Losartan과 Amlodipine의 병용투여에 의한 고혈압 및 혈관재협착 보호효과

한주희,정상혁,명창선 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-

Abstract - To examine the protective effect of combination treatment of angiotensin II AT1-receptor blockers (ARBs) with Ca2+ channel blockers (CCBs) for high blood pressure and neointima hyperplasia, losartan and amlodipine were orally injected into telemetered-spontaneous hypertensive rats and vascular injury induced by cuff-inserted neointimal formation model in vivo. For the measurement of blood pressure, random orders of losartan 0, 4.79, 9.58 mg/kg/day, amlodipine 0, 0.48, 0.96 mg/kg/day, or higher/lower doses in combination were administered in spontaneous hypertensive rats (SHRs; n=10). For the measurement of neointimal hyperplasia, 9.58 mg/kg/day of losartan or 0.96 mg/kg/day of amlodipine in alone or combination were given for 2 weeks to cuffed C57BL/6 mice (n=6). Our results suggest that the combination therapy of high doses of losartan and amlodipine are effective in lowering systolic blood pressure (SBP) and mean arterial pressure (MAP) as compared with monotherapy of each drug, but not in combined therapy of low doses of two drugs. In protection for vascular remodeling, the combination therapy of losartan with amlodipine synergistically decreased BrdU-positive cells in neointima and DNA synthesis in [3H]-thymidine incorporation by reducing cell proliferation. Therefore, present study implies that combination of losartan with amlodipine may be effective for the treatment of hypertension and vascular remodeling such as restenosis.

초고속 치과용 핸드피스 개발

한명철,김정관,최명욱,이왕근,김헌주 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

The dental high-speed handpiece is one of the most popular and important devices that has been widely used as the main means of cutting tooth structure and restorative materials in dentistry, In consideration of usage and marketability of the dental handpiece, it is obviously worthy of investigating it. In this paper, a high speed dendal handpiece is developed through reverse engineering with 3D X-Ray CT equipment and wire cutter for the Mark II model in NSK. The demension of the handpiece parts is obtained through this process, and 3D modeling is performed with CATIA V5. The interference between parts can be examined through the part assembly in CATIA, and the performance is finally compared with Mark II model in NSK.

Valsartan과 Amlodipine의 병용투여에 의한 혈압하강 상승 및 혈관손상 보호효과

한주희,명창선 충남대학교 약학대학 의약품개발연구소 2013 藥學論文集 Vol.28 No.-

This study was aimed to investigate the synergistic effect of valsartan combined with amlodipine on the anti-hypertensive effect and protective action in vascular injury mediated by cuff-induced neointimal formation model in vivo. For the measurement of blood pressure, spontaneous hypertensive rats (SHRs) were given in that random orders valsartan 0, 7.65, 15.3 mg/kg, amlodipine 0, 0.48, 0.96 mg/kg, or the higher/lower doses in combination. For the measurement of neointimal hyperplasia, 15.3 mg/kg of valsartan or 0.96 mg/kg of amlodipine in alone or combination were given for 2 weeks to cuffed C57BL/6 mice. The results showed that the combination therapy of high doses of valsartan and amlodipine significantly decreased in systolic blood pressure (SBP) and mean arterial pressure (MAP) as compared with monotherapy of each drug, but not in combined therapy of low doses of two drugs. In protection for vascular remodeling, valsartan 15.3 mg/kg and amlodipine 0.96 mg/kg in combination significantly decreased BrdU-positive cells in neointima and [3H]-thymidine, indicating the inhibition of cell proliferation including a progress of DNA synthesis comparing to respective effects. Therefore, present study implies that combination of valsartan and amlodipine may be fully effective for the treatment of hypertension and vascular remodeling.

효율적인 원격교육을 위한 웹 메일시스템의 설계 및 구현

한명성,이완주 용인대학교 학생생활연구소 2000 학생생활연구 Vol.8 No.-

In this thesis, I implement a wed-based mail system using PHP language and IMAP protocol. The web-based mail system will be useful not only as the effective mail system in the environment such as school with many students but little computers, but also as the assistance of the distance education program spread in our educational circumstance. The web-based mail system do not adopts POP protocol but IMAP protocol appropriate to use in "line"essage processing. IMAP protocol designed for "online" application thus, shows better performance in the circumstance of "online" such as the web-based mail system then POP protocol Therefore, 1 can guarantee that the web mail system based on IMAP protocol has the better capacity then based on IMAP protocol. Also, using the script language PHP, highlighted as a wed programming language for the next generation with the fast speed and security, it is designed to be able to respond quickly over a number of user. The web-based mail system provides various functions for user's conveniences such as controling mailbox of producing, deleting and changing, various functions for MIME message decoding controling addresses, registrating spam mail beside the basic functions like reading, sending, replying and deleting. The personal informations such as password and text informations registrating in spam mail and address control became more stabilized and secure through the database. This system is implemented in Solaris circumstance using Apache web server, but it can be used in all the circumstances of Unix, NT and Linux because most of web sever provides PHP 1anguage.

