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RISS 인기검색어
- 검색키워드
- 저자 : Kim Jae-Uoong (검색결과 3 건)
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양현웅,김연수,문희석,박기오,이엄석,김선문,서승원,성재규,나병규,이승민,이병석,김남재,이헌영 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1
Background/Aims : Wilson's disease in an autosomal recessive genetic disorder which is characterized by hepatic and neurologic manifestations due to defect in copper metabolism. The progression of hepatic damage and critical neurologic complication can be prevented by early diagnosis and treatment. Our study investigated the usefulness of clinical manifestations and laboratory findings in Wilson's disease to early diagnosis of wilson's disease. Method : We investigated the 10 patients who are diagnosed as Wilson's disease at Chungnam national university Hospital during the recent 5 years for clinical manifestation, laboratory findings and treatment. Results : 1. Females are 9 patients(90%) among 10 objective patients and the median age of patients is 30.2±14 years. The second and third decade are the more common prevalent and 5 patients(50%) have family history. 2. The clinical manifestations of Wilson's disease at time of diagnosis are hepatic manifestation in 9 patients (90%) except presymptomatic patient and the psycho-neurologic manifestations are appeared in 5 patients(50%). Three patients have the secondary amenorrhea, hemolytic anemia and recurrent spontaneous abortions in each case. 3. The serum ceruloplasmin concentrations were lower than 20mg/dl in 8 patient(80%) including presymptomatic patient and the 24 hours urine copper excretion is above 100μg/24hrs in 7 patients(70%). 4. Seven patients(70%) with symptomatic Wilson's disease have the detectable Kayser-Fleischer ring in slit lamp examinations but one presymptomatic patient has no Kayser-Fleischer ring. 5. The serum level of ceruloplasmin is increased in 3 patients (42.8%) among 7 patients who are had been treated by penicillamine(one patient is not followed up serum ceruloplasmin) and the 24 hours urine copper excretion was decreased in 6 patient(75%) among 8 patients treated by penicillamine. 6. Five patients died with hepatic failure related to uncompensated liver cirrhosis. Conclusion : The slit lamp examination should be recommended in patients with hepatic and neurologic disease of unknown etiology and sibling of the patients wilson's disease. The irrerersible damage of organs would be prevented by aggressive treatment at early state in patients diagnosed as Wilson's disease.
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만성 활동성 C형 간염 환자에서 알파 인터페론 2b 투여에 의한 HCV-RNA의 소실
이경태,김연수,문희석,박기오,이엄석,김선문,양현웅,서승원,성재규,나병규,이승민,이병석,김남재,이헌영 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1
Background/Aims : Interferon-alpha is the most effective agent for the treatment of chronic active hepatitis C(CAH-C). The purpose of this study are to evaluate the efficacy of alpha-interferon therapy for the CAH-C and to clarify the correlations between the biochemical and anti-viral responses. Methods : The presence of serum hepatitis C virus(HCV) with increased serum ALT(Alanine aminotransferase) activities were monitored in 18 patients with CAH-C confirmed by serologic studies and liver biopsy from July 1992 to July 1998. The patients were treated with interferon alpha 2b for 6 months and the other eight patients were selected as the control group. Results : The serum ALT levels became within normal limit in 9 of 10 patients(90%) after interferon treatment (End-of-treatment response;ETR). Sustained responses(SR) were achieved in 7 cases(70%) for follow-up period of 18 to 24 months (SR-12month). Two cases were relapsed responders who showed elevated ALT levels within 1-2 months after cessation of interferon therapy and the other case was a non-responders (NR). In all 7 sustained responders (SR), HCV-RNAs were negative at the end of the treatment. But HCV-RNA reappeared in the serum in the case of the relapsed responders during follow-up period after treatment. While none of 8 patients, control group showed normal ALT levels during 18-24 months follow-up period, and the HCV-RNA states did not change in all the control group. Conclusion : This study suggest that the 3 million units of interferon alpha 2b, T.I.W.(three times a week) for 6-month course is effective in the treatment of CAH-C, especially in younger age and shorter duration of disease. The disappearance of serum HCV-RNA is closely associated with the normalization of serum ALT levles, so that the serial measurement of HCV-RNA may be a reliable marker in the efficacy of interferon treatment and predicting relapse.
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하이패스플러스카드 시스템을 위한 LSAM시험 및 모듈 개발
이기한,윤현탁,김재웅,이승환,Lee Ki-Han,Yoon Hyun-Tak,Kim Jae-Uoong,Lee Seung-Hwan 한국ITS학회 2004 한국ITS학회논문지 Vol.3 No.1
한국도로공사는 선불형 플라스틱카드를 스마트카드 형태의 선불형 전자지불카드인 하이패스플러스카드로 교체하여 사용하고 있다. 하이패스플러스카드를 전자지불에 사용하기 위해서는 하이패스플러스카드에 가치를 저장하여야 하는데 이를 수행하는 스마트카드가 LSAM이다. 또한, LSAM은 PPSAM에 의해서 가치를 저장 받거나 환불할 수 있도록 설계되어있다. 따라서, LSAM의 기능 및 보안이 철저해야 한국도로공사의 전자지불시스템이 안전하다. 본 논문은 PPSAM에 의한 LSAM의 가치저장, PPSAM에 의한 LSAM의 가치환불, 그리고, LSAM에 의한 하이패스플러스카드로의 가치저장 기능 및 보안을 시험하기 위한 시험 방법, 시험 표준항목, 그리고 시험 절차 등을 포함한 시험 모듈을 개발했다. LSAM의 기능 및 보안 시험에 관한 시험 표준항목 및 시험 검사표는 한국도로공사 규격서에 준하여 ISO 표준에 적합한 항목을 기준으로 선정했다. 본 시험 모듈은 LSAM의 기능뿐 아니라 보안성 및 적합성을 시험하였다. 시험은 한국도로공사에서 사용되는 LSAM을 이용하여 실행하였다. 시험결과에 의하면, 한국도로공사에서 사용되는 LSAM은 모든 시험 기준을 통과하여 보안성 및 기능성이 적합하다고 평가되었다. Recently, the Korea Highway Company is replacing their prepaid plastic cards with a smart card, called $Hipass^{PLUS}$ Card. In order to use $Hipass^{PLUS}$Card in the prepaid payment system, LSAM, which is to store the value into $Hipass^{PLUS}$ Card is needed. LSAM is also responsible to store or retrieve the value from PPSAM. For the safety of Korea Highway electronic payment system, the functionality and security of LSAM should be faultless. This paper developed a test module including the test method, the test checklist, and the test procedure. The test module examines the functionality and security of loading the value from PPSAM to LSAM, retrieving the value from LSAM to PPSAM, and loading the value from LSAM to $Hipass^{PLUS}$ Card. The test module contains the method and the procedure to test the standard items by the test checklists. The test items and test checklists of LSAM was selected under the provision of the specification of Korea Highway Company and ISO standard. The test module evaluates the functionality, the security and the compatibility of LSAM. After the evaluation test of LSAM using the test module, LSAM satisfied the characteristics of the functionality, security, and compatibility.
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