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Joong-Hyeok Heo,Dal-Heui Lee,고동찬,Ho-Wan Chang 한국지질과학협의회 2007 Geosciences Journal Vol.11 No.3
The objective of this study is to evaluate the effect ofionic strength and hardnes of trichloroethylene (TCE)-contami-nated synthetic groundwater on remediation using granular acti-vated carbon (GAC). The TCE sorption rate onto GAC in syntheticfrom 86.2% to 100%. As the ionic strength and hardness of thesynthetic groundwater increased, the TCE sorption rates decreased.The sorption kinetics of the GAC were also analyzed by kineticmodels. The Elovich model was more successfuly applicable to thesorption kinetics than the Pseudo-first-order model. During thesorption, a greater amount of cations in groundwater were adsorbedthan anions. The sorption capacity of GAC was affected by cationsin groundwater. The GAC surface area was 958.98 m2/g and the2/g, whichcomprised 33.2 % of the GAC surface area. Our experimentsshowed that TCE remediation was influenced by the ionic strengthand hardness of groundwater. The results of these experimentswere confirmed by two different models and sorption areas.Therefore, the ionic strength and hardnes of groundwater mustbe considered in the remediation of TCE-contaminated ground-water using GAC.
김호중(Ho Joong Kim),최형석(Hyung Suk Choi),심태선(Tae Sun Shim),이혁표(Hyeok Pyo Lee),김영환(Young Whan Kim),허대석(Dae Seog Heo),한성구(Sung Koo Han),심영수(Young Soo Shim),김노경(Noe Kyeong Kim),김건열(Keun Youl Kim),한용철(Yong C 대한내과학회 1991 대한내과학회지 Vol.41 No.2
N/A Pulmonary toxicity is a potentially fatal complication of bleomycin, one of the well-known anti-cancer chemotherapeutics. The incidence of bleomyicn-induced pulmonary toxicity was reported as 2-40% and fatality, 1-2%. Bleomycin-induced pulmonary toxicity is sometimes progressive even after discontinuation of the drug, but there has been no specific treatment modalities other than prevention, Forced vital capacity (FVC) and carbon monoxide diffusing capacity (DLco) have been proposed as parameters valuable in predicting subclinical bleomycin-induced pulmonary toxicity, but there are still conflicting results. To discover the predicting factors for bleomycin-induced pulmonary toxicity, 15 patients treated with 6 cycles of cyclophophamide, vinblastine, prednisolone, bleomycin, adriamycin and procarbazine (COPBLAM- III) for non-Hodgkin's lymphoma at Seoul National University Hospital between March 1989 and March 1990 were studied prospectively. Routine physical examination, complete blood count, chest X-ray and pulmonary function test including DLco were done at initial diagnosis, then every 2 cycles and at restaging, and 1 month after the last treatment. The results were as follows: 1) Carbon monoxide diffusing dapacity (DLco) decreased from the 6th cycle (cumulative dose was average 347 u) and persisited thereafter, but the decrement was not dose-dependent. 2) There were no interval changes in forced vital capacity (FVC), forced expiratory volume 1-second (FEV1), FEU1/FVC, mean forced expiratory flow during middle half of the FVC (MEF), and MEF/FVC. 3) Based on radiological critieria, bleomycin-induced pulmonary toxicity developed in 1 patient (6.7%). At this point, the cumulative dosage of bleomycin was 312 u and DLco decreased by 57%. 4) If the predictive critieria was determined as 55% decrement of DLco, the false positive rate was 66.7%. In this study, no parameters were found to predict bleomycin-induced pulmonary toxicity. In conclusion, DLco is not a universally sensitive predictor of bleomycin-induced pulmonary toxicity, but may be a preceding parameter. It is recommended that for all patients who are administered over 300 u of bleomycin, a periodic physical examination, DLco and chest X-ray should be done for early detection of bleomycin-induced pulmonary toxicity. .
