[1.1.1.1]Paddlane과 할로겐 화합물과의 반응

李愚鵬,吳東元,黃悳海,權明淑,鄭宰準 慶北大學校 師範大學 科學敎育硏究所 2002 科學敎育硏究誌 Vol.26 No.-

[1.1.1]Paddlane has an inverted structure at two bridge-head carbon atoms. We will describe the reaction of [1.1.1]Paddlane and [1.1.1.1]Paddlane. The reaction of [1.1.1]propellane with singlet methylene affored 1,3-Dimethylene as the major product and [1.1.1.1]paddlane as the minor products were obtained. The reaction of [1.1.1]propellane with triplet methylene was carried out in the similar conditions. The result afforded 1,3-Dimethylenecylopropane as the major product and various side products were also obtained. But no trace of [1.1.1.1]paddlane was detected. After the synthesis of [1.1.1.1]paddlane, continuously [1.1.1.1]paddlane reacts with iodide. The product that I expected for 1,3-diiodo-tricyclo[1.1.1.1]hexane is different. and has unsymmetrical structure.

Soil Carbon Dynamics under Pinus koraiensis and Quercus acutissima Forest Floors in Relation to Nitrogen Addition

Ji-Suk Park(박지숙),Jong-Sung Kim(김종성),Tae-Kyu Lee(이태규),Seo-Yeon Lee(이서연),Min-Jin Lee(이민진),Hee-Myong Ro(노희명),Suk-Kwon Kim(김석권),Tae-Sung Kwon(권태성) 한국토양비료학회 2013 한국토양비료학회 학술발표회 초록집 Vol.2013 No.10

아버지의 성 상동형(sex-role stereotype)과 아동의 성 상동형과의 관계연구

권은정,김연신,노명희,박영미,원경록,이경열,이계숙,이진용,임희진,최여정,최혜영,홍성애 연세대학교 생활과학대학 1987 婦學 Vol.20 No.-

The purpose of this study was to explore the relationship between the sex-role stereotype of the father and the child. We investigated the following: ⑴ Is there a relationship between the sex-role stereotype of the father and the child? ⑵ Is the age of the child a variable in the relationship between the sex-role stereotype of the father and the child? ⑶ Is the sex of the child a variable in the relationship between the sex-role stereotype of the father and the child? The subjects were 193 13-year-old students attending a middle school in Seoul and their fathers and 70 5-year-olds attending a kindergarten in Kwachon and their fathers. The test for the 193 middle school students and their fathers was the Likert Scale of the Bem Sex-Role Inventory which was utilized by the experimenters after a pretest. The instrument for the 5-year-olds was the 22 story-picture card Williams and Bunnett test(1975) modified by Lee, Sook(1982). The kindergarten fathers were tested with the same instrument as the middle school fathers. The data from these 2 tests were then compared using χ^2 test and percent(%). The result of this study were: ⑴ A relationship between the sex-role stereotype of the father and the child was found only between the sex-role stereotype of the middle school students and their fathers. ⑵ Age of the child was found to be a variable in the relationship between the sex-role stereotype of the father and the child. That is, a significant relationship was found between the sex-role stereotype of the middle school students and their fathers, but not between the sex-role stereotype of the preschool children and their fathers. ⑶ Sex of the child was found to be a variable in the relationship between the sex-role stereotype of the father and the child. That is, a significant relationship was found between the sex-role stereotype of the middle school boys and their fathers, but not between the sex-role stereotype of the middle school girls and their fathers.

Induction and Proliferation of Callus in the Flower Stalk of Calanthe discolor Lindl. and its Antioxidant Properties

Dong-Myong Kim,Ju-Yeong Jung,Hyung-Kon Lee,Yong-Seong Kwon,Kwan-Ho Lee,Jin-Hoon Jang,In-Suk Han 한국피부과학연구원 2021 아시안뷰티화장품학술지 Vol.19 No.3

