도시유역내 식생저류지에 따른 유출저감 효과 분석

김재문 ( Kim Jaemoon ),장영수 ( Jang Youngsu ),김현정 ( Kim Hyunjeong ),김병성 ( Kim Byungsung ),신현석 ( Shin Hyunsuk ) 한국물환경학회 2020 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2020 No.-

도시화 및 기후변화로 인한 자연수재해 피해가 급증하고 있어 대응방안으로 자연상태의 수문순환체계를 회복하기 위한 저영향개발(Low Impact Development, LID) 기법이 대두되고 있다. LID 요소기술 중 하나인 식생저류지는 도심지 유역내에서 발생하는 유출수를 저류하고 침투하여 우수유출수 및 비점오염원으로 인한 오염저감 효과를 지니고 있다. 식생저류지의 정량적 저감효과 효율성을 분석하기 위해 본 연구에서는 수문해석 프로그램인 K-LIDM(Korea Low Impact Development Model,)을 이용하여 유역 내 식생저류지 배치 및 저류용량에 따른 유출저감 효과를 분석하였다. 모델링 분석결과 식생저류지 배치에 따라 5 ∼ 15 % 이상의 유출저감효과가 산정되었으며, 식생저류지 저류용량에 따라 20 % 이상의 유출저감 효과가 산정되었다. 추후에 다른 매개변수인 식생저류지의 저류깊이, 지반의 침투능 및 유출부의 직경과 높이 등을 고려하여 연구를 수행한다면 식생저류지의 물순환 효율성 분석을 통해 각 유역내 적정 제원에 따른 정량적 분석을 수행할 수 있을 것으로 사료된다.

차세대 고속전철 주행에 따른 이선현상이 전력변환 상호간에 미치는 영향분석

김재문(JaeMoon Kim),장진영(ChinYoung Chang),김양수(YangSoo Kim),안정준(JeongJoon Ahn),김연준(YeonJoon Kim) 대한전기학회 2009 대한전기학회 학술대회 논문집 Vol.2009 No.4

Electromagnetic Interference(EMI) in electric railway operation has become increasingly important. The components within very high power electronic, and the circuits for treating low-level signals, comprise complex system that must coexist and be highly reliable. To study it, It were included how much the HEMU-400X generates EMI and it has an effect on the power conversion units which resulted from Power Line Disturbance (PLD) phenomenon by contact loss during its running. In this study, the dynamic characteristic of a contact wire and pantograph suppling electrical power to high-speed trains are investigated. The analysis of the loss of contact based on Power Simulator program software is performed to develop power line disturbance model suitable for high speed operation. It is confirmed that a contact wire and pantograph model are necessary for studying the dynamic behavior of the pantograph system.

도시유역내 식생저류지에 따른 유출저감 효과 분석

김재문 ( Kim Jaemoon ),장영수 ( Jang Youngsu ),김현정 ( Kim Hyunjeong ),김병성 ( Kim Byungsung ),신현석 ( Shin Hyunsuk ) 한국물환경학회 2020 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2020 No.-

도시화 및 기후변화로 인한 자연수재해 피해가 급증하고 있어 대응방안으로 자연상태의 수문순환체계를 회복하기 위한 저영향개발(Low Impact Development, LID) 기법이 대두되고 있다. LID 요소기술 중 하나인 식생저류지는 도심지 유역내에서 발생하는 유출수를 저류하고 침투하여 우수유출수 및 비점오염원으로 인한 오염저감 효과를 지니고 있다. 식생저류지의 정량적 저감효과 효율성을 분석하기 위해 본 연구에서는 수문해석 프로그램인 K-LIDM(Korea Low Impact Development Model,)을 이용하여 유역 내 식생저류지 배치 및 저류용량에 따른 유출저감 효과를 분석하였다. 모델링 분석결과 식생저류지 배치에 따라 5 ∼ 15 % 이상의 유출저감효과가 산정되었으며, 식생저류지 저류용량에 따라 20 % 이상의 유출저감 효과가 산정되었다. 추후에 다른 매개변수인 식생저류지의 저류깊이, 지반의 침투능 및 유출부의 직경과 높이 등을 고려하여 연구를 수행한다면 식생저류지의 물순환 효율성 분석을 통해 각 유역내 적정 제원에 따른 정량적 분석을 수행할 수 있을 것으로 사료된다.

