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PBK drives PARP inhibitor resistance through the TRIM37/NFκB axis in ovarian cancer
Ma Hanlin,Qi Gonghua,Han Fang,Peng Jiali,Yuan Cunzhong,Kong Beihua 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Resistance to PARP inhibitors (PARPi) remains a therapeutic challenge in ovarian cancer patients. PDZ-binding kinase (PBK) participates in the chemoresistance of many malignancies. However, the role of PBK in PARPi resistance of ovarian cancer is obscure. In the current study, we demonstrated that overexpression of PBK contributed to olaparib resistance in ovarian cancer cells. Knockdown of PBK sensitized olaparib-resistant SKOV3 cells to olaparib. Inhibition of PBK using a specific inhibitor enhanced the therapeutic efficiency of olaparib. Mechanically, PBK directly interacted with TRIM37 to promote its phosphorylation and nuclear translocation. which subsequently activates the NFκB pathway. Additionally, PBK enhanced olaparib resistance of ovarian cancer by regulating the NFκB/TRIM37 axis in vitro and in vivo. In conclusion, PBK confers ovarian cancer resistance to PARPi through activating the TRIM37-mediated NFκB pathway, and targeted inhibition of PBK provided the new therapy to improve PARPi treatment outcomes for ovarian cancer patients.
Ma, Peng-Cheng,Liu, Ming-Yang,Zhang, Hao,Wang, Sheng-Qi,Wang, Rui,Wang, Kai,Wong, Yiu-Kei,Tang, Ben-Zhong,Hong, Soon-Hyung,Paik, Kyung-Wook,Kim, Jang-Kyo American Chemical Society 2009 ACS APPLIED MATERIALS & INTERFACES Vol.1 No.5
<P>Nanocomposites reinforced with hybrid fillers of carbon nanotubes (CNTs) and carbon black (CB) are developed, aiming at enhancing the electrical conductivity of composites with balanced mechanical properties while lowering the cost of the final product. Epoxy-based nanocomposites were prepared with varying combinations of CNTs and CB as conducting fillers, and their electrical and mechanical properties were evaluated. It was shown that the addition of CNTs in CB composites enhanced the electrical conductivity of composites: a low percolation threshold was achieved with 0.2 wt % CNTs and 0.2 wt % CB particles. The CB particles also enhanced the ductility and fracture toughness of nanocomposites, confirming the synergistic effect of CB as a multifunctional filler. The novelty of this work lies in the synergy arising from the combination of two conducting fillers with unique geometric shapes and aspect ratios as well as different dispersion characteristics, which have not been specifically considered previously.</P>
Mingming Ma,Yijun Cao,Qi Wang,Wei Shang,Ning Peng,Yuqing Wen 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.107 No.-
Flexible barrier films preventing corrosion are important for many industries ranging from engineering tomedical to electronic materials. It is necessary to improve the corrosion resistance of aluminum alloys. The aluminum alloy sample reacted with sodium hydroxide was immersed in a double -[3-(triethoxylated) silicon-propyl] tetrasulfide and graphene(BTESPT/rGO) and cured in an oven at100 C to prepare a BTESPT/rGO composite film and discuss its film forming mechanism. The resultsshown that the film was dense and hydrophobic, which helped to improve the barrier properties ofthe film to corrosive ions, and its corrosion resistance was significantly better than that of a singleBTESPT film. The corrosion current density of the BTESPT/rGO composite film was three orders of magnitudelower than that of the aluminum alloy substrate. The 240 h salt spray experiment shown thatthe BTESPT/rGO composite film greatly improved the corrosion resistance of the aluminum alloysubstrate.
Xuejin Fan,Qi Peng,Yanhua Chen,Zeke Ma,Xiaoguang He,Biying Deng,Hui Huang,Juan Zeng,Chuyun Cheng,Shaoji Liu,Xiaomei Lu 한국유전학회 2015 Genes & Genomics Vol.37 No.12
The aim of this study was to test the impact of variants rs900400 (located near LEKR1 and CCNL1) and rs9883204 (located in ADCY5) on birth weight in a Chinese population. We conducted a case–control study including 156 low-birth- weight infants as the case group and 100 normal-birth-weight infants as the control group. The rs900400 and rs9883204 variants were analyzed by gene sequencing in all the participants. Our results revealed a significant difference in the genotype distribution (v2 = 10.449, p = 0.005) and allele distribution (v2 = 9.277, p = 0.002) of rs900400 between the case group and the control group. The C allele of rs900400 was associated with lower birth weight (OR 1.771 [95 % CI 1.237–2.535]) in the Chinese population. However, the rs9883204 polymorphism was not informative in the Chinese population. Our study shows that the ‘‘birth weightlowering’’ variant rs900400 located near LEKR1 and CCNL1, which is strongly associated with birth weight in European cohorts, appears to have a similar association in Chinese cohorts. However, the rs9883204 variant located in ADCY5 does not appear to be correlated with low birth weight in the same population. Moreover, we found that the variant rs900400 may also be associated with premature birth, thereby supporting the need for further research in this area.
