http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Treatment effects of mandibular total arch distalization using a ramal plate
Jonghan Yu,Jae Hyun Park,Mohamed Bayome,Sungkon Kim,Yoon-Ah Kook,Yoonji Kim,Chang-Hyen Kim 대한치과교정학회 2016 대한치과교정학회지 Vol.46 No.4
Objective: The purpose of this study was to evaluate treatment effects after distalization of the mandibular dentition using ramal plates through lateral cephalograms. Methods: Pre- and post-treatment lateral cephalograms and dental casts of 22 adult patients (11 males and 11 females; mean age, 23.9 ± 5.52 years) who received ramal plates for mandibular molar distalization were analyzed. The treatment effects and amount of distalization of the mandibular molars were calculated and tested for statistical significance. The significance level was set at p < 0.001. Results: The mandibular first molar distalization at the crown and root were 2.10 mm (p < 0.001) and 0.81 mm (p = 0.011), respectively. In the evaluation of skeletal variables, there was a significant increase in the Wits appraisal (p < 0.001). In the evaluation of the soft tissue, there was no significant effect on upper lip position, but the lower lips showed a significant retraction of 2.2 mm (p < 0.001). Conclusions: The mandibular molars showed a significant amount of distalization accompanied by limited extrusion and mesiobuccal rotation of the crowns. A ramal plate may be a viable device for mandibular total arch distalization in Class III patients who are reluctant to undergo orthognathic surgery.
유정훈,송지한,DoYoung Lee,MyeongSang Yu,JongHan Jung,Sung Nam Chun,GaYoung Lee,김종호 한국대기환경학회 2021 Asian Journal of Atmospheric Environment (AJAE) Vol.15 No.3
For two bituminous coal-fired power plants with 500 MW and pulverized coal combustion type, the concentration of PMtotal, >PM10, PM2.5-10, PM2.5, NOx, and SO2 was measured, and their emission factors were calculated through field measurement. The measurement points started from the boiler downstream and continued to the air pollution control devices (APCDs) that are installed in series, namely, the selected catalytic reduction system (SCR), air preheater (APH), electrostatic precipitator (ESP) and wet flue gas desulfurization system (WFGD). The measurement was performed at one point for more than three times by using the Korean standard method for air pollutants. However, all measurement points, except for the stacks, were not representative of the standard test method. In addition, the PM concentration was too high to reduce the collection time due to isokinetic sampling. There is a limitation of how representative the measurement results can be. During the field measurement period, the power production rate of the two coal-fired power plants was 91.6% and 79.2% in the P-1 and P-2, respectively. Moreover, in the P-2, with a low power production rate, the concentration of PMtotal, PM10, PM2.5, and NOx was found to be low, and the emission factor calculated by dividing the measured concentration value by the fuel usage was also estimated to be low. Such results are due to the coal combustion chamber and various types of APCD being operated at a lower-load condition than the design capacity. In turn, the number of pollutants generated was less, and the removal efficiency of the pollutant became high. However, it was found that the concentration of SO2 generated and the emission factor are more significantly affected by the sulfur content of the coal than the load factor change. To this end, reducing the operation load of the coal-fired power plant improves the combustion efficiency and APCDs performance and decreases the emission factor, resulting in more reduction of the air pollutants than that based on the simple calculation.
Park, Sungmin,Lee, Jeong Eon,Yu, Jonghan,Paik, Hyun-June,Ryu, Jai Min,Kim, Isaac,Bae, Soo Youn,Lee, Se Kyung,Kim, Seok Won,Nam, Seok Jin,Kim, Eun-Kyu,Kang, Eunyoung,Yang, Eun Joo Elsevier 2018 Clinical breast cancer Vol.18 No.1
<P><B>Abstract</B></P> <P><B>Introduction</B></P> <P>The aim of our study was to analyze the risk of lymphedema (LE) according to the clinicopathologic factors and to investigate the serial change in body weight during neoadjuvant anthracycline plus cyclophosphamide followed by taxane and its correlation with the incidence of LE.</P> <P><B>Patients and Methods</B></P> <P>We performed a retrospective 2-center study of 406 patients who had undergone neoadjuvant chemotherapy (NAC) followed by surgery from 2007 to 2014. The regimen included 4 cycles of anthracycline plus cyclophosphamide, followed by 4 cycles of taxane. We investigated the presence and degree of LE using a telephone questionnaire assessment. Weight changes were calculated at each cycle of NAC, and the baseline and preoperative body weights were used to calculate the rate of change to account for the change in weight before and after NAC.</P> <P><B>Results</B></P> <P>Of the 406 patients, 270 answered the questionnaires, of whom 97 (35.9%) experienced LE. The increase in body weight was significant during the 4 cycles of taxane, but the change in weight was not significant during the 4 cycles of anthracycline plus cyclophosphamide. The change in body weight was most significant just after the fourth cycle of taxane (<I>P</I> < .001). The body mass index (BMI) was an independent factor of LE occurrence on multivariate analysis. However, the change in body weight was not a significant factor for the incidence of LE.</P> <P><B>Conclusion</B></P> <P>Because a BMI ≥ 25 kg/m<SUP>2</SUP> was an independent factor of LE occurrence on multivariate analysis, patients with a preoperative BMI ≥ 25 kg/m<SUP>2</SUP> should be closely monitored for LE given their increased risk, and monitoring and education should be initiated before surgery and continued throughout the course of NAC.</P>
