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Jae Han Lee,Won-Jin Son,Sangjoon Ann,Jongeun Byun,Byoung Kuk Lee 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
In this paper, a pulse density modulation (PDM) control for a semi-bridgeless rectifier in inductive power transfer (IPT) systems is proposed. The proposed PDM control can implement soft switching and continuous output voltage control using simple algorithm without additional hardware. In order to analyze the proposed method, the voltage gain of the semi-bridgeless rectifier with the proposed method is derived mathematically, and the performance of the proposed method is compared with the conventional control methods. Additionally, the result of the comparison is verified through simulation and experimental results.
( Jae Won Byun ),( Kyung Hyun Lee ),( Ha Young Kim ),( Soon Seek Yoon ),( Ji Youl Jung1 ),( Woo Seog Jeong1 ),( Jae Ku Oem ),( Jong Soo Lim ),( Myoung Heon Lee ),( You Chan Bae ) 한국예방수의학회(구 한국수의공중보건학회) 2013 예방수의학회지 Vol.37 No.1
Nine cattle among 18 in a native Korean herd died or were euthanized within 3 days. The affected cattle showed cowshed. The pigs and dogs had been fed leftover food originating from nearby restaurants, and the cattle could presumably reach the contaminated food in the pig troughs. Necropsy revealed a few chicken bones and red pepper pieces as well as large amounts of grain and rice straw hay mixed in the rumen. Botulism type D was isolated in the ruminal contents of one of the cattle. We speculated that the outbreak was associated with the cattle incidentally eating presumably contaminated leftover food from the pig trough.
Case report : Devastating botulism outbreak in cattle associated with contaminated soil
( Jae Won Byun ),( Byeong Yeal Jung ),( Ha Young Kim ),( Kyung Hyun Lee ),( Oun Kyung Moon ),( Soon Seed Yoon ),( So Young Park ),( O Soo Lee ),( Myoung Heon Lee ),( You Chan Bae ) 한국예방수의학회 2013 예방수의학회지 Vol.37 No.2
We describe her cases of botulism at two dairy cattle farms where the soil was submerged by flooding from an adjacent river. All cattle at farms 1 and 2, 91 and 56 head, respectively died or were euthanized with posterior flaccid paralysis and recumbency. Necropsy and histopathological examination showed no specific lesions. Botulinum toxin type B was detected in sera of the arrected cattle, and type D toxin was found in ruminal contents and soil from cattle pens at both farms.A likely source of the botulinum toxin is the soil of the adjacent river, from which toxins were introduced during flooding To our Knowledge, these appear to be the first cases of bovine botulism associated with contaminated pen soil after flooding.
Gait Variability Can Predict the Risk of Cognitive Decline in Cognitively Normal Older People
Byun, Seonjeong,Han, Ji Won,Kim, Tae Hui,Kim, Kayoung,Kim, Tae Hyun,Park, Jae Young,Suh, Seung Wan,Seo, Ji Young,So, Yoonseop,Lee, Kyoung Hwan,Lee, Ju Ri,Jeong, Hyeon,Jeong, Hyun-Ghang,Han, Kyuhee,Hon S. Karger AG 2018 DEMENTIA AND GERIATRIC COGNITIVE DISORDERS Vol.45 No.5
<P><B><I>Background:</I></B> The aim of this study was to investigate the association of gait speed and gait variability, an index of how much gait parameters, such as step time, fluctuate step-to-step, with risk of cognitive decline in cognitively normal elderly individuals. While high gait variability is emerging as an early indicator of dementing illnesses, there is little research on whether high gait variability predicts cognitive decline in cognitively normal elderly who have no evidence of cognitive impairment. <B><I>Methods:</I></B> In this 4-year prospective cohort study on 91 community-dwelling cognitively normal elderly individuals without cerebral ischemic burden or Parkinsonism, we evaluated gait speed and step time variability using a tri-axial accelerometer placed on the center of body mass, and diagnosed mild cognitive impairment (MCI) according to the International Working Group on MCI. We performed Kaplan-Meier analysis with consecutive log-rank testing for MCI-free survival by cohort-specific tertiles of gait speed; hazard ratios (HR) of incident MCI were estimated using Cox proportional hazards regression analysis adjusted for