조기위암의 복강경 보조 원위부 위절제술과 개복술의 비교

이상일(Sang-Il Lee),윤유석(Yoo-Seok Yoon),최유신(Yoo-Shin Choi),김형호(Hyung-Ho Kim),한호성(Ho-Seong Han),양한광(Han-Kwang Yang) 대한외과학회 2005 Annals of Surgical Treatment and Research(ASRT) Vol.68 No.3

급성 폐동맥색전증과 성인성호흡곤란증후군에서 산소운반과 산소섭취의 상관관계

이상도 ( Lee Sang Do ),한성구 ( Han Seong Gu ),심영수 ( Sim Yeong Su ),김건열 ( Kim Geon Yeol ),한용철 ( Han Yong Cheol ) 대한내과학회 1993 대한내과학회지 Vol.44 No.4

연구배경 : 성인성 호흡곤란증후군에서 PEEP을 적용할 때 산소운반을 최대로 하려는 노력은 결국 조직에서의 산소섭취를 최대로 하기 위해서이며, 이는 조직의 산소섭취가 산소운반에 비례한다는 가정에 근거하나 이에 대해서는 아직 이견이 많다. 한편 성인성 호흡곤란증후군과는 호흡부전의 기전이 다른 급성 폐동맥색전증에서 산소운반과 산소섭취의 상관관계에 대해서는 아직 알려진 바 없다. 방법 : 성인성 호흡곤란증후군과 급성 폐동맥색전증에서 산수운반과 산소섭취의 상관관계를 밝히고자 한국산 잡견 14마리중 7마리에는 oleic acid를 정주해 성인성호흡곤란증후군을 유발하고 나머지 7마리에는 자가혈병을 이용해 급성 폐동맥색전증을 유발한 후 PEEP 수준을 변화시키며 환기 및 혈류역학의 제지표를 측정해 다음과 같은 결과를 얻었다. 결과 : 1) 산소운반과 산소섭취 : ARDS군은 12~28ml/min/kg 의 산소운반 범위에서 산소운반의 감소에 따른 산소섭취의 감소를 관찰할 수 있었고, 산소운반의 변화와 산소섭취의 변화사이에는 유의한 상관관계가 있었다(r=0.55, p<0.05). 산소추출률(oxygen extraction ratio)과 산소운반 사이에는 유의한 상관관계가 없었다. 급성 폐동맥색전증군에서 역시 7~29ml/min/kg의 산소운반 범위에서 산소운반의 감소에 따른 산소섭취의 감소를 관찰할 수 있었고, 산소운반의 변화와 산소섭취의 변화 사이에 유의한 상관관계가 있었다(r=0.57, p<0.05). 산소추추률과 산소운반 사이에는 유의한 상관관계가 없었다. 2) 혼합정맥혈 산소분압 : ARDS군에서 산소운반의 변화와 혼합정맥혈 산소분압의 변화 사이에는 유의한 상관관계가 있었고 (r=0.79, p<0.05), 혼합정맥혈 산소분압의 변화와 심박출량의 변화사이에도 유의한 상관관계가 있었다(r=0.75, p<0.05). 급성 폐동맥색전증군에서 역시 산소운반의 변화와 혼합정맥혈 산소분압의 변화 사이에는 유의한 상관관계가 있었고(r=0.83, p<0.05), 혼합정맥혈 산소분압의 변화와 심박출량의 변화사이에도 유의한 상관관계가 있었다(r=0.72, p<0.05). 결론 : 이상의 결과로 산소공급에 대한 조직에서 산소 섭취의 의존성은 성인성 호흡곤란증후군에 국한된 현상이 아니고 급성 폐동맥색전증에서도 관찰되며, 혼합정맥혈 산소분압은 이 두 질환에서 조직에의 산소공급의 변화를 예견할 수 있는 유용한 지표로 생각된다. Background: In adult repiratory distress syndrome(ARDS) the pathologi supply dependence of oxygen consumption, whoch provide the basis for `best PEEP`, is suggested, but which is still in controversy. And in acute pulmonary embolism little is known about the relationship betwen oxygen transport and oxygen consumption. Methods: To evaluate the relationship betwen oxygen transport and oxygen consumption in ARDS and acute pulmonary embolism, experimental ARDS was induced in 7 mongrel doges with oleic acid and acute pulmonary emblism in 7 dogs with autologous blood clot. Then hemodynamic and gas exchange parameters were measured with serial increment of PEEP. Results: In ARDS group, blow the oxygen transport of 28 ml/min/kg, the change of oxygen consumption was linearly related to the change of oxygen transport(r=0.55, p<0.05). Oxygen extraction ratio didn`t correlate with oxygen transport. In acute pulmonary embolism group, below the oxygen transpot of 29ml/min/kg, change of oxygen consumption was linearly relatred to change of oxygen transport(r=0.57, p<0.05). Oxygen extraction ratio didn`t correlate with oxygen transport. In ARDS group there was a significant correlation between the change of oxygen tension (r=0.79, p<0.05). In acute pulmonary embolism group there was a significant correlation between the change of oxygen transport and change of mixed venous oxygen tension (r=0.83, p<0.05). Conclusion: These data suggest that a linear relationship between oxygen consumption and oxygen transport is not unique to ARDS. Mixed venous oxygen tension seems to be sensitive predictor of oxygen transport in both ARDS and acute pulmonary embolism.