목적: 본 연구는 새우난초의 난꽃 줄기(Calanthe discolor Lindl's Flower Stalk, CFS)로부터 캘러스를 유도하기 위한 적정 조건을 확 립하고 이러한 조건에서 생성된 CFS 캘러스 추출물의 항산화도 및 피부자극도를 분석함으로써 항산화능이 있는 기능성 화장품으 로의 이용 가치를 확인하기 위해 진행되었다. 방법: CFS 캘러스를 유도하기 위해 Murashige & Skoog 기초배지를 이용하였으며 이때 식물생장조절체의 적정 농도를 확인하기 위해 NB0 (α-naphthaleneacetic acid (NAA) 0, benzyladenine (BA) 0), NB1 (NAA 0.2 mg/L, BA 0.1 mg/L), NB5 (NAA 0.2 mg/L, BA 0.5 mg/L) 및 NB10 (0.2 mg/L, BA 1.0 mg/L)으로 나누어 배양하였다. 캘 러스 분말을 초음파 처리하여 추출하였으며, 추출물의 총 페놀함량, DPPH 항산화도 분석 및 인체 피부 자극시험을 진행하였다. 결 과: CFS 캘러스 샘플 NB5는 BA의 농도가 높아지는 조건에서 높은 캘러스 성장률을 보였으며, 본 조건에서의 캘러스의 질량은 4.2 ±0.3 g이었다. CFS 캘러스 추출물의 항산화도 분석 결과, NB0, NB1, NB5 및 NB10의 총 페놀 함량은 각각 33.71±0.27, 37.59 ±0.51, 46.26±0.18 및 55.92±0.33 mg GAE/g으로 식물생장조절체 BA의 첨가량이 높을수록 유의적으로 높은 페놀 함량을 가진 캘러스가 유도되었다. 또한, CFS 추출물 농도별 NB0, NB1, NB5, NB10의 2,2-diphenyl-1-picrylhydrazyl (DPPH) 라디칼 소거 활성 분석 결과, 캘러스 유도 시 식물생장조절체로 0.2 mg/L의 NAA 및 1.0 mg/L의 BA가 첨가된 처리군(NB10)에서 가장 활성이 높은 것으로 나타났다. 마지막으로 CFS 캘러스 추출물의 자극성을 확인하기 위하여 인체 피부 첩포시험을 실시하였으며 대조군은 10% SLS에 비하여 CFS 캘러스 추출물은 매우 낮은 자극성을 보였다. 결론: CFS 캘러스의 유도 적정 조건을 확립하였으며, 항산화 활성 및 저자극성을 확인함으로써 항산화능이 있는 기능성 화장품 원료로써 이용 가치를 확인하였다. Purpose: This study aims to establish the appropriate conditions for induction and proliferation of callus from the flower stalk of Calanthe discolor Lindl. (CFS) and to analyze the antioxidant properties as well as the skin irritation level of its extracts. Methods: Murashige & Skoog medium was used to induce the callus from CFS with NB0 (α-naphthaleneacetic acid (NAA) 0 mg/L, benzyl adenine (BA) 0 mg/L), NB1 (NAA 0.2 mg/L, BA 0.1 mg/L), NB5 (NAA 0.2 mg/L, BA 0.5 mg/L), and NB10 (0.2 mg/ L, BA 1.0 mg/L) as plant growth regulators (PGR). The callus powder was extracted by ultrasonic treatment, and the total phenolic contents (TPC), 2,2-diphenyl-1- picrylhydrazyl (DPPH) radical scavenging activity, and human skin irritation test using callus extracts were performed. Results: As a result of callus induction from CFS with PGR, NB5 showed the highest growth rate of callus with a weight of 4.2±0.3 g. The TPC of the callus extracts NB0, NB1, NB5, and NB10 were 33.71±0.27, 37.59±0.51, 46.26±0.18, and 55.92±0.33 mg GAE/g, respectively. NB10 showed the highest value of DPPH radical scavenging activity than that of NB0, NB1, NB5, and NB10, in various concentrations. CFS callus extract showed very low human skin irritation compared to that of the control group, 10% SLS. Conclusion: The optimal PGR condition for induction of CFS callus was established as NB10. CFS callus extracts can be used as functional materials for cosmetics as it has significant antioxidant activity and low skin irritation value.

Novel Composition of Multifunctional Sunblock from Eisenia bicyclis and Aloe vera Extracts and a Mixed Compound of Titanium Dioxide

Dong-Myong Kim,Ju-Yeong Jung,Hyung-Kon Lee,Sang-Keun Park,Yong-Seong Kwon,Seung-Koo Yang,In-Suk Han 한국피부과학연구원 2020 아시안뷰티화장품학술지 Vol.18 No.3

