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Ling-Ling Xie,Yuan-Dong Xu,Jie-Jie Zhang,Cheng-Peng Zhang,Xiao-Yu Cao,Ling-Bo Qu 대한금속·재료학회 2013 ELECTRONIC MATERIALS LETTERS Vol.9 No.4
Er-doped LiV3O8 as cathode material for secondary lithium batteries was prepared through a rheological phase reaction method. The as-prepared materials were investigated by x-ray diffraction (XRD), scanning electron microscopy (SEM), and galvanostatic discharge/charge measurements. The results indicate that Er doped phase preserves the layered structure of the pristine LiV3O8 and has an enlarged interlayer spacing. Compared to LiV3O8 sample, Er-doped LiV3O8 sample displays more uniform particles and large surface area. The electrochemical test shows that Er doping does not change the process of Li+ insertion/deinsertion. Er-doped LiV3O8 electrode exhibits an initial discharge capacity of 294.2 mAh g−1 and maintains a stable capacity of 220.7 mAh g−1 after 50 cycles, indicating a greatly improved good cycleability comparing with the undoped one.
Ling Chen,Jing Zhong,Jiang-Hua Liu,Duan-Fang Liao,Ying-Ying Shen,Xiao-Lin Zhong,Xiao Xiao,Wen-Jun Ding,Xiu-Da Peng,Wei Xiong,Xu-Yu Zu 한국유방암학회 2019 Journal of breast cancer Vol.22 No.1
Purpose: Pokemon, also known as ZBTB7A, belongs to the POZ and Krüppel (POK) family of transcription repressors and is implicated in tumor progression as a key proto-oncogene. This present study aimed at determining the mechanism by which Pokemon inhibits transforming growth factor β (TGFβ)-Smad4 pathway-dependent proliferation arrest of breast cancer cells via specificity protein 1 (SP1). Methods: Over-expressing plasmid or small interfering RNA (siRNA) transfection was used to regulate Pokemon levels. The EdU incorporation assay, MTS assay, and clone formation were used to identify the inhibitory effect of Pokemon siRNA on cell proliferation. Quantitative real-time polymerase chain reaction assay confirmed that Pokemon deletion inhibited the expression of proliferation-associated genes. The dual-luciferase reporter assay, electrophoretic mobility shift assay, and co-immunoprecipitation assay were used to analyze binding between Pokemon, Smad4, and SP1. Results: Pokemon deletion induced proliferation arrest of breast cancer cells and inhibited the expression of proliferation-associated genes, especially Smad4. Pokemon bound with SP1 to interdict Smad4 promoter activity. Information on clinical samples was obtained from The Cancer Genome Atlas data, in which the Pokemon mRNA levels showed a negative correlation with Smad4 levels in different subtypes of breast cancer in two independent datasets. Conclusion: We demonstrated that Pokemon binds to SP1 to down-regulate Smad4 expression, thereby promoting proliferation of breast cancer cells. This suggests that Pokemon is a potential TGFβ-signaling participant in breast cancer progression.
Finite Element Analysis and Test Study on Restraint of High-energy Pipe Whip in Conventional Island
Ling-yun Peng,Yu-ke Deng,Hua-ting Chen,Ying-jie Kang,Xiang-xiu Li 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.4
The effects of high-energy pipe whipping after rupturing are very important in an AP1000 nuclear power plant's conventional island and restraints of pipe whipping should be considered in the design. It is the first time in the country when reinforced concrete shear walls are used as restraint services. In this paper, the behaviors of walls and restraint services subjected to pipe whipping are analyzed through static and dynamic methods in the finite element software (ABAQUS), in which all kinds of nonlinearities are considered. In addition, a test study on the restraint of pipe whipping is conducted. The results show that the wall and the restraint service can prevent pipe whipping effectively under the design load, and anchor plates arranged around the wall opening can improve the local concrete compression performance of concrete to reduce the damage of concrete. Meanwhile, the study also provides the valuable reference for wall designing to prevent from pipe whipping.
