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정신분열병의 임상적 고위험군의 특징 : '서울청년클리닉'의 자연 추적 관찰 예비연구
유소영,이경진,강도형,이승재,하태현,위휘,이애라,송지연,김성년,권준수 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.1
Objectives : The aims of this study were to identify the intake and following process for subjects at high risk of transition to schizophrenia and to examine the neurocognitive, social, and emotional functions of the subjects compared with healthy controls. Methods : Symptomatic individuals judged at high risk for schizophrenia ('clinical high risk') within Youth Clinic were assessed and followed up. They performed a neurocognitive function test, a social function test and an affective function test. Twenty healthy controls were recruited in this study. Results : Among eighty-two subjects contacted through the Youth clinic, sixteen subjects were judged as the clinical high risk group. Fourteen subjects among the clinical high risk group showed deficits in several domains of neurocognitive functions, such as visual recall memory, verbal short term memory and executive function. Social and affective functions are also impaired in the Cli-nical high risk group compared with healthy controls. Two of 15 subjects (13%) developed a psychotic disorder within 6 months. Conclusion : This study illustrates the state of follow-up study for a clinical high risk group. Despite low numbers and short durations, some impairment of several functions in the clinical high risk group suggests possible predictors of psychosis.
Chiral Cu(Ⅱ)착화합물과 촉매로 유도된 Carbenoid반응에 의한 2-phenylcyclopropane-carboxylic acid의 광화학 이성체의 합성
조남숙,신대현,이종철,나도영 충남대학교 1985 忠南科學硏究誌 Vol.12 No.2
(-)-(IR, 2R)-trans-menthyl-2-phenylcyclopropanecarboxylate has been synthesized with aid of chiral Cu(Ⅱ) complex catalyst by the addition reaction of menthyldiazoacetate to the styrene. The yield was 80%, the purity of trans-compound over 90% and optical purity 75%. These results show the possibility of synthesis of (-)-(IR, 2R)-trans-2-phenylcyclopropane-carboxylic acid with high purities of optical activity and geometric specificity.
Acylation of 5-Amino-3H-1,3,4-Thiadiazolin-2-one
Ra, Do-Young,Cho, Nam-Sook,Cho, Jae-Joo 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1
Acylation of 5-amino-3H-l,3,4-thiadiazolin-2-one (2) was undertaken selectively at either the 3-NH position or at 5-amino group depending on reaction conditions. The 3-NH is highly acidic and acylation takes place with acid anhydrides at this position in high yields in the presence of pyridine or triethylamine. The diacylation of both the 3-position and the 5-amino group was only possible via the 5-amino-3-acyl-l,3,4-thiadiazolin-2-one intermediates 4. Under neutral conditions, acylation only occurs at the 5-amino group with acyl chlorides forming 5-acylamino-3H-l,3,4-thiadiazolin-2-ones 5. 5-Acetylamino-3H-1,3,4-thiadiazolin-2-one can also be synthesized by the thermal transformation of 5-amino-3-acetyl-l,3,4-thiadi-azolin-2-one in acetic acid.
Congenital uterine anomaly: Pitfalls of MRI based diagnosis
( Do Young Kim ),( Hyun Jin Kim ),( Sa Ra Lee ),( Sung Hoon Kim ),( Heedong Chae ),( Byung Moon Kang ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: The gold standard imaging modality of congenital uterine anomaly is known to be the pelvic magnetic resonance imaging (MRI). However, in some cases, even in textbooks, the MRI finding can lead to the misdiagnosis. The aim of this study was to analyze the concordance of MRI diagnosis with final diagnosis in patients with Mullerian Duct anomalies and to suggest the diagnostic clue of congenital uterine anomaly. Methods: A total of 80 cases of young female pelvic MRI (40 cases of congenital uterine anomaly and 40 cases of normal genital organ) taken from January 1995 to February 2019 at Seoul Asan Medical Center were reviewed. The age of the patients when underwent the pelvic MRI was 9 to 25years. The final diagnosis of the uterine anomaly was compared with the preoperative MRI findings in patients who underwent the corrective surgery. The MRI characteristics including the shape and wall thickness as well as the signal intensity of the hematometra or hematocolpos were collected. The biopsy result and un-operated uterus were reviewed to compare the uterus, cervix and vagina of the normal MR image to the actual physical examination. Results: The differential diagnosis of cervical agenesis and upper vaginal agenesis was extremely important and easily misinterpreted in MRI finding. The tissue biopsy taken on the leading edge of the hematometra or hematocolpos made us the accurate diagnosis on the difficult diagnosis. Two cases of upper vaginal dysgenesis and normal cervix was not matched with the final diagnosis. Moreover, 3 cases with transverse vaginal septum were previously read as vaginal stenosis or normal pelvic findings. Conclusion: MRI is a good imaging modality however, a clinician should be aware of this imaging modality’s limitations. The multidisciplinary access including physical examination and pathologic confirmation of the tissue thorough the biopsy of the leading edge can be essential for the accurate diagnosis and treatment of congenital uterine anomaly.
Statistical Evaluation of Smoke Analysis Technique through Asia Collaborative Study V.
