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Neuroprotective effects of tanshinone I from Danshen extract in a mouse model of hypoxia-ischemia
Jae-Chul Lee,Joon Ha Park,Ok Kyu Park,In Hye Kim,Bing Chun Yan,Ji Hyeon Ahn,Seung-Hae Kwon,Jung Hoon Choi,Jong-Dai Kim,Moo-Ho Won 대한해부학회 2013 Anatomy & Cell Biology Vol.46 No.3
Hypoxia-ischemia leads to serious neuronal damage in some brain regions and is a strong risk factor for stroke. The aim of this study was to investigate the neuroprotective effect of tanshinone I (TsI) derived from Danshen (Radix Salvia miltiorrhiza root extract) against neuronal damage using a mouse model of cerebral hypoxia-ischemia. Brain infarction and neuronal damage were examined using 2,3,5-triphenyltetrazolium chloride (TTC) staining, hematoxylin and eosin histochemistry, and Fluoro-Jade B histofluorescence. Pre-treatment with TsI (10 mg/kg) was associated with a significant reduction in infarct volume 1 day after hypoxia-ischemia was induced. In addition, TsI protected against hypoxia-ischemia-induced neuronal death in the ipsilateral region. Our present findings suggest that TsI has strong potential for neuroprotection against hypoxic-ischemic damage. These results may be used in research into new anti-stroke medications.
Yan, Luo,Baek, Min-Kyu,Park, Jong-Bae,Park, Yong-Gi,Roh, Jae Hyung The Korean Institute of Electrical Engineers 2017 Journal of Electrical Engineering & Technology Vol.8 No.1
This paper presents an optimal operation scheduling algorithm for a smart home with energy storage system, electric vehicle and distributed generation. The proposed algorithm provides the optimal charge and discharge schedule of the EV and the ESS. In minimizing the electricity costs of the smart home, it considers not only the cost of energy purchase from the grid but also the life cost of batteries. The life costs of batteries are calculated based on the relation between the depth of discharge and life time of battery. As the life time of battery depends on the charge and discharge pattern, optimal charge and discharge schedule should consider the life cost of batteries especially when there is more than one battery with different technical characteristics. The proposed algorithm can also be used for optimal selection of size and type of battery for a smart home.
Yan, Shi Run,Lee, Kyu Wan,Jun, Ki Won,Lee, Sang Bong,Choi, Myoung Jae,Hong, Ji Sook 한국화학공학회 1999 Korean Journal of Chemical Engineering Vol.16 No.3
The hydrogenation of CO₂ to hydrocarbons over a precipitated Fe-Cu-Al/K catalyst was studied in a slurry reactor for the first time. Reducibility of the catalyst and effect of reaction variables (temperature, pressure and H₂/CO₂ ratio of the feed gas) on the catalytic reaction performance were investigated. The reaction results indicated that the Fe-Cu-Al/K catalyst showed a good CO₂ hydrogenation performance at a relatively low temperature (533 K). With the increase of reaction temperature CO₂ conversion and olefin to paraffin (O/P) ratio in C₂-C₄ hydrocarbons as well as the selectivity to C₂-C₄ fraction increased, while CO and CH₄ selectivity showed a reverse trend. With the increase in reaction pressure, CO₂ conversion and the selectivity to hydrocarbons increased, while the CO selectivity and O/P ratio of C₂-C₄ hydrocarbons decreased. The investigation of H₂/CO₂ ratio revealed that CO₂ conversion and CH₄ selectivity increased while CO selectivity and O/P ratio of C₂-C₄ decreased with increasing H₂/CO₂ ratio.