Yu-qi He,Jian-qiu Sheng,Xian-long Ling,Lei Fu,Peng Jin,Lawrence Yen,Jianyu Rao 생화학분자생물학회 2012 Experimental and molecular medicine Vol.44 No.12
Estrogen has anti-colorectal cancer effects which are thought to be mediated by mismatch repair gene (MMR) activity. Estrogen receptor (ER) expression is associated with microRNA (miRNA) expression in ER-positive tumors. However, studies of direct link between estrogen (especially estradiol E2), miRNA expression, and MMR in colorectal cancer (CRC) have not been done. In this study, we first evaluated the effects of estradiol (E2) and its antagonist ICI182,780 on the expression of miRNAs (miR-31, miR-155 and miR-135b) using COLO205, SW480 and MCF-7 cell lines, followed by examining the association of tissue miRNA expression and serum E2 levels using samples collected from 18 colorectal cancer patients. E2inhibited the expressions of miRNAs in COLO205 cells,which could be reversed by E2 antagonist ICI 182.780. The expression of miR-135b was inversely correlated with serum E2 level and ER-β mRNA expression in CRC patients’ cancer tissues. There were significant correlations between serum E2 level and expression of ER-β, miR-135b, and MMR in colon cancer tissue. This study suggests that the effects of estrogen on MMR function may be related to regulating miRNA expression via ER-β, which may be the basis for the anti-cancer effect in colorectal cells.
Model Test Study on the Load-bearing Behaviour of Multi-tooth Piles under Different Bearing Layers
Peng Du,Yu Jia Fu,Xiao Ling Liu,GuangfanLi 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.3
In soft soil or karst areas, several problems exist, such as the poor properties of the pile tip bearing layer or difficulties in cutting the rock. Using multi-tooth piles, end-bearing piles can be turned into friction piles to solve these problems. Through the scale model device, three variables: the bearing layer, tooth length, and tooth number, are designed to experimentally explore the load-bearing behaviour of multi-tooth piles under different bearing layer conditions. The test results show that the model pile has better anti-settlement performance in the sand bearing layer than in the red clay bearing layer. Compared with smooth piles, multi-tooth piles can greatly improve the bearing capacity of pile foundations in bearing layers with poor stiffness. The tooth length and tooth number greatly impact the compressive bearing capacity and the pile-side resistance of the multi-tooth pile, respectively. The concept of roughness is innovatively introduced to quantify the roughness of pile surfaces, which provides an effective method for the subsequent experimental and theoretical research of multi-tooth piles and other similar piles with small cross-section modifications. This study can enrich the research field of small, modified cross-section piles and provide a reference for innovative research on pile foundations.
Reinforcement of Waterborne Polyurethane Films with Poly(acrylic acid)-Modified Palygorskite Fibers
Yu Mao,Lingli Ni,Changyou Yang,Peng Cai,Weigang Du,Xiaoyan Gao 한국섬유공학회 2020 Fibers and polymers Vol.21 No.9
Palygorskite (PAL) is a natural fibrous clay mineral which attracted tremendous attention as reinforcing agent topolymers. In this paper, a facile and environmental friendly modification process of PAL by poly acrylic acid (PAA) via insitupolymerization in PAL/water gel has been reported. The effects of PAA modified PAL (PAA-PAL) on the mechanical andthermal properties of waterborne polyurethane (WPU) nanocomposites have been investigated. Scanning electronmicroscopy (SEM) demonstrated that the dispersion of PAL has improved dramatically after PAA modification. Tensile testsshowed that PAA-PAL has a significant reinforcement effect on WPU matrix. Addition of 10 wt% PAA-PAL, the tensilestrength and the Young’s modulus of WPU composites increased 235 % and 388 %, respectively. Furthermore, the thermalstability of WPU also has been distinctly improved via addition of PAA-PAL.
Ding Yu,Wang Ma-Yin,Yang Ding-Hai,Hao Dai-Cheng,Li Wei-Shi,Ling Peng,Xie Shang-Qian 한국유전학회 2023 Genes & Genomics Vol.45 No.12
Background Phalaenopsis is an important ornamental plant that has great economic value in the world flower market as one of the most popular flower resources. Objective To investigate the flower colour formation of Phalaenopsis at the transcription level, the genes involved in flower color formation were identified from RNA-seq in this study. Methods In this study, white and purple petals of Phalaenopsis were collected and analyzed to obtained (1) differential expression genes (DEGs) between white and purple flower color and (2) the association between single nucleotide polymorphisms (SNP) mutations and DEGs at the transcriptome level. Results The results indicated that a total of 1,175 DEGs were identified, and 718 and 457 of them were up- and down-regulated genes, respectively. Gene Ontology and pathway enrichment showed that the biosynthesis of the secondary metabolites pathway was key to color formation, and the expression of 12 crucial genes (C4H, CCoAOMT, F3’H, UA3’5’GT, PAL, 4CL, CCR, CAD, CALDH, bglx, SGTase, and E1.11.17) that are involved in the regulation of flower color in Phalaenopsis. Conclusion This study reported the association between the SNP mutations and DEGs for color formation at RNA level, and provides a new insight to further investigate the gene expression and its relationship with genetic variants from RNA-seq data in other species.