EML4-ALK enhances programmed cell death-ligand 1 expression in pulmonary adenocarcinoma via hypoxia-inducible factor (HIF)-1α and STAT3

Koh, Jaemoon,Jang, Ji-Young,Keam, Bhumsuk,Kim, Sehui,Kim, Moon-Young,Go, Heounjeong,Kim, Tae Min,Kim, Dong-Wan,Kim, Chul-Woo,Jeon, Yoon Kyung,Chung, Doo Hyun Informa UK (Taylor Francis) 2016 Oncoimmunology Vol.5 No.3

<P>Programmed cell death (PD)-1/PD-1 ligand-1 (PD-L1)-targeted therapy has emerged as a promising therapeutic strategy for lung cancer. However, whether EML4-ALK regulates PD-L1 expression in lung cancer remains unknown. A total of 532 pulmonary adenocarcinomas (pADCs), including 58 ALK-translocated tumors, were immunohistochemically evaluated for PD-L1 and PD-1. H23 (EGFR(Wild-type)EML4-ALK(-)PD-L1(Low)) and H2228 (EGFR(Wild-type)EML4-ALK(+)PD-L1(High)) cells were transfected with EML4-ALK or ALK short interfering RNAs and used to investigate the alterations in PD-L1 expression. PD-L1 expression was detected in 81% of ALK-translocated pADCs; this value was significantly higher than those of pADCs with EGFR mutation, KRAS mutation or lacking ALK, EGFR or KRAS mutation (p<0.005 for all). Moreover, ALK-translocated pADC with PD-L1 expression showed significantly higher numbers of tumor-infiltrating PD-1(+) cells. ALK knockdown or inhibition (crizotinib treatment) in H2228 cells downregulated PD-L1 expression. Transfection of H23 cells with EML4-ALK enhanced PD-L1 expression, which was compromised by crizotinib treatment. This ALK-dependent upregulation of PD-L1 expression was mediated by STAT3 and hypoxia-inducible factor (HIF)-1 alpha under normoxia and hypoxia. Furthermore, EML4-ALK enhanced HIF-1 alpha expression through increasing transcription and decreasing ubiquitination of HIF-1 alpha. In ALK-translocated pADC tissues, significant positive correlations between PD-L1 and nuclear HIF-1 alpha (p < 0.05) or pSTAT3 expression levels (p<0.005) were observed. Among patients with ALK-translocated pADC, strong PD-L1 expression was significantly associated with shorter progression-free (p = 0.001) and overall survival (p = 0.002) after crizotinib treatment. Collectively, our findings demonstrate that ALK-derived pADCs increase PD-L1 expression via HIF-1 alpha and/or STAT3, thus providing a rationale for PD-1/PD-L1 pathway-targeted therapy in ALK-translocated lung cancer.</P>

DNA methylome and single-cell transcriptome analyses reveal CDA as a potential druggable target for ALK inhibitor–resistant lung cancer therapy

Heo Haejeong,Kim Jong-Hwan,Lim Hyun Jung,Kim Jeong-Hwan,Kim Miso,Koh Jaemoon,Im Joo-Young,Kim Bo-Kyung,Won Misun,Park Ji-Hwan,Shin Yang-Ji,윤미란,Cho Byoung Chul,Kim Yong Sung,Kim Seon-Young,김미랑 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

Acquired resistance to inhibitors of anaplastic lymphoma kinase (ALK) is a major clinical challenge for ALK fusion-positive non-small-cell lung cancer (NSCLC). In the absence of secondary ALK mutations, epigenetic reprogramming is one of the main mechanisms of drug resistance, as it leads to phenotype switching that occurs during the epithelial-to-mesenchymal transition (EMT). Although drug-induced epigenetic reprogramming is believed to alter the sensitivity of cancer cells to anticancer treatments, there is still much to learn about overcoming drug resistance. In this study, we used an in vitro model of ceritinib-resistant NSCLC and employed genome-wide DNA methylation analysis in combination with single-cell (sc) RNA-seq to identify cytidine deaminase (CDA), a pyrimidine salvage pathway enzyme, as a candidate drug target. CDA was hypomethylated and upregulated in ceritinib-resistant cells. CDA-overexpressing cells were rarely but definitively detected in the naïve cell population by scRNA-seq, and their abundance was increased in the acquired-resistance population. Knockdown of CDA had antiproliferative effects on resistant cells and reversed the EMT phenotype. Treatment with epigenome-related nucleosides such as 5-formyl-2′-deoxycytidine selectively ablated CDA-overexpressing resistant cells via accumulation of DNA damage. Collectively, our data suggest that targeting CDA metabolism using epigenome-related nucleosides represents a potential new therapeutic strategy for overcoming ALK inhibitor resistance in NSCLC.

