전면문제중심학습이 치의학교육의 자기주도적 학습, 의사소통, 문제해결 능력에 미치는 영향

이강욱 ( Kang-wook Lee ),홍진실 ( Jin-sil Hong ),장기완 ( Kee-wan Chang ) 대한구강보건학회 2016 大韓口腔保健學會誌 Vol.40 No.4

Objectives: The purpose of this study was to examine the effect of problem-based learning (PBL) on dental education to dental students. The following were investigated in this study: 1. Does PBL improve the ability of self-directed learning? 2. Does PBL change communication ability? 3. Does PBL change the strategy of problem solving? Methods: The participants of this study were 39 students in the experimental group and 68 students in the control group. The measurement tools of this study were self-directed learning, communication, and problem solving abilities tests designed by the Korean Educational Development Institute. The data was analyzed by the two-way ANOVA and ANOVA with repeated measures. Results: In self-directed learning ability during 3 semesters, the experimental group showed a U-shape change but the control group showed a reverse U-shape change. In the experimental group, the selfdirected learning ability was decreased after one year (after the first and second semester). The level of communication ability decreased every day during the three semesters monitored in both the control and experimental groups. The level of communication ability in the experimental group continuously decreased during the three semesters, with the exception of one semester. Finally, for the problem solving ability during the three semesters, the experimental group showed a reverse U-shape change while the control group showed a U-shape change. In the experimental group, there was no change after two semesters. Conclusions: On the basis of the findings in this study, the following conclusions can be made. First, problem-based learning has a positive educational effect compared to didactic-based learning within one year. Second, the appropriate length of PBL is two semesters, or one year. It could be recommended that dental education in Korea should be combined or hybridized with PBL; for example, PBL could be used in combination with brief lectures or block lectures by teachers.

Thermoplasma acidophilum의 20S Proteasome에 의한 ATPase-활성적 단백질분해에 관한 연구

우기민,장예진,조만희,김창세,김완종,조성호,이상한 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.1

The eukaryotic 26S proteasome is an ATP/ubiquitin-dependent proteolytic complex consisting of the 20S core particle and 19S ATPase complex. However, because of its complexity and unstable properties, this study was carried out to present more simple and stable model for the ATP-activated proteolytic complex in prokaryotes which can take the place of the eukaryotic 26S proteasome. For this purpose, recombinant Thermoplasma 20S proteasome (T20S) and Methanococcus MS4, a sequence homolog of one ATPase subunit in the 19S ATPase complex, were successfully isolated from Escherichia coli (E. coli). The α and β subunits of T20S expressed in E. coli could assemble for themselves, and showed the peptide-hydrolyzing activity. Whereas both T20S and R20S (the 20S complex from rabbit skeletal muscle) had the highest peptidase activity against Suc-LLVY-AMC, a good substrate for chymotrypsin-like peptidase activity, the specific activity of T20S was slightly lower than that of R20S. In addition, several reagents such as KCI, SDS, and ovalbumin were shown to have different effects on the peptidase activities between T20S and R20S. When the ATPase activity of the purified MS4 were assayed , the Km for ATP was about 0.5 mM, and casein could stimulate the activity more than 2 fold without the change in Km. This result implicates that protein-activated ATPase may induce the conformational change of casein, and therefore suggests that MS4 ATPase may activate the proteolytic activity of the 20S proteasome via accelerating the recognition and translocation of the protein substrates.

韓國 高等學生의 動·植物 生理에 對한 誤槪念

張楠基,鄭玩鎬 한국교원대학교 과학교육연구소 1993 청람과학교육연구논총 Vol.3 No.1

The major purpose of this research was to identify Korean high school students' misconceptions on animal and plant physiology. In order to find out high school students' misconception on animal and plant physiology, the paper and pencil test form of a questionnaire was constructed with 15 items and sent to 541 high shcool students. Their responses were collected and the data was analyzed. According to the analysis of the questionnaire on animal and plant physiology for students, the general lower academic level studends' group had more statistically significant misconceptions compared to higher level students' group in the areas of animal and plant physiology were concerned. But there was not the statistically significant difference in misconceptions about the concepts of amino acids between the two students' groups. The males had many misconceptions about sperm concepts. In the case of concepts on the excretory organ, especially the students from urban area had less misconceptions than the ones from rural area had.

