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클라우드 기반의 실험실정보관리 시스템 구축 및 SaaS 제공 방안에 관한 연구
임복출 ( Bock-chool Lim ),류기상 ( Ki-sang Ryu ) 한국정보처리학회 2020 한국정보처리학회 학술대회논문집 Vol.27 No.1
실험실정보관리시스템(LIMS)은 실험실 데이터를 저장, 가공, 검색 그리고 분석하기 위한 중앙화된 데이터베이스로서 정유, 석유화학, 정밀화학, 제조업, 금속, 제철, 식품, 의약, 연구소, 보건환경, 검사소 등 다양한 분야에 말라하여 적용이 가능한 시스템이다. LIMS를 재고 관리, 임상 연구, 프로젝트 관리 및 환자 데이터 관리를 위한 강력한 IT도구하고 하면서 특히 의료 분야에서 환자 치료가 향상 되고 서비스 효율성이 높아질 것이라고 하고, 운영 비용의 절감이 가능하다. 확장성 및 비용절감과 핵심 기능을 위주로 제공하는 클라우드 및 웹 기반 솔루션의 발전으로 제4차 산업혁명의 핵심기술의 산증인의 분야로 기대가 된다.
Oral Toxicity Study and Skin Sensitization Test of a Cricket
Ryu, Hyeon Yeol,Lee, Somin,Ahn, Kyu Sup,Kim, Hye Jin,Lee, Sang Sik,Ko, Hyuk Ju,Lee, Jin Kyu,Cho, Myung-Haing,Ahn, Mi Young,Kim, Eun Mi,Lim, Jeong Ho,Song, Kyung Seuk Korean Society of ToxicologyKorea Environmental Mu 2016 Toxicological Research Vol.32 No.2
Crickets have been attracting considerable interest in the field of nutrition and toxicology due to the global exhaustion of food resulting from a growing population. The cricket is normally eaten in several countries after roasting, similar to the grasshopper; however, safety evaluation data on cricket powder is limited. Here, we performed general toxicity studies of cricket powder including a single, 2-week repeated dose range evaluation test, a 13-week repeated oral dose toxicity test in Sprague-Dawley rats, a single oral dose toxicity test in Beagle dogs, and a skin sensitization test in guinea pigs following the Organization for Economic Cooperation and Development test guidelines 406 and 408 in addition to Good Laboratory Practice. To investigate the NOAEL and target organs of cricket powder, Sprague-Dawley rats were allocated to 4 groups: vehicle control, 1,250 mg/kg, 2,500 mg/kg, 5,000 mg/kg dose test groups and cricket powder was administered over 13 weeks after single dose and dose range finding studies in rats based on the results of the single oral administration toxicity study in rats and Beagle dogs. The results of the study showed that the NOAEL of cricket powder was over 5,000 mg/kg for both sexes of rats without adverse effects in a 13-week repeated oral toxicity study and there was no skin hypersensitivity reaction. Therefore, our results reveal that crickets can be widely used as a new substitute food or nutrient resource.
Lim, Ji-Young,Ryu, Da-Bin,Park, Mi-Young,Lee, Sung-Eun,Park, Gyeongsin,Kim, Tai-Gyu,Min, Chang-Ki Elsevier 2018 BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION Vol.24 No.12
<P><B>Abstract</B></P> <P>Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells with anti-inflammatory activity, and expanded murine MDSCs are capable of attenuating preclinical acute graft-versus-host disease (aGVHD) severity. Two murine cGVHD models were used to evaluate the effectiveness of ex vivo cultured human cord blood (hCB) MDSCs in chronic GVHD (cGVHD). First, GVHD recipients surviving in a classic C57BL/6 into MHC-mismatched BALB/c aGVHD model developed cGVHD. Second, donor pretreatment with granulocyte colony-stimulating factor (G-CSF) induced cGVHD. hCB-MDSCs (1 × 10<SUP>6</SUP>) were intravenously injected to determine their preventive effects (on days 5, 7, 10, and 21) or therapeutic effects (on days 21, 28, and 35). In the first model the onset of clinical cutaneous cGVHD was significantly delayed in preventive hCB-MDSCs–treated allogeneic recipients. Pathologic scoring of target organs confirmed these clinical results. Importantly, thymic tissues of GVHD mice treated with hCB-MDSCs were less severely damaged, showing higher numbers of double (CD4 and CD8) positive T cells with reduced expansion of donor-type CD4 and CD8 T cells. Moreover, late infusion of hCB-MDSCs controlled the severity of established cGVHD that had occurred in control recipients. In the second model, cGVHD induced by G-CSF–mobilized stem cell graft was associated with promotion of Th 17 and Th 2 differentiation. hCB-MDSCs attenuated clinical and pathologic cGVHD severity. Increased production of IL-17 and more infiltration of T cells and macrophages in cGVHD mice were markedly reduced after hCB-MDSCs treatment. Importantly, Foxp3<SUP>+</SUP> regulatory T cells and IFN-γ–producing T cells were expanded, whereas IL-17– and IL-4–producing T cells were decreased in allogeneic recipients of hCB-MDSCs. Taken together, these results showed that hCB-MDSCs have preclinical capability of attenuating cGVHD by preserving thymus function and regulating Th 17 signaling, suggesting a possible therapeutic strategy for clinical application.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Human cord blood (hCB) can be a source of immunosuppressive MDSCs. </LI> <LI> Administration of hCB-MDSCs attenuates cGVHD in preclinical models. </LI> <LI> hCB-MDSCs reduce thymic damage with less donor-derived T cell expansion. </LI> <LI> cGVHD protection by hCB-MDSCs correlate with reversal of Th 17 skewing. </LI> <LI> hCB-MDSCs modulate helper T cell subset and expand FoxP3 Treg. </LI> </UL> </P>
Interpretation of the Basic and Effective Reproduction Number
Lim Jun-Sik,Cho Sung-il,Ryu Sukhyun,박선일 대한예방의학회 2020 Journal of Preventive Medicine and Public Health Vol.53 No.6
In epidemiology, the basic reproduction number (R0) is a term that describes the expected number of infections generated by 1 case in a susceptible population. At the beginning of the coronavirus disease 2019 (COVID-19) pandemic, R0 was frequently referenced by the public health community and the wider public. However, this metric is often misused or misinterpreted. Moreover, the complexity of the process of estimating R0 has caused difficulties for a substantial number of researchers. In this article, in order to increase the accessibility of this concept, we address several misconceptions related to the threshold characteristics of R0 and the effective reproduction number (Rt). Moreover, the appropriate interpretation of the metrics is discussed. R0 should be considered as a population-averaged value that pools the contact structure according to a stochastic transmission process. Furthermore, it is necessary to understand the unavoidable time lag for Rt due to the incubation period of the disease.