신증동국여지승람의 항목체재와 '제영'에 대한 고찰

정의성,Jung Uee-Sung 한국문헌정보학회 1997 한국문헌정보학회지 Vol.31 No.4

신증동국여지승람의 항목체재는 모두 26개로 구성되어 있으며 그 중심 주제는 행정 군사 지리이다. 이는 본서가 범상한 지리서라기보다는 국가의 행정지침서나 군사요무를 위한 편람으로서의 역할을 담당한 포괄적인 정보자료였음을 시사해 주는 것이다. 특히 본서는 여타 지리지가 구비치 못한 '제영' 항목을 설정하여 인문적인 면을 보강하므로서 지리지의 격조를 한층 드높인 자료로 평가된다. 제영의 詩文은 충청 경상 전라도에 많이 등재되어 있으며 이 삼남지방에 게재된 것이 전체의 과반수를 넘고 있다. 이들 시문의 영탄대상은 산 강 성 릉묘 등이며 주로 자연지리적 현상이나 기념비적인 사적들이다. The content systems of Shinjung Tongguk Yoji Sungnam(신증동국여지승람, A Korean Geography Published in Chosen Dynasty) consist of 26 items and the main subject comprises administration, military and geography, This book does not suggest a simple geography but a comprehensive bibliography as an administrative guide book of a nation or a military operation manual. In particular, this book is made much of as a more valuable material in elevating the quality of the geographic book since it contained a 'Cheyong(제영)' item and reinforced the fields of humanities which could not be found out in other geography. The verses of Cheyong are recorded in the documents in the Chungchong, Kyungsang and Chulla Provinces, and these recorded verses In the tree provinces are more than half of the whole country's. The objects of recitation in the these verses are related to such natural phenomena and historic relics as the mountains, the livers, the wails and the royal tombs.

Thyroid dysfunction associated with follicular cell steatosis in obese male mice and humans.

Lee, Min Hee,Lee, Jung Uee,Joung, Kyong Hye,Kim, Yong Kyung,Ryu, Min Jeong,Lee, Seong Eun,Kim, Soung Jung,Chung, Hyo Kyun,Choi, Min Jeong,Chang, Joon Young,Lee, Sang-Hee,Kweon, Gi Ryang,Kim, Hyun Jin The Endocrine Society 2015 Endocrinology Vol.156 No.3

<P>Adult thyroid dysfunction is a common endocrine disorder associated with an increased risk of cardiovascular disease and mortality. A recent epidemiologic study revealed a link between obesity and increased prevalence of hypothyroidism. It is conceivable that excessive adiposity in obesity might lead to expansion of the interfollicular adipose (IFA) depot or steatosis in thyroid follicular cells (thyroid steatosis, TS). In this study, we investigated the morphological and functional changes in thyroid glands of obese humans and animal models, diet-induced obese (DIO), ob/ob, and db/db mice. Expanded IFA depot and TS were observed in obese patients. Furthermore, DIO mice showed increased expression of lipogenesis-regulation genes, such as sterol regulatory element binding protein 1 (SREBP-1), peroxisome proliferator-activated receptor γ (PPARγ), acetyl coenzyme A carboxylase (ACC), and fatty acid synthetase (FASN) in the thyroid gland. Steatosis and ultrastructural changes, including distension of the endoplasmic reticulum (ER) and mitochondrial distortion in thyroid follicular cells, were uniformly observed in DIO mice and genetically obese mouse models, ob/ob and db/db mice. Obese mice displayed a variable degree of primary thyroid hypofunction, which was not corrected by PPARγ agonist administration. We propose that systemically increased adiposity is associated with characteristic IFA depots and TS and may cause or influence the development of primary thyroid failure.</P>

Poster Session : PS 1028 ; GI Motility : The Immunohistochemical Expressions of STAT3, Bcl-xL and TNF-a Proteins in Gastric Adenoma and Adenocarcinoma

