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      • THE EFFECT OF CATHETER-DIRECTED ETHANOL SCLEROTHERAPY ON OVARIAN RESERVE IN PATIENTS WITH RECURRENT ENDOMETRIOSIS: COMPARATIVE ANALYSIS WITH PRIMARY ENDOMETRIOSIS

        ( Yeojin Lee ),( Jae Kyung Lee ),( Sanghwa Kim ),( Yeon Ju Lee ),( Kichang Han ),( Man-deuk Kim ),( Heeyon Kim ),( Seok Kyo Seo ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-

        Objective: Although the surgical treatment remains gold standared in endometrioma, ovarian reserve is injured after the hemostasis and excision of the cyst. Catheter-directed ethanol sclerotherpy is known to affect the ovarian function less, increase efficacy, and reduce complications. This study aims to investigate the changes in ovarian reserve after catheter-directed ethanol sclerotherpy in recurrent endometrioma. Methods: Electronic medical records and pictures in patients with endometrioma who underwent catheter-directed ethanol sclerotherpy were obtainted in single institution from August 2014 to April 2022. Patient with aged >18 years old and AMH level >1.0 and <5.0 were enrolled in the study and age, BMI, cyst diameter, unilaterality, number of loculation and AMH level and CA-125 level before and after 1month, 6month, 1year and 2year of sclerotherapy were obtained. Results: 139 patients were enrolled in the study under IRB. There was significant differnece in AMH level before sclerotherapy in primary and recurrent endometrioma(2.68 vs. 2.04, p-value=0.011). However, there was no statistically significant difference in delta value of AMH after sclerotherapy in primary and recurrent endometrioma in 1month, 6month, 1year and 2year after sclerotherpy(91.78% vs. 96.14%, 74.75% vs. 81.58%, 83.98% vs. 65.79%, 97.08% vs. 52.52%, with p-value=0.593, 0.695, 0.217, 0.069, respectively). Also, this results were consistent regardless of unilaterality and loculation and CA-125 level showed no differerence between primary and recurrent endometrioma on every 1month, 6month, 1year and 2year after sclerotherpy. Conclusion: The effect of Catheter-directed ethanol sclerotherpy on ovarian reserve is not inferior in recurrent endometrioma compared to primary endometrima. Since sclerotherapy is known to less deteriorate the ovarian function than surgical removal of endometrioma, clinician could consider this as the first-line therapy in patient with recurrent endometrioma.

      • SCISCIESCOPUS

        Secure authentication system that generates seed from biometric information

        Kim, Yeojin,Ahn, Jung-Ho,Byun, Hyeran The Optical Society 2005 Applied Optics Vol.44 No.5

        <P>As biometric recognition techniques are gradually improved, the stability of biometric authentication systems are enhanced. Although bioinformation has properties that make it resistant to fraud, biometric authentication systems are not immune to hacking. We show a secure biometric authentication system (1) to guarantee the integrity of biometric information by mixing data by use of a biometric key and (2) to raise recognition rates by use of bimodal biometrics.</P>

      • Catalytic co-pyrolysis of torrefied yellow poplar and high-density polyethylene using microporous HZSM-5 and mesoporous Al-MCM-41 catalysts

        Kim, Young-Min,Jae, Jungho,Kim, Beom-Sik,Hong, Yeojin,Jung, Sang-Chul,Park, Young-Kwon Elsevier 2017 Energy conversion and management Vol.149 No.-

        <P><B>Abstract</B></P> <P>The catalytic pyrolysis of lignocellulosic biomass with aluminosilicate catalysts is a promising method for the direct production of liquid hydrocarbon fuels consisting mainly of aromatic compounds (e.g., benzene, toluene, and xylenes). On the other hand, the economic and commercial viability of this process is limited by the low yields of aromatic hydrocarbons. In this study, the effects of biomass torrefaction, co-feeding of plastic wastes, their combination, and the catalytic upgrading mode (<I>in-situ</I> vs <I>ex-situ</I>) on the aromatic formation efficiency during the catalytic pyrolysis of yellow poplar were evaluated systematically to maximize the production of aromatic hydrocarbons. Two representative catalysts for catalytic pyrolysis (i.e., microporous HZSM-5 and mesoporous Al-MCM-41) were used in this case study. The torrefaction of yellow poplar led to the enhanced production of aromatic hydrocarbons in the catalytic co-pyrolysis of yellow poplar and high-density polyethylene over both catalysts. The experimental yields of aromatic hydrocarbons from the catalytic co-pyrolysis of torrefied yellow poplar and high-density polyethylene were also higher than their theoretical yields, highlighting the synergistic aromatic formation by the interaction of torrefied yellow poplar and high-density polyethylene. Between the two catalysts, microporous HZSM-5 exhibited much higher activity for aromatic production from catalytic co-pyrolysis owing to its strong acidity and appropriate pore structure. Compared to <I>ex-situ</I> catalytic co-pyrolysis, the <I>in-situ</I> catalytic co-pyrolysis of torrefied yellow poplar and high-density polyethylene produced larger amounts of aromatic hydrocarbons due to the more effective contact between the pyrolysis vapors and HZSM-5.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Catalytic copyrolysis of yellow poplar and high density polyethylene was performed. </LI> <LI> Torrefaction of yellow poplar produced large amounts of aromatics. </LI> <LI> HZSM-5 produced larger amounts of aromatics than Al-MCM-41. </LI> <LI> In-situ catalytic co-pyrolysis was more efficient than ex-situ reaction. </LI> </UL> </P>