T-50 고등 훈련기 엔진/기체 적합성 검증을 위한 추진계통 비행시험

이상효(Sang-Hyo Lee),정인면(InMyon Jeong),정주현(JooHyun Jung),심재광(JaeKwang Shim),강성수(SungSoo Kang),박성환(SungHwan Park),한병학(ByoungHak Han),문형래(HyungRae Moon),차재병(JaeByoung Cha),이부일(BooIl Lee) 한국항공우주학회 2007 韓國航空宇宙學會誌 Vol.35 No.10

항공기를 개발함에 있어 기체를 구성하는 계통의 성능이 항공기 요구도를 만족하는 수준으로 발휘되는지 확인하는 것이 중요하다. 특히, 엔진을 포함한 추진계통은 항공기를 구성하는 구성품 중 중요한 계통으로서, 추진계통과 기체와의 통합성을 검증하는 것이 항공기 개발에 있어 필수적 요소이다. T-50 고등훈련기 체계개발 시 추진계통 검증을 위해 엔진 공중재시동 시험 및 엔진 축마력 시험, backup throttle기능 시험 등의 다양한 비행시험을 수행하였으며, 이와 같은 항목의 비행시험을 통하여 T-50 고등 훈련기의 추진계통이 기체에 적합하게 설계/장착되었음을 확인하였다. 본 논문에서 추진계통 비행시험 항목에 대한 설명 및 시험 절차, 결과를 제시하였으며, 본 논문의 내용이 차후 타 항공기 개발 시 추진계통 관련 비행시험을 준비하는 과정에서 참고가 될 수 있을 것으로 기대한다. It is important during FSD(Full Scale Development) period to verify whether the aircraft system function meets the aircraft requirements and functional performance. Especially, the functionality of the integrated propulsion system should be verified to evaluate the compatibility with aircraft. Various flight tests such as the engine airstart test, the engine horsepower extraction test, the backup throttle functionality test had been performed to evaluate the engine/aircraft compatibility with T-50 during FSD period. Through such flight tests, it was confirmed that the propulsion system of T-50 was properly designed and installed to the aircraft. This paper shows description on each flight test item, test procedure and test results. It is expected that this paper could be a reference for preparing the propulsion flight test in other aircraft developments.

골반골절 환자의 골절위치와 출혈량간의 상관관계 분석을 통한 대량수혈 필요에 대한 간단한 예측도구 개발: 골반골 출혈 지수

이상식 ( Sang Sik Lee ),배병관 ( Byung Kwan Bae ),한상균 ( Sang Kyoon Han ),박성욱 ( Sung Wook Park ),류지호 ( Ji Ho Ryu ),정진우 ( Jin Woo Jeong ),염석란 ( Seok Ran Yeom ) 대한외상학회 2012 大韓外傷學會誌 Vol.25 No.4

Purpose: Hypovolemic shock is the leading cause of death in multiple trauma patients with pelvic bone fracures. The purpose of this study was to develop a simple prediction method for injury severity and amount of hemorrhage via an analysis of the correlation between the site of pelvic bone fracture and the amount of transfusion and to verify the usefulness of the such a simple scoring system. Methods: We analyzed retrospectively the medical records and radiologic examination of 102 patients who had been diagnosed as having a pelvic bone fracture and who had visited the Emergency Department between January 2007 and December 2011. Fracture sites in the pelvis were confirmed and re-classified anatomically as pubis, ilium or sacrum. A multiple linear regression analysis was performed on the amount of transfusion, and a simplified scoring system was developed. The predictive value of the amount of transfusion for the scoring system as verified by using the receiver operating characteristics (ROC). The area under the curve of the ROC was compared with the injury severity score (ISS). Results: From among the 102 patients, 97 patients (M:F=68:29, mean age=46.7±16.6 years) were enrolled for analysis. The average ISS of the patients was 16.2±7.9, and the average amount of packed RBC transfusion for 24 hr was 3.9±4.6 units. The regression equation resulting from the multiple linear regression analysis was ``packed RBC units=1.40×(sacrum fracture)+1.72×(pubis fracture)+1.67×(ilium fracture)+0.36`` and was found to be suitable (p=0.005). We simplified the regression equation to ``Pelvic Bleeding Score=sacrum+pubis +ilium``. Each fractured site was scored as 0(no fracture) point, 1(right or left) point, or 2(both) points. Sacrum had only 0 or 1 point. The score ranged from 0 to 5. The area under the curve (AUC) of the ROC was 0.718 (95% CI: 0.588-0.848, p=0.009). For an upper Pelvis Bleeding Score of 3 points, the sensitivity of the prediction for a massive transfusion was 71.4%, and the specificity was 69.9%. Conclusion: We developed a simplified scoring system for the anatomical fracture sites in the pelvis to predict the requirement for a transfusion (Pelvis Bleeding Score (PBS)). The PBS, compared with the ISS, is considered a useful predictor of the need for a transfusion during initial management. (J Trauma Inj 2012;25:139-144)

