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UPS Applying Big Data Analytics to Logistics:
Sung-Hee “Sunny” Park,Do-Hong Kim 한국경영정보학회 2014 한국경영정보학회 학술대회논문집 Vol.2014 No.1
Managing big data has become increasingly important to businesses as big data analytics can transform big data into insightful information. But, not many companies utilize it efficiently and effectively. While many companies in the transportation industry are facing many challenges with big data, United Parcel Service (UPS) is successfully applying big data analytics to logistics. UPS’s proprietary routing software, called ORION (On-Road Integrated Optimization and Navigation), uses package-level detail and customized online map data to provide drivers with optimized routing information. In 2013, ORION resulted in reductions of more than 1.5 million gallons of fuel and 14,000 metric tons of CO2 emissions. This paper discusses UPS’s innovative path to optimization from data gathering to visualization.
Lee, Sunny,Joshi, Mahesh Kumar,Tiwari, Arjun Prasad,Maharjan, Bikendra,Kim, Kyung Suk,Yun, Yeo-Heung,Park, Chan Hee,Kim, Cheol Sang Elsevier 2018 Chemical engineering journal Vol.347 No.-
<P><B>Abstract</B></P> <P>Low-density, high porous bioactive fibrous scaffolds have attracted significant attention for tissue engineering. However, fabrication of biomimetic fibrous scaffolds having three-dimensional architecture along with bioactive materials still remains a challenging task for biomaterial scientists. Herein, for the first time, we developed a novel strategy to fabricate highly porous ß-tricalcium phosphate (ß-TCP) incorporated Poly (<SMALL>L</SMALL>-lactide) (PLLA) fibrous scaffold for bone tissue engineering. Blending of PLLA with its monomer, lactic acid (LA) produced the fluffy type highly porous nanofibrous mesh. The mass composition of the constituents of the blend solution was varied to control the morphology and packing of the nanofibers in the scaffold. The results showed that LA played the vital role in the generation of the 3D fluffy type fibrous mesh. ß-TCP particles were incorporated in the blend solution prior to the electrospinning solution, to fabricate ß-TCP incorporated PLLA fibrous scaffold. Later, LA was leached out by washing with distilled water, to avoid its adverse effect on biocompatibility. Digital and SEM images revealed the formation of spongy, low-density fibrous mesh. TEM images, IR, and TGA analysis confirmed the presence of ß-TCP nanoparticles in the nanofibers after leaching of LA. Incorporation of the ß-TCP enhanced the water uptake ability, <I>in vitro</I> bio-mineralization, and bioactivity of the fibrous scaffold. Confocal microscopy images showed that the pre-osteoblast cells seeded on the fluffy type fibrous mesh infiltrated throughout the depth of the scaffold, compared to no penetrating growth for the 2D scaffold. <I>In vitro</I> biocompatibility evaluated by CCK assay showed significantly higher growth for cells on the fluffy type scaffold, compared to the 2D scaffold. We demonstrated scaffolds suitability for biocompatibility and osteogenic differentiation of hMSCs as well. We believe that the fabrication of bioactive particle incorporated highly porous 3D fibrous scaffold will open a new avenue for tissue engineering applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> 3-Dimensional novel biofunctional fluffy-type fiber was reported. </LI> <LI> Lactic acid was found to have a key role for formation. </LI> <LI> Ratio of PLLA/LA determines packing and morphology of fiber. </LI> <LI> Fluffy type fibrous mesh greatly improved the swelling properties, biomimetic mineralization, cell infiltration and growth. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Kim, Sung Hee,Hur, Haeng Jeon,Yang, Hye Jeong,Kim, Hyun Jin,Kim, Min Jung,Park, Jae Ho,Sung, Mi Jeong,Kim, Myung Sunny,Kwon, Dae Young,Hwang, Jin-Taek Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P>The antidiabetic effect of the <I>Citrus junos</I> Tanaka (also known as yuja or yuzu) was examined. Ethanol extract of yuja peel (YPEE) significantly stimulated 2-[<I>N</I>-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose (2-NBDG) uptake in C2C12 myotubes. However, ethanol extract of yuja pulp (YpEE) and water extract of yuja peel (YPWE) or pulp (YpWE) did not stimulate glucose uptake. In addition, peroxisome proliferator-activated receptor gamma (PPAR-<I>γ</I>) and AMP-activated protein kinase (AMPK) activities were increased by YPEE in a dose-dependent manner. Pretreatment of AMPK inhibitor decreased the glucose uptake stimulated by YPEE in C2C12 myotubes. We confirmed the anti-diabetic effect of YPEE in mice fed a high fat-diet (HFD). Compared with control mice on a normal diet (ND), these mice showed increased body weight, liver fat, insulin resistance, triacylglycerol (TG), and total cholesterol content. Addition of 5% YPEE significantly reduced the weight gain and rise in liver fat content, serum triacylglycerol (TG), total cholesterol, and insulin resistance found in mice fed a high-fat diet (HFD). Moreover, YPEE reduced the secretion of HFD-induced adipocytokines such as leptin and resistin. YPEE also resulted in increased phosphorylation of AMPK in muscle tissues. These results suggest that ethanol extract of yuja peel exerts anti-diabetic effects via AMPK and PPAR-<I>γ</I> in both cell culture and mouse models.</P>
