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Triamcinolone Acetonide가 배양 켈로이드 섬유아세포의 G1 세포주기 관련 유전자 발현에 미치는 영향
설정현,우상현,백원기,서성일,서민호 大韓成形外科學會 1998 Archives of Plastic Surgery Vol.25 No.2
The effect of triamcinolone acetonide(TA) on the expression of Gl related genes was investigated the cultured keloid fibroblast. The addition of TA to the culture medium resulted in growth inhibition of keloid fibroblast. TA reduced the expression of cyclin A, B, E and cyclin dependent kinase(CDK) 2 mRNA, but unexpectedly, the expression of cyclin C, Dl and CDK4 mRAN was not affected significantly as compared with those of normal fibroblast. Expressions of p16, p21 and p27, the wellestabilished CDK-inhibitors, were also investigated. The level of p16 was not detected in both normal and keloid fibroblasts and the expression of p27 was significantly decreased in keloid fibroblast. The expression of p21 was dramatically increased in keloid fibroblast but not significantly changed in normal fibroblast. Also the expressions of p53 and pRb, the well known tumor suppressor genes, were increased by the addition of TA. These data suggested that the observed growth inhibitory effect of TA may be related to transcriptional inactivation of cyclin A, B, E and CDK2 and to the transcriptional activation of p21, but the mechanisms of unchanged expression of cyclin C, Dl and CDK4 mRNA remain to be elucidated.
Baek, Ye-Seul,Jung, Jae-Ho,Min, Gi-Sik The Korean Society of Systematic Zoology 2011 Korean Journal of Systematic Zoology Special Issue Vol.27 No.3
The morphology of the two marine urostyloid ciliates, Pseudokeronopsis carnea (Cohn, 1866) and Uroleptopsis citrina Kahl, 1932, in the family Pseudokeronopsidae, collected from the Yellow Sea, and the East Sea, Korea, respectively, were studied using live observation and protargol impregnation. Additionally, the small subunit ribosomal RNA (SSU rRNA) gene was sequenced. These two species are firstly recorded in Korea. The main diagnostic key is as follows. Pseudokeronopsis carnea: body outline elongate-elliptical, brown-reddish or orange-red in colour in vivo; bicorona of 16-24 frontal cirri; one buccal and two frontoterminal cirri; 7-10 transverse cirri; 5-7 dorsal kineties; two types of cortical granules (one orange-red pigment, mainly grouped around cirri and dorsal bristles, arranged in typical rubra-pattern; the other, colourless and blood-cell-shaped, and densely distributed); contractile vacuole in the posterior half of the cell on the left side, usually in posterior 1/3-2/5. Uroleptopsis citrina: body outline elongate-elliptical, lemon-yellow in colour in vivo; two types of cortical granules (one yellow pigment; the other, blood-cell-shaped, densely distributed); bicorona of 12-18 frontal cirri; 2-3 frontoterminal cirri; two midventral rows comprising 26-35 cirri (consisting of anterior paired cirri, non-paired single cirri, and posterior paired cirri); three dorsal kineties. In addition, the SSU rRNA sequences of the two species were compared with public database of these species and consequently, showed high similarity.
Occurrence Patterns of Ramulus mikado in host plants
Seul-Ki Son,Cha Young Lee,Dong Gyu Min,Min Jeong Baek,Sun-Jae Park,Jong-Kook Jung 한국응용곤충학회 2023 한국응용곤충학회 학술대회논문집 Vol.2023 No.10
대벌레(Ramulus mikado)는 1990년 이후부터 2000년대 초반까지 경북을 중심으로 대발생을 하였던 돌발 해충 으로 2020~2023년에 수도권에서 대발생 사례가 다수 보고 되었다. 대벌레의 대발생 원인으로 기후변화가 지목되 고 있지만, 대벌레 개체군과 생물적·비생물적 환경 조건과의 관계를 이해하기 위한 연구는 매우 부족한 실정이 다. 본 연구에서는 주요 기주식물과 대벌레 발생 양상에 대한 관계를 이해하고자 수행하였다. 2022년부터 2023년 까지 대벌레 대발생 지역 중 하나인 청계산 일대 등산로를 따라 조사구를 선정한 뒤 주요 기주식물이자 우점종인 신갈나무, 아까시나무, 잔털벚나무를 대상으로 대벌레의 발생 밀도를 조사하였다. 그 결과, 조사지점 간의 대벌 레 평균 밀도는 유의한 차이가 발견되지 않았지만, 기주식물에 따른 밀도의 차이는 뚜렷하게 나타났다.
The reappraisal of the slide-swing skin flap: a versatile technique for surgical defects
( Seul-ki Lee ),( Min-soo Kim ),( Se-ha Park ),( Shin-young Song ),( Mihn-sook Jue ),( Joo Young Roh ),( Hee Joo Kim ),( Jin Ok Baek ),( Hyang-joon Park ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: The slide-swing skin flap is a combination of transposition and adjacent skin sliding and can be used to close large, round defects with a flap that is smaller than the primary defect to produce aesthetically good results. Objectives: To evaluate the efficacy and safety of the slide- swing skin flap for various surgical defects caused by skin tumor excisions. Methods: This retrospective case series, which includes 33 Asian patients between the ages of 25 and 86 years, describes the slide-swing skin flap after primary excision for malignant or premalignant skin conditions. The outcomes were assessed 12 weeks after surgery using the patient and observer scar assessment scale (POSAS). Results: Patients were 25 male and 8 female, and the causes of surgery were various malignant skin tumors including malignant melanoma, dermatofibrosarcoma protuberans, and malignant nodular hidradenoma. Tumors were on the lower limb in 11 patients, back in 9 patients, chest in 5 patients, face in 3 patients, buttock in 3 patients and 2 patients had tumors in other locations. The mean defect size was 3.5×3.1±1.9×2.2 cm. The mean patient POSAS total score was 9.7±3.0 and mean observer POSAS total score was 11.0±2.7. All flaps survived and postoperative recoveries were uneventful. Conclusion: The slide-swing skin flap is highly versatile and can be used to cover various surgical defects, irrespective of size and location, with excellent functional and cosmetic results.