A Lossless Embedded Compression Using Significant Bit Truncation for HD Video Coding

Jaemoon Kim,Chong-Min Kyung IEEE 2010 IEEE transactions on circuits and systems for vide Vol.20 No.6

<P>Increasing the image size of a video sequence aggravates the memory bandwidth problem of a video coding system. Despite many embedded compression (EC) algorithms proposed to overcome this problem, no lossless EC algorithm able to handle high-definition (HD) size video sequences has been proposed thus far. In this paper, a lossless EC algorithm for HD video sequences and related hardware architecture is proposed. The proposed algorithm consists of two steps. The first is a hierarchical prediction method based on pixel averaging and copying. The second step involves significant bit truncation (SBT) which encodes prediction errors in a group with the same number of bits so that the multiple prediction errors are decoded in a clock cycle. The theoretical lower bound of the compression ratio of the SBT coding was also derived. Experimental results have shown a 60% reduction of memory bandwidth on average. Hardware implementation results have shown that a throughput of 14.2 pixels/cycle can be achieved with 36 K gates, which is sufficient to handle HD-size video sequences in real time.</P>

Low-Cost VLSI Design for Motion Estimation Using a Bit-Truncation Scheme on Both Ends

Jaemoon Kim,Giwon Kim,Chong-Min Kyung 대한전자공학회 2010 대한전자공학회 학술대회 Vol.2010 No.6

Multicenter survey of symptoms, work life, economic status, and quality of life of complex regional pain syndrome patients

( Jaemoon Lee ),( Yun Hee Lim ),( Sung Jun Hong ),( Jae Hun Jeong ),( Hey Ran Choi ),( Sun Kyung Park ),( Jung Eun Kim ),( Eun Hi Park ),( Jae Hun Kim ) 대한통증학회 2021 The Korean Journal of Pain Vol.34 No.3

Background: Complex regional pain syndrome (CRPS) is an intractable pain disease with various symptoms. Here, we investigated the disease status, work life, sleep problems, medical insurance, economic status, psychological problems, and quality of life (QOL) of CRPS patients. Methods: CRPS patients from 37 university hospitals in South Korea were surveyed. The survey questionnaire consisted of 24 questions on the following aspects of CRPS patients: sex, age, occupation, cause of injury, activities of daily living (ADL), pain severity, sleep disturbance, level of education, economic status, therapeutic effect, and suicidal ideation. Additionally, the abbreviated World Health Organization Quality of Life (WHOQOL-BREF) questionnaire, consisting of 26 questions, was used to identify the status of QOL. Results: A total of 251 patients completed the questionnaire. According to the survey, 54.2% patients could not perform ADL on their own. Over the previous week, the mean pain score was 7.15 ± 1.78 (out of a total of 10 points); 92.1% of patients had sleep disorders and 80.5% had suicidal ideation, with most patients suffering from psychological problems. The average for each domain of WHOQOL-BREF was as follows: 21.74 ± 14.77 for physical, 25.22 ± 17.66 for psychological, 32.02 ± 22.36 for social relationship, and 30.69 ± 15.83 for environmental (out of a total of 100 points each). Occupation, ADL, sleep time, therapeutic effect, and suicidal ideation were statistically correlated with multiple domains. Conclusions: Most patients had moderate to severe pain, economic problems, limitations of their ADL, sleep problems, psychological problems, and a low QOL score.