( Seung Woo Lee ),( Sang Bum Kang ),( Dong Soo Lee ),( Jung Uee Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Signal transducers and activators of transcription 3(STAT3) is a key transcription factor for many regulatory factors that modulate gene transcription. Dysregulation of STAT3 by constitutive activation plays an important role in the initiation of infl ammation and cellular transformation in numerous cancers. STAT3 activation has been implicated in modulating the activity of downstream mediators such as Bcl-xL and TNF-a. The aim of this study was to investigate the immunohistochemical expressions of STAT3, Bcl-xL and TNF-a proteins in gastric adenoma and adenocarcinoma. Methods: Immunohistochemical staining with monoclonal STAT3, Bcl-xL,, TNF-a antibodies were performed on the paraffi n embedded specimens of 29 gastric adenocarcinomas and 16 gastric adenomas. Results: The expression of STAT3, Bcl-xL and TNF-a was increased in gastric adenoma as compared with gastric adenocarcinoma(P<0.05). The expression of Bcl-xL was higher in intestinal type adenocarcinomas and adenocarcinomas without lymphovascular invasion (p<0.05). The expression of TNF-a was higher in intestinal type, early T stage adenocarcinomas and adenocarcinomas without lymphovascular invasion (P<0.05). Conclusions: STAT3, Bcl-xL and TNF-a may play important roles in the initiation of tumorigenesis of gastric adenocarcinoma.

Expression of CXCR4 and SDF-1αin Primary Breast Cancers and Metastatic Lymph Nodes

Jong-Ok Kim,Kwang-Sun Suh,Dong-Ho Lee,Hae-Joung Sul,Jung-Uee Lee,Kyu-Sang Song 한국유방암학회 2009 Journal of breast cancer Vol.12 No.4

Purpose: A CXCR4/stroma derived factor-1α(SDF-1α, CXCL12) interaction is involved in many metastatic cancer mechanisms, including breast cancer. The primary objectives of this study were to investigate the correlation between CXCR4 and axillary lymph node metastasis and to clarify the interaction between CXCR4 in primary tumor cells and SDF-1αin metastatic lymph nodes. An analysis of the correlation between CXCR4, SDF-1αand clinicopathologic features was also performed. Methods: Representative areas from 44 invasive ductal carcinomas were selected for construction of tissue microarrays using a 5 mm punch. Breast cancers (n=44), metastatic axillary lymph nodes (n=18) and non-metastatic axillary lymph nodes (n=26) were immunohistochemically stained for CXCR4, SDF-1α, estrogen receptor (ER), progesterone receptor (PR) and HER2. The parameters of age, tumor size, nuclear grade, histologic grade, lymph node status and pathologic node (pN) stage pN0 to pN3 were evaluated. Results: CXCR4 expression was negatively correlated with increased age (p=0.005) and positively correlated with a large tumor size (p=0.043) and PR expression (p=0.027). CXCR4 expression was not correlated with metastatic lymph nodes (p=0.079) and SDF-1αexpression in metastatic lymph nodes (p=0.062). However, CXCR4 nuclear positivity is correlated with lymph node metastasis (p=0.044). SDF-1αwas not correlated with any clinicopathologic feature in a statistically significant manner. Conclusion: An evaluation of young age, large tumor size and PR expression helps predict lymph node metastasis and poor prognosis. Expression of CXCR4 nuclear positivity is correlated with a poor prognosis.

점막하 침윤 조기위암 환자에서 VEGF-C와 COX-2 발현의 임상적 의의

조윤정,이정의,이관주,박조현,박승만,전해명,안창준,김정구,이동호,이상철,Cho, Yun-Jung,Lee, Jung-Uee,Lee, Kwan-Ju,Park, Cho-Hyun,Park, Seung-Man,Jeon, Hae-Myung,Ahn, Chang-Joon,Kim, Jeong-Goo,Lee, Dong-Ho,Lee, Sang-Chul 대한위암학회 2009 대한위암학회지 Vol.9 No.3

