중국 연변 조선족자치주 성인과 한국 구리지역 성인의 식생활 양식 비교

이선희,백희영,김정순,문용,정효지 한국식생활문화학회 2001 韓國食生活文化學會誌 Vol.16 No.4

This study was conducted to investigate dietary patterns and assimilation of dietary culture of Korean descendants in Yanbian, China compared to Korean. A dietary survey was conducted using one 24-hour recall method from 730 adults over 30 years of age in Yanbian, China and 695 adults over 25 years of age in Kuri, Korea. The average number of food items consumed per day was 14 in Yanbian and 20 in Kuri and there was a significant difference between the two regions(p<0.001). The foods consumed most frequently were rice, salt, the M.S.G. in Yanbian and rice, green onion and garlic in Kuri. The foods consumed most by amount were rice, cucumber, Soju in Yanbian and rice, Kimchi and grape in Kuri. The average number of dishes consumed per day was 6.4 in Yanbian, 9.4 in Kuri and the difference between the two regions was significant(p<0.001). Total number of dishes appeared in the survey was 253 in Yanbian and 494 in Kuri. The dishes consumed most frequently were cooked-rice, beverages, Kimchi, stir-fried eggplant in Yanbian and cooked-rice, Kimchi, coffee, soybean paste stew, in Kuri. The dish groups appeared most frequently were rice, stir-fried foods, vegetables and Kimchi in Yanbian and rice, Kimchi, beverages and fruits in Kuri. Male subjects in Yanbian Consumed alcohol frequently while adults in Kuri consumed coffee more frequently than Yanbian. The major meal patterns were rice+side dish, rice+soup, rice+side dish+Kimchi in Yanbian and rice+soup+side dish+Kimchi, rice+side dish+Kimchi, rice+soup+Kimchi in Kuri. Stir-fried foods, which were consumed 46.6% of all the meals, were dominant side dish in Yanbian, but stir-fried food, seasoned vegetables and grilled food appeared aver 10% in Kuri. There results show that variety of diet of Korean-Chinese in Yanbian was lower than Kuri. Korean-Chinese tend to keep traditional Korean dietary patterns of consuming rice as staple but were adapted to Chinese dietary patterns of consuming stir-fried side dishes. Efforts should be directed toward preserving Korean traditional patterns of dietary culture among Korean-Chinese population.

Design and applications of fluorescent detectors for peroxynitrite

Wang, Shan,Chen, Liyan,Jangili, Paramesh,Sharma, Amit,Li, Wei,Hou, Ji-Ting,Qin, Caiqin,Yoon, Juyoung,Kim, Jong Seung Elsevier 2018 Coordination chemistry reviews Vol.374 No.-

<P><B>Abstract</B></P> <P>Peroxynitrite (ONOO<SUP>−</SUP>) is one of the endogenous reactive oxygen species (ROS), which causes damage to a wide array of molecular components in the cells, including DNA and proteins, owing to its high oxidizing as well as nitrating properties. However, the precise pathogenic roles played by this substance in biological systems have not yet been elucidated completely owing to its short lifetime, high reactivity, low concentration and elusive nature in the <I>in vivo</I> applications. Thus, the development of more sensitive and selective techniques for detecting ONOO<SUP>−</SUP>, with high biocompatibilities, sensitivities, and site-specificities, is a significant goal. This review summarizes the recent advances that have been made in developing fluorescent sensors for ONOO<SUP>−</SUP> and their biological applications in diverse living systems.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The general significance of ONOO<SUP>−</SUP> detection. </LI> <LI> The design strategies of functional ONOO<SUP>−</SUP> probes. </LI> <LI> The diverse platforms to design ONOO<SUP>−</SUP> probes, including small molecules, proteins and nanocarriers. </LI> <LI> The diverse biological applications of fluorescent ONOO<SUP>−</SUP> probes. </LI> <LI> Perspectives and potential future directions. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>In this review, the development of fluorescent probes for peroxynitrite detection since 2013 is described. The chemical sensor’s designs has been classified by their reaction based sensing patterns.</P> <P>[DISPLAY OMISSION]</P>

