호밀 (Secale cereale L.)유식물의 질산환원효소의 활량과 단백질함량에 관한 Cycloheximide의 영향

권오용,이영하,오희목,박흥순,이진철 충남대학교 자연과학연구소 1988 忠南科學硏究誌 Vol.15 No.2

This work was accomplished with 6 day-old rye (Secale cereale L.) seedlings to determine the effect of the antibiotics by cycloheximide on in vivo nitrate reductase activity, protein and RNA content. The nitrate reductase activity by treating 0.1μM and 0.1 mM cycloheximide was lower than that of the control group. The optimum pH for the nitrate reductase of the control group was 7.6 in the range of pH 5.6-8.0, but, in the case of 0.1mM cycloheximide treatment group, the optimum pH was decreased to 6.8 within the weak the acid region. The protein content of shoot and root in the 0.1μM and 0.1 mM cycloheximide treatment groups were respectively found at the 96%, 82% level of that in the control group. In the higher cycloheximide treatment (0.1 mM CH), not only nitrate reductase activity and protein content but also RNA content was greatly decreased. In this fact, it was suggested that the 0.1 mM cycloheximide had affected on the RNA polymerase. On the basis of there results, it was concluded that the decreased nitrate reductase activity by treating cycloheximide occurred primarily according to the decreased nitrate uptake, and the decreased protein and RNA content depended upon the results of the direct and indirect effect of cycloheximide on the protein synthesis.

금강유역 수질오염 실태조사

최신석,오희목,강명규,조통래,이규승,유종국,이영하 忠南大學校 環境問題硏究所 1988 環境硏究 Vol.6 No.1

조사 구역 상류 지점의 평균 수질은 pH가 7.1, DO가 8.3mg/ℓ, BOD가 1.7mg/ℓ, COD가 1.7mg/ℓ, SS가 15.4mg/ℓ, 분변성 대장균이 1.1x10³ MPN/100ml고 상수원 수 1급 내지 2급의 양호한 상태이고 하류지점의 수질은 pH가 6.8, DO가 7.7mg/ℓ, BOD가 2.2mg/ℓ, COD가 2.4mg/ℓ, 분변성 대장균이 1.7x10³MPN/100ml로 상수원 수 2급 내지 3급의 상태를 나타내 하류로 내려가면서 오염도가 증가하는 것으로 나타났다. 청주시의 영향을 크게 받는 미호천 하류의 평균수질은 pH가 7.2, DO가 6.3mg/ℓ, BOD가 16.2mg/ℓ, COD가 15.1mg/ℓ, 분변성 대장균이 1.6x10??MPN/100ml로 심각한 오염 상태를 보여 청주시와 대전시가 금강 본류의 주 수질 오염원으로 나타났다. 영양 염류 (NH₃-N, NO₂-N, NO₃-N, PO₄-P)와 무기성 유해 성분 (Cl-, CN-, F-)의 함량은 지천의 일부 지점을 제외하고는 극히 낮은 수준으로 검출되었으며, 유기인, 페놀류, PCB 성분은 조사기간 중 전혀 검출되지 않았다. 또한 Fe, Zn, Cu, Mn, Cr, Pb, Cd, Hg등의 중금속은 검출되지 않거나 하천 수질 기준 또는 식용수 수질 기준의 허용치를 초과하지 않는 양호한 수준으로 나타났다.

가와사끼병 환아의 혈청 프로테옴 지도 비교

백승연,이영목,이광훈,김동수 대한소아과학회 2004 小兒科 Vol.47 No.1

Myocardial atrophy in children with mitochondrial disease and Duchenne muscular dystrophy

Lee, Tae Ho,Eun, Lucy Youngmin,Choi, Jae Young,Kwon, Hye Eun,Lee, Young-Mock,Kim, Heung Dong,Kang, Seong-Woong The Korean Pediatric Society 2014 Clinical and Experimental Pediatrics (CEP) Vol.57 No.5

