LETTER TO THE EDITOR : Occurrence of colonic liposarcoma after retroperitoneal liposarcoma

( Jin Hwa Choi ),( In Gyu Hwang ),( Seong Jae Cha ),( Tae Jin Lee ),( Joung Soon Jang ) 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.1

증례 : 소화기 ; 독사교상으로 인한 위장관 출혈 1예

이정화 ( Joung Hwa Lee ),한군희 ( Koon Hee Han ),이경원 ( Kyoung Won Lee ),김영돈 ( Young Don Kim ),정우진 ( Woo Jin Jeong ),강길현 ( Gil Hyun Kang ),천갑진 ( Gab Jin Cheon ) 대한내과학회 2011 대한내과학회지 Vol.80 No.4

독사교상에 의한 임상 증상의 발현 양상은 매우 다양한 것으로 알려져 있다. 환자들은 특이한 임상증상 없이 교상자국 만을 남기는 것에서부터 근육 연축, 마비, 의식저하, 근력저하와 같은 신경증상이 일어날 수 있으며, 심한 경우에는 혈액응고장애, 혈관투과성의 증가로 인한 위장관 출혈로 생명을 위협하는 증상을 보일 수 있다. 저자들은 독사교상 이후 발생한 혈관응고장애에 의한 다량의 위장관 출혈을 일으킨 환자를 수혈을 포함한 보존적 치료로 호전시킨 증례를 경험하였기에 이를 문헌고찰과 함께 보고한다. The clinical presentation of snake bites varies greatly. Symptoms range from only bite marks to muscle spasms, paralysis, altered mental status, and muscle weakness. In severe cases, symptoms may include life threatening coagulopathy or gastrointestinal bleeding owing to increased vascular permeability. In this report, the patient presented with massive gastrointestinal bleeding after a snake bite and recovered with conservative treatment. (Korean J Med 2011;80:443-448)

“개인화된 규범적 피드백”이 대학생 절주 의도에 미치는 효과

최정화(Joung Hwa Choi),박동진(Dong Jin Park),김도진(Do Jin Kim) 한국광고홍보학회 2014 한국광고홍보학보 Vol.16 No.3

본 연구는 “개인화된 규범적 피드백(personalized normative feedback: PNF)”이 대학생 절주행위에 미치는 영향을 탐색하고 있다. 구체적으로, 명령적 및 규범적 PNF가 대학생들의 음주 수준에 대한 위험 자각, 자율적 절주 동기, 그리고 절주 의도에 미치는 효과를 살펴보고자 했다. 이와 더불어 권위적인 기관들이 제시하는 지침, 즉 권위적 규범에 기반한 PNF의 효과를 명령적 및 규범적 PNF에 대비해 검증하고자 했다. 고위험 음주자인 대학생들(N=233)을 대상으로 인터넷을 통해 온라인 패널을 활용한 실험을 실시한 결과, 규범의 종류에 따라서 PNF가 미치는 영향력에 차이가 있는 것으로 나타났다. 즉, 명령적 PNF에 비해 묘사적 PNF가 종속변인에 미치는 영향력이 큰 것으로 나타났으며, 권위적 규범은 전반적으로 묘사적 PNF나 명령적 PNF에 비해 효과가 큰 것으로 나타났다. 한편 이와 같은 규범적 정보가 개인의 행동의도에 미치는 영향력은 간접적임을 경로분석을 통해 확인할 수 있었다. 즉, PNF는 일차적으로는 위험 자각에 직접적 영향을 미치는 것으로 나타났으며, 위험 자각은 다시 자율적 절주 동기에 영향을 미치고, 이는 다시 절주 의도에 긍정적 영향을 미치는 것으로 나타났다. 본 연구의 결과와 관련하여, 대학생을 대상으로 한 효과적인 절주 캠페인 전략을 위한 이론적·실무적 함의가 논의된다. The present study explores the effects of personalized normative feedbacks (PNF) on college students` drinking behaviors, Specifically, we attempted to explore the effects that injunctive and descriptive PNF have on college students` risk perception about their own drinking behavior, autonomous motivation and intention for low-risk drinking. Furthermore, this study explore the effects of PNF based on authority norms, i.e. norms recommended by health authorities (e.g., government institutions) in comparison to injunctive and descriptive PNF. An survey of high-risk college drinkers (N=233) using an online panel revealed that the effects of PNF vary by the type of norms. Descriptive PNF showed a greater influence on dependent variables compared to injunctive PNF. Authority PNF appeared more effective than descriptive or injunctive PNF. A post-hoc path analysis showed that the influence of PNF on behavioral intention is realized indirectly: PNF first influenced risk perception, in turn autonomous motivation, and finally behavioral intention for low-risk drinking. Practical and theoretical implications of this study are discussed in conjunction to public anti-drinking campaign strategies targeting college students.

