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Kwi-Young Yun,Masanori Okuyama,Minoru Noda 한국물리학회 2003 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.42 No.IV
BiFeO3 (BFO) thin lms have been prepared on platinized silicon substrates by chemical solution deposition (CSD) and annealed at 600 C for 1 hour under various atmospheres, i.e., O2, Air and N2. Eects of annealing atmospheres on the crystallization and electrical properties of BFO lms were investigated. Crystallization behavior and electrical properties of BFO lms depend on the oxygen partial pressure of the annealing atmosphere. The BFO thin lm annealed in N2 atmosphere showed a good crystallinity. The surface roughness of the BFO lm decreased with lowering oxygen partial pressure of the annealing atmosphere. Low leakage current density and P-E hysteresis were found only in the BFO lm annealed at 600 C under N2 atmosphere. Leakage current density, polarization (at zero electric eld) and electric eld (at zero polarization) of the BFO lm annealed at 600 C under N2 are 510..7A/cm2 at 1 V, 0.2 C/cm2 and 15 kV/cm, respectively.
Kwi-Young Yun,Dan Ricinschi,Masanori Okuyama,Minoru Noda,Saburo Nasu 한국물리학회 2005 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.46 No.1
Multiferroic BiFeO3 thin flms have been deposited on Pt/TiO2/SiO2/Si substrates by pulsedlaser deposition. From the X-ray diffraction analysis, the BiFeO3 thin lm consists of perovskite single-phase and shows a tetragonal structure with a space group P4mm. Ferroelectric hysteresis saturate well and a remanent polarization is 73 C/cm2 for a maximum applied voltage of 4 V. A saturated ferromagnetic hysteresis loop has been also obtained and a saturation magnetization is 3.5 emu/cm3 for a maximum magnetic feld of 10 kOe at room temperature.
A STUDY ON A CATALYTIC CONVERTER OBD BEFORE LIGHT-OFF
Yun, Seung-Won,Son, Geon-Seog,Lee, Kwi-Young The Korean Society of Automotive Engineers 2002 International journal of automotive technology Vol.3 No.1
Increasingly stringent emission regulations of EU and CARB (California Air resource Board) require mandatory OBD (On Board Diagnostics) far the catalytic converters of a vehicle. It demands that MIL(Malfunction Indication Light) should be tuned on to inform the driver of catalytic converter failures. Currently dual oxygen sensor method Is widely used for the converter OBD. However, since it works only alter converter light-off, it has a serious limitation when applied to TLEV or more stringent emission regulations where more than 85% of total emission is coming out before converter light-off. In addition, a recent development in catalyst material. coating technology and additive catalysts leads to a much improved OSC (Oxygen Storage Capacity) after converter light-off, current methods are very difficult to determine levels of converter aging. Therefore, it is desired to develop an OSC detecting method before converter light-off to diagnose converter failures with higher reliability. In this study, OSCs of converters are measured by an absolute measuring method and a dynamic measuring method, and some of fundamental ideas are suggested about converter OBD before converter light-off. The converters are aged with two different aging methods; those are a furnace aging and an engine bench aging: to represent aging conditions in actual field applications. Dual oxygen sensor method at the lower temperature than light-off is also studied at a model gas bench with the converters. It is fecund that there is a certain point in temperature lower than light-off where difference due to aging level becomes maximum, thus a proper dynamic method to effectively monitor catalytic converters could be implemented fur the range lower than light-off temperatures. With this result, the aging level of converters is examined at an engine bench.