Aptamer-modified magnetic nanoprobe for molecular MR imaging of VEGFR2 on angiogenic vasculature

Kim, Bongjune,Yang, Jaemoon,Hwang, Myeonghwan,Choi, Jihye,Kim, Hyun-Ouk,Jang, Eunji,Lee, Jung Hwan,Ryu, Sung-Ho,Suh, Jin-Suck,Huh, Yong-Min,Haam, Seungjoo Springer 2013 Nanoscale research letters Vol.8 No.1

<P>Nucleic acid-based aptamers have been developed for the specific delivery of diagnostic nanoprobes. Here, we introduce a new class of smart imaging nanoprobe, which is based on hybridization of a magnetic nanocrystal with a specific aptamer for specific detection of the angiogenic vasculature of glioblastoma via magnetic resonance (MR) imaging. The magnetic nanocrystal imaging core was synthesized using the thermal decomposition method and enveloped by carboxyl polysorbate 80 for water solubilization and conjugation of the targeting moiety. Subsequently, the surface of the carboxylated magnetic nanocrystal was modified with amine-functionalized aptamers that specifically bind to the vascular growth factor receptor 2 (VEGFR2) that is overexpressed on angiogenic vessels. To assess the targeted imaging potential of the aptamer-conjugated magnetic nanocrystal for VEGFR2 markers, the magnetic properties and MR imaging sensitivity were investigated using the orthotopic glioblastoma mouse model. In <I>in vivo</I> tests, the aptamer-conjugated magnetic nanocrystal effectively targeted VEGFR2 and demonstrated excellent MR imaging sensitivity with no cytotoxicity.</P>

Comparative analysis of PD-L1 expression between primary and metastatic pulmonary adenocarcinomas

Kim, Sehui,Koh, Jaemoon,Kwon, Dohee,Keam, Bhumsuk,Go, Heounjeong,Kim, Young A,Jeon, Yoon Kyung,Chung, Doo Hyun Elsevier 2017 European journal of cancer Vol.75 No.-

<P><B>Abstract</B></P> <P>Programmed death-ligand 1 (PD-L1) expression in pulmonary adenocarcinomas (pADCs) was implicated in predicting anti-PD-1/PD-L1 therapy efficacy. However, the differential expression of PD-L1 between primary and metastatic pADC remains unclear. Thus, we addressed this issue. In total, 161 paired primary and metastatic tumour tissues from 146 patients with pADC were collected. Most of the cases had regional nodal metastasis (134/161, 83.2%). PD-L1 expression was categorised based on the proportion of immunostained tumour cells using cutoff values of 1%, 5%, 10% and 50%. In primary tumours, PD-L1 positivity was observed in 28.1% (41/146), 27.4% (40/146), 22.6% (33/146) and 13.0% (19/146) of cases using cutoff values of 1%, 5%, 10% and 50%, respectively. The overall concordance rate for PD-L1 expression between primary and metastatic tumours was 75.2% (121/161). The concordance rate in primary tumours expressing PD-L1 in <1% or ≥50% of tumour cells was 87.2% (102/117) or 70% (14/20), respectively. In contrast, the concordance rate in tumours expressing PD-L1 in ≥1% to <50% of cells was only 20.8% (5/24). After dichotomising the cases using cutoff values of 1% and 50%, the concordance rate increased to 80.1% (129/161) and 90.7% (146/161) in all paired cases and to 70.4% (19/27) and 85.2% (23/27) in cases with distant metastases, respectively. This study demonstrates that the concordance of PD-L1 expression between primary and metastatic pADC is high when using cutoff values of 1% and 50%. Thus, evaluation of PD-L1 in either primary or metastatic tumours would be helpful for guiding anti–PD-1/PD-L1 immunotherapy in patients with advanced pADC.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The concordance of programmed death-ligand 1 (PD-L1) expression between primary and metastatic pulmonary adenocarcinoma (pADC) was high when using cutoff values of 1% and 50%. </LI> <LI> PD-L1 expression of primary and corresponding metastatic pADCs was similar, irrespective of the EGFR mutation status. </LI> <LI> The concordance of PD-L1 expression was relatively preserved in metachronously or distantly metastatic tumours. </LI> <LI> PD-L1 expression in primary pADC can be a surrogate for the PD-L1 status in metastatic tumours, and vice versa. </LI> </UL> </P>