허혈성 대장염 없이 전신성 홍반성 루푸스에서 발현한 직장 궤양
손기창 ( Ki Chang Sohn ),허원각 ( Won Gak Heo ),주민수 ( Min Su Chu ),김의중 ( Eui Joong Kim ),정종혁 ( Jong Hyeok Chung ),최석채 ( Suck Chei Choi ),윤기중 ( Ki Jung Yun ),서검석 ( Geom Seog Seo ) 대한소화기학회 2019 대한소화기학회지 Vol.73 No.5
Rectal involvement by systemic lupus erythematosus (SLE) is quite rare. Approximately 14 cases have been reported worldwide, but only one with ischemic colitis has been reported in Korea. A 17-year-old female patient was hospitalized with abdominal pain and hematochezia. Sigmoidoscopy revealed only a simple rectal ulcer without ischemic colitis. cytomegalovirus and bacterial infections were excluded. A sigmoidoscopic rectal biopsy indicated a rectal invasion by SLE, but the patient showed an acute worsening conditions that did not respond to treatment. This paper reports a case of rectal ulcer that developed in SLE without ischemic colitis with a review of the relevant literature. (Korean J Gastroenterol 2019;73:299-302)
대장암 및 대장용종 환자에서 상부위장관 병변의 동반 빈도
신운건(Woon Geon Shin),김학양(Hak Yang Kim),허필석(Pil Seog Heo),이자영(Ja Young Lee),김억(Aukk Kim),김진봉(Jin Bong Kim),서중산(Joong San Suh),이진헌(Jin Hyon Lee),김종혁(Jong Hyeok Kim),장웅기(Woong Ki Chang),김동준(Dong Joon Kim) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.5
Background/Aims: It is unclear whether further evaluation for upper gastrointestinal tract is needed in the patients with colorectal lesions. We conducted this study to investigate the prevalence of simultaneous upper gastrointestinal lesion in the patients with colon cancer or polyp. Methods: Data of 904 consecutive patients who received both colonoscopic and gastroduodenoscopic examination from July 1997 to August 2000 were analyzed retrospectively. Gastroduodenal mucosal lesions such as gastric ulcer, duodenal ulcer, gastric polyp or gastric cancer were classified as clinically significant lesions. We compared the prevalence of upper gastrointestinal mucosal lesions between the patients with and without colonic lesions. Results: Fifty-five (25.9%) of 212 patients with colonic lesions and 87 (12.6%) of 692 patients without colonic lesions had simultaneous gastroduodenal lesions. The patients with colonic polyp or cancer had more gastroduodenal lesions than those without colonic lesions (p<0.05). According to histologic finding of colonic lesion, the prevalence of gastroduodenal lesions was higher in the patients with hyperplastic polyp (p<0.05) and tubular adenoma (p<0.05) than in the patients without colonic lesions. Conclusions: It is suggested that many of the patients who have colonic hyperplastic polyp and tubular adenoma may have simultaneous colonic and gastroduodenal lesions. Therefore, upper gastrointestinal endoscopy should be performed in the patients with colon neoplasia. (Korean J Gastroenterol 2001;38:336-341)
오미자칠해목 추출물의 과산화수소로 유발된 PC12뇌세포 사멸과 스코폴라민으로 유발된 렛드 동물모델에 대한 개선 효과
박은국,한경훈,허재혁,김남기,배문형,서영하,용윤중,정선용,최춘환,Park, Eun-kuk,Han, Kyung-Hoon,Heo, Jae-Hyeok,Kim, Nam-Ki,Bae, Mun-Hyoung,Seo, Young-Ha,Yong, Yoon-joong,Jeong, Seon-Yong,Choi, Chun-Whan 한국식품영양학회 2020 韓國食品營養學會誌 Vol.33 No.3
Cognitive impairment is considered to be key research topics in the field of neurodegenerative diseases and in understanding of learning and memory. In the present study, we investigated neuroprotective effects of Schisandra chinensis (SC) and Ribes fasciculatum (RF) extracts in hydrogen peroxide-induced neuronal cell death in vitro and scopolamine-induced cognitive impairment in Sprague Dawley<sup>®</sup> (SD) rat in vivo. Apoptotic cell death in neuroblastic PC12 cell line was induced by hydrogen peroxide for 1 hour at 100 μM. However, mixture of SC and RF treatment prevented peroxide induced PC12 cell death with no neurotoxic effects. For in vivo experiment, the effect of SC and RF extracts on scopolamine-induced cognitive impairment in SD rat was evaluated by spontaneous alternation behavior in Y-Maze test. After 30 min scopolamine injection, the scopolamine-induced rats presented significantly decreased % spontaneous alteration and acetylcholine level, compared to non-induced group. However, treatment of SC+RF extracts rescued the reduced % spontaneous alteration with acetylcholine concentration from hippocampus in scopolamine-induced rats. These results suggested that mixture of SC and RF extract may be a potential natural therapeutic agent for the prevention of cognitive impairment.