Ra, Do-Young,Rhee, Moon-Soo,Kim, Yoon-Dong,Hwang, Keon-Joong The Korean Society of Tobacco Science 1998 한국연초학회지 Vol.20 No.1
This study was conducted to evaluate the techniques or analyzing tobacco smoke by statistical treatment method for the analytical data through Asia Collaborative Study V. In addition to five smoke components analysis, consisting of TPM, water, nicotine, NFDPM, and puff count of four cigarettes samples, statistical parameters such as mean, standard deviation, box-and-whisker plots, h plots, k plots, regression coefficients, reproducibility (R), and repeatability (r) were also calculated. Analysis of water content of cigarette smoke was the most difficult task, whereas puff count analysis was the easiest as well recognized by all laboratories. Analysis of nicotine and puff count accounted for both the lowest and the highest variation among four parameters. The water coefficients indicated more randomness or variation in the slops. The NFDPM data exhibited both types of deviations from linearity. Water content of sample D indicated the highest difference between two single results and between two interlaboratory test results. As a whole, KGTRI ranked higher in the analytical techniques for statistical evaluation of results when compared with the practices of 28 other laboratories.
Kim, Do-Young,Lee, Young-Woo,Han, Sang-Beom,Ko, A-Ra,Kim, Hyun-Su,Kim, Si-Jin,Oh, Sang-Eun,Park, Kyung-Won The Korean Electrochemical Society 2012 한국전기화학회지 Vol.15 No.2
We report nanostructure electrodes with $TiO_2$ as a core and carbon as a shell ($TiO_2$@C) for oxygen reduction in alkaline solution. The structure of core-shell electrodes is characterized by transmission electron microscopy, Raman spectroscopy, X-ray diffraction method, and X-ray photoelectron microscopy. The electrochemical properties of the $TiO_2$@C electrodes are characterized using a potentiostat and compared with those of carbon supported Pt catalyst. In particular, the core-shell electrode with dominant pyridinic-N component exhibits an imporved electrocatalytic activity for oxygen reduction reaction in alkaline solution.
Pelvic organ prolapse is correlated with osteoporosis: HIRA NPS Data analysis
( Yu Ra Ko ),( Hyun Jin Kim ),( Do Young Kim ),( Sa Ra Lee ),( Sung Hoon Kim ),( Hee Dong Chae ),( Byung Moon Kang ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: Deficiencies in pelvic collagen are believed to exist in pelvic organ prolapse (POP). Conversely, a predisposition to POP is identified in women with generalized connective tissue disorders. However few data were reported on the relationship between the POP and osteoporosis (OP). Therefore To examine the association between OP and POP in Korean women. Methods: We used the Health Insurance Review and Assessment Service-National Patient Samples (HIRA-NPS) between 2015 and 2017. The HIRA-NPS, including approximately 1.4 million individuals, is a stratified random sample of 3% of the entire Korean population using 16 age groups and 2 sex groups. Total 4,368,141 individuals were included in HIRA-NPS between 2015 and 2017 and a total of 842,228 individuals aged 50 years and above were included in the final analysis. POP patients were defined by KOICD (KCD-7, N81 or N99.3) and patients who proceeded pelvic reconstructive operation. The OP patients were defined by KOICD (KCD-7, R4113, R3620, R0402) & Patients who prescribed medication(BP, SERM, PTH, Denosumab). 1:10 Age-stratified Matching and Chi-squared test was used for statistical analysis and P<0.05 was considered as significant. Results: A total of 7,359 women were included in this analysis. The advanced pelvic organ prolapse is correlated with osteoporosis in Korean women aged 50 years and above in 2015-2017(P<.0001). After adjusting the age, advanced pelvic organ prolapse is correlated with osteoporosis in 2015, 2016, 2017 dataset (P = 0.013, 0.0009, 0.0119, respectively). Conclusion: The advanced pelvic organ prolapse is correlated with osteoporosis in Korean women aged 50 years and above. Evaluation of the osteoporosis and education about the bone health can be especially important even in relatively young, aged 50-59 years, POP patients.
임도선 ( Do Seon Lim ),반유희 ( Yu Hee Ban ),민영은 ( Young Eyn Min ),박진주 ( Jin Joo Park ),유예진 ( Ye Jin Yu ),인소라 ( So Ra In ),주현지 ( Hyun Ji Ju ),정선영 ( Sun Young Jung ),황영선 ( Young Sun Hwang ) 한국치위생과학회 2015 치위생과학회지 Vol.15 No.4
Due to the attractive benefits with regard to bone health, digestion, and hydration, carbonated water consumption have rapidly grown over the past few years. However, the acidic drink has latent potential for enamel erosion. The most experimental studies about the enamel erosion have focused on the carbonated beverages with sugar and artificial sweeteners. Here, we determined the enamel erosion potential by commercially available carbonated waters with bovine teeth. The erosion was verified by pH value, calcium concentration, and scanning electron microscope. Then plaque accumulation by bacterial adhesion was determined on the enamel erosion surface to measure roughness. In the present study, we observed that the increased calcium content after being immersed in carbonated waters result from the overall enamel erosion. There were no significant differences between general carbonated waters and mineral waters for erosive capacity. Therefore, commercially available carbonated waters are potentially erosive. In addition, oral bacteria strongly adhered to the erosive enamel surfaces thereby facilitating the development of dental plaque. Thus, it is urgently necessary to provide food safety information on the carbonated water as acidic drink to prevent the enamel erosion.