      • KCI등재

        Association between Fractures and Low Muscle Mass in Korean Menopausal Women: Data from Korean National Health and Nutrition Survey (2010–2011)

        Yeojin Lee,Songhyeon Je,Hae‑Rim Kim,Jae Kyung Lee,Euna Choi,Jin Kyung Baek,Heeyon Kim,Bo Hyon Yun,Seok Kyo Seo 대한폐경학회 2023 대한폐경학회지 Vol.29 No.2

        Objectives: This study used the Korean National Health and Nutrition Examination Survey (KNHANES) to determine the association between fractures and low muscle mass.Methods: This cross-sectional study used the 2010–2011 KNHANES data. Low muscle mass was defined as (appendicular skeletal muscle mass [kg]/Height2 [m2]) < 5.45 kg/m2, which is < 2 SD below the sex-specific mean of a young reference group. Patients with T-scores between –1.0 and –2.5 indicated osteopenia, whereas those with T-scores lower than –2.5 indicated osteoporosis.Results: Out of 1,306 women enrolled in the study, 330 were diagnosed with low muscle mass according to the abovementioned diagnostic criterion. The prevalence of fractures at various sites was significantly higher in postmenopausal women with low muscle mass than in those without low muscle mass (relative risk [RR], 1.64; odds ratio [OR], 1.62; 95% confidence interval [CI], 1.06–2.48; P = 0.027). Furthermore, the prevalence of fractures was increased by the presence of osteopenia or osteoporosis in addition to low muscle mass (RR, 1.59; OR, 1.60; 95% CI, 1.02–2.49; P = 0.039) and by osteoporosis only (RR, 2.12; OR, 2.29; 95% CI, 1.11–4.70; P = 0.025).Conclusions: Fracture was more prevalent in postmenopausal women with low muscle mass than in those without low muscle mass. This finding is consistent in a subgroup analysis that included women who had osteoporosis or osteopenia. Moreover, the risk of fractures increased as low muscle mass worsened.

      • Heat Treatment and TG-DTA Analysis of Uranyl Nitrate and Uranium Oxides

        Yeojin Kim,Gun Young Yoon,Gyun Seob Song,Yulim Lee,Jae Hak Cheong,Sangjoon Ahn,Jaeyeong Park,Won Pyo Jeong,Seungyeon Choi,Kwang Heon Park 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2

        The solid-state chemistry of uranium is essential to the nuclear fuel cycle. Uranyl nitrate is a key compound that is produced at various stages of the nuclear fuel cycle, both in front-end and backend cycles. It is typically formed by dissolving spent nuclear fuel in nitric acid or through a wet conversion process for the preparation of UF6. Additionally, uranium oxides are a primary consideration in the nuclear fuel cycle because they are the most commonly used nuclear fuel in commercial nuclear reactors. Therefore, it is crucial to understand the oxidation and thermal behavior of uranium oxides and uranyl nitrates. Under the ‘2023 Nuclear Global Researcher Training Program for the Back-end Nuclear Fuel Cycle,’ supported by KONICOF, several experiments were conducted at IMRAM (Institute of Multidisciplinary Research for Advanced Materials) at Tohoku University. First, the recovery ratio of uranium was analyzed during the synthesis of uranyl nitrate by dissolving the actual radioisotope, U3O8, in a nitric acid solution. Second, thermogravimetric-differential thermal analysis (TG-DTA) of uranyl nitrate (UO2(NO3)2) and hyper-stoichiometric uranium dioxide (UO2+X) was performed. The enthalpy change was discussed to confirm the mechanism of thermal decomposition of uranyl nitrate under heating conditions and to determine the chemical hydrate form of uranyl nitrate. In the case of UO2+X, the value of ‘x’ was determined through the calculation of weight change data, and the initial form was verified using the phase diagram for the U-O system. Finally, the formation of a few UO2+X compounds was observed with heat treatment of uranyl nitrate and uranium dioxide at different temperature intervals (450°C-600°C). As a result of these studies, a deeper understanding of the thermal and chemical behavior of uranium compounds was achieved. This knowledge is vital for improving the efficiency and safety of nuclear fuel cycle processes and contributes to advancements in nuclear science and technology.

