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Hue, Jin Joo,Lee, Hu-Jang,Jon, Sangyong,Nam, Sang Yoon,Yun, Young Won,Kim, Jong-Soo,Lee, Beom Jun The Korean Society of Veterinary Science 2014 大韓獸醫學會誌 Vol.54 No.4
This study was investigated the change of concentration and toxicity of thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION) on tissues of Sprague-Dawley rats. TCL-SPION at the dose of 15 mg/kg body weight was intravenously injected into the tail vein of the male Sprague-Dawley rats. The fate of TCL-SPION in serum, urine and tissues was observed during 28 days. Serum iron level was maximal at 0.25 h post-injection and gradually declined thereafter. In addition, the sinusoids of liver and the red pulp area of spleen were mainly accumulated iron from 0.5 h to 28-day post-injection. In kidney, iron deposition was detected in the tubular area until 0.5 h after injection. Malondialdehyde concentration in the liver slightly increased with time and was not different with that at zero time. In the liver and spleen, TNF-${\alpha}$ and IL-6 levels of TS treated with TCL-SPION were not different with those of the control during the experimental period. From the results, TCL-SPION could stay fairly long-time in certain tissues after intravenous injection without toxicity. The results indicated that TCL-SPION might be useful and safe as a contrast for the diagnosis of cancer or a carrier of therapeutic reagents to treat diseases.
Anti-obesity activity of diglyceride containing conjugated linoleic acid in C57BL/6J ob/ob mice
Jin-Joo Hue,Ki Nam Lee,정재황,이상화,Young Ho Lee,Seong-woon Jeong,남상윤,윤영원,이범준 대한수의학회 2009 JOURNAL OF VETERINARY SCIENCE Vol.10 No.3
This study was to investigate the anti-obesity effects of diglyceride (DG)-conjugated linoleic acid (CLA) containing 22% CLA as fatty acids in C57BL/6J ob/ob male mice. There were four experimental groups including vehicle control, DG, CLA, and DG-CLA. The test solutions of 750 mg/kg dose were orally administered to the mice everyday for 5 weeks. CLA treatments significantly decreased mean body weight in the obese mice throughout the experimental period compared to the control (p < 0.01). All test solutions significantly decreased the levels of triglyceride, glucose and free fatty acids in the serum compared with control (p < 0.05). The levels of total cholesterol were also significantly reduced in DG and DG-CLA groups compared with the control group (p < 0.05). CLA significantly decreased weights of renal and epididymal fats compared with the control (p < 0.05). DG and DGCLA also significantly decreased the epididymal fat weights compared with the control (p < 0.05). A remarkable decrease in the number of lipid droplets and fat globules was observed in the livers of mice treated with DG, CLA, and DG-CLA compared to control. Treatments of DG and CLA actually increased the expression of peroxisome proliferator-activated receptor gamma. These results suggest that DG-CLA containing 22% CLA have a respectable anti-obesity effect by controlling serum lipids and fat metabolism.
Protective Effect of Carnosine Against Zn-Mediated Toxicityin Cortical Neuronal Cells
Jin-Joo Hue,Ah-Ram Lee,Yea Eun Lee,Min-Hang Cho,Ki-Nam Lee,남상윤,윤영원,Jae-Hwang Jeong,Sang-Hwa Lee,이범준 한국독성학회 2007 Toxicological Research Vol.23 No.1
Zinc is an endogenous transition metal that can be synaptically released during neuronal activity. However, zinc may contribute to the neuropathology associated with a variety of conditions. Carnosine expressed in glial cells can modulate the effects of zinc on neuronal excitability as a zinc chelator. We hypothesize that carnosine may protect against neurotoxicity of zinc in cortical neuronal cells. The cortical neuronal cells from newborn rats were prepared and exposed to zinc chloride and/or carnosine at various concentrations. Zinc at the doses of 0 to 500 μM decreased neuronal cell viability in a dosedependent manner. Additionally, at the concentrations of 100 and 200 μM, it significantly decreased cell viability in an exposed time-dependent manner (p < 0.05). Treatment with carnosine at the concentrations of 20 and 200 μM significantly increased neuronal cell proliferation by approximately 14% and 20%, respectively, compared to the control (p < 0.05). At the concentrations of 100 and 200 μM zinc, 20 μM carnosine significantly increased the viability of neuronal cells by 18.3% and 12.1%, and 200 μM carnosine also increased it by 33.5% and 28.6%, respectively, compared to the normal control group (p < 0.01). These results suggest that carnosine at a physiologically relevant level may protect against zinc-mediated toxicity in neuronal cells as an endogenous neuroprotective agent
Effect of Sodium Silicate on Hair Growth in C57BL/6 Mice
Jin-Joo Hue,Bum-Ki Jo,Bong Su Kang,Jun-hyeong Kim,Sang Yoon Nam,Young Won Yun,Jong Soo Kim,Jae-Hwang Jeong,Sang-Hwa Lee,Jun Bae Ahn,Beom Jun Lee 한국실험동물학회 2010 Laboratory Animal Research Vol.26 No.1
A promoting effect of Na₂SiO₃ on hair regrowth was investigated using an animal model of C57BL/6 mice. There were four experimental groups including distilled water (DW, a negative control), 5% minoxidil (MXD, a positive control), 50% Na₂SiO₃, and 100% Na₂SiO₃ solution. The animals were shaved with an electric clipper and then test solutions applied daily with a volume of 0.2 ㎖ per to the dorsal skin of mice for 3 weeks. Body weight and food and water consumption were measured weekly. Photographs of hair regrowth were taken at experimental day 0, 4, 7, 10, 14, 17, and 21. Activities of alkaline phosphatase and γ-glutamyl transpeptidase as well as expressions of growth factors were also determined in the dorsal skin of mice. The animal body weight were not significantly changed among the experimental groups. The MXD and Na₂SiO₃ accelerated hair regrowth compared with DW. The elongation of hair follicles were evidently observed in MXD and 50 or 100% Na₂SiO₃ groups. MXD significantly increased γ-glutamyl transpeptidase at day 14, compared with DW (P<0.05). But the activities of alkaline phosphatase and γ-glutamyl transpeptidase were not significantly increased in Na₂SiO₃ groups, compared with DW. The expression of epidermal growth factor was significantly increased in MXD and Na₂SiO₃ groups, compared with DW (P<0.05). The expression of vascular endothelial growth factor was not significantly changed by MXD or Na₂SiO₃ treatments. The expression of transforming growth factor (TGF)-β1 was clearly decreased in MXD and Na₂SiO₃ groups, compared with DW. These results indicate that Na₂SiO₃ may have a hair growth-promoting activity and it can be used for treatment of alopecia or boldness in humans.