Release dynamics of As, Co, and Mo in a biochar treated soil under pre-definite redox conditions

El-Naggar, Ali,Shaheen, Sabry M.,Hseu, Zeng-Yei,Wang, Shan-Li,Ok, Yong Sik,Rinklebe, Jö,rg Elsevier 2019 The Science of the total environment Vol.657 No.-

<P><B>Abstract</B></P> <P>This study assessed the impact of pre-definite redox potential (E<SUB>H</SUB>) on the release dynamics and distribution of As, Co, and Mo between the dissolved and colloidal phases as well as their potential mobility and phytoavailability in the sediment phase of a mining soil treated with rice hull biochar (BC). The experiment was conducted from controlled moderately-reducing to oxidizing conditions using an automated biogeochemical microcosm system. Arsenic and Mo were more abundant in the dissolved phase due to their predominant in potential mobile fractions, while Co was more abundant in the colloidal phase due to its association with Fe-(hydr)oxides. Biochar increased the dissolved and colloidal concentrations of As, the dissolved concentration of Co, and the colloidal concentration of Mo under oxidizing condition. On the other hand, the application of BC decreased the dissolved concentration of Mo and the colloidal concentration of Co in the first redox cycle under reducing-acidic condition, due to lower pH values, and chemistry of sulfide-sulfate and Fe/Mn oxides. The phytoavailability of As and Co were higher than their potential mobility in the sediment phase, while the same trend was not discerned for Mo. The potential mobility and phytoavailability of As and Co were high under oxic-acidic conditions. The potential mobility and phytoavailability of Mo might be increased under oxic condition due to the dissolution of Fe and Mn oxides under lower pH conditions, especially in the BC treated soil. Application of such rice hull BC to soil might stimulate the release of As, Co, and Mo under flooding conditions, which might increase the environmental and health risks in such wetland ecosystems.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The E<SUB>H</SUB> showed a converse relation with pH in biochar treated and non-treated soils. </LI> <LI> Arsenic and Mo were abundant in the dissolved phase, but Co in the colloidal phase. </LI> <LI> Biochar increased the dissolved As and Co under oxidizing conditions. </LI> <LI> Biochar decreased the dissolved Mo under acidic conditions in the first redox cycle. </LI> <LI> Potential mobility and phytoavailability were higher under low pH and high E<SUB>H</SUB>. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Systematic Functional Annotation of Somatic Mutations in Cancer

Ng, Patrick Kwok-Shing,Li, Jun,Jeong, Kang Jin,Shao, Shan,Chen, Hu,Tsang, Yiu Huen,Sengupta, Sohini,Wang, Zixing,Bhavana, Venkata Hemanjani,Tran, Richard,Soewito, Stephanie,Minussi, Darlan Conterno,Mo Cell Press 2018 CANCER CELL Vol. No.

<P><B>Summary</B></P> <P>The functional impact of the vast majority of cancer somatic mutations remains unknown, representing a critical knowledge gap for implementing precision oncology. Here, we report the development of a moderate-throughput functional genomic platform consisting of efficient mutant generation, sensitive viability assays using two growth factor-dependent cell models, and functional proteomic profiling of signaling effects for select aberrations. We apply the platform to annotate >1,000 genomic aberrations, including gene amplifications, point mutations, indels, and gene fusions, potentially doubling the number of driver mutations characterized in clinically actionable genes. Further, the platform is sufficiently sensitive to identify weak drivers. Our data are accessible through a user-friendly, public data portal. Our study will facilitate biomarker discovery, prediction algorithm improvement, and drug development.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Developed a versatile functional genomic platform for somatic mutation annotation </LI> <LI> Annotated >1,000 genomic aberrations, doubling the number of known driver mutations </LI> <LI> Assessed performance of existing algorithms for mutation functional predictions </LI> <LI> Built a user-friendly, open-access data portal for community-based investigation </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>

Antiviral activity of Herba Patrinea (a Chinese medicinal herb) against respiratory syncytial virus in vitro