목적: Vascular endothelial growth factor (VEGF)-C와 -D 및 Cyclooxygenase (COX)-2는 위암에서 림프절 전이와 연관이 있다고 알려져 있다. 이에 저자들은 점막하 침윤 조기위암에서 VEGF-C와 -D 및 COX-2의 발현과 림프절 전이 등을 포함하는 다양한 임상병리학적 인자와의 관련성을 알아 보고자 하였다. 대상 및 방법: 1991년 1월부터 2007년 10월까지 본원에서 점막하 침윤 조기위암으로 수술을 시행 받은 85명의 환자를 대상으로 VEGF-C, -D 및 COX-2와 VEGF-C에 대한 면역 조직화학 염색을 시행하였다. 염색의 결과에 따라 환자군을 나누어 다양한 임상병리학적 인자와의 연관성을 조사하였고, 또 이 세 가지 인자들 상호 간의 연관 관계를 분석하였다. 결과: 전체 85명의 환자 중 16명이 림프절 전이가 있었다(18.8%). VEGF-C는 34.1% VEGF-D는 22.3% 그리고 COX-2는 37.6%가 양성으로 판정되었다. 이 중 VEGF-C와 COX-2 모두 림프절 전이와 유의한 상관관계를 보였고(P<0.001, P=0.023). VEGF-D와 연관성을 보이는 인자는 확인하지 못하였다. 또 VEGF-C와 COX-2의 발현은 밀접한 상관관계를 보였다(P=0.001). 결론: 점막하 침윤 조기위암에서 VEGF-C와 COX-2는 림프절 전이와 연관이 있고, 따라서 이 두 인자가 점막하 침윤 조기위암의 림프절 전이를 예측하는 인자로서의 가능성이 있다고 할 수 있겠다. Purpose: Lymph node metastasis is an important factor in determining prognosis and therapeutic options for early gastric cancer (EGC) patients. Vascular endothelial growth factor (VEGF)-C and D are known as lymphangiogenic factors, and cyclooxygenase (COX)-2 is thought to play a role in lymph node metastasis in gastric carcinoma. This study was designed to determine whether the expression of VEGF-C, VEGF-D, and COX-2 is associated with clinicopathologic factors, especially lymph node metastasis in EGCs invading the submucosa. Materials and Methods: Tissue samples were obtained from 85 Patients undergoing standard gastrectomy with lymph node dissection between 1991 and 2007 in the Department of Surgery of Daejeon St. Mary's Hospital in Daejeon, Korea. All patients were diagnosed with gastric cancers and submucosal invasion. We examined the expression of VEGF-C, VEGF-D, and COX-2 using immunohistochemical methods. Results: Of the 85 patients, 16 (18.8%) had lymph node metastasis. VEGF-C, VEGF-D, and COX-2 were positively expressed in 34.1% (29/85), 22.3% (19/85), and 37.6% (32/85) of the patients. VEGF-C and COX-2 expression was significantly correlated with lymph node metastasis (P<0.05). A positive correlation existed between VEGF-C and COX-2 expression (P< 0.001). Conclusion: VEGF-C and COX-2 expression is associated with lymph node metastasis in gastric cancer with submucosal invasion. VEGF-C and COX-2 may thus be predictive markers for lymph node metastasis in EGC patients with submucosal invasion.

Mitochondrial Localization and Regulation of BRAF^V600Ein Thyroid Cancer: A Clinically Used RAF Inhibitor Is Unable to Block the Mitochondrial Activities of BRAF^V600E

Lee, Min Hee,Lee, Seong Eun,Kim, Dong Wook,Ryu, Min Jeong,Kim, Sung Jin,Kim, Sung Joong,Kim, Yong Kyoung,Park, Ji Hoon,Kweon, Gi Ryang,Kim, Jin Man,Lee, Jung Uee,De Falco, Valentina,Jo, Young Suk,Shon The Endocrine Society 2011 The Journal of clinical endocrinology & metabolism Vol.96 No.1

MicroRNA Expression Profiles in Korean Non-Small Cell Lung Cancer

( Ji Woong Son ),( Young Jin Kim ),( Hyun Min Cho ),( Soo Young Lee ),( Jin Sung Jang ),( Jin Eun Choi ),( Jung Uee Lee ),( Min Gyu Kang ),( Yu Mi Lee ),( Sun Jung Kwon ),( Eu Gene Choi ),( Moon Jun N 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.67 No.5