Purpose: Mitochondrial disease (MD) and Duchenne muscular dystrophy (DMD) are often associated with cardiomyopathy, but the myocardial variability has not been isolated to a specific characteristic. We evaluated the left ventricular (LV) mass by echocardiography to identify the general distribution and functional changes of the myocardium in patients with MD or DMD. Methods: We retrospectively evaluated the echocardiographic data of 90 children with MD and 42 with DMD. Using two-dimensional echocardiography, including time-motion (M) mode and Doppler measurements, we estimated the LV mass, ratio of early to late mitral filling velocities (E/A), ratio of early mitral filling velocity to early diastolic mitral annular velocity (E/Ea), stroke volume, and cardiac output. A "z score" was generated using the lambda-mu-sigma method to standardize the LV mass with respect to body size. Results: The LV mass-for-height z scores were significantly below normal in children with MD ($-1.02{\pm}1.52$, P<0.001) or DMD ($-0.82{\pm}1.61$, P =0.002), as were the LV mass-for-lean body-mass z scores. The body mass index (BMI)-for-age z scores were far below normal and were directly proportional to the LV mass-for-height z scores in both patients with MD (R =0.377, P<0.001) and those with DMD (R =0.330, P=0.033). The LV mass-for-height z score correlated positively with the stroke volume index (R =0.462, P<0.001) and cardiac index (R =0.358, P<0.001). Conclusion: LV myocardial atrophy is present in patients with MD and those with DMD and may be closely associated with low BMI. The insufficient LV mass for body size might indicate deterioration of systolic function in these patients.

소설, 공간, 정치 -모하메드 딥의 "알제리 3부작"의 공간 묘사-

( Young Mock Lee ) 서울대학교 인문학연구원 2013 人文論叢 Vol.69 No.-

Dihydroceramide is a key metabolite that regulates autophagy and promotes fibrosis in hepatic steatosis model

Lee, Ah Young,Lee, Jae Won,Kim, Ji-Eun,Mock, Hyuck Jun,Park, Sungjin,Kim, Sanghwa,Hong, Seong-Ho,Kim, Ji-Young,Park, Eun-Jung,Kang, Kyung-Sun,Kim, Kwang Pyo,Cho, Myung-Haing Academic Press 2017 Biochemical and biophysical research communication Vol. No.

<P><B>Abstract</B></P> <P>Non-alcoholic fatty liver disease (NAFLD) is an increasingly common chronic liver disease worldwide. Sphingolipids are a family of lipids that play essential roles as critical regulators in metabolic disorders. Some sphingolipids are known key factors in metabolic dysfunction. However, the precise effect of dihydroceramide on NAFLD remains unknown. Here, we report how dihydroceramide in autophagosome accumulation activates fibrogenesis in human liver Chang cells treated with free fatty acids (FFA). According to LC/MS lipid profiling, FFA increased the levels of sphingolipids and triacylglycerol (TG). To demonstrate the potential role of dihydroceramide metabolism in autophagy, several sphingolipid synthesis inhibitors were used. Increased dihydroceramide led to impairment of autophagic flux, resulting in increased TG storage in lipid droplets (LD) and upregulated expression of fibrosis markers. Hepatic stellate cells (HSCs, LX-2 cells) were co-cultured with Chang cells to assess the potential fibrogenic response to dihydroceramide, Treatment with rapamycin recovered autophagic flux in Chang cells and fibrogenesis in the co-culture system. Our results identified a critical function of dihydroceramide metabolism in autophagy. It could play an important role in the progression of NAFLD associated with lipid over-accumulation. Therefore, preventing autophagic flux by regulating dihydroceramide could be a potential strategic approach for providing therapy for NAFLD.</P> <P><B>Highlights</B></P> <P> <UL> <LI> FFA uptake increases sphingolipids in liver cells. </LI> <LI> Dihydroceramide product correlates with autophagosome accumulation. </LI> <LI> Dihydroceramide impairs autophagic flux and increases lipid droplets. </LI> <LI> Rapamycin recuperates fibrosis by recovering autophagic flux by increased dihydroceramide. </LI> </UL> </P>

右側 胸部 前外側 및 腋窩部에 發生한 海線狀 血管腫 治驗 1例

文英木,李榮喆,邊永壽,李英淳 최신의학사 1973 最新醫學 Vol.16 No.1

A case of hemangioma on the antero-lateral aspect of right chest and axillary region is reported. This case was 20 years old Korean female who Complained of the large mass and pain over the antero-lateral aspect of right chest and axillary region without limitted range of the shoulder motion and sensory change for a year.... The roentgenological examination was revealed a large lobulated mass on the antero-lateral chest and axillary region. Excised mass showed dark red sponge like, lobulated mass measured 18XX1X14cm, filled with dark blood like fluid.