목적: 본 연구에서는 자외선 차단분체와 적외선 및 열선 차단분체의 혼합분체에 대황(Eisenia bicyclis) 및 알로에(Aloe vera)의 복 합추출물을 혼합함으로써 피부 온도가 상승하는 것을 억제하는 다기능성 썬 제형 조성물(Novel Composition of Multi-Functional Sunblock, NCMFS)을 제조하였다. 방법: 마이크론 이산화티타늄과 나노 이산화티타늄을 이용해 혼합분체를 제조하였으며, 이 혼 합분체에 대황 및 알로에 추출물을 혼합하여 NCMFS를 제조하였다. 혼합분체의 물성(형태 및 입도)을 분석하였으며, 각각 자외선 차단분체, 혼합분체, 그리고 NCMFS의 자외선, 적외선 및 열 차단 효과를 분석하였다. 또한 NCMFS의 미세먼지 부착도 및 내수성 을 평가하였다. 결과: 혼합분체의 물성분석 결과, 혼합 시 최적 중량 비율인 2.5:7.5가 확인되었다. 알로에 추출물, 대황 추출물 및 NCMFS를 대상으로 SPF 수치와 PA 수치를 측정한 결과, 각각 34.35±0.36 및 34.87±0.36로 NCMFS에서 가장 높은 값을 보였다. 마찬가지로, 단일 차단분체, 혼합분체, NCMFS를 대상으로 SPF 수치와 PA 수치를 측정한 결과, 각각 34.39±0.41 및 34.37±0.52 로 NCMFS가 가장 높은 값을 보였다. 자외선/적외선 열화상 카메라를 통해 NCMFS의 사용 전후의 비교 사진 촬영을 통해 자외선, 적외선 및 열선 차단 효과를 가지는 것이 확인되었다. 또한, 우수한 미세먼지 부착도 및 내수성을 가지는 것이 확인되었다. 결론: 본 연구를 통해 무기 자외선 차단제인 이산화티타늄 혼합분체의 최적 중량 비율을 규명하였다. 대황 및 알로에 복합추출물을 함께 혼 합하여 자외선, 적외선 및 열선을 동시에 차단함으로써 높은 자외선 수치를 가지는 다기능성 썬 제형 조성물이 확인었되다. Purpose: The objective of this study was to develop a novel composition of multifunctional sunblock (NCMFS) by combining extracts from Eisenia bicyclis (E. bicyclis ) and Aloe vera (A. vera ) with a mixture of micron- and nano-titanium dioxide (TiO2) powders, which are MP-100 and MPT-136, respectively, characterized by ultraviolet (UV)-blocking properties. Methods: The mixed compound was prepared by combining micron-TiO2 and nano-TiO2 particles. The NCMFS was prepared by combining E. bicyclis and A. vera extracts with the mixed compound. The physicochemical properties (particle shape and size) of the mixed compound and UV, infrared (IR), and thermal blocking efficiency of each compound were analyzed. Results: Analysis of the physicochemical properties of the mixed compounds showed that the optimum ratio of mixing MP-100 and MPT-136 was 2.5:7.5. Measurement of sun protection factor (SPF) and protection grade of UV-A (PA) values of A. vera , E. bicyclis , and mixed extracts and NCMFS showed that the NCMFS mixture had the highest values, which were 34.35±0.36 and 34.87±0.36, respectively. Similarly, upon measuring the SPF and PA values, the highest values, 34.39±0.41 and 34.37±0.52, respectively, were measured for NCMFS and compared to the values of each single compound or the mixed compound. In addition, it was found NCMFS has excellent antifine dust adhesion rate and water-resistant properties. Conclusion: Therefore, our results suggested that the NCMFS consisting of the mixture of TiO2 and E. bicyclis and A. vera extracts has not only UV, IR, and thermal-blocking activity but also antidust protectant and water-resistance properties.

Temporal Change in Soil Carbon Dynamics under Pinus Koraiensis and Quercus Acutissima Forest Floors

Ji-Suk Park,Hee-Myong Ro,Min-Jin Lee,Seo-Yeon Lee,Joo-Han Sung,Tae-Sung Kwon 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6

하치조신경 마취 후 전기치수검사기(Electric pulp tester)를 이용한 하순부 감각 변화 평가

구명숙(Myong-Suk Ku),김진욱(Jin Wook Kim),전영훈(Young Hoon Jeon),권대근(Tae Geon Kwon),이상한(Sang Han Lee) 대한구강악안면외과학회 2011 대한구강악안면외과학회지 Vol.37 No.6

Introduction: As dental implant surgery is becoming increasingly popular, it has become one of the causes for the hypesthesia of the inferior alveolar nerve, along with other surgical procedures, such as a third molar extraction. In addition, it tends to cause legal problems between the operator and patient. Therefore, there must be a proper method that is reliable, objective and economical to assess the nerve impairment. For this reason, an attempt was made to use an Electric Pulp Tester to assess inferior alveolar nerve block anesthesia. Materials and Methods: Thirty patients were tested. Electric pulp testing of the lower jaw skin was performed at the three different times, before anesthesia, at the onset of sensory changes and after 15 minutes waiting from the onset, and on the 10 points of the chin, which produced 10 sections on the skin area. Results: Twenty seven patients (90%) could feel the electric stimulus on the chin at all 10 points before local anesthesia and the scores represent the statistical differences between the right and left points except R4 and L4. After anesthesia, the difference between the right and left points (L3-R3, L4-R4, L5-R5) increased significantly with time but two points (L2, R2) showed no significant difference. The scores on the left chin (L3, L4, L5) increased, whereas the other points (R1-R5, L1, L2) showed no significant differences. Conclusion: This study highlights the potential clinical use of an electric pulp tester for an assessment of inferior alveolar nerve impairment.

