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이현경,문일환,이선영,서기열,신태림,김승정 대한소화기학회 1998 대한소화기학회지 Vol.32 No.2
Biliary cystadenocarcinoma is a rare malignancy and occurs predominantly in middle aged woman. Its clinical manifestation is nonspecific and not distinctive from benign cystic lesion. Sonography and computed tomography usually show a septated, multiloculated cystic mass with varying degrees of mural and septal thiekening. Ultrasonography and/or CT have been used for guidance in the percutaneous aspiration of the cystic fluid and needle biopsy. We report one case of biliary cystadenocarcinoma, which arised from cystadenoma in a 67-year-old man, with a review of literature.
M.S. Sidhu,EunKyung Kim,Suk-Yi Woo,MinCheol Song,SaeChae Jeoung,Youn-Il Park 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.2
We report the disruption of a porcine retina and retinal blood vessels in the fluence range between 0.7 J/cm2 and 99.4 J/cm2 of an ultrafast laser at a wavelength of 800 nm with a pulse width of 150 fs. A histological analysis and scanning electron microscopy of cryosectioned slices of the lesion tissue were applied to characterize the tissues irradiated with a fs-laser beam under single-shot configuration. The ablation threshold for the inner limiting membrane (ILM) of a porcine retina is 2.2 ± 0.9 J/cm2. The threshold for optoperforation of primary blood vessels is 5.85 ± 1.49 J/cm2. The ablation depth as a function of the laser fluence shows two different regimes in its semilogarithmic plot. For the laser fluence lower than 25.3 J/cm2, the dependence can be described with an optical penetration depth of 8.2 ± 2.2 μm while at the higher fluence (>25.3 J/cm2); there is steeper rise in ablation depth, which is governed by an electronic heating effect. A concerted ablation of the porcine retina layers and its primary blood vessels is discussed in terms of the optical penetration depth and electronic heating depth, followed by multiphoton excitation of the tissues at a near-infrared (NIR) fs-laser wavelength of 810 nm. We report the disruption of a porcine retina and retinal blood vessels in the fluence range between 0.7 J/cm2 and 99.4 J/cm2 of an ultrafast laser at a wavelength of 800 nm with a pulse width of 150 fs. A histological analysis and scanning electron microscopy of cryosectioned slices of the lesion tissue were applied to characterize the tissues irradiated with a fs-laser beam under single-shot configuration. The ablation threshold for the inner limiting membrane (ILM) of a porcine retina is 2.2 ± 0.9 J/cm2. The threshold for optoperforation of primary blood vessels is 5.85 ± 1.49 J/cm2. The ablation depth as a function of the laser fluence shows two different regimes in its semilogarithmic plot. For the laser fluence lower than 25.3 J/cm2, the dependence can be described with an optical penetration depth of 8.2 ± 2.2 μm while at the higher fluence (>25.3 J/cm2); there is steeper rise in ablation depth, which is governed by an electronic heating effect. A concerted ablation of the porcine retina layers and its primary blood vessels is discussed in terms of the optical penetration depth and electronic heating depth, followed by multiphoton excitation of the tissues at a near-infrared (NIR) fs-laser wavelength of 810 nm.
Femtosecond laser-assisted selective reduction of neovascularization in rat cornea
Sidhu, Mehra S.,Choi, Min-Yeong,Woo, Suk-Yi,Lee, Hyun-Kyu,Lee, Heung-Soon,Kim, Kyu-Jin,Jeoung, Sae Chae,Choi, Jun-Sub,Joo, Choun-Ki,Park, Il-Hong Springer London 2014 LASERS IN MEDICAL SCIENCE Vol.29 No.4
<P>Nonlinear multiphoton absorption induced by focusing near infrared (NIR) femtosecond (fs) laser pulses into a transparent cornea allows surgery on neovascular structures with minimal collateral damage. In this report, we introduce an fs laser-based microsurgery for selective treatment of rat corneal neovascularizations (in vivo). Contiguous tissue effects are achieved by scanning a focused laser pulse below the corneal surface with a fluence range of 2.2–8.6 J/cm<SUP>2</SUP>. The minimal visible laser lesion (MVL) threshold determined over the corneal neovascular structures was found to be 4.3 J/cm<SUP>2</SUP>. Histological and optical coherence tomography examinations of the anterior segment after laser irradiations show localized degeneration of neovascular structures without any unexpected change in adjacent tissues. Furthermore, an approximately 30 % reduction in corneal neovascularizations was observed after 5 days of fs laser exposure. The femtosecond laser is thus a promising tool for minimally invasive intrastromal surgery with the aid of a significantly smaller and more deterministic photodisruptive energy threshold for the interaction between the fs laser pulse and corneal neovascular structures.</P>