Jiao, De-Chao,Zhou, Qi,Han, Xin-Wei,Wang, Ya-Feng,Wu, Gang,Ren, Jian-Zhuang,Wang, Yan-Li,Ding, Peng-Xu,Ma, Ji,Fu, Ming-Ti Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2
To evaluate efficacy of microwave ablation in a primary clinical study, sixty patients (44 men, 16 women; mean age 53 years) with 96, 1-8 cm (mean $3.20{\pm}0.17$ cm) liver cancers were treated with 2,450-MHz internally cooled-shaft antenna. Complete ablation (CA) and local tumor progression (LTP) rates as well as complications were determined. CA rates in small (< 3.0 cm), intermediate (3.1-5.0 cm) and large (5.1-8.0 cm) liver cancers were 96.4% (54/56), 92.3% (24/26) and 78.6% (11/14), respectively. During a mean follow-up period of $17.17{\pm}6.52$ months, LTP occurred in five (5.21%) treated cases. There was no significant difference in the CA and LTP rates between the HCC and liver metastasis patient subgroups (P<0.05). Microwave ablation provides a reliable, efficient, and safe technique to perform hepatic tumor ablation.
Yang, Dang-Wei,Ma, Zhan-Guo,Qi, Fu-Zhou,Gong, Peng,Liu, Dao-Ping,Zhao, Guo-Zhen,Zhang, Ray Ruichong Techno-Press 2017 Geomechanics & engineering Vol.13 No.2
This paper proposes gob-side entry retaining by roof break and filling in thick-layer soft rock conditions based on the thick-layer soft rock roof strata migration law and the demand for non-pillar gob-side entry retaining projects. The functional expressions of main roof subsidence are derived for three break roof direction conditions: lateral deflection toward the roadway, lateral deflection toward the gob and vertically to the roof. These are derived according to the load-bearing boundary conditions of the main roadway roof stratum. It is concluded that the break roof angle is an important factor influencing the stability of gob-side entry retaining surrounding rock. This paper studies the stress distribution characteristics and plastic damage scope of gob-side entry retaining integrated coal seams, as well as the roof strata migration law and the supporting stability of caving structure filled on the break roof layer at the break roof angles of $-5^{\circ}$, $0^{\circ}$, $5^{\circ}$, $10^{\circ}$ and $15^{\circ}$ are studied. The simulation results of numerical analysis indicate that, the stress concentration and plastic damage scope to the sides of gob-side entry retaining integrated coal at the break roof angle of $5^{\circ}$ are reduced and shearing stress concentration of the caving filling body has been eliminated. The disturbance of coal mining to the roadway roof and loss of carrying capacity are mitigated. Field tests have been carried out on air-return roadway 5203 with the break roof angle of $5^{\circ}$. The monitoring indicates that the break roof filling section and compaction section are located at 0-45 m and 45-75 m behind the working face, respectively. The section from 75-100 m tends to be stable.
Improved Pupil-Size Diversity Technology for High-Resolution Imaging with Faint Objects
Xinxin Yang,Ge Ren,Haotong Ma,Qi Peng,Yufeng Tan,Jihong Wang 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.76 No.1
Phase aberration is one of the prime factors that degrade the quality of observed images. Pupil-size diversity technology (PSDT) is a newly developed post-processing method for aberration correction and image reconstruction. However, images reconstructed using PSDT suffer from massive grains when imaging astronomical faint objects, which extremely limits its further application. In this paper, we propose an improved PSDT with embedded denoising reprocessing to overcome this drawback. Diversity raw images, generated by modulating the size of the pupil, are firstly processed by blocking-matching and 3D filtering (BM3D), a state-of-art denoising algorithm. Then, the traditional PSDT can be employed to estimate the wavefront and reconstruct a high-resolution image. Both numerical simulations and experiment demonstrations show that our proposed strategy exhibits superior performance for aberrations correction and image restoration of faint objects in view of its efficiency and robustness. Being capable of realizing high-resolution imaging with faint objects, this proposed method may have important application prospects in the fields of astronomical object detection, remote sensing, \textit{etc.}
Shu-Jun Wang,Yu-Ling Peng,Cheng-Gen Zhang,Qi Peng Ma,Xiao Xia Peng,Li Lei Ren 대한화학회 2017 Bulletin of the Korean Chemical Society Vol.38 No.7
Two kinds of free-base tailed porphyrins modified with 2-chloronicotinic acid and the corresponding Zn porphyrins have been synthesized. They have been characterized by elemental analysis and NMR, UV/Vis, fluorescence spectra, and infrared spectroscopies. Their configurations have been optimized through theoretical calculations. The fluorescence quantum yields were determined by a comparative method. The interactions between the Zn porphyrins and human serum albumin have been studied by means of fluorescence spectra. The experimental results showed that the interaction mechanism involved a combined fluorescence quenching process (static and dynamic quenching) and that the main driving force was hydrophobic in nature. Quenching constants, binding constants, thermodynamic parameters, and binding distances have been determined.