일차성, 이차성 그리고 삼차성 부갑상선 기능 항진증 환자의 수술 후 임상결과: 서울대학교 병원에서의 14년 경험
최윤석 ( Yun Suk Choi ),이규언 ( Kyu Eun Lee ),박귀원 ( Kwi Won Park ),노동영 ( Dong Young Noh ),오은미 ( Eun Mee Oh ),최준영 ( June Young Choi ),윤여규 ( Yeo Kyu Youn ),오승근 ( Seung Keun Oh ),구도훈 ( Do Hoon Koo ) 대한임상종양학회 2011 Korean Journal of Clinical Oncology Vol.7 No.1
목적: 일차성, 이차성, 삼차성 부갑상선 기능 항진증은 각각 원인과 치료방법 그리고 임상 경과가 서로 다르지만 부갑상선 절제술이 표준치료로 알려져 있다. 본 연구에서는 각각의 부갑상선 항진증의 수술 전후의 임상적 변화를 알아보고 부갑상선 절제술의 의미를 재고 해보고자 하였다. 방법: 1996년부터 2009년까지 총 126명이 서울대학교 병원에서 부갑상선 절제술을 시행 받았으며 각각 일차성 96명, 이차성 24명, 삼차성 6명이었다. 환자들의 나이, 성별, 생화학적 검사, 수술방법, 병리학적 검사 결과를 전자 의무기록을 통해 후향적으로 분석하였다. 결과: 모든 세 군의 환자에서 혈청 칼슘, 부갑상선 호르몬, 이온화 칼슘이 수술 전보다 호전을 보였다. 이차성 환자군은 다른 두 군에 비해 수술 전, 후의 부갑상선 호르몬이 높았으며(p<0.001, p=0.036), 수술 후 지속적인 부갑상선 기능 항진증(30.4%) 및 일과성 저칼슘혈증(87.5%)도 다른 두 군에 비해 많이 발생하였다.(p< 0.001) 일과성 저칼슘혈증의 대부분(90.4%) 은 6개월 이내 회복 되었다. 이차성 환자에서 부갑상선 아전 및 전 절제술을 시행 받은 경우 수술 후 일과성 저칼슘혈증이 많이 나타났으나(71.4%), 제한적 절제술을 시행 받은 경우 지속적 부갑상선 기능항진증이 더 많이 나타났다.(50%) 결론: 부갑상선 절제술은 생화학 검사상의 호전을 위한 치료 방법으로 추천될 수 있으며, 이차성에서는 제한적 절제를 하는 경우 지속적 부갑상선 항진증의 빈도가 더 높으므로 부갑상선 아전 및 전 절제술을 시행해야 한다. Purpose: Primary hyperparathyroidism(PHPT), secondary hyperparathyroidism(SHPT) and tertiary hyperparathyroidism(THPT) are different in the cause, treatment and prognosis. However the parathyroidectomy has been an efficient treatment in all hyperparathyroidism groups. A single institution`s 14 year experience of surgical treatment was analyzed to investigate perioperative changes of clinical characteristics and reconsider the value of parathyroidectomy as the treatment option. Materials and Methods: From 1996 to 2009, 126 patients underwent parathyroidectomy at single institute and the number of patients with PHPT, SHPT and THPT were 96, 24 and 6 retrospectively. The electronic medical records of age, sex, biochemical analysis, operative method, and pathologic results were reviewed retrospectively. Results: Postoperative calcium (Ca), parathyroid hormone (PTH), ionized calcium (iCa) levels were improved definitely than preoperative Ca, PTH, iCa level in all three groups. Pre and postoperative PTH level in SHPT was higher than in PHPT and THPT(p<0.001, p=0.036) and postoperative persistent PTH increased status were more common in SHPT.(30.4%, p<0.001) Postoperative temporary hypocalcemia was more common in SHPT(87.5%, p<0.001), almost of them (90.4%) were recovered in 6 month. In SHPT group, temporary hypocalcemia were more common in subtotal or total parathyroidectomy group than in limited resection group (94.1%) but persistent iPTH increase were more common in limited resection group (50%). . Conclusion: Parathyroidectomy is highly recommended to improve biochemical laboratory findings in patients with hyperparathyroidism. And in SHPT, subtotal or total parathyroidectomy is more appropriate surgical method for reducing the high incidence of persistent hyperparathyroidism.
Jung, Yun-A,Kim, Hee Kyoung,Bae, Kwi-Hyun,Seo, Hye-Young,Kim, Hye-Soon,Jang, Byoung Kuk,Jung, Gwon-Soo,Lee, In-Kyu,Kim, Mi-Kyung,Park, Keun-Gyu Nature Publishing Group 2014 Experimental and molecular medicine Vol.46 No.1
<P>Hepatic steatosis is common in obese individuals with hyperinsulinemia and is an important hepatic manifestation of metabolic syndrome. Sterol regulatory binding protein-1c (SREBP-1c) is a master regulator of lipogenic gene expression in the liver. Hyperinsulinemia induces transcription of SREBP-1c via activation of liver X receptor (LXR) and specificity protein 1 (Sp1). Cilostazol is an antiplatelet agent that prevents atherosclerosis and decreases serum triglyceride levels. However, little is known about the effects of cilostazol on hepatic lipogenesis. Here, we examined the role of cilostazol in the regulation of SREBP-1c transcription in the liver. The effects of cilostazol on the expression of SREBP-1c and its target genes in response to insulin or an LXR agonist (T0901317) were examined using real-time RT-PCR and western blot analysis on cultured hepatocytes. To investigate the effect of cilostazol on SREBP-1c at the transcriptional level, transient transfection reporter assays and electrophoretic mobility shift assays (EMSAs) were performed. Cilostazol inhibited insulin-induced and LXR-agonist-induced expression of SREBP-1c and its downstream targets, acetyl-CoA carboxylase and fatty acid synthase, in cultured hepatocytes. Cilostazol also inhibited activation of the SREBP-1c promoter by insulin, T0901317 and Sp1 in a luciferase reporter assay. EMSA analysis showed that cilostazol inhibits SREBP-1c expression by repressing the binding of LXR and Sp1 to the promoter region. These results indicate that cilostazol inhibits insulin-induced hepatic SREBP-1c expression via the inhibition of LXR and Sp1 activity and that cilostazol is a negative regulator of hepatic lipogenesis.</P>