age, sex, education level, Cumulative Illness Rating Scale score, GDS score, and presence of the apolipoprotein E ε4 allele. <B><I>Results:</I></B> Out of the 91 participants in the baseline assessment, 87 completed one or more 2-year follow-up assessments, and the median duration of follow-up was 47.1 months. Kaplan-Meier curves of incident MCI show evident differences in risk by gait variability group (χ<SUP>2</SUP> = 9.64, <I>p</I> = 0.002, log-rank test). Mean MCI-free survival in the high variability group was 12% shorter than in the mid-to-low tertile group (47.4 ± 1.74 [SD] vs. 54.04 ± 0.52 months), while it was comparable between gait speed groups (51.59 ± 0.70 vs. 50.64 ± 1.77 months; χ<SUP>2</SUP> = 1.16, <I>p</I> = 0.281). In multivariate analysis, subjects with high gait variability showed about 12-fold higher risk of MCI (HR = 11.97, 95% CI = 1.29–111.37) than those with mid-to-low variability. However, those with slow gait speed showed comparable MCI risk to those with mid-to-high speed (HR = 5.04, 95% CI = 0.53–48.18). <B><I>Conclusions:</I></B> Gait variability may be a better predictor of cognitive decline than gait speed in cognitively normal elderly individuals without cerebral ischemic burden or Parkinsonism.</P>
Byun, Joo-Yun,Kim, Min-Jung,Eum, Da-Young,Yoon, Chang-Hwan,Seo, Woo-Duck,Park, Ki Hun,Hyun, Jin-Won,Lee, Yun-Sil,Lee, Jae-Seong,Yoon, Moon-Young,Lee, Su-Jae American Society for Pharmacology and Experimental 2009 Molecular pharmacology Vol.76 No.4
<P>Naturally occurring triterpenoid compounds have long been used as anti-inflammatory, antimalarial, and insecticidal agents. It has become evident that some of the natural or synthetic triterpenoids have promising clinical potential as both a therapeutic and chemopreventive agent for cancer. However, the molecular basis for the antitumor activity of triterpenoid has yet to be defined. In this study, we show that pristimerin, a natural triterpenoid, induces mitochondrial cell death in human cervical cancer cells and that reactive oxygen species (ROS)-dependent activation of both Bax and poly(ADP-ribose) polymerase-1 (PARP-1) is critically required for the mitochondrial dysfunction. We also showed that c-Jun N-terminal kinase (JNK) is involved in ROS-dependent Bax activation. Treatment of pristimerin induced an increase in intracellular ROS, JNK activation, conformational change, and mitochondrial redistribution of Bax, mitochondrial membrane potential loss, and cell death. The PARP-1 was also found to be activated by pristimerin treatment. An antioxidant, N-acetyl-l-cysteine (NAC), inhibited pristimerin-induced JNK activation, Bax relocalization, and PARP-1 activation, as well as mitochondrial cell death. Moreover, inhibition of JNK clearly suppressed conformational change and mitochondrial translocation of Bax and subsequent mitochondrial cell death but did not affect PARP-1 activation. Inhibition of PARP-1 with 1,5-dihydroxyisoquinoline (DIQ) or with small interfering RNA of PARP-1 significantly attenuated pristimerin-induced mitochondrial membrane potential loss and cell death but did not affect JNK activation and Bax relocalization. These results indicate that the natural triterpenoid pristimerin induces mitochondrial cell death through ROS-dependent activation of both Bax and PARP-1 in human cervical cancer cells and that JNK is involved in ROS-dependent Bax activation.</P>
The Study of the Electromagnetic Robot with a Four-wheel Drive and Applied I-PID System
Jae-Hoon Jeong,Dong-Heon Lee,Min Kim,Won-Hyun Park,Gi-Sig Byun,Sei-Woong Oh 대한전기학회 2017 Journal of Electrical Engineering & Technology Vol.12 No.4
The purpose of this study is based on the electromagnet robot with a four-wheel drive which can climb up and down on structures of iron wall instead of human workers. Many of studies strive to develop wall riding-robots in terms of absorption system. However, the system needs additional devices too much to work out as well as electromagnetic wheel system also has much expense to make it. In this regard, this study makes efforts to find the way how to keep steady distance between wheel and wall while using general electromagnet to reduce motor load and to move robot so easily.