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- 저자 : GaYoung Lee (검색결과 181 건)
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Lee, Gayoung,Joung, Jin-Yong,Cho, Jung-Hyo,Son, Chang-Gue,Lee, Namhun Hindawi 2018 Evidence-based Complementary and Alternative Medic Vol.2018 No.-
<P><B>Objectives</B></P><P> Multidrug resistance (MDR) is the major reason for the failure of chemotherapy in colorectal cancer (CRC), and the primary determinant of MDR in CRC patients is active drug efflux owing to overexpression of P-glycoprotein (P-gp) in cancer tissues. Despite research efforts to overcome P-gp-mediated drug efflux, the high toxicity of P-gp inhibitors has been a major obstacle for the clinical use of these agents. The aim of this study was to review the literature for potential P-gp reversal agents among traditional herbal medicines, which offer the advantages of safety and potential synergetic effects in CRC chemotherapy.</P><P><B> Methods</B></P><P> We searched ten databases including 3 English databases, 1 Chinese medical database, and 6 Korean medical databases up to July 2018 and included in vivo and in vitro studies evaluating the effects of herbal medicines as P-gp reversal agents in CRC.</P><P><B> Results</B></P><P> A total of 28 potentially related studies were identified and 16 articles were included. Involving 3 studies about<I> Salvia miltiorrhiza</I> and 2 studies about<I> Curcuma longa</I>, finally we found 14 kinds of traditional herbal medicines—<I>Salvia miltiorrhiza, Curcuma longa, Sinomenium acutum, Stephania tetrandra, Bufo gargarizans, Coptis japonica, Piper nigrum </I>and<I> Piper longum, Hedyotis diffusa, Schisandra chinensis, Glycyrrhiza glabra, Glycyrrhiza inflate, Daphne genkwa, Stemona tuberosa </I>Lour, and<I> Andrographis paniculata</I>—as showing efficacy as P-gp inhibitors in anticancer drug-resistant CRC cells in vitro and in vivo.</P><P><B> Conclusions</B></P><P> This brief account provides insight into the relationship between P-gp and CRC. Further studies on herbal medicines with demonstrated effects against P-gp overexpression will aid in improving the efficacy of chemotherapy in CRC.</P>
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Metal microparticle – Polymer composites as printable, bio/ecoresorbable conductive inks
Lee, Seungae,Koo, Jahyun,Kang, Seung-Kyun,Park, Gayoung,Lee, Yung Jong,Chen, Yu-Yu,Lim, Seon Ah,Lee, Kyung-Mi,Rogers, John A. Elsevier 2018 Materials today Vol.21 No.3
<P>Biologically and environmentally resorbable electronic devices support application possibilities that cannot be addressed with conventional technologies. This paper presents highly conductive, water-soluble composites that can be printed to form contacts, interconnects, antennas, and other important features that are essential to nearly all systems of this type. An optimized material formulation involves in situ polymerization to yield a polyanhydride containing a dispersion of molybdenum microparticles at appropriate concentrations. Comparisons of essential physical and electrical properties of these materials to those of composites formed with other polymers and other metal microparticles reveal the relevant considerations. Various functional demonstrations of screen-printed test structures and devices illustrate the suitability of these conductive inks for use in water-soluble electronic devices. A key advantage of the material introduced here compared to alternatives is its ability to maintain conductance over significant periods of time while immersed in relevant aqueous solutions. Studies involving live animal models establish the biocompatibility.</P>
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Anion Transport or Nucleotide Binding by Ucp2 Is Indispensable for Ucp2-Mediated Efferocytosis
Lee, Suho,Moon, Hyunji,Kim, Gayoung,Cho, Jeong Hoon,Lee, Dae-Hee,Ye, Michael B.,Park, Daeho Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.7