Background: MicroRNAs (miRNAs) play an important role in the regulation of cell proliferation, apoptosis, development and differentiation. Several studies have shown that aberrant expression of miRNAs is involved in cancer development and progression by regulating the expression of proto-oncogenes or tumor suppressor genes. In this study, we investigated miRNA expression profiles in Korean patients with non-small cell lung cancer (NSCLC). Methods: We performed miRNA microarray analysis containing 60∼65 bp oligonucleotide probes representing human 318 miRNAs and validated the results of the microarray with Northern blot analysis or quantitative RT-PCR. Next, we examined the correlation between miRNA expression and the target gene transcriptional profile using a human whole-genome-expression microarray. Results: We showed that 35 miRNAs were expressed differentially in the NSCLCs and corresponding non-malignant lung tissues. We showed that 35 miRNAs were expressed differentially in the NSCLCs and corresponding nonmalignant lung tissues. Thirteen of the 35 differentially expressed miRNAs were newly identified in the present study. Of the 35 miRNAs, 2 (miR-371 and miR-210) were over-expressed in lung cancers, and 33 miRNAs, including miR-145, were under-expressed in lung cancers. miR-99b expression consistently showed a negative correlation with FGFR3 expression. Conclusion: Albeit a small number of patients were examined, these results suggest that miRNA expression profiles in Korean lung cancers may be somewhat different from the expression profiles reported on lung cancers in Western populations. The findings suggest that miR-99b might be a tumor suppressor through its up-regulation of FGFR3.

MicroRNA Expression Profiles in Korean Non-Small Cell Lung Cancer

Son, Ji Woong,Kim, Young Jin,Cho, Hyun Min,Lee, Soo Young,Jang, Jin Sung,Choi, Jin Eun,Lee, Jung Uee,Kang, Min Gyu,Lee, Yu Mi,Kwon, Sun Jung,Choi, Eugene,Na, Moon Jun,Park, Jae Yong The Korean Academy of Tuberculosis and Respiratory 2009 Tuberculosis and Respiratory Diseases Vol.67 No.5

Background: MicroRNAs (miRNAs) play an important role in the regulation of cell proliferation, apoptosis, development and differentiation. Several studies have shown that aberrant expression of miRNAs is involved in cancer development and progression by regulating the expression of proto-oncogenes or tumor suppressor genes. In this study, we investigated miRNA expression profiles in Korean patients with non-small cell lung cancer (NSCLC). Methods: We performed miRNA microarray analysis containing 60~65 bp oligonucleotide probes representing human 318 miRNAs and validated the results of the microarray with Northern blot analysis or quantitative RT-PCR. Next, we examined the correlation between miRNA expression and the target gene transcriptional profile using a human whole-genome-expression microarray. Results: We showed that 35 miRNAs were expressed differentially in the NSCLCs and corresponding non-malignant lung tissues. We showed that 35 miRNAs were expressed differentially in the NSCLCs and corresponding nonmalignant lung tissues. Thirteen of the 35 differentially expressed miRNAs were newly identified in the present study. Of the 35 miRNAs, 2 (miR-371 and miR-210) were over-expressed in lung cancers, and 33 miRNAs, including miR-145, were under-expressed in lung cancers. miR-99b expression consistently showed a negative correlation with FGFR3 expression. Conclusion: Albeit a small number of patients were examined, these results suggest that miRNA expression profiles in Korean lung cancers may be somewhat different from the expression profiles reported on lung cancers in Western populations. The findings suggest that miR-99b might be a tumor suppressor through its up-regulation of FGFR3.

Mitochondrial Localization and Regulation of BRAFV600E in Thyroid Cancer: A Clinically Used RAF Inhibitor Is Unable to Block the Mitochondrial Activities of BRAFV600E

Lee, Min Hee,Lee, Seong Eun,Kim, Dong Wook,Ryu, Min Jeong,Kim, Sung Jin,Kim, Sung Joong,Kim, Yong Kyoung,Park, Ji Hoon,Kweon, Gi Ryang,Kim, Jin Man,Lee, Jung Uee,De Falco, Valentina,Jo, Young Suk,Shon The Endocrine Society 2010 Molecular endocrinology Vol.24 No.11

東國輿地勝覽의 編纂·刊行 經緯

丁義聲 광주대학교 인문과학연구소 1996 인문과학 Vol.2 No.-

The motivation and aim of Tongguk Yeoji Sungnam is to make an efficient management in politics, economy and military by publishing a book which rages from the topography of our country to products, personages, natural scenary and customs. In the meantime, the reputed officials who were representative of the contemporary intellectuals took part in the edition of this book. Since it was published for the first time in the 12th year of King Sung-jong(A.D.1481), it had been newly edited several times and then it was published as Shinjung Tongguk Yeoji Sungnam in the 26th year of King Jung-jong(A.D.1531). This book was not only a unique geography but it also established a steady position as a source for general information.