무가압침투법으로 제조된 SiC 입자 강화 A1 합금 기지 복합재료의 고온 크립 거동에 기지 합금 조성이 미치는 영향

김용석,권훈,송명훈 대한금속재료학회(대한금속학회) 2001 대한금속·재료학회지 Vol.39 No.5

High temperature creep behaviour of 20 vol.% SiC particle reinforced 5052 Al, 6061 Al and 7075 Al alloy matrix composites was studied at temperatures of 633, 663, and 693K under the applied stress range of 25∼100 ㎫. The composites were manufactured by the pressureless infiltration technique. The composites showed high apparent stress exponent and activation energy. The 7075 Al matrix composite showed the highest creep strength at 633K, while at 693K the 5052 Al matrix composite had the highest creep resistance. The creep strength of the 7075 Al matrix composite decreased rapidly with increase of the temperature. True stress exponent of the composites was measured as 5 and major creep mechanism of the composites was found to be lattice self-diffusion of the matrix alloy. Different temperature-dependence of the composites' creep strength and the threshold stress (including its origin) were attributed to different amount of precipitates and aluminum nitrides in the matrix alloys.

알로에 베라 부정근 추출물을 함유하는 피부 개선용 화장료 조성물에 관한 연구

김동명(Dong-Myong Kim),정주영(Ju-Yeong Jung),이형곤(Hyung-Kon Lee),권용성(Yong-Seong Kwon),백진홍(Jin-Hong Baek),한인석(In-Suk Han) 한국생물공학회 2020 KSBB Journal Vol.35 No.3

The objective of this study was to investigate whether extracts of aloe vera adventitious root produced by plant tissue culture technology has better effects on anti-wrinkle effect and skin-brightening than aloe vera extracts by performing in vitro assays. Aloe vera adventitious root and aloe vera were extracted by either water or 70% ethanol. Among water extract of aloe vera, water extract of aloe vera adventitious root, ethanol extract of aloe vera (AVE) and ethanol extract aloe vera adventitious root (AVRE), nitric oxide production inhibitory activity was the highest at AVRE, with a value of 62.28%. Inhibitory activities of matrix metalloproteinase (MMP)-1 and MMP-3 syntheses were highest at AVRE (65.11 and 37.21%, respectively). When analyzing synthetic activity of type I procollagen which has an antiwrinkle effect, AVRE showed higher value by 379.43% than UV-irradiated control group. The anti-melanogenic activity which correlates skin-brightening effect was also the highest at AVRE (83.77%), although, inhibitory activity of tyrosinase was not shown. Moreover, the value of DPPH radical scavenging activity of AVRE was higher than that of AVE by more than 10 times. From these results, it was confirmed that aloe vera adventitious root has better effect on wrinkle prevention and skin-brightening than aloe vera.

식용 제비집으로부터 비극성 비드기술을 활용한 시알산의 분리정제방법에 관한 연구

김동명(Dong-Myong Kim),정주영(Ju-Yeong Jung),이형곤(Hyung-Kon Lee),권용성(Yong-Sung Kwon),백진홍(Jin-Hong Baek),한인석(In-Suk Han) 한국해양바이오학회 2020 한국해양바이오학회지 Vol.12 No.2

Sialic acid, which is contained in about 60-160 mg/kg in the edible bird’s nest(EBN), is known to facilitate in the proper formation of synapses and improve memory function. The objective of this study is to extract effectively the sialic acid from edible bird’s nest using affinity bead technology (ABT). After preparing the non-polar polymeric bead “KJM-278-28A” having a porous network structure, and then desorbed sialic acid was concentrated and dried. The analysis of the physicochemical properties of bead “KJM-278-28A” showed that the particle size was 400-700 μm, the moisture holding capacity was 67-70%, the surface area (BET) was 705-900 m²/g, and the average pore diameter 70-87 Å. The adsorption capacity of the bead “KJM-278-28A” for sialic acid was shown a strong physical force to bind sialic acid to the bead surface of 400 mg/L. In addition, as a result of analyzing the adsorption and desorption effects of sialic acid on water, ethanol, and 10% ethanol on the bead, it was confirmed that desorption effectively occurs from the beads when only ethanol is used. As a result of HPLC measurement of the separated sialic acid solution, a total of four sialic acid peaks of N-acetyl-neuraminic acid (Neu5Ac), α,β-anomer of Neu5Ac and N-glycoly-neuraminic acid were identified. Through these results, it was confirmed that it is possible to separate sialic acid from EBN extract with efficient and high yield when using ABT.