<i>Banha-sasim-tang</i> improves gastrointestinal function in loperamide-induced functional dyspepsia mouse model

Jeon, Yoo-Jin,Lee, Jin-Seok,Cho, Yong-Rae,Lee, Sung-Bae,Kim, Won-Young,Roh, Seong-Soo,Joung, Jin-Yong,Lee, Hwa- Dong,Moon, Sung-Ok,Cho, Jung-Hyo,Son, Chang-Gue Elsevier 2019 Journal of Ethnopharmacology Vol.238 No.-

<P><B>Abstract</B></P> <P><B>Ethnopharmacological relevance</B></P> <P> <I>Banha-sasim-tang</I> (BST; <I>Hange-shashin-to</I> in Kampo medicine; <I>Banxia xiexin tang</I> in traditional Chinese medicine) is a traditional Chinese harbal medicine that has been commonly used for gastrointestinal disorders.</P> <P><B>Aim of the study</B></P> <P>To investigate the pharmacological effects of BST, a standardized herbal drug, on main symptoms of functional dyspepsia including delayed gastric emptying, and underlying mechanisms of action in mouse model<I>.</I> </P> <P><B>Methods and materials</B></P> <P>Balb/C mice were pretreated with BST (25, 50, 100 mg/kg, <I>po</I>) or mosapride (3 mg/kg, <I>po</I>) for 3 days, and then treated with loperamide (10 mg/kg, <I>ip</I>) after 19 h fasting. A solution of 0.05% phenol red (500 μL) or 5% charcoal diet (200 μL) was orally administered, followed by scarifying and assessment of gastric emptying or gastro-intestinal motility. C-kit (immunofluorescence), nNOS (western blot) and gastric contraction-related gene expression were examined in stomach tissue.</P> <P><B>Results</B></P> <P>The loperamide injection substantially delayed gastric emptying, while the BST pretreatment significantly attenuated this peristaltic dysfunction, as evidenced by the quantity of stomach-retained phenol red (<I>p</I> < 0.05 or 0.01) and stomach weight (<I>p</I> < 0.05 or 0.01). The BST pretreatment significantly tempered the loperamide-induced inactivation of c-kit and nNOS (<I>p</I> < 0.05 or 0.01) as well as the contraction-related gene expression, such as the 5HT<SUB>4</SUB> receptor (5HT<SUB>4</SUB>R), anoctamin-1 (ANO1), ryanodine receptor 3 (RYR3) and smooth muscle myosin light chain kinase (smMLCK). The BST pretreatment also significantly attenuated the alterations in gastro-intestinal motility (<I>p</I> < 0.01).</P> <P><B>Conclusion</B></P> <P>Our results are the first evidence of the prokinetic agent effects of <I>Banha-sasim-tang</I> in a loperamide-induced FD animal model. The underlying mechanisms of action may involve the modulation of peristalsis via activation of the interstitial cells of Cajal and the smooth muscle cells in the stomach.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

소화기 ; 숙변대장염의 임상적 결과

정형주 ( Hyoung Chu Joung ),한군희 ( Koon Hee Han ),조민형 ( Min Hyoung Cho ),이정화 ( Joung Hwa Lee ),정우진 ( Woo Jin Jeong ),김영돈 ( Young Don Kim ),이상진 ( Sang Jin Lee ),강종원 ( Jong Won Kang ),안재홍 ( Jae Hong Ahn ),강 대한내과학회 2011 대한내과학회지 Vol.80 No.2

목적: 숙변대장염은 대장에 분변이 꽉 채워져 장관 내 압력이 증가되고 이와 관련되어 장벽의 허혈 및 압력 괴사를 초래하여 발생하는 대장염이다. 숙변대장염은 드문 질환으로 예후가 불량하다. 저자들은 숙변대장염의 임상적 특징과 치료 전략에 따른 결과를 알아보고자 한다. 방법: 2004년 1월부터 2009년 8월까지 본원에서 CT검사와 대장내시경 검사를 통해 숙변대장염으로 진단된 11명의 환자를 대상으로 하여 후향적 연구를 하였다. 대상환자들의 임상적 특징을 조사하고 수술적 치료와 보존적인 치료에 따른 임상적 결과를 조사하였다. SIRS, 패혈증 혹은 패혈성 쇼크가 동반된 경우를 중한 숙변대장염이라 정의하였다. 결과: 총 11명의 환자가 포함되었으며 이들 중 3명이 남자였고, 8명은 여자였다. 평균 연령은 70±8세였다. 10명의 환자들은 변비의 유발요인들을 갖고 있는 고령의 환자였다. 저자들의 정의에 의해 9명의 환자가 심한 숙변대장염으로 진단되었고, 이들 중 5명은 수술적인 치료를 받았으며 나머지 4명은 보존적인 치료를 받았다. 수술적 치료를 받은 5명 중 1명(20%)이 사망하였고, 보존적인 치료를 받은 환자(n=4)들은 모두 사망하였다. 결론: 만성 변비의 유발요인을 갖는 고령의 환자가 복통을 호소하고 CT상에서 분변박힘 소견과 함께 대장 벽의 국소적인 비후가 관찰되거나 장 주위 지방침윤이 동반되면 숙변대장 염의 가능성을 고려하여야 한다. 더욱이 환자가 SIRS, 패혈증 혹은 패혈성 쇼크가 합병된 중한 숙변대장염으로 진단된 경우라면 조기의 수술적 치료가 사망률을 감소시킬 것으로 생각된다. Background/Aims: Stercoral colitis is an inflammatory condition related to increased intraluminal pressure, itself caused by impacted fecal material. Stercoral colitis is a rare condition and has a generally poor prognosis. The aims of this study were to investigate the clinical characteristics and outcomes of stercoral colitis according to management strategy. Methods: From January 2004 to August 2009, 11 patients were diagnosed with stercoral colitis at our center. The medical records of these individuals were reviewed retrospectively with regard to the clinical characteristics, management strategy, and clinical outcomes. We defined severe stercoral colitis as stercoral colitis complicated by systemic inflammatory response syndrome, sepsis, or septic shock. Results: Eleven patients (three men and eight women) with a mean age of 70±8 years were included. Ten patients were elderly with constipation as a predisposing factor. Nine patients had severe stercoral colitis according to out criteria. Of these, five patients underwent surgery, and the other four were treated with a conservative management strategy. One patient (20%) in the surgical group and all patients in the conservative management group (n=4) died. Conclusions: Stercoral colitis should be considered in elderly patients with predisposing factors and presents as fecal impaction with colonic wall thickening or pericolic fat stranding on CT scan. In patients with severe stercoral colitis, early surgery may be effective in reducing mortality. (Korean J Med 2011;80:187-192)