Rapid and efficient engulfment of apoptotic cells is an essential property of phagocytes for removal of the large number of apoptotic cells generated in multicellular organisms. To achieve this, phagocytes need to be able to continuously uptake apoptotic cells. It was recently reported that uncoupling protein 2 (Ucp2) promotes engulfment of apoptotic cells by increasing the phagocytic capacity, thereby allowing cells to continuously ingest apoptotic cells. However, the functions of Ucp2, beyond its possible role in dissipating the mitochondrial membrane potential, that contribute to elevation of the phagocytic capacity have not been determined. Here, we report that the anion transfer or nucleotide binding activity of Ucp2, as well as its dissipation of the mitochondrial membrane potential, is necessary for Ucp2-mediated engulfment of apoptotic cells. To study these properties, we generated Ucp2 mutations that affected three different functions of Ucp2, namely, dissipation of the mitochondrial membrane potential, transfer of anions, and binding of purine nucleotides. Mutations of Ucp2 that affected the proton leak did not enhance the engulfment of apoptotic cells. Although anion transfer and nucleotide binding mutations did not affect the mitochondrial membrane potential, they exerted a dominant-negative effect on Ucp2-mediated engulfment. Furthermore, none of our Ucp2 mutations increased the phagocytic capacity. We conclude that dissipation of the proton gradient by Ucp2 is not the only determinant of the phagocytic capacity and that anion transfer or nucleotide binding by Ucp2 is also essential for Ucp2-mediated engulfment of apoptotic cells.
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ELD-Net: An Efficient Deep Learning Architecture for Accurate Saliency Detection
Lee, Gayoung,Tai, Yu-Wing,Kim, Junmo IEEE 2018 IEEE transactions on pattern analysis and machine Vol.40 No.7
<P>Recent advances in saliency detection have utilized deep learning to obtain high-level features to detect salient regions in scenes. These advances have yielded results superior to those reported in past work, which involved the use of hand-crafted low-level features for saliency detection. In this paper, we propose ELD-Net, a unified deep learning framework for accurate and efficient saliency detection. We show that hand-crafted features can provide complementary information to enhance saliency detection that uses only high-level features. Our method uses both low-level and high-level features for saliency detection. High-level features are extracted using GoogLeNet, and low-level features evaluate the relative importance of a local region using its differences from other regions in an image. The two feature maps are independently encoded by the convolutional and the ReLU layers. The encoded low-level and high-level features are then combined by concatenation and convolution. Finally, a linear fully connected layer is used to evaluate the saliency of a queried region. A full resolution saliency map is obtained by querying the saliency of each local region of an image. Since the high-level features are encoded at low resolution, and the encoded high-level features can be reused for every query region, our ELD-Net is very fast. Our experiments show that our method outperforms state-of-the-art deep learning-based saliency detection methods.</P>
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Lee, Seong Hyun,Kim, Gayoung,Lim, Jung Wook,Lee, Kyu-Seok,Kang, Man Gu Elsevier 2018 Solar energy materials and solar cells Vol.186 No.-
<P><B>Abstract</B></P> <P>We investigated the thermal stability of multilayered transparent electrodes composed of ZnO:Ga (GZO)/Ag/GZO layers for the application of large-scale perovskite solar cell (PSC) modules, which require a post-annealing temperature of 450 °C. The sheet resistance and transmittance of the GZO/Ag/GZO (50 nm/12 nm/50 nm) electrodes were encouragingly improved by an annealing test with a temperature variation from 25° to 450°C. The optimum value of the sheet resistance was 4.48 Ω/square at an annealing temperature of 450 °C. By a simulation of PSC module performance, we confirmed that PSC modules with our GZO/Ag/GZO multilayered transparent electrodes (4–5 Ω/square) suffer less performance degradation compared to those with conventional FTO transparent electrodes (8–15 Ω/square).