정체성, 기억, 역사: 아르키와 그 자녀들의 경우

이영목 ( Young Mock Lee ) 한국불어불문학회 2006 불어불문학연구 Vol.0 No.66

자동인형의 악몽 : E. T. A. 호프만의 『 모래남자 』

이영목(Young Mock Lee) 한국불어불문학회 2001 불어불문학연구 Vol.46 No.-

L`homme au sable, un des Contes nocturnes d`Hoffmann, doit partiellement sa ce´le´brite´ a` un article que lui a consacre´ Sigmund Freud. Dans son Inquie´tante e´trangete´, celui-ci nous propose une `histoire de l`oeil`, c`est-a`-dire une interpre´tation selon laquelle le sujet principal dans ce conte serait l`angoisse du complexe de castration infantile. A partir du re´sume´ et des observations, parfois contestables, du psychanalyste, nous voulons reconstituer une autre histoire, celle de l`automate. D`abord, nous attribuons la cause profonde des malheurs cauchemardesques du jeune e´tudiant a` son incapacite´ de l`identification. Il est incapable de discerner si la personne qu`il aime est un e^tre humain ou bien un automate et il n`est pas su^r de sa propre identite´ comme e^tre humain. Cette incapacite´, quant a` elle, trouve son origine dans son expe´rience traumatisante pendant laquelle fut remise en question son identite´ en tant qu`e^tre humain. Or, cette confusion d`identite´ n`est pas, selon nous, un proble`me isole´ et individuel dun esprit de´re´gl´e, mais pluto^t un proble`me historiquement concret auquel tous les hommes modernes sont plus ou moins expose´s. Pour e´tayer notre the`se, nous replac¿ons l`histoire de Nathanae¨l dans un contexte historique plus vaste qu`est l`histoire de la conception me´canique ou me´caniste de l`homme. Ensuite est examine´e, en vue de comparaison, la question fondamentale que leur monisme mate´rialiste a fait poser aux mate´rialistes franc¿ais du XVIIIe sie`cle comme La Mettrie et Diderot. Cette question des philosophes et celle qui est pre´sente´e sous une forme litte´raire par Hoffmann, bien qu`elles partagent les me^mes fondements historiques et the´oriques, ne sont pas identiques. Nous constatons enfin que la question pose´e par Hoffmann est celle qui aurait du^, du point de vue logique, se poser, mais que les philosophes de l`e´poque, qu`ils soient partisans de cette conception me´caniste ou du mate´rialisme, n`en ont pratiquement pas pris une conscience claire et distincte. Voila` pourquoi nous de´finissons ce conte comme une re´action litte´raire d`Hoffmann contre la conception me´caniste de l`homme.

파농의 문제적 정체성; 알베르 메미의 “파농의 불가능한 삶”의 비판적 독서

이영목 ( Young Mock Lee ) 한국불어불문학회 2013 불어불문학연구 Vol.0 No.95

“La Vie impossible de Fanon”, interpretation libre de l`aventure identitaire de Fanon par Albert Memmi, ne resiste pas malgre sa grande force de persuasion, aux analyses textuelles et factuelles. Mais la lecture critique de ce texte nous fournit l`occasion d`assister a la confrontation de deux manieres de concevoir l`identite, elaborees par deux principaux champions et theoriciens de la lutte anti-coloniale. La logique de Memmi est celle d`une logique implacable de la necessite. L`identite pour lui est une entite monolithique et s`il lui arrive a se transformer, elle subit une evolution lineaire. Par contre, la conception fanonienne d`identite est plus souple : l`identite, qu`elle soit individuelle ou collective, est mouvante, sur-determinee et complexe. Ce qui permet a la conception fanonienne de repondre plus efficacement aux exigences de la lutte emancipatrice dans un contexte actuelle qui n`est plus typiquement coloniale. Mais la conception fanonienne de l`identite a surtout cette valeur problematique, au sens ou elle nous exige a nous interroger sans cesse sur notre propre identite.