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( Sung Won Lee ),( Hae Lim Lee ),( Jung Hyun Kwon ),( Jun Suh Lee ),( Young Chul Yoon ),( Yu Ri Shin ),( Hye Ji Kim ),( Eun Chung ),( Young Woon Kim ),( Jeong Won Jang ),( Soon Woo Nam ),( Nam Ik Han 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Intraoperative radiofrequency ablation (RFA) is one of the treatment options for hepatocellular carcinoma (HCC) patients with relatively poor liver function to undergo surgical resection or when percutaneous approach for RFA is not feasible due to the difficult location of the tumor. The aim of this study is to investigate the clinical outcomes of intraoperative RFA compared to surgical resection. Methods: A total of 76 consecutive patients who received either intraoperative RFA (n=23) or surgical resection (n=53) with curative intent at the Incheon St Mary``s hospital from June 2012 to September 2015 were enrolled. Disease free survival and overall survival rates were analyzed. Results: The median follow-up period was 20.1 months (range, 0.9-41.5). The mean baseline Model for End-Stage Liver Disease (MELD) score was higher in the RFA group compared to the resection group (11.5±4.7 vs. 7.8±1.5, p=0.001). The resection group consisted of larger tumors with the median diameter of 2.7cm (range, 1-16) compared to 2cm (range, 1-5) of the RFA group (p=0.002). However, there was no difference in the number of tumors and the tumor stage between the two groups. The disease free survival rates at 6 and 12 months were 81.6%, 74.8% in the RFA group and 92.2%, 86.2% in the resection group, respectively (p=0.256). The overall survival rates at one year were 91.3% in the RFA group and 94.3% in the resection group, respectively (p=0.635). In the RFA group, 5 patients (21.7%) received liver transplantation (LT) after median interval of 10.9 months (range, 9.2~26.4) since the intraoperative RFA. Conclusions: The patients who received intraoperative RFA presented with relatively poor liver function but the disease free survival and overall survival rates were non-inferior compared to the patients who underwent resection. Therefore, intraoperative RFA may be considered as a useful option for patients ineligible to percutaneous RFA and surgical resection, or as a bridge therapy before liver transplantation.
Subcutaneous toxicity of melittin-dKLA in ICR mice
Sung Jiham,Kim Yura,Yu Pei Fu,김연섭,Han Ik-Hwan,배현수 대한독성 유전단백체 학회 2021 Molecular & cellular toxicology Vol.17 No.4
Background Melittin, a major component of honeybee venom, is known to possess anti-allergic, anti-inflammatory, anti-arthritis, and anti-cancer. Despite its great promise as an agent for various diseases, the therapeutic applications of melittin have been severely limited by its nonspecific cytotoxicity and hemolytic activity. Objective We synthesized a hybrid peptide (melittin-dKLA), composed of melittin and the pro-apoptotic peptide (dKLA), and evaluated its potential toxicity in ICR mice following a single or repeated subcutaneous dose administration. Results Mice administered a single subcutaneous dose of melittin-dKLA showed no mortality or abnormal clinical signs in all animals. Similarly, mice administered a repeated subcutaneous dose of melittin-dKLA resulted in no deaths. Crust formation and induration were observed in the male and female mice in the 5 and 20 mg/kg, respectively. The hematological parameters and serum biochemical analysis did not show any changes by melittin-dKLA. In repeated subcutaneous dose study, the mice in the 20 mg/kg group showed a significant increase in the relative weight of the spleen compared to the control group. Although the difference was not statistically significant. Mice exhibited a common pattern of change. Conclusion Taken together, our results suggest that the toxicity of melittin-dKLA is higher than 20 mg/kg both as a single and a repeated subcutaneous administration in ICR mice. Thus, it is suggested that it will be an important data in the development of new drug for melittin-dKLA.
Sang-Ik Oh,Ha-Young Kim,Jae-Won Byun,Myungju Chae,Jong Ho Kim,Yu-Ran Lee,Bun Seung Jo,Ji-Sun Yoon,Jong Wan Kim 한국예방수의학회(구 한국수의공중보건학회) 2017 예방수의학회지 Vol.42 No.1
The seroprevalence of major infectious abortion agents was investigated in native Korean goats from Jeonnam province using ELISA. A total of 98 blood samples were collected from goats. Overall, 48 (49.0%), 11 (11.2%), and 1 (1.0%) serum samples tested positive for C. burnetii, T. gondii, and C. abortus, respectively, while none of the samples were positive for B. abortus or N. caninum. Moreover, a PCR assay conducted to detect C. burnetii antigens in goats with a history of abortion revealed 18 (38.3%) of 47 goats were C. burnetii positive by both the ELISA and PCR assay.