Drosophila melanogaster 韓國 自然集團에 있어서 P-M System에 依據한 Cytotype 分布 硏究

成耆昌,安成晥 성균관대학교 기초과학연구소 1988 論文集 Vol.39 No.1

Hybrid dysgenesis, aberrant phenomena, found in certain interstrain hybrids of Drosophila melanogaster, is caused by the interaction of chromosomal and cytoplasmic factors. 10 natural populations of D. melanogaster from Korea were investigated in order to determine the distribution of P factor and M cytotype, two components of P-M system. The results showed that: 1) The P factor activity for potential GD sterility is absent or present at only very low frequencies in these populations. 2) All locations show rather similar distributions, indicating weak M cytotype. The levels of activity of M cytotype were appeared to be variable among 10 populations. 3) Q cytotype, which cause immune to the P factor, was found at high frequencies in these populations. 4) The results seem to suggest that polymorphism of M and Q cytotype exists in Korean natural population.

Fe-29%Ni-17%Co 코바 합금의 고온 내산화성 및 열간 가공성에 미치는 Mo 첨가의 영향

이기안,조창완,성병근,김병문,김문철 대한금속ᆞ재료학회 2006 대한금속·재료학회지 Vol.44 No.3

全羅北道 道民의 永久齒 拔去原因比重

전재규,장기완 대한구강보건학회 2003 大韓口腔保健學會誌 Vol.27 No.1

The purpose of this study was to analyze the cause of tooth extracted in the residents of Chollabuk-do Province. General dental practioners of 4 dental clinics at Chonju having a population about 600 thousands-habitants, general dental practioners of 2 dental clinics in 2 rural ateas at Chungeub, Kimjae having a population less than 200 thousands such as complexed cities of urban and rural ateas was chosen. In the complexed cities, half of the population lives in urban atea and the other half in rural area. To ensure extracted teeth directly by visual inspection, the author collected 2,852 permanent teeth from extracted by general dental practitioners. The author analyzed the cause of teeth extracted by age, sex, area, tooth-kind. The cause of teeth extracted were dental caries, periodontal disease, dental caries with periodontal disease, orthodontic treatment, trauma, preparation of prosthetic treatment and others. The results obtained were as follows; 1. Among the causes of tooth extraction, dental caries was 53.6%, periodontal disease 28.8%, and dental caries with periodontal disease 7.2%. 2. Dental caries was the major cause of tooth extraction and continues throughout life for both sex, but periodontal disease was remarkably increasing in those aged 35year old and over. 3. Although the molars were most extracted in the all kinds of teeth, the main reasons of the extraction were pericoronitis impaction and dental caries. Especially, the third molars were extracted, due to only the cause of third molars itself more than other reasons. Because dental caries and the periodontal disease are the major cause of teeth extracted in Korea, the dental health policy should be focused on the prevention and treatment of these two diseases in the government level.

신경외과 환자에서 발생한 폐 색전증에 대한 고찰

권오기,오창완,정영섭,한대희 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.9

The purpose of this study was to understand the general features of pulmonary embolism in neurosurgical patients. The authors retrospectively reviewed 24 cases of pulmonary embolism from 1981 to 1994. The overall incidence of pulmonary embolism was 0.2%, but in the most prevalent year(1994) it was 1.3%. Lower extremity weakness and immobilization was the most common predisposing condition. Of 24 patients with pulmonary embolism, 23 patients showed lower extremity weakness, and the mean duration of immobilization was 47 days. Most patients (80%) had symptoms of pulmonary embolism within 4 weeks after operation. Medical prophylactic method had not been used in patients other than physical prophylactic method-graduated compression stocking. position change or physical therapy. Heparinization was given to 18 patients(75%), and minor hemorrhagic complication developed in 2 patients, but no major bleeding occurred. Inferior vena cava filter was applied in 2 patients. Only one patient suffered from recurrence and it was not fatal. Of the 24 patients. 7 died, however only one patient died of pulmonary embolism. In our study, the prognosis of pulmonary embolism was not as serious as it has been reported in the literature. However, more precise studies will be needed to understand the fate of pumonary embolism in Korean neurosurgical patients.

