. </LI> </UL> </P>
An Inductive 2-D Position Detection IC With 99.8% Accuracy for Automotive EMR Gear Control System
Kim, SangYun,Abbasizadeh, Hamed,Ali, Imran,Kim, Hongjin,Cho, SungHun,Pu, YoungGun,Yoo, Sang-Sun,Lee, Minjae,Hwang, Keum Cheol,Yang, Youngoo,Lee, Kang-Yoon IEEE 2017 IEEE transactions on very large scale integration Vol.25 No.5
<P>In this paper, the analog front end (AFE) for an inductive position sensor in an automotive electromagnetic resonance gear control applications is presented. To improve the position detection accuracy, a coil driver with an automatic two-step impedance calibration is proposed which, despite the load variation, provides the desired driving capability by controlling the main driver size. Also, a time shared analog-todigital converter (ADC) is proposed to convert eight-phase signals while reducing the current consumption and area to 1/8 of the conventional structure. A relaxation oscillator with temperature compensation is proposed to generate a constant clock frequency in vehicle temperature conditions. This chip is fabricated using a 0.18-mu m CMOS process and the die area is 2 mm x 1.5 mm. The power consumption of the AFE is 23.1 mW from the supply voltage of 3.3 V to drive one transmitter (Tx) coil and eight receiver (Rx) coils. The measured position detection accuracy is greater than 99.8 %. The measurement of the Tx shows a driving capability higher than 35 mA with respect to the load change.</P>
Kim, Hye Jin,Choi, Sunghun,Lee, Seung Jong,Seo, Myung Won,Lee, Jae Goo,Deniz, Erhan,Lee, Yong Ju,Kim, Eun Kyung,Choi, Jang Wook American Chemical Society 2016 Nano letters Vol.16 No.1
<P>Despite the recent considerable progress, the reversibility and cycle life of silicon anodes in lithium-ion batteries are yet to be improved further to meet the commercial standards. The current major industry, instead, adopts silicon monoxide (SiOx, x approximate to 11), as this phase can accommodate the volume change of embedded Si nanodomains via the silicon oxide matrix. However, the poor Coulombic efficiencies (CEs) in the early period of cycling limit the content of SiOx, usually below 10 wt % in a composite electrode with graphite. Here, we introduce a scalable but delicate prelithiation scheme based on electrical shorting with lithium metal foil. The accurate shorting time and voltage monitoring allow a fine-tuning on the degree of prelithiation without lithium plating, to a level that the CEs in the first three cycles reach 94.9%, 95.7%, and 97.2%. The excellent reversibility enables robust full-cell operations in pairing with an emerging nickel-rich layered cathode, Li[Ni0.8Co0.15Al0.05] O-2, even at a commercial level of initial areal capacity of 2.4 mAh cm(-2), leading to a full cell energy density 1.5-times as high as that of graphite-LiCoO2 counterpart in terms of the active material weight.</P>