납 작업자들의 혈청 δ-aminolevulinic acid와 납 노출 지표들과의 관련성

김진호,황보영,김용배,김화성,이용진,함정오,정창웅,이성수 순천향대학교 의학연구소 2009 Journal of Soonchunhyang Medical Science Vol.14 No.3

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Combined Therapy With Functional Electrical Stimulation and Standing Frame in Stroke Patients

Joung Bok Lee,Sang Beom Kim,Kyeong Woo Lee,Jong Hwa Lee,Jin Gee Park,Sook Joung Lee 대한재활의학회 2019 Annals of Rehabilitation Medicine Vol.43 No.1

Objective To investigate the effects of combination functional electrical stimulation (FES) and standing frame training on standing balance in stroke patients. Methods Patients who had hemiparesis and postural instability after stroke were randomly assigned to one of the two groups; study group underwent FES on the quadriceps and tibialis anterior muscle simultaneously with standing balance training. The control group received standing frame training and FES separately. Both the groups received their respective therapies for 3 weeks. Stability index in Biodex Balance master system, Berg Balance Scale (BBS), manual muscle test, the Korean version of Modified Barthel Index, and Korean version of Mini- Mental State Examination were used to evaluate the effects of the treatment. Results In total, 30 patients were recruited to the study group and 30 to the control group. Three weeks after treatment, both the groups showed improvement in postural stability scores and physical and cognitive functions. When changes in postural stability were compared between the groups, the study group showed more significant improvement than the control group with regards to the scores of BBS and the stability indices. Conclusion In this study, we found the therapeutic effectiveness of combined therapy of FES and standing frame in subacute stroke patients. The presented protocol is proposed as time-saving and can be applied easily in the clinical setting. Thus, the proposed combined therapy could be a useful method for improving standing balance in subacute stroke patients.

Flight-to-Quality and Correlation between Currency and Stock Returns

Jin-Wan Cho,Joung Hwa Choi,Taeyong Kim,Woojin Kim 한국재무학회 2012 한국재무학회 학술대회 Vol.2012 No.09

Pair-wise analyses of a sample of nine developed and 12 emerging markets suggest that emerging country currency returns are positively correlated with their stock returns. These strong ties between currency and stock returns appear generated by international capital flows based on “flight-to-quality” in down-markets. The positive correlation of global equity markets implies that currencies provide added risks for investors in developed nations investing in emerging markets and natural hedges for investors in emerging nations investing in developed countries. Analyses of a unique sample of 27 “Siamese Twin” Korean international mutual fund pairs holding identical underlying foreign assets but offering different currency hedging alternatives suggest that hedging currency risks undoes the natural hedge and increases the total return volatility.

Biochemistry, Molecular Biology : Apigenin, Tyrosinase Inhibitor Isolated from the Flowers of Hemisteptia lyrata Bunge

Tae Joung Ha,Sun Woo Hwang,Hwa Jin Jung,Ki Hun Park,Min Suk Yang 한국응용생명화학회 2002 Journal of Applied Biological Chemistry (J. Appl. Vol.45 No.4

From the flowers of Hemisteptia lyrata Bunge, two flavonoids, apigenin (1) and acacetin (2), were isolated. Their structures were established by UV, one- and two-dimensional NMR, and mass spectroscopic methods. Apigenin showed significant inhibition agains

국내 장수명주택 인증제도의 실태분석 및 개선방안 연구

최진화(Jin-Hwa Choi),이정노(Jeong-Noh Lee),정광섭(Kwang-Sub Joung) 대한설비공학회 2016 대한설비공학회 학술발표대회논문집 Vol.2016 No.6