The causal association between sarcopenia and colorectal cancer: a Mendelian Randomization analysis

( Shu Ran ),( Min-fei Zhao ),( Bao-lin Liu ) 대한내과학회 2023 The Korean Journal of Internal Medicine Vol.38 No.2

Fatty Acid Binding Protein 5 (FABP5) Promotes Aggressiveness of Gastric Cancer Through Modulation of Tumor Immunity

Shu Zhang,Mei-qing Qiu,Hui-jun Wang,Ya-fei Ju,Zhen Liu,Tao Wang,Shi-feng Kan,Zhen Yang,Ya-yun Cui,You-qiang Ke,Hong-min He,Li Sun 대한위암학회 2023 Journal of gastric cancer Vol.23 No.2

Purpose: Gastric cancer (GC) is the second most lethal cancer globally and is associated with poor prognosis. Fatty acid-binding proteins (FABPs) can regulate biological properties of carcinoma cells. FABP5 is overexpressed in many types of cancers; however, the role and mechanisms of action of FABP5 in GC remain unclear. In this study, we aimed to evaluate the clinical and biological functions of FABP5 in GC. Materials and Methods: We assessed FABP5 expression using immunohistochemical analysis in 79 patients with GC and evaluated its biological functions following in vitro and in vivo ectopic expression. FABP5 targets relevant to GC progression were determined using RNA sequencing (RNA-seq). Results: Elevated FABP5 expression was closely associated with poor outcomes, and ectopic expression of FABP5 promoted proliferation, invasion, migration, and carcinogenicity of GC cells, thus suggesting its potential tumor-promoting role in GC. Additionally, RNA-seq analysis indicated that FABP5 activates immune-related pathways, including cytokine-cytokine receptor interaction pathways, interleukin-17 signaling, and tumor necrosis factor signaling, suggesting an important rationale for the possible development of therapies that combine FABP5-targeted drugs with immunotherapeutics. Conclusions: These findings highlight the biological mechanisms and clinical implications of FABP5 in GC and suggest its potential as an adverse prognostic factor and/or therapeutic target.

Magnetism and Thermodynamic Properties of a Spin-1/2 Ferrimagnetic Diamond XY Chain in Magnetic Fields at Finite Temperatures

Tai-Min Cheng,Yan-Ming Ma,Chong-Yuan Ge,Shu-Sheng Sun,Wei-Ye Jia,Qing-Yun Li,Xiao-Fei Shi,Lin Li,Lin Zhu 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.1

The elementary excitation spectra of a one-dimensional ferrimagnetic diamond chain in the spin- 1/2 XY model at low temperatures have been calculated by using an invariant eigen-operator (IEO) method, the energies of elementary excitations in different specific cases are discussed, and the analytic solutions of three critical magnetic field intensities (<i>H</i>_C1, <i>H</i>_C2, and <i>H</i>_peak) are given. The magnetization versus external magnetic field curve displays a 1/3 magnetization plateau at low temperatures, in which <i>H</i>_C1 is the critical magnetic field intensity from the disappearance of the 1/3 magnetization plateau to spin-flop states, <i>H</i>_C2 is the critical magnetic field intensity from spin-flop states to the saturation magnetization, and Hpeak is the critical magnetic field intensity when the temperature magnetization shows a peak in the external magnetic field. The temperature dependences of the magnetic susceptibility and the specific heat show a double peak structure. The entropy and the magnetic susceptibility versus external magnetic field curves also exhibit a double peak structure, and the positions of the two peaks correspond to <i>H</i>_C1 and <i>H</i>_C2, respectively. This derives from the competition among different types of energies: the temperature-dependent thermal disorder energy, the potential energy of the spin magnetic moment, the ferromagnetic exchange interaction energy, and the anti-ferromagnetic exchange interaction energy. However at low temperatures, the specific heat as a function of external magnetic field curve exhibits minima at the above two critical points (<i>H</i>_C1 and <i>H</i><sub>C2<sub>). The origins of the above phenomena are discussed in detail.

Memory Event-triggered Sliding Mode Control for UAV Formation Under Communication Delay and Wake Interferences

Ming-Fei Ji,Tao Li,Shu-Min Fei,Xian-Lin Zhao 제어·로봇·시스템학회 2024 International Journal of Control, Automation, and Vol.22 No.3

This paper studies the formation control for unmanned aerial vehicles (UAVs) under communicationdelay and wake disturbances, in which the inner-loop and outer-loop control strategy is adopted. Firstly, as for thedynamical models of follower UAVs, the wake interferences are considered and their influences are respectivelyestimated by using the sliding model disturbance observers (SMDOs). Secondly, since the outer-loop informationin the UAVs exchanges via communication network, by adding an internal dynamic variable, an adaptive memorybased event-triggered mechanism (METM) is proposed to alleviate transmission burden with maintaining idealcontrol performance. Thirdly, by using the designed METM and an intermediate vector, a sliding mode controller isderived to accomplish the desired control target, which can compensate the communication delay in control input. Fourthly, as for the overall closed-loop system, a sufficient condition on asymptotical stability is established and aco-design method of checking the triggering parameters and controller gains is expressed in term of linear matrixinequalities (LMIs). Moreover, in order to tackle the wake interferences of the inner-loop, an adaptive attitudetracking controller is put forward to ensure the bounded stability of tracking errors by solving the reference signal. Finally, a simulated example is exploited to illustrate the validity of the proposed scheme.

