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VAMP2-NRG1 Fusion Gene is a Novel Oncogenic Driver of Non-Small-Cell Lung Adenocarcinoma
Jung, Yeonjoo,Yong, Seunghui,Kim, Pora,Lee, Hee-Young,Jung, Yeonhwa,Keum, Juhee,Lee, Sanghyuk,Kim, Jhingook,Kim, Jaesang Elsevier 2015 JOURNAL OF THORACIC ONCOLOGY Vol.10 No.7
<P>Neuregulin 1 (NRG1) has been discovered as the tail moiety of fusion genes with several distinct partner head genes in lung cancers. These fusion genes activate ERBB2/ERBB3 receptor-mediated cell signaling and thereby function as oncogenic drivers.</P>
정주희 ( Juhee Jung ),오경수 ( Kyoungsu Oh ) 한국정보처리학회 2014 한국정보처리학회 학술대회논문집 Vol.21 No.1
프로젝션 맵핑은 사물 위에 연출된 영상을 입힘으로써 사물에 시각적 효과를 주는 기법 이다. 하지만 기존 방법은 사물의 위치, 방향을 맞추기 위해 여러 가지 비용과 노력이 필요하다. 우리는 직소 퍼즐과 증강현실을 이용해 기존 방법의 한계를 개선한 새로운 프로젝션 맵핑 기법을 제안한다. 사용자는 직소 퍼즐을 맞춤으로써 콘텐츠 제작에 자연스럽게 참여하며, 완성된 퍼즐 이미지는 마커로 사용된다. 사물에 투영될 최종 영상은 인식된 마커의 방향을 따르기 때문에 사물과 투영 영상을 맞추기 위한 노력이 필요하지 않다. 또한 제안된 방법은 미디어 아트, 교육용 콘텐츠, 컴퓨터 비전 애플리케이션 등 다양한 분야에 응용 가능하다.
서준혁,Jung-Hyun Kim,Juhee Jung,Kyunghyun Kim,Seul Gi Lee,Hyun-Deok Cho,Yura Jung,한상범 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.6
A novel green aqueous mobile phase modified with room temperature ionic liquids (RTILs) was employed in the absence of volatile organic solvents or ion-pairing reagents to analyze thiamine, a very polar compound, by reverse phase high performance liquid chromatography (RP-HPLC). Due to its strongly hydrophilic nature, thiamine was eluted near the column dead time (t0) using a mobile phase without adding RTILs or ion-pairing reagents, even if a 100% aqueous mobile phase, which has weak elution power under reverse phase conditions, was used. Thus, 1-ethyl-3-methyl-imidazolium hexafluorophosphate ([EMIM][PF6]), which has the strongest chaotropic effect, was selected as a mobile phase additive to improve retention and avoid baseline disturbances at t0. Various mobile phase parameters such as cation moiety, chaotropic anion moiety, pH and concentration of RTILs were optimized to determine thiamine at the proper retention time. Method validation was performed to assess linearity, intra- and inter-day accuracy and precision, recovery and repeatability; all results were found to be satisfactory. The developed method was also compared to the current official United States Pharmacopoeia (USP) and Korean Pharmacopoeia (KP) methods using an organic mobile phase containing an ionpairing reagent by means of evaluating various chromatographic parameters such as the capacity factor, theoretical plate number, peak asymmetry and tailing factor. The results indicated that the proposed method exhibited better efficiency of thiamine analysis than the official methods, and it was successfully applied to quantify thiamine in pharmaceutical preparations.
