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신부전이 동반된 당뇨병 환자에서 발생된 침습성 모균증 : 수술과 Liposomal amphotericin B 및 GM-CSF 병합 요법에 의한 성공적인 치험 1예
이원영,오기원,임국희,장재혁,이동건,최정현,강무일,신완식,차봉연,이광우,손호영,강성구 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.4
저자들은 신부전이 동반된 당뇨병 환자에서 발생된 부비동형 모균증에 대하여 수술과 함께 liposomal amphotericin B 및 GM-CSF의 복합치료를 하여 성공적으로 치료한 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Mucormycosis (zygomycosis) primarily affects diabetic or immunocompromised patients and typically progresses rapidly, necessitating surgical excision and antifungal therapy with amphotericin B. Large doses of amphotericin B are needed for cure, but it has the risk of causing significant renal toxicity. The recent development of liposomal amphotericin B allows antifungal therapy to be administered with potentially improved efficacy and reduced nephrotoxicity. We have experienced a case of paranasal mucormycosis successfully treated with surgery, liposomal amphotericin B and GM-CSF. A 59-year-old male suffering from diabetes mellitus for 6 years was admitted with pain at left maxillary area. He was diagnosed as mucormycosis after cytologic exam on the necrotic nasal mucosa, which showed typical hyphae. He have had diabetic nephropathy with macroproteinuria and had rapidly rising serum creatinine levels with the amphotericin B treatment: creatinine levels reverted to basal level with the use of liposomal amphotericin B. Despite surgical excision and continued antifungal therapy, his infection was not effectively controlled. Therefore, GM-CSF was administered additionally to improve phagocytic activity of leukocytes. He was finally cured after receiving a combination of aggressive surgery, liposomal amphotericin B and GM-CSF. To our knowledge, this is the first detailed clinical description of the treatment of mucormycosis with liposomal amphotericin B in Korea.
Son, Ho Sung,Shin, Yeon Myung,Park, Kwang Kuk,Seo, Kyung Won,Yoon, Ki Young,Jang, Hee Kyung,Lee, Sang-Ho,Yang, Song I,Kim, Jeong Hoon The Korean Gastric Cancer Association 2014 Journal of gastric cancer Vol.14 No.3
Purpose: At present, a human epidermal growth factor receptor 2 (HER2)-based concept of tumor biology has been established, and trastuzumab ($Herceptin^{(R)}$; Genentech/Roche, San Francisco, CA, USA), a monoclonal humanized antibody directed against HER2, is a pivotal agent for the management of HER2 positive (HER2+) metastatic breast cancer. It is also known that HER2 has a predictive value in gastric cancer; however, its association with the prognosis of this disease remains uncertain. The purpose of this study was to evaluate both the relationship between HER2 overexpression in the tumors of gastric cancer patients, and the prognosis of these patients who have had curative resection. Materials and Methods: A total of 139 consecutive patients with gastric cancer who underwent surgery at the Kosin University Gospel Hospital between October 2011 and March 2012 were included in this retrospective study. All tumor samples were examined for HER2 expression by immunohistochemistry. A retrospective review of the medical records was conducted to determine the correlation between the presence of HER2 overexpression and clinicopathological factors. Results: The HER2+ rate was 15.1%. HER2 overexpression was associated with histological grade (P=0.044) and Lauren classification (P=0.036). There was no significant difference in the 2-year overall survival between HER2+ and HER2- patients (P=0.396). Multivariate analysis showed that HER2 was not an independent prognostic factor. Conclusions: HER2 overexpression in tumors was associated with histological grade and Lauren classification in gastric cancer patients with curative resection. However, HER2 was not an independent prognostic factor for gastric cancer in our study.
Analysis of the Impact LEED-NC Criteria on Appraised Unit Land Value
Son, Kiyoung,Kim, Gwang-Hee,Park, Young Jun,Kim, Sun-Kuk The Korean Institute of Building Construction 2012 한국건축시공학회지 Vol.12 No.6
In recent years, LEED-NC (Leadership in Energy and Environmental Design for New Construction) has become one of the most widely adopted environmental certification systems in the United States. However, according to some researchers, the adoption of the LEED-NC is perceived to add to construction cost and duration compared to conventional building standards. Therefore, it is necessary to examine the economic benefits of LEED-NC to consider how it can be applied worldwide. This study focuses on the impact of LEED-NC on the appraised unit value of parcels in San Francisco County based on the number of LEED-NC Public Transportation Access (PTA) qualified buses, light rail and commuter rail stops, distance to the closest bus, light rail and commuter rail stops, zoning class and parcel size. As a population of interest, San Francisco County was chosen since it is known as a region with well-organized transportation systems including bus, light rail and commuter rail systems. According to the correlation results, this study shows that the appraised land value is significantly affected by LEED-NC PTA, and is correlated to a higher appraised unit value of land parcels.
