부산지역 무균성 뇌막염 원인 바이러스의 분리 및 동정 : 1998년을 중심으로

김영희,정영기,김기순,지영미,윤재득,김병준,구평태,민상기,정구영,김만수,조경순 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1

The incidence of aseptic meningitis infection is ensuing and threatening the health of children. Enteroviruses are the major agents of aseptic meningitis and identification of virus has been a clue to diagnosis and epidemiology. The outbreak of aseptic meningitis occurred in Pusan, 1998. Patients were concentrated from April through November. Children were more susceptible than adults. Among 306 cases of specimens from stool, throat swab tested, only 7.2% were positive on virus isolation, 12 cases from stool and 10 from throat, respectively. All isolated 7 serotypes of viruses represented cytopathic effect on cultured cells. Three types of echovirus 6, 25, 30 and coxsackievirus B2, B3, B4, B6 were identified by neutralizing anti body test. Isolated coxsackievirus and echovirus were observed by an electron microscope with negative staining.

황금(Scutellaria baicalensis)의 열수 추출물이 병원성 세균에 미치는 항균활성

김은님,백종윤,김용현,한만덕 순천향대학교 기초과학연구소 2008 순천향자연과학연구 논문집 Vol.14 No.1

This study was investigated antibacterial activity of aqueous fractions from ScuteItaria baicalensis against various pathogenic bacteria. Extracts were obtained from the roots of 5. baicatensis which has shown selective antibactehal effects on various strains of bacteria. The aqueous extract of S. baicatensis was tested on 19 species of human pathogenic bacteria. The bacteria were cultured in nutrient broth, and YM broth then incubated aerobically at 37℃ for 18-24 hours. Antimicrobial activities tested by paper disc and radial diffusion assay methods. The aqueous extracts of 5. baicatensis inhibited the growth of most human pathogenic bacterial and showed 62.5㎎/㎖ of MIC values against StaphyIococcus aureus SG511 and 125㎎ /㎖ of MIC values against Staphytococcus aureus 285 and Staphylococcus aureus 503. These results suggest that S. baicaIensis extract can be used as an effective natural antibiotics.

영지 (Ganoderma lucidum) 자실체 다당류의 분자량에 따른 생리활성

한만덕;김용현;이현수;권현정;전미애;한국일 순천향대학교 기초과학연구소 2010 순천향자연과학연구 논문집 Vol.16 No.2

The study was conducted to investigate the biological activities of an protein-bound polysaccharide (GLP) isolated from the fruit body of Ganoderma lucidum. GLP was extracted by hot water and then it was purified high (GLP-HM) and low (GLP-LM) molecular weight fraction by ethanol precipitation. Both of GLP-HM and GLP-LM at doses of 20 mg/kg in vivo had the ability to inhibit the tumor growth of Sarcoma 180 tumor-bearing mice. Inhibition rates of tumor (%) were inhibited 60.6% and 38.7% by GLP-HM and GLP-LM, respectively. In assay of anti-complementary activity in vitro, the GLP-HM were higher than that of the GLP-LM polysaccharide. And also, the GLP-HM enhanced nitric oxide production of mouse bone marrow cells. When the GLP-HM was injected intraperitoneally in tumor-bearing mouse at doses of 20 mg/kg, the concentration of TNF-α in vivo was 140.9 pg/ml in the serum, 269.6 pg/ml in sarcoma tumor mass and 879.4 pg/ml in liver. This study shows that the high molecular polysaccharide from mushroom can enhance more the bioactivities than that of the low molecular polysaccharide.

계면적을 고려한 형상기억합금 Fiber 금속기 복합재료의 기계적 거동해석

안득만,김동현 釜山大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.53 No.-

본 논문에서는 matrix와 fiber간의 계면적을 고려한 형상기억합금 fiber 알루미늄 복합재료의 강화기구가 연구되었다. 형상기억효과에 의해 기지재료의 축방향 압축잔류응력으로부터 복합재료의 인장성질이 강화된다. TiNi 연속섬유 Al 복합재료의 거동해석에 있어서 잔류응력과 계면적을 고려한 혼합법칙과 계면적을 고려한 Eshelby형태의 모델을 이용하여 복합재료의 강화기구를 설명할수 있는 모델을 제안하였다. 이 모델을 이용하여 실험에서 확인된 fiber와 matrix사이의 계면적에 따른 항복응력의 변화를 설명할 수 있었다. In this paper, strengthening mechanism of shape memory alloy fiber metal matrix composite considering interface area were studied. The tensile property of the composite material is strengthened from the compressive residual stress of the longitudinal direction due to shape memory effect. In analyzing the behavior of TiNi continuous fiber-Al composite, a law of mixture and Eshelby type model considering residual stress and interface area were introduced. From these models, we can explain the variation of tensile yield stress due to interface area.

