기관까지 침범한 후두 열탕화상 1례

김중환,권평중,홍영호 대한이비인후과학회 1981 대한이비인후과학회지 두경부외과학 Vol.24 No.3

급성 후방십자인대 단독 손상의 보존적 치료 : 전향적 연구 Prospective Study

정영복,김진수,정호중,정평호 대한슬관절학회 2002 대한슬관절학회지 Vol.14 No.2

목적: 후방십자인대 단독 손상 환자에 있어서 보존적 치료를 시행 후 결과를 알아보고자 하였다. 재료 및 방법: 1999년 8월부터 2001년 12월까지 본원에 내원 하여 후방십자인대 단독 손상으로 진단된 11례에 대해서 보존적 치료를 시행하였다. 초기 진단은 이학적 검사와 Telos 기구를 이용한 후방전위 사진(push stress view)으로 하였고 추시 평가는 전향적으로 하였으며 6주, 3개월, 6개월, 1년, 그 후 매년마다 이학적 검사와 International Knee Documentation Committee(IKDC) score와 Orthopadishe Arbeitsguppe Knie(OAK) score를 이용한 임상적 평가를 하는 것을 기준으로 하였으며 6개월 후에는 후방 전위 사진과 단순 전후 및 좌우 방사선을 시행하였다. 치료방법은 6주간 슬관절 완전 신전 상태로 후방 전위 방지 지지대를 부착한 하지 부목 후 6주간 슬관절 후방 전위 방지 보조기를 시행하였다. 이들의 평균 추시 시간은 17.5개월(7~35)이었다. 결과: 11례중 2례에서는 후방전위에 후 외측 회전 불안정성 동반이 발견되어 수술적 치료를 시행하였으며 보존적 치료를 유지하였던 9례에서는 최근 추시 임상적 평가에서 OAK score상 평균 93.2점, IKDC score상 A가 5례, B가 4례이었다. 결론: 동반손상이 없는 후방십자인대 단독 손상에 있어서 보존적 치료가 일차적 치료 방법으로 생각되며 향후 불안정성의 진행과 이차적 퇴행성관절염의 발생 여부 및 상관 관계에 대해서 장기적 추시 관찰 예정이다. Purpose: We assessed prospectively the results of acute, isolated, posterior cruciate ligament injuries treated conservatively. Materials and Methods: Between August 1999 and December 2001, the study population consited of 11 patients. The patients were treated conservatively and were prescribed full extension long leg splint with posterior tibial support for 6 weeks and then posterior tibial support brace for another 6 weeks. Patients completed a sujetive and objective evaluation at 6 weeks, 3 month, 6 month and each year for an average of 17.5 months. Results: Two patients underwent reconstructive surgery because of combined posterolateral rotatory instability. The nine patients were treated conservatively, the mean Orthopadishe Arbeitsguppe Knie score was 93.2 points. International Knee Documentation Committee score in 5 patients was A and 4 patients was B. Conclusion: Our study suggests that patients with acute, isolated posterior cruciate ligament injuries treated conservatively may get good clinical results, but we are planning a long term follow-up evaluation to reveal change in laxity, incidence of arthrosis and their correlation.

Dietary Exposure to Transgenic Rice Expressing the Spider Silk Protein Fibroin Reduces Blood Glucose Levels in Diabetic Mice: The Potential Role of Insulin Receptor Substrate-1 Phosphorylation in Adipocytes

