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오상오,김창수,이종달 慶北大學校 1979 論文集 Vol.27 No.-
In the application of magnetic separation procedures, ferrite and δ-FeOOH particles are proposed as magnetic seeding materials to remove many metal ions from waste water. New style of high gradient magnetic separation apparatus were prepared and obtained with good efficiency for removing the heavy metal ion from waste water. A mechanism for removing the heavy metal from the waste water has heen proposed to substitute iron ion of ferrite or δ-FeOOH for the other metal ion.
용철순,이경희,최진석,박병주,정세현,김용일,박상만,배명수,김귀자,김영식,유창훈,강성룡,유봉규,이종달,최한곤 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1
To develop and aceclofenac soft capsule, four preparations with various solubilizers were prepared and their dissolution test was carried out. Among four preparations tested, a preparation with ethanolamine was selected a formula of aceclofenac soft capsule (Clanza S^(™), since it showed the fastest dissolution rate. Bioequivalence of aceclofenac tablet, Airtal^(™)(Dae-Woong Pharmaceutical Co., Ltd.) and aceclofenac soft capsule, Clanza S^(™)(Korea United Pharmaceutical Co., Ltd.) was evaluated according to the guideline of KFDA. Fourteen normal male volunteers (age 20-25 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After oral administration of one tablet or capsule containing 100 ㎎ of aceclofenac, blood ws taken at predetermined time intervals and the concentration of aceclofenac in plasma wa determined with an HPLC method under UV detector. The pharmacokinetic parameters (C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters using logarithmically transformed AUC_(t), C_(max) and T_(max) between Airtal tablet and Clanza soft capsule were 2.89%, 0.18% and 43.0%, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.250(e.g.log(0.81) - log(1.23) and log(0.89) - log(1.14)) for AUC_(t) and C_(max), respectively. Thus, the criteria of the KDFA guidelines for the equivalence was satisfied, indicating that Clanza S^(™) soft capsule is bioequivalent to Airtal^(™) tablet.
프레탈정 (실로스타졸 100mg)에 대한 실로스탄정 (한국유나이티드 제약)의 생물학적 동등성
용철순,이경희,최진석,박병주,정세현,김용일,박상만,유봉규,이종달,최한곤 한국병원약사회 2003 병원약사회지 Vol.20 No.2
Bioequivalence of one cilostazol tablets, the Pletaal^(R)(Korea Otsuka Pharmaceutical Co., Ltd.) and Cilostan^(R)(Korea united Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA. Sixteen normal male volunteers(age 20~30 years old)were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 100㎎ of cilostazol were orally administered, blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters(C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameter. The results showed that the differences in C_(max), T_(max) and AUC_(t) between one tablet were 16.08%, 18.88% and 17.57%, respectively. The powers (1-β) for C_(max), T_(max) and AUC_(t) were 85.03%, 83.92% and 80.12%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%, and confidence interval of all the parameters were also less than 20% at the significance level(α) of 0.05. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Cilostan^(R) tablet is bioequivalent to Pletaal^(R) tablet.
Leptin inhibits rosiglitazone-induced adipogenesis in murine primary adipocytes
Rhee, Sang Dal,Sung, Yoon-Young,Jung, Won Hoon,Cheon, Hyae Gyeong Elsevier 2008 Molecular and cellular endocrinology Vol.294 No.1
<P><B>Abstract</B></P><P>Leptin mainly acts on the hypothalamus in the brain, in which it regulates food intake and energy expenditure. However, the direct effects of leptin on adipocytes have been controversial in the cellular level. In this study, the effects of leptin on rosiglitazone-induced adipocyte differentiation were investigated in the primary preadipocytes prepared from subcutaneous fat tissues of C57BL/6-<I>Lep</I><SUP><I>ob/ob</I></SUP> mouse. We found that acute and prolonged treatment of leptin on preadipocytes inhibited the rosiglitazone-induced transcription factor expression and adipocyte differentiation, respectively, accompanied with decreased expression of PPARγ and aP2. Either PD98059, an ERK inhibitor or fludarabine, a STAT1 inhibitor restored leptin-inhibited PPARγ expression and subsequent lipid accumulation, but inhibitors for PI-3K (LY294002) and for STAT3 (piceatannol) did not. Furthermore, leptin decreased PPARγ expression also in fully differentiated adipocytes, which was reversed by either PD98059 or fludarabine. Taken together, these data suggest that leptin has a direct inhibitory effect on the rosiglitazone-induced adipocyte differentiation and PPARγ expression, in which ERK1/2 MAP kinase and JAK/STAT1 signaling pathways are involved.</P>
Sang Dal Rhee,Hee-Youn Kim,Won Hoon Jung,Ji Young Sohn,Min Soo Kho,Hyae Gyeong Cheon 한국실험동물학회 2009 Laboratory Animal Research Vol.25 No.4
The previously reported methods for genotyping Lep<SUP>ob</SUP> mice have shortcoming of either inconveniency or poor reproducibility. Therefore we improved up these protocols by adding the mismatched base pairs in the allele-specific primers for stable discrimination of single base pair mismatch and amplifying the polymerase chain reaction (PCR) product in one tube. This new simplified genotyping method results in higher reproducibility even with crudely prepared DNA. When the method was used to select heterozygotic breeders to produce obese mice, 256 pairs of the all 287 mating pairs produced obese offspring, providing 90% or greater genotyping efficiency. This method using PCR with mismatched allele specific primers is appropriate and efficient for genotyping a large number of Lep<SUP>ob</SUP> mutants.