Cheong, Jae-Ho,Yang, Han-Kwang,Kim, Hyunki,Kim, Woo Ho,Kim, Young-Woo,Kook, Myeong-Cherl,Park, Young-Kyu,Kim, Hyung-Ho,Lee, Hye Seung,Lee, Kyung Hee,Gu, Mi Jin,Kim, Ha Yan,Lee, Jinae,Choi, Seung Ho,Ho Elsevier 2018 LANCET ONCOLOGY Vol.19 No.5
<P><B>Summary</B></P> <P><B>Background</B></P> <P>Adjuvant chemotherapy after surgery improves survival of patients with stage II–III, resectable gastric cancer. However, the overall survival benefit observed after adjuvant chemotherapy is moderate, suggesting that not all patients with resectable gastric cancer treated with adjuvant chemotherapy benefit from it. We aimed to develop and validate a predictive test for adjuvant chemotherapy response in patients with resectable, stage II–III gastric cancer.</P> <P><B>Methods</B></P> <P>In this multi-cohort, retrospective study, we developed through a multi-step strategy a predictive test consisting of two rule-based classifier algorithms with predictive value for adjuvant chemotherapy response and prognosis. Exploratory bioinformatics analyses identified biologically relevant candidate genes in gastric cancer transcriptome datasets. In the discovery analysis, a four-gene, real-time RT-PCR assay was developed and analytically validated in formalin-fixed, paraffin-embedded (FFPE) tumour tissues from an internal cohort of 307 patients with stage II–III gastric cancer treated at the Yonsei Cancer Center with D2 gastrectomy plus adjuvant fluorouracil-based chemotherapy (n=193) or surgery alone (n=114). The same internal cohort was used to evaluate the prognostic and chemotherapy response predictive value of the single patient classifier genes using associations with 5-year overall survival. The results were validated with a subset (n=625) of FFPE tumour samples from an independent cohort of patients treated in the CLASSIC trial (NCT00411229), who received D2 gastrectomy plus capecitabine and oxaliplatin chemotherapy (n=323) or surgery alone (n=302). The primary endpoint was 5-year overall survival.</P> <P><B>Findings</B></P> <P>We identified four classifier genes related to relevant gastric cancer features (<I>GZMB, WARS, SFRP4</I>, and <I>CDX1</I>) that formed the single patient classifier assay. In the validation cohort, the prognostic single patient classifier (based on the expression of <I>GZMB, WARS</I>, and <I>SFRP4</I>) identified 79 (13%) of 625 patients as low risk, 296 (47%) as intermediate risk, and 250 (40%) as high risk, and 5-year overall survival for these groups was 83·2% (95% CI 75·2–92·0), 74·8% (69·9–80·1), and 66·0% (60·1–72·4), respectively (p=0·012). The predictive single patient classifier (based on the expression of <I>GZMB, WARS</I>, and <I>CDX1</I>) assigned 281 (45%) of 625 patients in the validation cohort to the chemotherapy-benefit group and 344 (55%) to the no-benefit group. In the predicted chemotherapy-benefit group, 5-year overall survival was significantly improved in those patients who had received adjuvant chemotherapy after surgery compared with those who received surgery only (80% [95% CI 73·5–87·1] <I>vs</I> 64·5% [56·8–73·3]; univariate hazard ratio 0·47 [95% CI 0·30–0·75], p=0·0015), whereas no such improvement in 5-year overall survival was observed in the no-benefit group (72·9% [66·5–79·9] in patients who received chemotherapy plus surgery <I>vs</I> 72·5% [65·8–79·9] in patients who only had surgery; 0·93 [0·62–1·38], p=0·71). The predictive single patient classifier groups (chemotherapy benefit <I>vs</I> no-benefit) could predict adjuvant chemotherapy benefit in terms of 5-year overall survival in the validation cohort (p<SUB>interaction</SUB>=0·036 in univariate analysis). Similar results were obtained in the internal evaluation cohort.</P> <P><B>Interpretation</B></P> <P>The single patient classifiers validated in this study provide clinically important prognostic information independent of standard risk-stratification methods and predicted chemotherapy
Luo Yan,Min-Kyu Baek,Jong-Bae Park,Yong-Gi Park,Jae Hyung Roh 대한전기학회 2017 Journal of Electrical Engineering & Technology Vol.12 No.4
This paper presents an optimal operation scheduling algorithm for a smart home with energy storage system, electric vehicle and distributed generation. The proposed algorithm provides the optimal charge and discharge schedule of the EV and the ESS. In minimizing the electricity costs of the smart home, it considers not only the cost of energy purchase from the grid but also the life cost of batteries. The life costs of batteries are calculated based on the relation between the depth of discharge and life time of battery. As the life time of battery depends on the charge and discharge pattern, optimal charge and discharge schedule should consider the life cost of batteries especially when there is more than one battery with different technical characteristics. The proposed algorithm can also be used for optimal selection of size and type of battery for a smart home.