박지은,정연재,박준범,김혜영,유영현,이광식,양원태,김도훈,김종민 한국발생생물학회 2019 발생과 생식 Vol.23 No.3

Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance (IR). T2DM is correlated with obesity and most T2DM medications have been developed for enhancing insulin sensitivity. Silk protein fibroin (SPF) from spiders has been suggested as an attractive biomaterial for medical purposes. We generated transgenic rice (TR) expressing SPF and fed it to diabetic BKS.Cg-m+/+Leprdb mice to monitor the changes in blood glucose levels and adipose tissue proteins associated with energy metabolism and insulin signaling. In the present study, the adipocyte size in abdominal fat in TR-SPF-fed mice was remarkably smaller than that of the control. Whereas the adenosine monophosphate-activated protein kinase (AMPK)-activated protein kinase and insulin receptor substrate 1 (IRS1) protein levels were increased in abdominal adipose tissues after TR-SPF feeding, levels of six-transmembrane protein of prostate 2 (STAMP2) proteins decreased. Phosphorylation of AMPK at threonine 172 and IRS1 at serine 307 and tyrosine 632 were both increased in adipose tissues from TR-SPFfed mice. Increased expression and phosphorylation of IRS1 at both serine 307 and tyrosine 632 in adipose tissues indicated that adipocytes obtained from abdominal fat in TR-SPF-fed mice were more susceptible to insulin signaling than that of the control. STAMP2 protein levels decreased in adipose tissues from TR-SPF-fed mice, indicating that STAMP2 proteins were reducing adipocytes that were undergoing lipolysis. Taken together, this study showed that TR-SPF was effective in reducing blood glucose levels in diabetic mice and that concurrent lipolysis in abdominal adipocytes was associated with alterations of AMPK, IRS1, and STAMP2. Increased IRS1 expression and its phosphorylation by TR-SFP were considered to be particularly important in the induction of lipolysis in adipocytes, as well as in reducing blood glucose levels in this animal model.

電氣工學敎育의 發展方向에 關한 硏究

李鎭局,徐相壽,朴魯峰,李忠鎬,劉鍾哲,金洪奎,趙武濟,韓運東,池平植 충주대 2003 産業科學論文集 Vol.11 No.-

In this paper, we discuss actual conditions for running school of electrical and electronic engineering in domestic universities. Also, we catch hold of industrial circles's demands in electrical engineering education and analyze questionary results according to goes into effect school of electrical and electronic & information engineering in major of electrical and electronec engineering's students. Conclusively, we present suitable model in electrical engineering by correction of problems.

Bone Age Assessment Using Artificial Intelligence in Korean Pediatric Population: A Comparison of Deep-Learning Models Trained With Healthy Chronological and Greulich-Pyle Ages as Labels

Kim Pyeong Hwa,Yoon Hee Mang,Kim Jeong Rye,Hwang Jae-Yeon,Choi Jin-Ho,Hwang Jisun,Lee Jaewon,Sung Jinkyeong,Jung Kyu-Hwan,Bae Byeonguk,Jung Ah Young,Cho Young Ah,Shim Woo Hyun,Bak Boram,Lee Jin Seong 대한영상의학회 2023 Korean Journal of Radiology Vol.24 No.11

Objective: To develop a deep-learning-based bone age prediction model optimized for Korean children and adolescents and evaluate its feasibility by comparing it with a Greulich-Pyle-based deep-learning model. Materials and Methods: A convolutional neural network was trained to predict age according to the bone development shown on a hand radiograph (bone age) using 21036 hand radiographs of Korean children and adolescents without known bone development-affecting diseases/conditions obtained between 1998 and 2019 (median age [interquartile range {IQR}], 9 [7–12] years; male:female, 11794:9242) and their chronological ages as labels (Korean model). We constructed 2 separate external datasets consisting of Korean children and adolescents with healthy bone development (Institution 1: n = 343; median age [IQR], 10 [4–15] years; male: female, 183:160; Institution 2: n = 321; median age [IQR], 9 [5–14] years; male: female, 164:157) to test the model performance. The mean absolute error (MAE), root mean square error (RMSE), and proportions of bone age predictions within 6, 12, 18, and 24 months of the reference age (chronological age) were compared between the Korean model and a commercial model (VUNO Med-BoneAge version 1.1; VUNO) trained with Greulich-Pyle-based age as the label (GP-based model). Results: Compared with the GP-based model, the Korean model showed a lower RMSE (11.2 vs. 13.8 months; P = 0.004) and MAE (8.2 vs. 10.5 months; P = 0.002), a higher proportion of bone age predictions within 18 months of chronological age (88.3% vs. 82.2%; P = 0.031) for Institution 1, and a lower MAE (9.5 vs. 11.0 months; P = 0.022) and higher proportion of bone age predictions within 6 months (44.5% vs. 36.4%; P = 0.044) for Institution 2. Conclusion: The Korean model trained using the chronological ages of Korean children and adolescents without known bone development-affecting diseases/conditions as labels performed better in bone age assessment than the GP-based model in the Korean pediatric population. Further validation is required to confirm its accuracy.