Kim, Sangmin,You, Daeun,Jeong, Yisun,Yu, Jonghan,Kim, Seok Won,Nam, Seok Jin,Lee, Jeong Eon Elsevier 2018 Phytomedicine Vol.50 No.-
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Interleukin-8 (IL-8) expression is associated with metastasis in a variety of cancer cells.</P> <P><B>Purpose</B></P> <P>Here, we investigated the regulatory mechanism of IL-8 expression as well as the pharmacological effect of berberine (BBR) on IL-8 expression in triple-negative breast cancer (TNBC) cells.</P> <P><B>Methods</B></P> <P>The clinical value of IL-8 was analyzed by from a public database [Kaplan‑Meier plotter database. IL-8 mRNA and protein expression was analyzed by real-time PCR and ELISA, respectively. Cell invasion was analyzed by Boyden chamber assay. Tumor cell growth was analyzed by colony forming assay.</P> <P><B>Results</B></P> <P>Clinically, we observed that breast cancer patients with highly expressed IL-8 are associated with poor outcomes in areas such as relapse-free, overall, and distant metastasis-free survival. We showed that IL-8 expression is higher in TNBC cells than in non-TNBC cells. In addition, the rates of cell invasion were significantly increased by IL-8 treatment. These IL-8 levels were decreased by EGFR (Neratinib and Afatinib) and MEK (PD98059) inhibitors in TNBC cells. Finally, we observed that BBR dramatically suppresses IL-8 expression. In addition, BBR also inhibited cell invasiveness and anchorage-independent growth. Interestingly, our results showed that BBR down-regulates EGFR protein expression and dose-dependently inhibits MEK and ERK phosphorylation.</P> <P><B>Conclusion</B></P> <P>Here, we demonstrate that BBR may be a promising drug to suppress cell invasiveness and growth of TNBC through IL-8-related mechanisms.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Suh, Eui Jin,Kabir, Mohammad Humayun,Kang, Un-Beom,Lee, Jong Won,Yu, Jonghan,Noh, Dong-Young,Lee, Cheolju Korean Society for Biochemistry and Molecular Bion 2012 Experimental and molecular medicine Vol.44 No.1
Breast cancer is the most common cancer in women worldwide. It is necessary to identify biomarkers for early detection, to make accurate prognoses, and to monitor for any recurrence of the cancer. In order to identify potential breast cancer biomarkers, we analyzed the plasma samples of women diagnosed with breast cancer and age-matched normal healthy women by mTRAQ-based stable isotope-labeling mass spectrometry. We identified and quantified 204 proteins including thrombospondin-1 (THBS1) and bromodomain and WD repeat-containing protein 3 (BRWD3) which were increased by more than 5-fold in breast cancer plasma. The plasma levels of the two proteins were evaluated by Western blot assay to confirm for their diagnostic value as serum markers. A 1.8-fold increase in BRWD3 was observed while comparing the plasma levels of breast cancer patients (n = 54) with age-matched normal healthy controls (n = 30), and the area under the receiver operating characteristic curve (AUC) was 0.917. THBS1 was detected in pooled breast cancer plasma at the ratio similar to mTRAQ ratio (>5-fold). The AUC value for THBS1 was 0.875. The increase of THBS1 was more prominent in estrogen receptor negative and progesterone receptor negative patients than receptor-positive patients. Our results are evidence of the diagnostic value of THBS1 in detecting breast cancer. Based on our findings, we suggest a proteomic method for protein identification and quantification lead to effective biomarker discovery.
Eui Jin Suh,Mohammad Humayun Kabir,Un-Beom Kang,Jong Won Lee,Jonghan Yu,노동영,이철주 생화학분자생물학회 2012 Experimental and molecular medicine Vol.44 No.1
Breast cancer is the most common cancer in women worldwide. It is necessary to identify biomarkers for early detection, to make accurate prognoses, and to monitor for any recurrence of the cancer. In order to identify potential breast cancer biomarkers, we analyzed the plasma samples of women diagnosed with breast cancer and age-matched normal healthy women by mTRAQ-based stable isotope-labeling mass spectrometry. We identified and quantified 204 proteins including thrombospondin-1 (THBS1) and bromodomain and WD repeat-containing protein 3(BRWD3) which were increased by more than 5-fold in breast cancer plasma. The plasma levels of the two proteins were evaluated by Western blot assay to confirm for their diagnostic value as serum markers. A 1.8-fold increase in BRWD3 was observed while comparing the plasma levels of breast cancer patients (n = 54) with age-matched normal healthy controls (n = 30), and the area under the receiver operating characteristic curve (AUC) was 0.917. THBS1 was detected in pooled breast cancer plasma at the ratio similar to mTRAQ ratio (>5-fold). The AUC value for THBS1 was 0.875. The increase of THBS1 was more prominent in estrogen receptor negative and progesterone receptor negative patients than receptor-positive patients. Our results are evidence of the diagnostic value of THBS1 in detecting breast cancer. Based on our findings, we suggest a proteomic method for protein identification and quantification lead to effective biomarker discovery.