Li, Hong-Yuan,Li, Shan-Shan,Liu, Dian-Li,Dong, Yan-Mei,Tian, Wen-Jing Kyung Hee Oriental Medicine Research Center 2003 Oriental pharmacy and experimental medicine Vol.3 No.2

Respiratory syncytial virus (RSV) has long been considered an important cause of severe lower respiratory tract infection in infants and young children throughout the world. Unfortunately, no effective treatment of RSV exists. Therefore, New agents are needed to reduce the impact of RSV. We have studied the anti-viral effect of traditional Chinese midicinal herbs for over ten years and find Herba Patrinea (a Chinese medicinal herb) has the anti-RSV effect in vitro. In this study, the Herba Patrinea was extracted with hot water, condensed and sterilized. The cytotoxicity of the aqueous extract was tested by adding the diluted extract directly to HeLa cells and its effect on anti-RSV was estimated by the CPEI assay. As a result, the median cytotoxic concentration $(CC_{50})$ of Herba Patrinea was 32 mg/ ml by morphological observation, the median effective concentration (50% effective concentration, $EC_{50}$) of the Herba Patrinea against replication of the Long strain of RSV in HeLa cells were 1.25 mg/ml. The selectivity index $(SI=CC_{50}/EC{50})$ is 25.6. Moreover, Herba Patrinea gave a dose-dependent response in inhibiting RSV. In time of addition experiment, Herba Patrinea inhibited replication of RSV in HeLa cells when it was added at 0h, 2h, and 4h after virus infection. In summary, the results of this study suggest Herba Patrinea may be a novel anti-RSV drug and it is worthy of further studying.

Luminescent characteristics of Sr2ZnSi2O7 : Eu3+ phosphor for ultraviolet light emitting diodes

Shan-shan Yao,Li-hong Xue,You-wei Yan,Yuan-yuan Li,Mi-fang Yan 한양대학교 세라믹연구소 2010 Journal of Ceramic Processing Research Vol.11 No.6

Red-emitting phosphors Sr2-xZnSi2O7 : Eux 3+ was prepared by a combustion-assisted synthesis method and an efficient red emission under near-ultraviolet (UV) was observed. The luminescence, crystallinity, and particle sizes were investigated using luminescence spectrometry, X-ray diffractometry, and field scanning electron microscopy. The emission spectrum shows that the most intense peak is located at 614 nm, which corresponds to the 5D0→ 7F2 transition of Eu3+. The phosphor has two main excitation peaks located at 394 and 465 nm, which match the emission of UV and blue light-emitting diodes, respectively.

Chemoresistance in ovarian cancer: exploiting cancer stem cell metabolism

Shan-Shan Li,Jing Ma,Alice S. T. Wong 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.2

Ovarian cancer is most deadly gynecologic malignancies worldwide. Chemotherapy is the mainstay treatment for ovarian cancer. Despite the initial response is promising, frequent recurrence in patients with advanced diseases remains a therapeutic challenge. Thus, understanding the biology of chemoresistance is of great importance to overcome this challenge and will conceivably benefit the survival of ovarian cancer patients. Although mechanisms underlying the development of chemoresistance are still ambiguous, accumulating evidence has supported an integral role of cancer stem cells (CSCs) in recurrence following chemotherapy. Recently, tumor metabolism has gained interest as a reason of chemoresistance in tumors and chemotherapeutic drugs in combination with metabolism targeting approaches has been found promising in overcoming therapeutic resistance. In this review, we will summarize recent studies on CSCs and metabolism in ovarian cancer and discuss possible role of CSCs metabolism in chemoresistance.