Endovascular Treatment with Intravenous Thrombolysis versus Endovascular Treatment Alone for Acute Anterior Circulation Stroke : A Meta-Analysis of Observational Studies

Kim, Chul Ho,Jeon, Jin Pyeong,Kim, Sung-Eun,Choi, Hyuk Jai,Cho, Yong Jun The Korean Neurosurgical Society 2018 Journal of Korean neurosurgical society Vol.61 No.4

Objective : The aim of this study was to determine outcome of ischemic stroke patients in the anterior circulation treated with endovascular treatment (EVT) with intravenous thrombolysis (IVT) versus EVT alone group. Methods : A systemic literature review was performed using online database from January 2004 to January 2017. Primary outcomes were successful recanalization seen on finial angiography and good outcome at three months. Secondary outcomes were mortality and the development of symptomatic intracranial hemorrhage (S-ICH) after the procedure. A fixed effect model was used when heterogeneity was less than 50%. Egger's regression test was used to assess publication bias. Results : Five studies were included for final analysis. Between EVT with IVT and EVT alone group, successful recanalization (odds ratio [OR] 1.467, p=0.216), good clinical outcome at three months (OR 1.199, p=0.385), mortality (OR 0.776, p=0.371), and S-ICH (OR 1.820, p=0.280) did not differ significantly. Egger's regression intercept with 95% confidence interval (CI) was 1.99 (95% CI -2.91 to 6.89) in successful recanalization and -0.27 (95% CI -6.35 to 5.80) in good clinical outcome, respectively. Conclusion : The two treatment modalities, EVT with IVT and EVT alone, could be comparable in treating acute anterior circulation stroke. Studies to find specific beneficiary group for EVT alone, without primary IVT, are needed further.

An Evaluation of Machinability and Tool Life In Micro-milling of Die/Mold Materials

Pyeong-Ho Kim,Jeong-Suk Kim,Ik-Soo Kang,Joon-Young Koo 한국생산제조학회 2012 한국생산제조시스템학회 학술발표대회 논문집 Vol.2012 No.10

Physicochemical Properties of Non-glutinous, Dull, and Glutinous Rice Grain in Segregating Populations of Dull/Glutinous Crosses

Kim, Kwang-Ho,Kim, Eun-You,Jeong, Young-Pyeong The Korean Society of Crop Science 1999 Korean journal of crop science Vol.44 No.3

Dull grains segregated from F$_3$ and F$_4$ of the crosses between two dull mutants and a glutinous cultivar were compared with non-glutinous and glutinous segregants for their physicochemical properties. Amylose content of dull rice grain segregated from the dull/glutinous cross showed the intermediate value between glutinous and non-glutinous rice grain, whether it is controlled by the recessive or dominant gene. Alkali digestibility value (ADV) of dull rice grain was lower than that of glutinous or non-glutinous rice. A positive correlation was found between ADV and amylose content of homozygous non-glutinous or dull F$_4$ grains, but a negative relationship was observed in glutinous grains. Protein content of dull grain was significantly higher than that of glutinous or non-glutinous grain segregated from the same cross, while those of glutinous and non-glutinous grains were not different. Among gelatinization characteristics, initial pasting temperature and peak viscosity of dull grains were higher than glutinous rice, and were not different with non-glutinous grain. Hot, cool and consistency viscosities of dull grain were intermediate between glutinous and non-glutinous rices. Dull grains showed the highest breakdown viscosity and the lowest setback viscosity among the three endosperm types.

