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        Wernicke’s Encephalopathy and Peripheral Polyneuropathy Developed during Long Term Metronidazole Therapy in a Patient with a Brain Abscess- A Case Report -

        Nyo Kyung Park,권범선,박진우,이호준,류기형,Sang Wuk Jeong,Sang Mi Noh 대한재활의학회 2011 Annals of Rehabilitation Medicine Vol.35 No.1

        Metronidazole can induce serious neurologic problems including peripheral neuropathy, seizures, and encephalopathy. We examined a patient with acute Wernicke’s encephalopathy and peripheral polyneuropathy that had developed after prolonged metronidazole therapy without a history of chronic alcoholism or poor nutritional intake. The 68-year-old man had been hospitalized for a brain abscess and was treated for 10 weeks with metronidazole (2 grams per day). This patient, who showed symptoms of numbness and tingling in the legs, was referred for electromyography (EMG) and was diagnosed with peripheral polyneuropathy. A few days later, he developed sudden ataxia, dizziness, and diplopia. The neurologic examination revealed nystagmus and ophthalmoplegia, and the FLAIR brain MRI showed symmetrical high signal intensity lesions in the cerebellar dentate nucleus, midbrain, tegmentum around the periaqueductal gray matter, and tectum. After administering intravenous thiamine and stopping the metronidazole therapy, he recovered from the ophthalmoplegia and ataxia. Brain MR showed complete recovery within 3 weeks; however the EMG remained abnormal for a further 6 months, although the symptoms were almost completely resolved by this time.

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        율무, 보리, 미강 유기용매 추출물의 항산화능과 포도당 및 지방산 대사에 미치는 영향

        박태식 ( Tae Sik Park ),이수연 ( Su Yeon Lee ),김현진 ( Hyun Jin Kim ),김경탁 ( Kyung Tack Kim ),김영준 ( Young Jun Kim ),정인혜 ( In Hye Jeong ),도완녀 ( Wan Nyo Do ),이혜정 ( Hye Jeong Lee ) 한국식품영양학회 2009 韓國食品營養學會誌 Vol.22 No.3

        Adlay, barley and rice bran were extracted using various concentrations of methanol(10% and 80%) and chloroform: methanol(2:1) to examine the biological activities of these raw grains. Extraction with 80% methanol resulted in high Vitamin C Equivalent Antioxidant Capacity(VCEAC), in the order of barley>rice bran>adlay, as determined by DPPH and ABTS assays. In addition, the extracts of adlay and rice bran showed high cellular antioxidant activity in HepG2 cells possibly due to the presence of polyphenol glycosides in these grains. We examined the expression of glucose/fatty acid metabolizing genes in differentiated 3T3-L1 adipocyte cells. Glut1 was downregulated after treatment with rice bran and no changes in the expression of Glut4 was observed. In contrast, genes involved in fatty acid metabolism, CD36 and aP2, were upregulated. Since these physiological changes were matched with peroxisome proliferator activating receptor γ(PPAR γ) agonism, we suggest that the extracts from adlay, barley and rice bran may play preventive roles against aging and diabetes via antioxidant activity and increased uptake of fatty acids by adipocytes.

      • 사무직 근로자에서 전방 두부 위치와 경추 주위 근육통의 관계

        최종호,류기형,남기연,박성준,박여경,임현술 東國大學校醫學硏究所 2007 東國醫學 Vol.14 No.1

        전방 두부 위치는 부적절한 자세와 연관이 있으며 후경부 통증의 원인이 된다. 트라벨이 제안한 전방 두부 위치 측정방법을 사용하여 후경부의 관막통 증후군과 전방 두부 위치 관계을 검사하였다. 경추부 외상이 없는 사무직 근로자 35명 을 대상으로 전방 두부 위치를 측정하였다. 또한 설문지를 이용하여 두경부 통증의 강도, 양상 등을 조사하였다. 이학적 검사는 하두부 근육, 후경부 근육, 상부 승모근을 실시하였다. 후두하근에 근막통 증후군으로 진단된 대상자는 9명으로 전방 두부 위치의 측정치는 3.62±0.89 cm 이었으며 , 근막통 증후군이 없는 대상자는 26명으로 전방 두부 위치의 측정치는 3.23±0.84 cm로 유의한 차이는 관찰되지 않았다. 후경추근에 근막통 증후군으로 진단된 대상자는 9명으로 전방 두부 위치의 측정치는 3.51±0.92 cm이 었으며, 근막통 증후군이 없는 대상자는 26명으로 전방 두부 위치의 측정치는 3.27±0.87 cm로 유의한 차이는 관찰되지 않았다. 상부 승모근에 근막통 증후군으로 진단된 대상자는 28명으로 전방 두부 위치의 측정치는 3.38±0.86 cm 이었으며 , 근막통 증후군이 없는 대상자는 7명으로 전방 두부 위치의 측정치는 3.16±0.89 cm로 유의한 차이는 관찰되지 않았다. 후경부 근막통 증후군과 전방 두부 위치의 검사 측정치는 통계적으로 유의한 관계는 없었다. Travel 이 제시한 전방 두부 위치의 선볕검사에서 측정한 정상 수치 6 cm는 힌국인에게 적용하기에 부적절하다. To evaluate the relationship between anterior head position and myofascial pain syndrome at posterior cervical muscles. Thirty five subjects were participated in this study. All subjects were official workers and did not have history of cervical trauma. Anterior head position is evaluated by Travel's method. Questionare was used for nature and intensity at posterior cervical area. We did physical examination for the evaluation of myofacial pain syndrome at suboccipitalis, posterior cervical muscle and upper trapezius. The subjects with myofascial pain syndrome at suboccipitalis were nine and data by Travel's method is 3.62cm and the subjects without myofascial pain syndrome at suboccipitalis were twenty six and data by Travel's method was 3.23cm(no statistically significant difference). The subjects with myofascial pain syndrome at posterior cervical muscle were nine and data by Travel's method is 3.51cm and the subjects without myofascial pain syndrome at posterior cervical muscle were twenty six and data by Travel's method was 3.23cm(no statistically significant difference). The subjects with myofascial pain syndrome at upper trapezius were twenty eight and data by Travel's method was 3.38cm and the subjects without myofascial pain syndrome at posterior cervical muscle were seven and data by Travel's method was 3.16cm (no statistically significant difference). There were no significant differences between anterior head positioning and myofascial pain syndrome at posterior neck muscles. Normal distance (6cm) proposed by Travel is not suitable in Korean.

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