Lee, Cheol-Jung,An, Hyun-Jung,Kim, Seung-Min,Yoo, Sun-Mi,Park, Juhee,Lee, Ga-Eun,Kim, Woo-Young,Kim, Dae Joon,Kang, Han Chang,Lee, Joo Young,Lee, Hye Suk,Cho, Sung-Jun,Cho, Yong-Yeon National Academy of Sciences 2020 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.117 No.1
<P><B>Significance</B></P><P>The physiological relevance of STAT2 (a member of STAT family) in melanoma formation is clearly shown using a human skin tissue array. Moreover, FBXW7-mediated STAT2 protein stability regulation via ubiquitination is shown to play an essential role in melanoma cell proliferation in monolayer and anchorage-independent 3D culture systems. The molecular mechanisms that regulate STAT2 protein stability by FBXW7 include the interaction between CCD and DBD domains of STAT2 and the WD40 domain of FBXW7. STAT2 phosphorylation at the putative degron motifs that contain Ser381, Thr385, and Ser393 might be mediated by GSK3β. These serve as critical amino acids that form hydrogen bonds with the WD40 domain of FBXW7. Thus, the FBXW7–STAT2 signaling axis is an important target for melanoma treatment.</P><P>In this study, we provide critical evidence that STAT2 stability regulation plays an essential role in melanoma cell proliferation and colony growth. We found that the interaction of FBXW7 and STAT2 induced STAT2 destabilization via a ubiquitination-mediated proteasomal degradation pathway. Notably, GSK3β-mediated STAT2 phosphorylation facilitated STAT2–FBXW7 interactions via the DNA binding domain of STAT2 and domains 1, 2, 6, and 7 of FBXW7 WD40. Importantly, the inverse correlation between protein levels of STAT2 and FBXW7 were observed not only in human melanoma cells but also in a human skin cancer tissue array. The relationship between protein levels of STAT2 and FBXW7, cell proliferation, and colony growth were similarly observed in the melanoma cell lines SK-MEL-2, -5, and -28. Moreover, STAT2 knockdown in melanoma cells suppressed melanoma cell proliferation and colony formation. These data demonstrated that FBXW7-mediated STAT2 stability regulation plays an essential role in melanoma cell proliferation and cancer growth.</P>
Jung, Ki-Young,Cho, Jae-Wook,Joo, Eun Yeon,Kim, Sun Hwa,Choi, Kyung Mook,Chin, Juhee,Park, Kun-Woo,Hong, Seung Bong Elsevier 2010 CLINICAL NEUROPHYSIOLOGY - Vol.121 No.9
<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>To evaluate the effect of topiramate (TPM) on event-related potentials (ERPs) in patients with epilepsy.</P> <P><B>Methods</B></P> <P>Neuropsychological tests and ERP study using auditory oddball paradigm were conducted before and after treatment with TPM in drug-naive epilepsy patients. To detect target brain regions in which ERP changed during the cognitive task, cortical current densities of ERP components were analysed using standardised low-resolution electromagnetic tomography (sLORETA).</P> <P><B>Results</B></P> <P>Neuropsychological tests (<I>n= </I>18 patients) showed that TPM significantly decreased the score in digit span, Corsi block and Controlled Oral Word Association word fluency. Repeated-measures analysis of variance of ERP data (<I>n= </I>13 patients) revealed that P2 amplitude was significantly increased at Fz electrode following treatment with TPM. Statistical non-parametric map of sLORETA between pre- and post-TPM ERPs revealed that current density of P200 component was significantly reduced by TPM in bilateral parieto-occipital, temporolimbic and dorsolateral right prefrontal regions.</P> <P><B>Conclusions</B></P> <P>Our findings suggest that TPM affects selective brain regions which may be related to cognitive side effects.</P> <P><B>Significance</B></P> <P>Source localisation of ERPs can be helpful in identifying target brain regions for the cognitive side effects of anti-epileptic drugs.</P>
Analysis of Trans Fat in Edible Oils with Cooking Process
Juhee Song,Joohyeok Park,Jinyeong Jung,Chankyu Lee,Seo Yeoung Gim,HyeJung Ka,BoRa Yi,Mi-Ja Kim,Cho-il Kim,JaeHwan Lee 한국독성학회 2015 Toxicological Research Vol.31 No.3
Trans fat is a unsaturated fatty acid with trans configuration and separated double bonds. Analytical methods have been introduced to analyze trans fat content in foods including infrared (IR) spectroscopy, gas chromatography (GC), Fourier transform-infrared (FT-IR) spectroscopy, reverses-phase silver ion high performance liquid chromatography, and silver nitrate thin layer chromatography. Currently, FT-IR spectroscopy and GC are mostly used methods. Trans fat content in 6 vegetable oils were analyzed and processing effects including baking, stir-frying, pan-frying, and frying on the formation of trans fat in corn oil was evaluated by GC. Among tested vegetable oils, corn oil has 0.25 g trans fat/100 g, whereas other oils including rapeseed, soybean, olive, perilla, and sesame oils did not have detectable amount of trans fat content. Among cooking methods, stir-frying increased trans fat in corn oil whereas baking, pan-frying, and frying procedures did not make changes in trans fat content compared to untreated corn oils. However, the trans fat content was so low and food label can be declared as ‘0’ trans based on the regulation of Ministry of Food ad Drug Safety (MFDS) (< 2 g/100 g edible oil).