U-드로우 굽힘 마찰시험에 의한 마찰계수 평가

이승욱(S. U. Lee),문지훈(J. H. Mun),홍상휘(S. H. Hong),김정호(J. H. Kim),곽성훈(S. H. Kwak),김영석(Y. S. Kim) 한국기계가공학회 2013 한국기계가공학회 춘추계학술대회 논문집 Vol.2013 No.5

High-resolution electrohydrodynamic inkjet printing of stretchable metal oxide semiconductor transistors with high performance

Kim, S.-Y.,Kim, K.,Hwang, Y. H.,Park, J.,Jang, J.,Nam, Y.,Kang, Y.,Kim, M.,Park, H. J.,Lee, Z.,Choi, J.,Kim, Y.,Jeong, S.,Bae, B.-S.,Park, J.-U. The Royal Society of Chemistry 2016 Nanoscale Vol.8 No.39

<P>As demands for high pixel densities and wearable forms of displays increase, high-resolution printing technologies to achieve high performance transistors beyond current amorphous silicon levels and to allow low-temperature solution processability for plastic substrates have been explored as key processes in emerging flexible electronics. This study describes electrohydrodynamic inkjet (e-jet) technology for direct printing of oxide semiconductor thin film transistors (TFTs) with high resolution (minimum line width: 2 mu m) and superb performance, including high mobility (similar to 230 cm(2) V-1 s(-1)). Logic operations of the amplifier circuits composed of these e-jet-printed metal oxide semiconductor (MOS) TFTs demonstrate their high performance. Printed In2O TFTs with e-jet printing-assisted high-resolution S/D electrodes were prepared, and the direct printing of passivation layers on these channels enhanced their gate-bias stabilities significantly. Moreover, low process temperatures (<250 degrees C) enable the use of thin plastic substrates; highly flexible and stretchable TFT arrays have been demonstrated, suggesting promise for next-generation printed electronics.</P>

왕겨에 의한 신령버섯균사체 액체배양액의 생쥐 항복수암성 증가

Young S. Kim(김영숙),Wook J. Jang(장욱진),Md. A. Rakib(라키브),Jung M. Kwon(권정민),Chae R. Ahn(안채린),So Y. Kim(김소영),Yong U. Cho(조용운),Young K. Ha(하영권),Jeong O. Kim(김정옥),Yeong L. Ha(하영래) 한국생명과학회 2010 생명과학회지 Vol.20 No.9

왕겨가 Agaricus blazei Murill (AB: 신령버섯)균사체 액체배양 추출물의 항암성을 증가시키는지에 관한 연구를 수행하였다. AB균사체를 대두박을 기본으로 한 액체배지에 다양한 조건으로 배양하여, β-glucan 함량, Brix, 균사체를 측정하여 적정 생육조건을 선정하고, 이들의 열수추출물의 S-180 cell로 유도한 mouse 복수암에 대한 항암성을 조사하였다. AB균사체는 25℃에서 5일간 배양하였을 때 최적 생육을 나타내었고, 이 배양물이 다른 조건에서 배양한 배양물보다 우수한 항암성을 나타내었다. AB균사체의 생육 및 항암성은 변온배양에 따른 효과는 없었다. 따라서 이 최적배양조건(25℃, 5일 배양)에서 AB균사체를 1% 왕겨분말이 함유된 액체배지에 배양하고, 이의 열수 추출물의 항암성을 검증하였다. 1% 왕겨가 함유된 액체배지에서 배양한 열수추출물의 항암성은 왕겨가 함유되지 않은 배지의 열수추출물보다 항암성이 유의성 있게 증가되었다(p<0.05). 왕겨의 첨가는 AB균사체의 생육을 오히려 촉진시켰다. 이 결과는 왕겨가 AB균사체 뿐 만 아니라 다른 버섯균사체 액체배양물의 항암성 증진을 위한 원료로 활용될 수 있을 것임을 의미한다. The effects of rice hull (RH) powder on the anticarcinogenic activity of submerged-liquid cultures of Agaricus blazei Murill (AB) were assessed for mouse ascites cancers induced by mouse Sarcoma S-180 (S-180) cancer cells. Optimal growth of AB mycelia in the basal liquid culture medium, containing soybean meal, was achieved by culturing at 25℃ for 5 days, when evaluated by β-glucan content, Brix, and mycelial weight, relative to other culture conditions. Hot-water extract (HWE) of the submergedliquid culture of AB mycelia grown at 25℃ for 5 days exhibited a stronger anticarcinogenic activity, relative to HWE from other culture conditions. No such effects were obtained from AB mycelial cultures by alternative temperature-controlling cultures. Both cytotoxicity for S-180 cells and anticarcinogenic potentials for mouse ascites cancer of the HWE from AB mycelia grown in the basal medium containing 1% RH powder for 5 days at 25℃ were significantly (p<0.05) enhanced, relative to HWE from the AB mycelia culture of the basal medium without RH powder. These results indicate that HWE of submerged-liquid culture of AB mycelia, incubated in media containing 1% RH powder at 25℃ for 5 days, enhanced anticarcinogenic activity against S-180 cell-induced mouse ascites cancer, and suggest that RH powder is an excellent ingredient for the improvement of the anticarcinogenic potentials of the submerged-liquid culture of mushroom mycelia.