Analysis of Anti-Allergic Activities by Extracts from Persimmon Sap-Stained Rayon and Cotton Fabrics

Sang-Han Lee(이상한) 한국생명과학회 2010 생명과학회지 Vol.20 No.5

알러지성 피부염은 현재 영유아 4인 중 1명이 발병할 정도로 심각한 질환으로 보고되어 있다. 본 연구는 청도 감물염색을 한 직물 2종(인견과 면)의 물 추출물이 알러지성 피부염 유도 동물모델에서 피부의 표피에 면역관련의 세포의 수를 감소시킴을 H&E 염색으로 확인하였으며, 알러지성 피부염에 직접 관련이 있는 분자표적인 CD4? cell의 분포를 비교하여 본 결과, 유의성 있게 항알러지성 피부염 활성을 보유하고 있는 것을 확인하였다. MMP-2와 MMP-9의 면역조직화학적 분석을 수행한 결과, 이들의 발현도 감소함으로 감물염색에 사용된 감의 유용성분 예를 들면 폴리페놀 성분 등이 알러지성 피부염의 억제활성에 관련이 있을 것으로 추정된다. Allergic dermatitis is one of the most prevalent diseases in young/juvenile children worldwide. In this research, extracts with persimmon sap-stained fabrics (rayon and cotton) exhibited an elevation in CD4? cell numbers. MMP-2 and MMP-9 expressions by Hematoxylin-Eosin staining and immunohistochemistry revealed that the expressions were decreased by addition of the extracts. The present results collectively suggest that the active ingredients of persimmon sap-stained fabrics play an important role in inhibition of DNFB-induced-atopic symptoms in vivo.

다원주 군파일의 침식방지효과에 관한 실험적 연구

이상화(Lee, Sang-Hwa),장은철(Jang, Eun-Cheul),이한승(Lee, Han-Seung),정석재(Jeong, Seok-Jae) 한국해안해양공학회 2011 한국해안해양공학회 논문집 Vol.23 No.2

연안역 파랑제어 구조물의 설계와 연안역 관리에 있어서 안전성문제 뿐만 아니라 환경문제는 가장 중요한 요인 중 하나이다. 본 연구에서는 파랑을 효율적으로 제어할 뿐만 아니라 연안역 보존에도 유리한 구조물로써 다원주 군파일을 제안하였다. 이 구조물의 침식방지효과를 파악하기위하여 수리모형실험을 수행하였다. 본 연구에서는 콘크리트를 사용한 기존의 파제제와 다원주 군파일을 이용한 구조물을 동일 평면배치 상에 두고 실험을 하여 침식방지효과를 분석하였다. 다원주 군파일 구조물을 설치했을 경우 구조물 양끝단에서의 침식현상은 줄어들었으며, 구조물 배후의 퇴적경향은 뚜렷하게 나타남을 확인할 수 있었다. Environmental and safety problems are one of the most important factors in designing coastal wave control structures and maintaining facilities in coastal zone. This study suggests the multi-cylinder piles as a profitable structure for preserving coastal zone as well as controlling the wave effectively. The hydraulic model experiment was performed to investigate the effect of erosion control of the structure. The experimental study was carried out to research the effect of erosion control in the coastal zone for existing a concrete wave breaker and the structure with multi-cylinder piles placing at the same location. As a result multi-cylinder piles reduced erosion at each sides of structure and occured sedimetation at front of structure.