뇌동정맥기형 환자의 수술후 경련 치료 성적

권오기,오창완,한대희 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.6

This study was intended to investigate the pre- and postoperative profile of seizures in the patients with cerebral arteriovenous malformations(AVM's), and to evaluate various preoperative factors to predict the postoperative occurence of seizures. The patients consisted of 46 consecutive cases with supratentorial AVM's operated on from May 1987 to May 1993. Their mean follow-up duration was 40 months. The pre- and postoperative seizure profiles were similar to each other. The overall incidence of patients experiencing seizure were 50% preoperatively and 52% postoperatively, and the incidence of intractable seizure was 15%, which was the same in both the pre- and postoperative period. The presence of preoperative seizure and large size of AVM were significant indicators of high incidence of postoperative seizures(P<0.05), while other factors such as preoperative intracerebral hemorrhage or embolization showed no significant influence on the occurrence of postoperative seizures. About 70% of the patients with preoperative seizures also had postoperative seizures, while those without preoperative seizures developed new ones only in 35% of the cases postoperatively. The mean size of the AVM's in the group with postoperative seizures was larger than that of the group without postoperative seizures(4.50 vs. 3.02 cm). Regarding postoperative intractable seizures, 57% of the group with preoperative intractable seizures remained intractable postoperatively and groups with preoperatively controlled and groups without seizures demonstrated postoperative intractablity only in 13% and 4% respectively. In conclusion, surgery of AVM's did not change the overall incidence of seizures, both controlled and intractable and patients with preoperative seizures and large sized AVM's had significantly higher possibility of postoperative seizures. Patients with preoperative intractable seizures resulted in control of seizures in 43% after removal of AVM, while 57% remained intractable. Extirpation of epileptic foci, after localization with preoperative study, seems to be needed to improve the outcome of the postoperative seizures.

Sodium Valproate(Depakine^(�)) 정맥주사의 임상적 효능에 관한 연구 : 신경외과 수술후 1주일간의 간질억제효과와 안전성 Antiepileptic Effect and Safety Assessment During the Postoperative Seven Days in Neurosurgical Patients

백선하,왕규창,오창완,정천기,김동규,정희원,김현집,조병규,최길수,한대희 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.7

Diphenylhydantoin(DPH) has been used intravenously as a drug of choice in conditions which seizure patients are incapable of oral Teeding or in a state of status epilepticus However, its clinical use has limitations because of its serious side effects o# cardiac depression or systemic hypotension In Western countries. the recently do- veloped intravenous sodium valproate has been reported as safe and e#Tective for seizure control in such patients To assess the safety and effectiveness in seizure control we investigated the serum levels of the drug at f4 hours 48 hours and 7 days after intravenous administration of sodium valproate(Depakine른. occurrence of seizures in the perioperative period and the side eT#ects of the drugs in 30 neurosurgical patients older than 3 years of age The mean serum concentrations of valproic acid after bolus injection To IS mg/kg followed by continuous infusion with the rate To OSmg/kg/hour, were over 450 rg/ml . 좌S 0± IS 3 ff/ml at 운4 hours, 504±fl 0 f(g/ml at 좌』 hours and 58 9±tO 7 賠,/1 at 7 days aTter the sta「t of the adinistration All the Patients whose se「u vaIProic acid levelwas witHin the therapeutic range(40-100 rr/ml). had never experienced an episode of seizure attack during the perioperative days There was no evidence of elevated liver enzyme activity, but there were evidence of some tendencyof decreased platelet count in the peripheral blood at f days a#ter the administration of intravenous Yalproic acid Four patients experienced episodes of mild nausea and/or vomiting in conclusion per'ioperat'ive intravenous administration of valproic acids in neurosurgical patients was safe and effective in seizure control However it must be used precauciously in the patients with compromized coagulation system

신경세포이주장애질환을 가진 간질환자에 대한 수술 체험

황승균,정천기,오창완,이상건,지제근,김현집,한대희,이상복 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.3

Neuronal migration disorders(NMD's) are a rare group of development structural lesions characterized by disorganization of cortical architecture with aberrant columnar and laminar neuronal arrangement, often causing intractable seizures. During September 1994 to February 1995, we operated on six patients with NMD to treat intractable seizures. Male to female ratio of these 6 patients was 2 : 4, and mean age at seizure onset was 14 years old(range 6-28 years), indicating early onset of epilepsy. Mean age at seizure surgery was 29 years old(range 23-41 years), and mean follow-up duration after operation was 4 months(range 3-6 months). In their past medical history, three patients had experienced febrile seizure at pediatric age, and one of them had a history of anoxic damage during delivery. Following preoperative localization, the lesion was removed completely in five patients. In the other one patient, part of the lesion was located in the speech and motor area, leading to partial removal. On histologic examination two of them showed cortical dysplasia and the other four revealed microdysgenesis. During follow-up for six months, five patients were free of seizure and in the other one patient, whose lesion was removed incompletely, the frequency of seizure decreased by 95%.