Performance Improvement of Near Earth Space Survey (NESS) Wide-Field Telescope (NESS-2) Optics
Yu, Sung-Yeol,Yi, Hyun-Su,Lee, Jae-Hyeob,Yim, Hong-Suh,Choi, Young-Jun,Yang, Ho-Soon,Lee, Yun-Woo,Moon, Hong-Kyu,Byun, Yong-Ik,Han, Won-Yong 한국우주과학회 2010 Journal of Astronomy and Space Sciences Vol.27 No.2
Sung Woo Kim,Min Soo Kim,Yeonhui Yu,Chan-Lan Kim,Ik Soo Jeon,Chongdae Kim 한국동물생명공학회(구 한국동물번식학회) 2017 Reproductive & Developmental Biology(Supplement) Vol.41 No.2
This study examined factors affecting the analysis of motility of chicken semen. The viability of spermatozoa was estimated using varying dilution ratios and supplementation with BSA or fatty acid free (FAF)-BSA as protein sources in semen diluent. Fresh semen was examined after preparing dilutions in BPSE of 1/8, 1/16 and 1/32 at 25℃. The motility of incubated semen at each dilution was observed at 3 min (89.9%, 69.9 % and 53.2%), 30 min (86.7%, 71.4% and 51.7%), 1 h (89.5%, 74.0% and 53.5%) and 3 h (78.5%, 66.5% and 45.7%), respectively. The addition of BSA or FAF-BSA to BPSE diluent significantly increased the viability of semen in 1/32 dilution with results of 53.2% (control), 84.8% (BSA) and 92.9% (FAF-BSA) (p<0.05). This phenomenon was also observed in the dilution of frozen semen, where FAF-BSA treatment increased the viability of thawed semen from 17.6% to 34.0% in a 1/8 dilution (p<0.05). When the protein sources were used in the dilution, the survival rates of diluted chicken semen were also increased with time lapse. These results show that FAF-BSA may act to protect chicken semen and is suitable as a basic component of chicken semen diluent for the method of analyzing rooster semen after freezing.
( Ik Sung Choi ),( Kil Jong Yu ),( Dae Hyeon Cho ),( Ji Enu Oh ),( Chang Wook Jeong ),( Kwang Min Kim ),( Hyoun Soo Lee ),( Jung Won Lee ),( Dong Kyu Lee ),( Byung Soo Kwan ),( Sang Goon Shim ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: A direct-acting antiviral (DAA) drug is in the spotlight for the treatment of patients with chronic hepatitis C. The combination of sofosbuvir and ribavirin is more effective than the peg IFN and ribavirin in patients with genotype 2 HCV. The aim of this study was to evaluate the treatment efficacy and safety for GT2 HCV patients treated with sofosbuvir and ribavirin in a single center. Methods: The study was performed retrograde from May 2016 to December 2017 in GT2 HCV patients treated with sofosbuvir (400mg) plus ribavirin (800-1200mg; based on body weight) treatment. The primary endpoint was sustained virologic response at 12 weeks (SVR12). The secondary endpoint was the occurrence of side effects during treatment. Results: A total of 95 patients with GT2 HCV infection were enrolled, of which 92 were genotype 2a (96.8%) and 3 were 2b (3.2%). 2 patients were follow up loss, 1 patient discontinued treatment voluntarily. SVR12 was confirmed in 91 of 92 patients (98.91%). 1 patient with failed treatment were combined LC and HCC, HCV RNA was not detected at 4 weeks and 8 weeks after initiation of treatment, but HCV RNA detected at 12 weeks. Liver cirrhosis was diagnosed on the imaging studies or clinical manifestations and 24 patients were included (CTP-A; n=23, C; n=1). SVR12 with cirrhotic patients was 95.83%. The average HCR RNA titer was 2.46x10<sup>6</sup> IU/ml. Hemoglobin decrease (Mean ± SD; 2.95±1.19 g/dl) occurred in 21 patients during treatment and ribavirin dose reduction was required. Conclusions: This study was performed on a small group of patients compared with other studies, but showed that treatment with sofosbuvir and ribavirin was highly effective in patients with GT2 HCV infection. In aspect of safety, there was no serious side effects about treatment although hemoglobin decrease.
Relief of Postherpetic Neuralgia with Transforaminal Epidural Injection of Magnesium -A Case Report-
Yu, Ho-Kyoung,Lee, Joon-Ho,Cho, Sung-Hwan,Kim, Yong-Ik The Korean Pain Society 2011 The Korean Journal of Pain Vol.24 No.1
Although postherpetic neuralgia (PHN) is a common chronic pain syndrome, the pathophysiology of this disorder is not well known and management is often very difficult. N-methyl-D-Aspartate (NMDA) receptor antagonists are known to be effective in PHN, and magnesium, a physiological blocker of NMDA receptors, is widely used to treat various chronic pain disorders. Here, we present a case of the PHN refractory to conventional treatment, which was treated successfully with transforaminal epidural injection of magnesium sulphate at the affected dermatome.