본 교실에서 시행한 악교정 수술 증례에 관한 임상적 연구

이상한(Sang-Han Lee),박인숙(In-Sook Park),이창환(Chang-Hwan Lee),권대근(Tae-Geon Kwon),Yun Man,Deng Fangchen 대한구강악안면외과학회 2005 대한구강악안면외과학회지 Vol.31 No.3

We observed 469 cases (male 217 cases, female 252 cases) with dento-facial deformity for 10 years from Jan 1994 to Dec 2003. The ratio of male to female was 1:1.2 and the mean age was 23.3 years (male 24.0 years, female 22.6 years) ranged from 11 to 43 years.1) The most dominant group was related to mandibular prognathism (80.4%). A rate of 83.8% demonstrated mandibular protrusion according to Slavicek’s classification (n=160), and 85.4% were classified as skeletal Class III type according to Sugawara’s classification (n=151) Surgical method were divided into 355 cases of one jaw surgery (single method), 26 cases of one jaw surgery (combined method), and 77 cases of two jaw surgery. Sagittal split osteotomy were performed on 316 cases (69.0%). The average operation time and blood loss in SSRO were 4.1 ± 2.2 hrs. and 138.8 ± 222.6 ml (n=152)

Twin converter를 이용한 전자식 안정기에 관한 연구

이상집(Sang-Chip Lee),한홍일(Hong-Il Han),성낙규(Nark-Kuy Sung),백동현(Dong-Hyun Baek),김성남(Sung-Nam Kim),한경희(Kyung-Hee Han) 전력전자학회 2000 전력전자학술대회 논문집 Vol.2000 No.11

The rectifier circuit has been used in the various fields of inverter progress. This is simple and low price. Otherwise, it has many problems in harmonic, low power factor and etc.<br/> This paper use the twin converter of two jewel booster. It doesn't need the detection of voltage, current and control PWM. The twin converter has stably the rectification source. Also, the circuit is used a half-bridge inverter in the electronic ballast for lighting. Therefore, this method is confirmed in high efficiency.

출혈성 식도 정맥류의 내시경적 요법에 대한 연구

이상운(Sang Yoon Lee),이한기(Han Ki Lee),김정호(Jeong Ho Kim),강명원(Myung Weon Kang),박순희(Sun Hi Park),여향순(Hyang Soon Yeo),정판기(Pan Ki Jeoung),박홍배(Hong Bae Park) 대한내과학회 1987 대한내과학회지 Vol.32 No.6

N/A Hemorrhage from esophageal varices is a difficult problem for which there is no completely solution, Sixty-three patients (eight-five cases) have been treated with endoscopic injection sclerotherapy (EIS). All patients had documented variceal hemorrhage and underwent EIS while bleeding or shortly thereafter. The observed results are summarized as follows: 1) The duration of EIS from onset of hematmesis and/or melena was within 72 hours mostly, and the frequency of EIS was one to six times. 2) There were no noticable changes in Hemoglobin, SGOT, Serum bilirubin and serum albumin before and after EIS. 3) The amounts of blood transfusion was decreased significantly after EIS. 4) There were mild complications after EIS, but were serious complication or death relate to EIS. 5) The mortality rate was 13% in follow up period. Based on these results, we concluded that EIS is recommanded for managing variceal hemorrhage with- out serious complication.

3-D CT를 이용한 악교정술 전후의 하악과 설골의 위치에 관한 연구

이상한(Sang-Han Lee),남정훈(Jeong-Hun Nam),정창욱(Chang-Wook Jung),권대근(Tae-Geon Kwon) 대한구강악안면외과학회 2003 대한구강악안면외과학회지 Vol.29 No.3

Purpose : This study was intended to evaluate the positional relationship between the hyoid bone and the mandible in patients with mandibular protrusion after mandibular set-back surgery by means of 3D-CT. Materials and methods : Preoperative(3 weeks before) and postoperative (6 weeks after) 3D-CT & cephalogram were taken on 32 patients(12 male, 20 female, mean age of 23.2) treated by bilateral sagittal split osteotomy with rigid fixation. The angular measurement on 3D-CT basilar view were deviation of Me & H, long axis angle of left & right cornu majus. The lineal measurement on 3D-CT basilar view were composed of intercondylar line and coordinates(x,y) of Me & H. The angular & lineal measurement of lateral cephalogram were composed of mandibular plane angle, SNA, SNB, ANB, FH-NA & FH-NB, and coordinates(x,y) of B, Pog, Me & H, PAS, Lpw, MPH and IAS. On the frontal cephalogram, deviation of Me were evaluated. Results : The mean mandibular set-back was 8.0mm horizontally and mandibular plane angle was slightly increased. The hyoid bone was displaced postero-inferiorly, the distance between MP(mandibular plane) and H(hyoid bone) was increased and the posterior airway space values (PAS, Lpw, IAS) were decreased. The coordinates Me(x,y), H(x,y) and deviation angle Me’& H’were revealed the strong positive correlation. Conclusion : The results revealed that the horizontal, vertical and transverse relationship of the mandibular and the hyoid bone movements were significantly correlated in patients performed mandibular set-back surgery.