Ergotamine-Induced Upper Extremity Ischemia: A Case Report

Man Deuk Kim,이건,신성욱 대한영상의학회 2005 Korean Journal of Radiology Vol.6 No.2

Ergotamine-induced limb ischemia is an extremely rare case. We present a case of a 64-year-old man, who developed ischemia on the right upper extremity due to long-term use of Ergot for migraine headache. Angiography revealed diffused, smooth, and tapered narrowing of the brachial artery. The patient was successfully treated with intravenous nitroprusside.

Review of New Regulatory Guidelines in Relation to the Off-site Dose Calculation

Deuk-Man Kim,Seok-Ju Hwang,Cheon-Woo Kim 한국방사성폐기물학회 2022 한국방사성폐기물학회 학술논문요약집 Vol.20 No.2

In 2022, new regulatory guidelines were announced in relation to the off-site dose calculation (ODC), and accordingly, measures to improve the off-site does calculation program (ODCP), kdose60, were reviewed. The main consideration is, first, that if multiple nuclear facilities are operated on the same site, the boundaries of the restricted areas shall be set as the overlapping outer boundaries of the restricted areas determined by calculation for each nuclear facility. Second, the external exposure caused by direct radiation from a number of nuclear facilities in the same site must be partially or fully applied depending on the facility and site characteristics. Third, the dose conversion coefficient should be evaluated by checking whether the effect of the daughter nuclides is properly reflected. Fourth, the soil contamination period is a factor to consider that radioactive substances deposited on the surface, such as particulate nuclides, affect residents over a long period of time. Fifth, due to the recent construction of Shin-Kori Units 5 and 6, there is a change in the site boundary of the Kori/Saeul site, so as the site boundary is expanded, it is required to add an exposure dose assessment point due to gas effluents and change the exposure dose assessment point according to crop intake. Therefore, through this study, the direction for improving the ODCP will be prepared by reviewing the recent revision of the regulatory guidelines.

The Improvement of the Off-site Dose Calculation Program to Enhance the Efficiency and Reliability of the Evaluation Process

Deuk-Man Kim,Seok-Ju Hwang,Cheon-Woo Kim 한국방사성폐기물학회 2022 한국방사성폐기물학회 학술논문요약집 Vol.20 No.1

The off-site dose calculation is regularly carried out at the nuclear power plants in order to evaluate off-site dose from gaseous and liquid effluent during normal operation. In 2009, the off-site calculation program (K-DOSE60) was developed in accordance with ICRP-60 by KHNP. This software needs meteorological data, gaseous and liquid effluent data, and various other input parameters to evaluate off-site dose. As a result, it takes a certain amount of time for the user to enter accurate input data and verify calculated results, and it is difficult to intuitively determine them because of providing textbased calculated results. Therefore, in this study, the improvement of the calculation program was considered so that a more reliable and effective evaluation could be performed when calculating the off-site dose. The main improvements of the off-site dose calculation program (ODCP) are as follows. First, it is developed as the network-based program to link with meteorological data, and gaseous and liquid effluent data to remove input errors and simplify data transfer. Second, through validation process of input data, input errors are eliminated. Third, the input data and calculated results are visually provided so that the user can easily determine the evaluation results. Fourth, database of input and calculated results is constructed to facilitate evaluation result history management.

Development Status of Off-Site Dose Calculation Program

Deuk-Man Kim,Seok-Ju Hwang,Si-Young Kim,Jung-Kwon Son 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2

In order to evaluate the exposure dose of residents living near nuclear power plants, a Off-site Dose Calculation Program (ODCP) has been developed based on SAP since 2021. The ODCP consists of social environmental factor, atmospheric diffusion factors, liquid/gas dose evaluation, and comprehensive analysis, and was developed by dividing it into functional modules. The offsite dose calculation can be carried out monthly, quarterly, semi-annual, and annual, and resident dose evaluation is conducted by entering air diffusion factors and emissions for each period. It also enables comprehensive evaluation result management by developing history management functions together.

Pharmacoklnetic studies on ADME of G009

(Man Deuk Han),(Hoon Jeong),(June Woo Lee),(Su Ung Kim),(Seung Yong Lee),(Jae Jin Song),(Sung Kyun Chung),(Kee Nam Kim),(Seong Jin Back),(Yong Seok Kim),(Seung Mok Lee),(A . M hackett) 한국응용약물학회 1995 학술대회 Vol.1995 No.1

Design of Control System of Vitrification Facility

Deuk-Man Kim,Seok-Ju Hwang,Jung-Kwon Son 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.1

A vitrification facility control area is formed to control and monitor the vitrification facility process, and the control system is designed to manage the vitrification facility more safely and effectively. The control system is largely composed of a process control system and an off-gas monitoring system. The process control system is operated so that operation variables can be maintained in a normal state even in normal and transient conditions, and is designed so that the vitrification facility can be stably maintained in the event of an abnormality in the facility. The process control system consists of Programmable Logic Controller (PLC) and Local Control Panel (LCP), which controls and monitors each unit device. In addition, operation variables are provided to the operator so that the operator can manage operation variables during process control in a centralized manner for the operation of the vitrification facility. The off-gas monitoring system is operated to monitor whether the off-gas discharged to the environment is stably maintained within the standard level, and the off-gas is monitored through an independent monitoring system.