Compatibility effects of ginseng and Ligustrum lucidum Ait herb pair on hematopoietic recovery in mice with cyclophosphamide-induced myelosuppression and its material basis

Jiahong Han,Min Dai,Yan Zhao,Enbo Cai,Lianxue Zhang,Xiaohuan Jia,Nian Sun,Xuan Fei,Hui Shu 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.2

Background: Ginseng (G) and Ligustrum lucidum Ait (LLA) are core traditional Chinese medicines intreating myelosuppression formula. The present study was designed to profile effect of G and LLA herbpair (G-LLA) on myelosuppressed mice. Methods: The mice myelosuppression model was established by intraperitoneal (i.p.) injection ofcyclophosphamide (Cy). Hematopoietic function of bone marrow was measured by hemopoietic progenitorcell culture and peripheral blood count, and serum hemopoietic factors were tested by enzymelinkedimmunosorbent assay. Bone marrow cell cycle was performed by flow cytometry. HPLC was usedto measure 20 potential chemical components related to myelosuppression, including ginsenoside Rg1,Re, Rb1, Rc, Rb2, Rb3, Rd, Rk3, Rh4, 20 (S)-Rg3, 20 (R)-Rg3, Rk1, Rg5, salidroside, and so on. Results: G, LLA, and G-LLA improved the amount of peripheral blood cells and bone marrow cellsof myelosuppressed mice (P < 0.01). They significantly increased the colony quantity of colony-formingunitegranulocyte macrophage, burst-forming unit erythroid, colony-forming unit erythroid, and colony-forming unit megakaryocyte and amount of G2/M and S phase cells (P < 0.01). They also significantlydecreased the amount of hematopoiesis-related cytokines (P < 0.01). The content of chemicalcomponents in G-LLA changed, and the change of rare saponin was the most obvious. Conclusion: These results show that G-LLA herb pair might produce synergistic or complementarycompatibility effects on bone marrow suppression after chemotherapy. It suggests that the substancebasis of G-LLA for treating bone marrow suppression may be effective chemical components.

IRS-2 Partially Compensates for the Insulin Signal Defects in IRS-1−/−Mice Mediated by miR-33

Chen-Yi Tang,Xiao-Fei Man,Yue Guo,Hao-Neng Tang,Jun Tang,Ci-La Zhou,Shu-Wen Tan,Min Wang,Hou-De Zhou 한국분자세포생물학회 2017 Molecules and cells Vol.40 No.2

Insulin signaling is coordinated by insulin receptor substrates (IRSs). Many insulin responses, especially for blood glucose metabolism, are mediated primarily through Irs-1 and Irs-2. Irs-1 knockout mice show growth retardation and insulin signaling defects, which can be compensated by other IRSs in vivo; however, the underlying mechanism is not clear. Here, we presented an Irs-1 truncated mutated mouse (Irs-1−/−) with growth retardation and subcutaneous adipocyte atrophy. Irs-1−/− mice exhibited mild insulin resistance, as demonstrat-ed by the insulin tolerance test. Phosphatidylino-sitol 3-kinase (PI3K) activity and phosphorylated Protein Kinase B (PKB/AKT) expression were elevated in liver, skeletal muscle, and subcu-taneous adipocytes in Irs-1 deficiency. In addition, the expression of IRS-2 and its phosphorylated version were clearly elevated in liver and skeletal muscle. With miRNA microarray analysis, we found miR-33 was down-regulated in bone marrow stromal cells (BMSCs) of Irs-1−/− mice, while its target gene Irs-2 was up-regulated in vitro studies. In addition, miR-33 was down-regulated in the presence of Irs-1 and which was up-regulated in fasting status. What’s more, miR-33 restored its expression in re-feeding status. Meanwhile, miR-33 levels decreased and Irs-2 levels increased in liver, skeletal muscle, and subcutaneous adipocytes of Irs-1−/− mice. In primary cultured liver cells transfected with an miR-33 inhibitor, the expression of IRS-2, PI3K, and phosphorylated-AKT (p-AKT) increased while the opposite results were observed in the presence of an miR-33 mimic. Therefore, decreased miR-33 levels can up-regulate IRS-2 expression, which appears to compensate for the defects of the insulin signaling pathway in Irs-1 deficient mice.