Kim, Myung-Sunny,Kim, Soon-Hee,Park, Su-Jin,Sung, Mi Jung,Park, Jaeho,Hwang, Jin-Taek,Yang, Hye Jeong,Kim, Sunmi,Seo, Daebang,Shin, Song Seok,Hur, Haeng Jeon Elsevier 2017 Journal of Functional Foods Vol.35 No.-
<P><B>Abstract</B></P> <P>This study investigated the effect and the underlying mechanism of ginseng berry (GB) in a mouse model of type 2 diabetes, supplied with 0.05% or 0.1% dietary GB for 12weeks. GB significantly improved hyperglycemia and insulin resistance, as demonstrated by the blood glucose and insulin levels, HOMA-IR, and GTT. Moreover, the expression of gluconeogenic genes such as PEPCK and G6Pase and the hepatic metabolites involved in the pathway of gluconeogenesis, such as glucose-6-phosphate and dihydroxyacetone phosphate, were significantly reduced by GB. Hepatic steatosis was also significantly ameliorated; TG content and expression of lipogenic enzymes and transcriptional factors such as FAS, ACC, and SREBP1 were reduced by GB. Simultaneously, AMPK phosphorylation was increased both in fatty liver and in lipid-accumulated HepG2 cells by GB. In conclusion, GB improved hyperglycemia by downregulating hepatic glucose production and hepatic steatosis, and AMPK appeared to be an important regulator of these effects.</P> <P><B>Highlights</B></P> <P> <UL> <LI> GB significantly improves obesity-induced hyperglycemia and insulin resistance. </LI> <LI> Anti-diabetic effects of ginseng berry is mediated by downregulating hepatic glucose production and hepatic steatosis. </LI> <LI> AMPK may be an important contributing regulator in the GB-mediated suppression of hepatic glucose production. </LI> </UL> </P>
Kim, Do-Sung,Kwon, Dae-Young,Kim, Myung-Sunny,Kim, Hye Kyung,Lee, Yong Chul,Park, Seong Ju,Yoo, Wan Hee,Chae, Soo-Wan,Chung, Myoung-Ja,Kim, Hyung-Ryong,Chae, Han-Jung Pharmaceutical Society of Great Britain 2010 Journal of pharmacy and pharmacology Vol.62 No.2
<P>Objectives We have investigated whether endoplasmic reticulum stress and Bcl-2 proteins were linked to the protective effect exerted by flavonoids on ischaemia/reperfusion-induced cardiac damage. Methods Cell viability and immunoblotting were performed. Key findings H9c2 cardiac muscle cells were exposed to flavonoids such as biochanin A, daidzein, genistein, luteolin, quercetin and rutin, followed by ischaemia 12 h/reperfusion 4 h. The flavonoids protected against cell death induced by ischaemia/reperfusion. Flavonoid treatment significantly increased the expression level of the anti-apoptotic protein, Bcl-2, but decreased that of the proapoptotic protein, Bax. The flavonoids down-regulated the expression levels of endoplasmic reticulum stress proteins, glucose-regulated protein-78, activating transcription factor 6alpha, X-box binding protein 1, inositol-requiring protein-1, phosphor-eukaryotic initiation factor 2alpha, and C/EBP-homologous protein. Conclusions This study suggested that the protective mechanisms of flavonoids included regulation of Bcl-2/Bax proteins as well as the endoplasmic reticulum stress proteins.</P>
외상 후 스트레스 장애 동반 여부에 따른 정신분열병 환자의 임상증상과 치료효과의 비교 : 1년간의 전향적 추적연구
박성종,김남희,정재열,이선이,Park, Sung-Jong,Kim, Nam Hee,Jeong, Jae-Yeol,Lee, Sunny 대한생물정신의학회 2009 생물정신의학 Vol.16 No.4
Objectives : The aims of this study were to assess a) the prevalence of trauma and posttraumatic stress disorder(PTSD) in schizophrenic patients and b) the differences in symptomatology and outcome after 1year treatment between those with and without PTSD. Methods : Twenty eight schizophrenia and schizoaffective disorder patients completed the Positive and Negative Syndrome Scale(PANSS), Life Stressor Checklist-Revised(LSCL-R), Clinician-Administered PTSD Scale(CAPS), Dissociative Experiences Scale(DES), Hamilton Psychiatry Rating Scale for Depression(HAM-D), and Rosenberg Self-Esteem Scale(RSE). Results : Twenty six patients(92.9%) had at least one trauma in their life time. Eleven patients(39.3%) were diagnosed with PTSD. PTSD group had significantly higher scores on HAM-D and DES but lower scores on RSE. PTSD group also had significantly lower score in the baseline PANSS Negative score. Higher CAPS scores were significantly correlated with lower baseline PANSS Negative score and greater change after 1year of PANSS Negative score. Conclusion : These results showed that the prevalences of trauma and PTSD are high in schizophrenic patients and suggested that PTSD and trauma-related symptoms affected the symptomatology and treatment outcome. More research is warranted to better understand the effects of PTSD in schizophrenic patients.