Prediction of stone-free status and complication rates after tubeless percutaneous nephrolithotomy: a comparative and retrospective study using three stone-scoring systems and preoperative parameters

Choi, S. W.,Bae, W. J.,Ha, U. S.,Hong, S. H.,Lee, J. Y.,Kim, S. W.,Cho, H. J. Springer Science + Business Media 2017 World journal of urology Vol.35 No.3

<P>To investigate the factors predictive of surgical outcomes of tubeless percutaneous nephrolithotomy (TPCNL) and to compare the predictability and accuracy of the Guy's stone score, S.T.O.N.E. nephrolithometry, and CROES nomogram. We reviewed retrospectively the surgical outcomes recorded consecutively and imaging data of preoperative computed tomography scans of 141 patients who had undergone TPCNL from June 2012 to October 2015. Guy's, S.T.O.N.E., and CROES stone-scoring systems (SSSs) and other prognostic factors were assessed using univariate and multivariate statistical analyses. The initial stone-free and complication rates after TPCNL were 78.7 (111/141) and 17.0 % (24/141). On univariate analysis, all three scoring systems were identified as significant factors in terms of stone-free rate (SFR). The multivariate logistic regression analysis showed that the Guy's stone score and stone burden 385 mm(2) had significant correlations with stone-free status [odds ratios (OR) = 3.220, p = 0.001 and OR = 6.451, p = 0.002, respectively]. Guy's stone score (OR = 1.879, p = 0.013) was an independent risk factor for the development of complications. The area under the receiver operating characteristic (ROC) curves for the Guy's, S.T.O.N.E., and CROES SSSs and stone burden showed good results (0.821, 0.816, 0.820, and 0.800, respectively). Pairwise comparison of ROC curves showed that there was no significant difference between each final score and stone burden. Of the three scoring systems, Guy's stone score was the only significant predictive factor for SFR and complication rates after TPCNL in the multivariate logistic regression analysis. Stone burden was significantly associated with a postoperative stone-free status (SFS).</P>

Quantitative ED-EPMA combined with morphological information for the characterization of individual aerosol particles collected in Incheon, Korea

Kang, S.,Hwang, H.,Kang, S.,Park, Y.,Kim, H.,Ro, C.U. Pergamon Press ; Elsevier [distribution] 2009 Atmospheric environment Vol.43 No.22

A quantitative single-particle analytical technique, called low-Z particle electron probe X-ray microanalysis, combined with the utilization of their morphological information on individual particles, was applied to characterize six aerosol samples collected in one Korean city, Incheon, during March 9-15, 2006. The collected supermicron aerosol particles were classified based on their chemical species and morphology on a single-particle basis. Many different particle types were identified and their emission source, transport, and reactivity in the air were elucidated. In the samples, particles in the ''soil-derived particles'' group were the most abundant, followed by ''reacted sea-salts'', ''reacted CaCO<SUB>3</SUB>-containing particles'', ''genuine sea-salts'', ''reacted sea-salts + others'', ''Fe-containing particles'', ''anthropogenic organics'', (NH<SUB>4</SUB>)<SUB>2</SUB>SO<SUB>4</SUB>, ''K-containing particles'', and ''fly ash''. The application of this single-particle analysis, fully utilizing their chemical compositional and morphological data of individual particles, clearly revealed the different characteristics of the six aerosol samples. For samples S3 and S5, which were sampled during two Asian dust storm events, almost all particles were of soil origin that had not experienced chemical modification and that did not entrain sea-salts during their long-range transport. For sample S1, collected at an episodic period of high PM<SUB>10</SUB> concentration and haze, anthropogenic, secondary, and soil-derived particles emitted from local sources were predominant. For samples S2, S4, and S6, which were collected on average spring days with respect to their PM<SUB>10</SUB> concentrations, marine originated particles were the most abundant. Sample S2 seems to have been strongly influenced by emissions from the Yellow Sea and Korean peninsula, sample S4 had the minimum anthropogenic influence among the four samples collected in the absence of any Asian dust storm event, and sample S6 seems to have entrained air pollutants that had been transported from mainland China over the Yellow Sea to Korea.