황로사상의 문자 와당문양을 응용한 바디페인팅 작품 제작

이산산(Shan-Shan Li),한지수(Ji-Soo Han) 한국화장품미용학회 2022 한국화장품미용학회지 Vol.12 No.2

Huang Laos Thought, which is based on traditional Chinese religious thought, especially the basic idea of Taoism, has meaning and history as a value of the times that greatly influenced the entire Chinese civilization. It was the early national ideology of the Han Dynasty, which formed the united culture in China, and flourished under the reign of the emperor and Laozi. The emperor was symbolized as a divine representing legal thought as the discoverer of the law, and Laozi, the founder of the Taoism, said that he copes with the world through the grudges of vanity and futility, and became embedded in the divine theory. The traditional patterns, which are in the spotlight for their symbolic meanings, have various meanings expressed in dots, lines, faces and colors according to culture and periods. Among the Wadang patterns, which are comprehensively classified into designed pattern and letter patterns, the letter Wadang symbolizes the golden age of Wadang pattern development. This study aims to expand the expression area of body painting by presenting original and creative work production and various expression techniques by mixing body painting into art categories by applying text patterns as aesthetic ideas of Wadang patterns and new ideas. Through consideration of the shape of the Wadang pattern, the formability shown in Wadang was understood, and it was produced as a body painting work based on the design of the letter pattern. By modernly designing the Wadang pattern of ideas, the body painting design was attempted with embodying the soft and curved realism of the Wadang pattern on the body. It was intended to find the infinite possibility of independent art expression and value of body painting.

Correlation between DNA methylation and Thymic Stromal Lymphopoietin expression in asthmatic airway epithelial cells

Yan‑Li Li,Xi‑Qian Xing,Yi Xiao,Yan‑Hong Liu,Yu‑Shan Zhou,Min Zhuang,Chao‑Qian Li 한국유전학회 2020 Genes & Genomics Vol.42 No.12

Background: The overexpression of TSLP and DNA methylation in asthma were both risk factors the relationship was not clear. Objective: This study aimed to investigate the relationship between methylation status of TSLP promoter and mRNA/protein expression in asthmatic airway epithelial cells. Methods: Human bronchial epithelial cells were cultured in vitro and divided into: Control group, treated with PBS, model group, sensitized with LPS (10 μg/mL) for 12 h (37 °C, 5% CO2). Other groups were cultured with the pCMV3 plasmid (M + NC/pCMV), pGPH1 plasmid (M + NC/pGPH), DNMT1/pCMV3 plasmid (M + DNMT1/pCMV), and DNMT1/pGPH1 plasmid (M + DNMT1/pGPH) for 48 h. The expression of DNA methyltransferase 1 and TSLP were measured using real-time PCR and western blotting. Results: Compared with the control group, TSLP mRNA (1.00 ± 0.00 vs. 2.82 ± 0.81 vs. 1, P < 0.001) and protein (1.07 ± 0.04 vs. 1.46 ± 0.11, P < 0.01) were significantly greater, and the methylation of promoter was lower (92.75 ± 1.26 vs. 58.57 ± 3.34, P < 0.05) in the model group. Compared with the model group, TSLP mRNA (2.82 ± 0.81 vs. 1.17 ± 0.10, P < 0.001) decreased, but TSLP promoter methylation increased (58.57 ± 3.34 vs. 92.58 ± 7.30, P < 0.05) in M + DNMT1/pCMV. TSLP mRNA and protein were higher (2.82 ± 0.81 vs. 5.32 ± 0.21, P < 0.001; 1.46 ± 0.11 vs. 1.94 ± 0.11, respectively, P < 0.01), TSLP promoter methylation was lower (58.57 ± 3.34 vs. 33.57 ± 4.29, P < 0.05) in M + DNMT1/pGPH. Conclusions: Overexpression of TSLP in asthmatic airway epithelial cells may be regulated by DNA demethylation.

Diacylglycerol acyltransferase 1 (DGAT1) inhibition by furofuran lignans from stems of Acanthopanax senticosus

BanBan Li,Jia Lin Li,Na Li,Shi-Zhou Qi,이현선,Le Zhang,Shan-Shan Xing,Zhen Dong Tuo,Long Cui 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.11

Two new furofuran lignans were isolated fromthe stems of Acanthopanax senticosus, along with sevenknown compounds. Their structures were all determined byspectroscopic analyses and chemical methods. All theisolates were evaluated for in vitro inhibitory activityagainst DGAT1 and DGAT2. Compounds 1 and 2 werefound to exhibit selective inhibitory activity on DGAT1with IC50 values 89.5 ± 1.5 and 57.5 ± 1.3 lM,respectively.