Son Ji-Chang,Yeo Han-Kyeol,Kim Ji-Yeon,Lee Dong-Hee,Lim Dong-Kuk 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.1
In this paper, three-dimensional (3D) static fnite element analysis (S-FEA) is proposed to perform a conceptual design when the analysis target is 3D permanent magnet synchronous motor (PMSM) models, such as axial fux PMSM or radial fux PMSM with an overhang structure. As the proposed 3D S-FEA excludes the analysis of the other periodic cycles, and conducts the FEA only for the initial rotor position, calculation time could be drastically reduced. The superior performances of the 3D S-FEA were verifed by comparing the calculation time, torque at operating point, and memory usage of analysis result. The 3D S-FEA showed signifcantly reduced calculation time and memory usage, and acceptable analysis accuracy was obtained considering the calculation time reduction. Proposed method is expected to be efciently utilized in the early design stage of the PMSMs requiring 3D FEA.
Carbon nanotubes as cancer therapeutic carriers and mediators
Son, Kuk Hui,Hong, Jeong Hee,Lee, Jin Woo DOVE MEDICAL PRESS 2016 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.11 No.-
<P>Carbon nanotubes (CNTs) have received increasing attention in biomedical fields because of their unique structures and properties, including high aspect ratios, large surface areas, rich surface chemical functionalities, and size stability on the nanoscale. Particularly, they are attractive as carriers and mediators for cancer therapy. Through appropriate functionalization, CNTs have been used as nanocarriers for anticancer drugs including doxorubicin, camptothecin, carboplatin, cisplatin, paclitaxel, Pt(II), and Pt(IV), and genes including plasmid DNA, small-interfering RNA, oligonucleotides, and RNA/DNA aptamers. CNTs can also deliver proteins and immunotherapy components. Using combinations of light energy, they have also been applied as mediators for photothermal therapy and photodynamic therapy to directly destroy cancer cells without severely damaging normal tissue. If limitations such as a long-term cytotoxicity in the body, lack of size uniformity during the synthetic process, loading deviations for drug–CNT complexes, and release controllability at the target point are overcome, CNTs will become one of the strongest tools that are available for various other biomedical fields as well as for cancer therapy.</P>
Anti-cancer effect of fenbendazole- incorporated PLGA nanoparticles in ovarian cancer
Chi-Son Chang,Ji-Yoon Ryu,June-Kuk Choi,Young-Jae Cho,Jung-Joo Choi,Jae Ryoung Hwang,Ju-Yeon Choi,Joseph J. Noh,Chan Mi Lee,Ji Eun Won,Hee Dong Han,Jeong-Won Lee 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.5
Objective: Fenbendazole (FZ) has potential anti-cancer effects, but its poor water solubility limits its use for cancer therapy. In this study, we investigated the anti-cancer effect of FZ with different drug delivery methods on epithelial ovarian cancer (EOC) in both in vitro and in vivo models. Methods: EOC cell lines were treated with FZ and cell proliferation was assessed. The effect of FZ on tumor growth in cell line xenograft mouse model of EOC was examined according to the delivery route, including oral and intraperitoneal administration. To improve the systemic delivery of FZ by converting fat-soluble drugs to hydrophilic, we prepared FZ-encapsulated poly(D,L-lactide-co-glycolide) acid (PLGA) nanoparticles (FZ-PLGA-NPs). We investigated the preclinical efficacy of FZ-PLGA-NPs by analyzing cell proliferation, apoptosis, and in vivo models including cell lines and patient-derived xenograft (PDX) of EOC. Results: FZ significantly decreased cell proliferation of both chemosensitive and chemoresistant EOC cells. However, in cell line xenograft mouse models, there was no effect of oral FZ treatment on tumor reduction. When administered intraperitoneally, FZ was not absorbed but aggregated in the intraperitoneal space. We synthesized FZ-PLGA-NPs to obtain water solubility and enhance drug absorption. FZ-PLGA-NPs significantly decreased cell proliferation in EOC cell lines. Intravenous injection of FZ-PLGA-NP in xenograft mouse models with HeyA8 and HeyA8-MDR significantly reduced tumor weight compared to the control group. FZ-PLGA-NPs showed anti-cancer effects in PDX model as well. Conclusion: FZ-incorporated PLGA nanoparticles exerted significant anti-cancer effects in EOC cells and xenograft models including PDX. These results warrant further investigation in clinical trials.