CK2α/CSNK2A1 Phosphorylates SIRT6 and Is Involved in the Progression of Breast Carcinoma and Predicts Shorter Survival of Diagnosed Patients

Bae, J.S.,Park, S.H.,Jamiyandorj, U.,Kim, K.M.,Noh, S.J.,Kim, J.R.,Park, H.J.,Kwon, K.S.,Jung, S.H.,Park, H.S.,Park, B.H.,Lee, H.,Moon, W.S.,Sylvester, K.G.,Jang, K.Y. American Association of Pathologists and Bacteriol 2016 The American journal of pathology Vol.186 No.12

<P>Recently, the roles of sirtuins (SIRTs) in tumorigenesis have been of interest to oncologists, and protein kinase CK2 alpha 1 (CSNK2A1) has been shown to be involved in tumorigenesis by phosphorylating various proteins, including SIRT1. Therefore, we evaluated the roles of CSNK2A1, SIRT6, and phosphorylated SIRT6 and their relationships in breast carcinoma. Nuclear expression of CSNK2A1 and SIRT6 predicted shorter overall survival and relapse-free survival by multivariate analysis. Inhibition of CSNK2A1 decreased the proliferative and invasive activity of cancer cells. In addition, CSNK2A1 was bound to SIRT6 and phosphorylated SIRT6; evidence for this is provided from immunofluorescence staining, co-immunoprecipitation of CSNK2A1 and SIRT6, a glutathione S-transferase pull-down assay, an in vitro kinase assay, and transfection of mutant CSNK2A1. Knockdown of SIRT6 decreased the proliferation and invasiveness of cancer cells. Overexpression of SIRT6 increased proliferation, but mutation at the Ser338 phosphorylation site of SIRT6 inhibited the proliferation of MCF7 cells. Moreover, both knockdown of SIRT6 and a mutation at the phosphorylation site of SIRT6 decreased expression of matrix metallopeptidase 9, beta-catenin, cyclin D1, and NF-kappa B. Especially, SIRT6 expression was associated with the nuclear localization of B-catenin. This study demonstrates that CSNK2A1 and SIRT6 are indicators of poor prognosis for breast carcinomas and that CSNK2A1-mediated phosphorylation of SIRT6 might be involved in the progression of breast carcinoma.</P>

Sea-urchin-like iron oxide nanostructures for water treatment

Lee, H.U.,Lee, S.C.,Lee, Y.C.,Vrtnik, S.,Kim, C.,Lee, S.,Lee, Y.B.,Nam, B.,Lee, J.W.,Park, S.Y.,Lee, S.M.,Lee, J. Elsevier Scientific Pub. Co 2013 Journal of hazardous materials Vol.262 No.-

To obtain adsorbents with high capacities for removing heavy metals and organic pollutants capable of quick magnetic separation, we fabricated unique sea-urchin-like magnetic iron oxide (mixed γ-Fe<SUB>2</SUB>O<SUB>3</SUB>/Fe<SUB>3</SUB>O<SUB>4</SUB> phase) nanostructures (called u-MFN) with large surface areas (94.1m<SUP>2</SUP>g<SUP>-1</SUP>) and strong magnetic properties (57.9emug<SUP>-1</SUP>) using a simple growth process and investigated their potential applications in water treatment. The u-MFN had excellent removal capabilities for the heavy metals As(V) (39.6mgg<SUP>-1</SUP>) and Cr(VI) (35.0mgg<SUP>-1</SUP>) and the organic pollutant Congo red (109.2mgg<SUP>-1</SUP>). The u-MFN also displays excellent adsorption of Congo red after recycling. Because of its high adsorption capacity, fast adsorption rate, and quick magnetic separation from treated water, the u-MFN developed in the present study is expected to be an efficient magnetic adsorbent for heavy metals and organic pollutants in aqueous solutions.