장민규(Min-Kyu Jang),Yan-Jiating,정영득(Yeong-Deug Jeong),곽재섭(Jae-Seob Kwak) 대한기계학회 2009 대한기계학회 춘추학술대회 Vol.2009 No.5
BMT turret is an indispensable part in CNC lathe turning center. A good driving ASS'Y in BMT turret can improve productivity by reducing tool changeover time. With this in mind, it is essential to design the BMT driving ASS'Y to meet the ever-increasing demand of precision machine tools. In this study, a simulation-based multi-objective design optimization methodology was implemented to improve the efficiency of BMT driving ASS'Y. First, three-dimensional finite element structural and vibration analysis were performed by using ANSYS/Workbench on the initial geometric models of BMT driving ASS'Y. After analyzing stress and deformation concentration zones, several new geometrical models were designed and evaluated by design of experiment and ANSYS/DesignXplorer. Through a series of analysis-evaluation-modification cycles, it was found that designed geometric models were effectively in determining optimal geometric sizes of BMT driving ASS'Y.
Ha Park, Joon,Yoo, Ki-Yeon,Hye Kim, In,Cho, Jeong-Hwi,Lee, Jae-Chul,Hyeon Ahn, Ji,Jin Tae, Hyun,Chun Yan, Bing,Won Kim, Dae,Kyu Park, Ok,Kwon, Seung-Hae,Her, Song,Su Kim, Jin,Hoon Choi, Jung,Hyun Lee, Oxford University Press 2016 TOXICOLOGICAL SCIENCES Vol.154 No.2
<P>Hydroquinone (HQ), a major benzene metabolite, occurs naturally in various plants and is manufactured for commercial use. Although HQ displays various biological effects, its neuroprotective effects following ischemic insults have not been investigated. In this study, we first examined neuroprotective effects of HQ in a rat model of transient focal cerebral ischemia. Animals were subjected to transient middle cerebral artery occlusion for 120 min. HQ (50 or 100 mg/kg) or vehicle was intraperitoneally administered once at 30 min after ischemia-reperfusion. Neuroprotection by treatment with 100 mg/kg of HQ was shown using evaluation of neurological deficits, positron-emission tomography (PET) and 2,3,5triphenyltetrazoliumchloride (TTC) staining. In addition, HQ treatment significantly attenuated ischemia-induced Evans blue dye extravasation from blood vessels and significantly increased immunoreactivities of SMI-71 (an endothelial BBB marker) and glucose transporter-1 (GLUT-1, an endothelial cell marker) in ischemic cortex compared to the vehicle-treated ischemia-operated group. Confocal microscopy and western blot analysis also showed that HQ treatment maintained expressions of tight junction proteins (zonula occludens-1 and occludin) in the ischemic cortex. Post-treatment with HQ protected neurons from transient focal cerebral ischemic injury and the neuroprotective effect of HQ might be closely associated with prevention of BBB disruption via maintaining SMI-71 and GLUT-1 expressions as well as prevention of the degradation of zonula occludens-1 and occludin proteins.</P>
Jong-Soo Choi(Jong-Soo Choi),Seon-Hwa Lim(Seon-Hwa Lim),Lingamdinne Prasanna Lakshmi(Lingamdinne Prasanna Lakshmi),Se-yeon Park(Se-yeon Park),Janardhan Reddy Koduru(Janardhan Reddy Koduru),Jae-Kyu Yan 유기성자원학회 2022 유기성자원학회 학술발표대회논문집 Vol.2022 No.추계
Industrial wastewater containing Volatile Organic Compounds (VOCs) that are contaminating groundwater or surface water in urban areas. This is not only polluting the water, but also polluting atmosphere by emitted into the atmosphere. The most common treatment method of treating VOCs in aqueous system is adsorption of volatilized VOCs separated from the water by steam stripping using activated carbon. However, the activated carbon's adsorption efficiency is reduced because of the high moisture content of the VOCs generated during the vaporization process. As a result, it is necessary to develop an adsorption medium with high adsorption efficiency and low moisture sensitivity. Polyaniline (PANI) creates a porous 3D structure by polymerizing monomer aniline into randomly entangled rod shapes. When phytic acid is mixed with such polyanline, a structure with a certain structure is formed, and through this, an adsorbent with a large specific surface area can be prepared. The optimal condition was determined through PANI and ACP characterization as well as phenol and VOC adsorption tests in water (Benzene, Toluene, Ethylbenzene, Trichloroethylene (TCE), Tetrachloroethylene (PCE)). Characterization (FE-SEM, HR-TEM, BET, FTIR, XRD) of PANI and ACP were also carried out.