</P> <P><B>Highlights</B></P> <P> <UL> <LI> GZO/Ag/GZO multilayered transparent electrodes are studied. </LI> <LI> A low sheet resistance (< 5 Ω/sq.) and high transmittance (> 85%) are achieved. </LI> <LI> The sheet resistance and transmittance are improved by an annealing test. </LI> <LI> The optimal sheet resistance is 4.48 Ω/sq. at an annealing temperature of 450 °C. </LI> <LI> PSC modules with our GZO/Ag/GZO electrodes suffer less performance degradation. </LI> </UL> </P>
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Lee Gayoung,Lee Juyoung,Jeon Ga Won,Jun Yong Hoon 대한소아청소년과학회 2023 Clinical and Experimental Pediatrics (CEP) Vol.66 No.1
Background: Although preterm infants often experience desaturation or bradycardia during oral feeding, specific guidelines for its management are lacking.Purpose: This study aimed to investigate the effects of a commercial thickened formula (TF) on oxygen saturation and heart rate stabilization during oral feeding in preterm infants.Methods: This retrospective study included 122 infants born at a median (interquartile range [IQR]) 31<sup>+6</sup> weeks (29<sup>+4</sup> −34<sup>+6</sup> weeks) of gestation weighing 1,725 g (1,353–2,620 g) and fed commercial cornstarch-containing TF due to feeding-associated desaturation or bradycardia. We excluded infants fed TF to treat symptomatic regurgitation. Desaturation and bradycardia events were compared between 3 days prior to the change and 3 days after the change to TF. Desaturation and bradycardia were defined as SpO<sub>2</sub> <85% and heart rate <100 beats/min during or immediately after oral bottle feeding, respectively.Results: The median (IQR) postmenstrual age and weight were 36<sup>+1</sup> weeks (34<sup>+6</sup>–38<sup>+0</sup> weeks) and 2,395 g (2,160–2,780 g), respectively, at the time of change to TF. The frequency of desaturation significantly decreased after TF feeding (median [IQR]: 2.3 [1.3–3.3] events/day vs. 0.3 [0–1.7] events/day, <i>P</i>< 0.001). Bradycardia also decreased after TF feeding (0.3 [0–1] events/day vs. 0 [0–0.7] events/day, <i>P</i>=0.006). There were no cases of diarrhea or electrolyte abnormalities after TF feeding. Defecation frequency decreased (<i>P</i>=0.037), and polyethylene glycol was prescribed to 27% of the TF-fed infants. In a subgroup analysis of 16 infants with bronchopulmonary dysplasia, the frequency of desaturation was reduced (2.3 [1.8–3.8] events/day vs. 0.5 [0–1.5] events/day, <i>P</i>=0.042), and weight gain improved (22.5 [3.1–36.3] g/day vs. 41.3 [28.1–55.1] g/day, <i>P</i>=0.019), after TF feeding.Conclusion: TF feeding significantly reduces oral feeding-associated oxygen desaturation and bradycardia in preterm infants. TF may be useful for stabilizing oxygen saturation and heart rate among preterm infants with difficulties in oral feeding.
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Gayoung Lee,Huryul Lee,엄명헌,강미숙 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.9
To investigate the scattering layer effect of a TiO2 multilayer in dye-sensitized solar cells (DSSCs), we designed a new DSSC system, assembled with a CdS-TiO2 scattering layer electrode. A high-magnification SEM image exhibited hollyhock-like particles with a width of 1.5-2.0 μm that were aggregated into 10-nm clumps in a hexagonal petal shape. The efficiency was higher in the DSSC assembled with a CdS-TiO2 scattering layer than in the DSSC assembled with TiO2-only layers, due to the decreased resistance in electrochemical impedance spectroscopy (EIS). The short-circuit current density (Jsc) was increased by approximately 7.26% and the open-circuit voltage (Voc) by 2.44% over the 1.0 wt % CdS-TiO2 composite scattering layer and the incident photon-to-current conversion efficiency (IPCE) in the maximum peak was also enhanced by about 5.0%, compared to the DSSC assembled without the CdS-TiO2 scattering layer.
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