한국인 CCR5 유전자에서의 돌연변이 빈도

오명돈,김성순,김은영,이선희,김남정,박근용,김유석,김소마,김태규,최강원,이주실 국립보건연구원 2000 국립보건원보 Vol.37 No.-

실험계획법을 이용한 선박용 벨로우즈의 형상최적화에 관한 연구

김종필(J. P. Kim),김형준(H. J. Kim),김현수(H. S. Kim),조우석(U. S. Cho),제승봉(S. B. Jeo) 한국정밀공학회 2005 한국정밀공학회 학술발표대회 논문집 Vol.2005 No.10월

The mechanical properties of bellows, such as the extensibility and the strength can be changed depending on the shape. For the shipbuilding material, it is favorable that the fatigue life is long due to the elastic property and the reduction of thermal stress in piping system. Nowadays, the domestic production and design of bellows are based on the E.J.M.A Code. Therefore, the design standard is in need because of much errors and lack of detailed analysis. In this study, it is attempted to find out the optimal shape of U-type ship"s bellows that is applied to design of experiment using the finite element method. The effective factors, mountain height, length, thickness, and number of mountains and the length of joint are considered and the proper values are chosen for the simulation. The number of mountains are increased, the volume increases above the standard volume and the stress obviously increases. In addition, the effect of the thickness of bellows on the stress is very large. Both of the volume and stress are decreasing at a certain lower value region.

왜 韓國人에는 冠狀動脈硬化性心臟病이 적은가?

李圭澤,權五鉉,金庚植,南相哲,金東洛,金相煜,郭然植,金聖倍,韓龍燮,金源准 慶北大學校 1960 論文集 Vol.4 No.-

A relationship between the amount of dietary fat, the concentration of serum lipids and the development of coronary heart disease has been one of the most important medical problems in the recent years. Accumulated data indicate that striking differences exist among different populations in the incidence and severity of coronary heart disease and these differences tend to correlate with dietary factors rather than with racial or other factors. Extensive studies on healthy peoples in various parts of the world lead to the conclusion that the incidence of coronary heart disease is directly to related the average level of serum cholesterol and this cholesterol level is directly related to the percentage of calories provided by fats in the diet, particularly common saturated fats of meats and dairy products. Such a study has never been carried out in Korea and studies in other countries of the Far· East have indicated that their diets are extremely low in the fat content and their serum cholesterol and frequency of the coronary heart disease are also remarkably low. In an attempt to correlate the dietary fat intake, blood lipid level and the Incidence of coronary heart disease in Korean people, the following population groups are selected. 319 farmers, 100 Taegu City people, 50 upper class people, 129 Buddhist Monks, and 90 Korean soldiers attached to the United States Army who have been fed American diet for from 1 to 18 months and 60 American soldiers and officers. On all of those people an analysis of dietary constituents, complete blood lipid analysis including total and free cholesterol, cholesterol ester, total esterified fatty acid . lipid phosphorus, neutral fat. C/P ratio and cholesterol ester/total cholesterol ratio and 12 leads electrocardiogram for evidences of the coronary heart disease were performed and the data thus obtained were analyzed and correlated. The most striking difference in diets of various groups is the fat content. The fat intake of Buddhist Monks and farmers is significantly lower than any other groups and their serum lipid level and the incidence of abnormal electrocardiogram are also lowest in the whole groups. Among Koreans upper class people of Taegu city have the highest fat intake and also the highest serum lipid level and the incidence of abnormal electrocardiogram. The dietary fat intake of Korean is significantly lower than that of American and the serum lipid level and the incidence of coronary heart disease are also significantly lower than American. The results of current study indicate that there is direct correlation between the dietary fat intake, the serum lipid level and the incidence of coronary heart disease and it seems to be reasonable to conclude that among many factors which may affect the remarkably low incidence of the coronary heart disease in Koreans the low dietary fat intake is the most important factor.