Neuroimaging Findings in Patients with COVID-19: A Systematic Review and Meta-Analysis

Kim Pyeong Hwa,Kim Minjae,Suh Chong Hyun,Chung Sae Rom,Park Ji Eun,Kim Soo Chin,Choi Young Jun,Lee Jeong Hyun,Kim Ho Sung,Baek Jung Hwan,Choi Choong Gon,Kim Sang Joon 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.11

Objective: Central nervous system involvement in coronavirus disease 2019 (COVID-19) has been increasingly reported. We performed a systematic review and meta-analysis to evaluate the incidence of radiologically demonstrated neurologic complications and detailed neuroimaging findings associated with COVID-19. Materials and Methods: A systematic literature search of MEDLINE/PubMed and EMBASE databases was performed up to September 17, 2020, and studies evaluating neuroimaging findings of COVID-19 using brain CT or MRI were included. Several cohort-based outcomes, including the proportion of patients with abnormal neuroimaging findings related to COVID-19 were evaluated. The proportion of patients showing specific neuroimaging findings was also assessed. Subgroup analyses were also conducted focusing on critically ill COVID-19 patients and results from studies that used MRI as the only imaging modality. Results: A total of 1394 COVID-19 patients who underwent neuroimaging from 17 studies were included; among them, 3.4% of the patients demonstrated COVID-19-related neuroimaging findings. Olfactory bulb abnormalities were the most commonly observed (23.1%). The predominant cerebral neuroimaging finding was white matter abnormality (17.6%), followed by acute/subacute ischemic infarction (16.0%), and encephalopathy (13.0%). Significantly more critically ill patients had COVID-19-related neuroimaging findings than other patients (9.1% vs. 1.6%; p = 0.029). The type of imaging modality used did not significantly affect the proportion of COVID-19-related neuroimaging findings. Conclusion: Abnormal neuroimaging findings were occasionally observed in COVID-19 patients. Olfactory bulb abnormalities were the most commonly observed finding. Critically ill patients showed abnormal neuroimaging findings more frequently than the other patient groups. White matter abnormalities, ischemic infarctions, and encephalopathies were the common cerebral neuroimaging findings.

Meta-Analysis of Endovascular Treatment for Acute M2 Occlusion

Kim, Chul Ho,Kim, Sung-Eun,Jeon, Jin Pyeong The Korean Neurosurgical Society 2019 Journal of Korean neurosurgical society Vol.62 No.2

Objective : Endovascular treatment (EVT) outcomes for acute M2 segment of middle cerebral artery occlusion remains unclear because most results are obtained from patients with large artery occlusion in the anterior circulation. The objective of this study was to assess procedural outcomes for acute M2 occlusion and compare outcomes according to thrombus location (M1 vs. M2). Methods : A systematic review was performed for online literature published from January 2004 to December 2016. Primary outcome was successful recanalization rate and symptomatic intracranial hemorrhage (S-ICH) after the procedure. A fixed effect model was used if heterogeneity was less than 50%. Results : Eight articles were included. EVT showed successful recanalization rate of 69.1% (95% confidence interval [CI], 54.9-80.4%) and S-ICH rate of 6.1% (95% CI, 4.5-8.3%). The rates of good clinical outcome at 3 months and mortality were 59.4% (95% CI, 49.9-68.2%) and 14.9% (95% CI, 11.4-19.3%), respectively. According to thrombus location (M1 vs. M2), successful recanalization (odds ratio [OR], 1.539; 95% CI, 0.293-8.092; p=0.610) and S-ICH (OR, 1.313; 95% CI, 0.603-2.861; p=0.493) did not differ significantly. Good clinical outcome was more evident in M2 occlusion after EVT than that in M1 occlusion (OR, 1.639; 95% CI, 1.135-2.368; p=0.008). However, mortality did not differ significantly according to thrombus location (OR, 0.788; 95% CI, 0.486-1.276; p=0.332). Conclusion : EVT seems to be technically feasible for acute M2 occlusion. Direct comparative studies between EVT and medical treatment are needed further to find specific beneficiary group after EVT in patient with M2 occlusion.