구리냄비의 구리용출에 미치는 산성조미료의 영향

한재숙,최영희,김명선,송주은,南出隆久 동아시아식생활학회 2000 동아시아식생활학회지 Vol.10 No.3

Effects of acetic acid, malic acid and citric acid on copper dissolution from new and used copper saucepans at different concentrations (0, 0.02, 0.04, 0,1, 0.2, 0.4, 1,0, 2,0, 4.0%), different boiling times (0, 10, 20, 30, 40, 50, 60mins.), and different temperatures (5, 20, 40, 60, 80, 100%)were investigated. As acetic acid concentration increases, copper content increases. Copper dissolution concentration from copper saucepans at boiling in malic acid increases more than in acetic acid or citric acid, At above 60℃, as the temperature increases, the concentration of copper dissolved from copper saucepans also increases. As boiling time increases, the concentration of copper dissolved from copper saucepans also increases. In addition, through repeated use, the concentration of copper increases as well. And copper concentration dissolves in large amounts from used saucepans rather than new saucepans. The dissolution of copper with distilled water by repeated use does not dissolve at all. 1% acetic acid dissolves in large quantities.

Candesartan과 Lercanidipine의 병용투여에 의한 혈압 하강 상승효과

한주희,이정진,김요한,명창선 충남대학교 약학대학 의약품개발연구소 2011 藥學論文集 Vol.26 No.-

HPLC를 이용한 육류중의 cholesterol의 분석

한명주 慶熙大學校 1992 論文集 Vol.21 No.-

Analysis of free cholesterol in beef longissimus muscle was achieved by HPLC using a disposable silica column and a mass detector. The longissimus muscle of beef contained 52.3mg of free cholesterol/100g. A linear response the ratio of cholesterol peak area to stigmasterol peak area (r=0.997) was found and recovery was 96.5%.

Irbesartan과 Amlodipine의 병용투여에 의한 혈관 손상 보호 효과

한주희,명창선 충남대학교 약학대학 의약품개발연구소 2012 藥學論文集 Vol.27 No.-

The protective effects of irbesartan and amlodipine on neointimal hyperplasia have been well characterized. However, little is known about the beneficial effects of combination therapy of these two drugs for the protection of neointimal hyperplasia. This study was designed to investigate the synergistic effect of irbesartan combined with amlodipine on the magnitude of protective action in vascular injury mediated by cuff-induced neointimal hyperplasia model in spontaneous hypertensive rats. Irbesartan at 1.53 mg/kg (p.o.) or amlodipine at 0.48 mg/kg (p.o.) significantly decreased BrdU-positive cells in neointima, indicating the inhibition of cell proliferation including a progress of DNA synthesis. The combined treatment of same doses of irbesartan with amlodipine significantly decreased in BrdU incorporation. Interaction index calculated by isobolar method indicated that the combination therapy of these two drugs were synergistic. Therefore, these results suggest that the combined therapy of irbesartan with amlodipine be fully effective for the treatment of vascular remodeling such as restenosis.

精神病院 長期入院 患者의 病的反射

金柱漢,明好鎭 大韓神經精神醫學會 1982 신경정신의학 Vol.21 No.3

Ten pathologic reflexes were tested in 464 mental hospital inpatients and 200 normal subjects. The ages of the subjects ranged from 11 through 66 years old. The incidences of pathologic reflexes in the patient group were, 40% in the glabella reflex, 20 in the palmomental, eight in the Hoffmann and six in the snout. Whereas in control group, the glabella reflex was positive in only five %, the palmomental 20, the Hoffmann eight and the snout six. Incidences of the palmomental, snout, glabella, and Hoffmann reflex in control group increased with advancing age. The palmomental and snout reflexes in patients group also showed an increasing pattern with advancing age. The glabellar, palmomental and Hoffmann reflex appeared earlier in the age and more often in the patients group than control group. It appears that some primitive reflexes are normal phenomena in a significant proportion of the healthy population.

〈바람과 함께 사라지다〉의 복식 분석 : 여주인공 복식을 중심으로 In the Reference to Scarlett O'Hara's Costume

徐恩柱,韓明淑 服飾文化學會 1997 服飾文化硏究 Vol.5 No.2