      • Effect of Leachant Type on the Leaching Behavior of Technetium and Iodine Inside the Cement Solidified Waste

        Yeojin Kim,Youjin Oh,Hyeongjin Byeon,Jaeyeong Park 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2

        Wasteform is the first barrier to prevent radionuclide release from repositories into the biosphere. Since leaching rates of nuclides in wasteform significantly impact on safety assessment of the repository, clarifying the leaching behavior is critical for accurate safety assessment. However, the current waste acceptance criteria (WAC) of the Gyeongju repository only evaluates leachability indexes for Cs, Sr, and Co, which are tracers for nuclear power plant waste streams. Furthermore, ANS 16.1, the current leaching test method used in WAC, applies deionized water (DI) as leachant. However, the interactions between wasteform and groundwater environment in the repository may not be reflected. Therefore, it is necessary to review the current leaching test method and nuclides that may require the extra evaluation of leachability beyond the Cs, Sr, and Co. Tc and I are key nuclides contributing to high radioactive dose in safety assessment due to their high mobility and low retardation factor. The groundwater conditions within the repository, such as pH and Eh significantly affect the chemical form of Tc and I. For example, Tc in H2O system tends to form hydroxide precipitates in neutral pH condition and TcO4 - in strong alkaline environments according to the Pourbaix diagram. In case of I, it generally exists in the form of I-, while it exists as IO3 - as Eh increases. Although the current leaching test at the Gyeongju repository applies DI as a leachant, the actual repository is expected to have a highly alkaline environment with a substantial amount of various ions in the groundwater. Consequently, the leaching behavior in the ANS 16.1 test and the actual disposal condition is different. Thus, it is necessary to analyze the leaching behavior of Tc and I with reflecting the actual disposal environment. In this study, the leaching behavior of Tc and I is investigated by following ANS 16.1 leaching test method. The solidified waste specimens containing 10 mmol of Re and I were manufactured with cement, which is widely used as a solidification material. Re was applied instead of Tc, which has similar chemical behavior to Tc, and NH4ReO4 and NaI were used as surrogates for Re and I. As a leachant, deionized water and cement-saturated groundwater were prepared and the concentration of nuclides in the leachant is analyzed by ICP-OES. As the result of this study, experimental data can be applied to improve the WAC and disposal concentration standards in the future.

      • KCI등재

        Selective cytotoxicity of a novel mitochondrial complex I inhibitor, YK-135, against EMT-subtype gastric cancer cell lines due to impaired glycolytic capacity

        Yeojin Sung,Seungbin Cha,Sang Bum Kim,Hakhyun Kim,Seonghwi Choi,Sejin Oh,Minseo Kim,Yunji Lee,Gino Kwon,Jooyoung Lee,Joo-Youn Lee,한균희,김현석 생화학분자생물학회 2022 BMB Reports Vol.55 No.12

        Epithelial-to-mesenchymal transition (EMT)-subtype gastric cancershave the worst prognosis due to their higher recurrence rate,higher probability of developing metastases and higher chemoresistancecompared to those of other molecular subtypes. Pharmacologicallyactionable somatic mutations are rarely found inEMT-subtype gastric cancers, limiting the utility of targeted therapies. Here, we conducted a high-throughput chemical screenusing 37 gastric cancer cell lines and 48,467 synthetic smallmoleculecompounds. We identified YK-135, a small-moleculecompound that showed higher cytotoxicity toward EMT-subtypegastric cancer cell lines than toward non-EMT-subtype gastriccancer cell lines. YK-135 exerts its cytotoxic effects by inhibitingmitochondrial complex I activity and inducing AMP-activatedprotein kinase (AMPK)-mediated apoptosis. We found that thelower glycolytic capacity of the EMT-subtype gastric cancer cellsconfers synthetic lethality to the inhibition of mitochondrialcomplex I, possibly by failing to maintain energy homeostasis. Other well-known mitochondrial complex I inhibitors (e.g., rotenoneand phenformin) mimic the efficacy of YK-135, supportingour results. These findings highlight mitochondrial complex Iinhibitors as promising therapeutic agents for EMT-subtype gastriccancers and YK-135 as a novel chemical scaffold for further drugdevelopment.

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