Compatibility effects of ginseng and Ligustrum lucidum Ait herb pair on hematopoietic recovery in mice with cyclophosphamide-induced myelosuppression and its material basis

Han, Jiahong,Dai, Min,Zhao, Yan,Cai, Enbo,Zhang, Lianxue,Jia, Xiaohuan,Sun, Nian,Fei, Xuan,Shu, Hui The Korean Society of Ginseng 2020 Journal of Ginseng Research Vol.44 No.2

Background: Ginseng (G) and Ligustrum lucidum Ait (LLA) are core traditional Chinese medicines in treating myelosuppression formula. The present study was designed to profile effect of G and LLA herb pair (G-LLA) on myelosuppressed mice. Methods: The mice myelosuppression model was established by intraperitoneal (i.p.) injection of cyclophosphamide (Cy). Hematopoietic function of bone marrow was measured by hemopoietic progenitor cell culture and peripheral blood count, and serum hemopoietic factors were tested by enzyme-linked immunosorbent assay. Bone marrow cell cycle was performed by flow cytometry. HPLC was used to measure 20 potential chemical components related to myelosuppression, including ginsenoside Rg₁, Re, Rb₁, Rc, Rb₂, Rb₃, Rd, Rk₃, Rh₄, 20 (S)-Rg₃, 20 (R)-Rg₃, Rk₁, Rg₅, salidroside, and so on. Results: G, LLA, and G-LLA improved the amount of peripheral blood cells and bone marrow cells of myelosuppressed mice (P < 0.01). They significantly increased the colony quantity of colony-forming unit-granulocyte macrophage, burst-forming unit-erythroid, colony-forming unit-erythroid, and colony-forming unit-megakaryocyte and amount of G₂/M and S phase cells (P < 0.01). They also significantly decreased the amount of hematopoiesis-related cytokines (P < 0.01). The content of chemical components in G-LLA changed, and the change of rare saponin was the most obvious. Conclusion: These results show that G-LLA herb pair might produce synergistic or complementary compatibility effects on bone marrow suppression after chemotherapy. It suggests that the substance basis of G-LLA for treating bone marrow suppression may be effective chemical components.

Integrated Map-matching Algorithm Based on Fuzzy Logic and Dead Reckoning

Yan-Lan Yang,Hua Ye,Shu-Min Fei 제어로봇시스템학회 2010 제어로봇시스템학회 국제학술대회 논문집 Vol.2010 No.10

Based on the concept of fuzzy logic, a new map-matching algorithm was proposed to reduce the GPS positioning error by means of position correction in use of the digital map. Firstly, three fuzzy rules are introduced in different aspects which may influent the credibility judgment of the best matching road. And the corresponding membership functions are defined in details separately for sub-evaluations of the direction consistency, the proximity and the track similarity against the original GPS position and its candidate road, where dead reckoning technique is referred. Secondly, the comprehensive evaluation performing as the unique basis for final judgment is made by doing simple addition of the results of these sub-evaluations with certain weights according to their contributions towards the credibility judgment. Finally, the original GPS position is revised by making a vertical projection onto the best matching road. Experimental results demonstrate the effectiveness and applicability of this algorithm in improving the GPS positioning accuracy.

New Delay-range-dependent Exponential Estimates for Singular Systems with Time-varying Delay

Jin-Xing Lin,Xian-Lin Zhao,Shu-Min Fei 제어·로봇·시스템학회 2011 International Journal of Control, Automation, and Vol.9 No.2

This paper considers the problem of exponential stability for continuous-time singular systems with in-terval time-varying delay. By defining a novel Lyapunov-Krasovskii function and giving a tighter up-per bound of its derivative, a new delay-range-dependent exponential admissibility criterion, which not only guarantees the regularity, absence of impulses and exponential stability of the system but also gives the estimates of decay rate and decay coefficient, is established in terms of linear matrix inequality (LMI). The resulting criterion has advantages over the result previously reported by Haidar et al. [17] in that it involves fewer matrix variables but has less conservatism, which is established theoretically. Examples are provided to demonstrate the advantage of the proposed criterion.

Stability and Controller Design of Discrete-time Switched Systems Based on Transferring-dependent Lyapunov Function Approach

Fu-Peng Li,Rui-Hua Wang,Shu-Min Fei 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.4

This paper studies stability and controller design for discrete-time switched systems with unstable subsystems under the slow/fast admissible edge-dependent average dwell time (AED-ADT) switching. Different from the previous research results, it is the first time to propose transferring-dependent convex Lyapunov function (CLF) and transferring-dependent Lyapunov function (LF). Then, considering a slow/fast AED-ADT switching scheme, some excellent stability criteria are established according to transferring-dependent CLF and transferring-dependent LF, which have less restrictiveness compared with existing results. Corresponding to the novel transferring-dependent LFs and the properties of slow/fast AED-ADT switching, the new transferring-dependent convex controller (TDCC) and transferring-dependent ordinary controller (TD-OC) are devised to stabilize the underlying system. Finally, the effectiveness of the proposed approach is verified by two numerical examples.