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제주도 지하수 질산염 농도의 시·공간적 변화 특성: 장기(1993-2015) 모니터링 자료의 평가
김호림(Ho-Rim Kim),오준섭(Junseop Oh),도현권(Hyun-Kwon Do),이경진(Kyung-Jin Lee),현익현(Ik-Hyun Hyun),오상실(Sang-Sil Oh),감상규(Sang-Kyu Kam),윤성택(Seong-Taek Yun) 대한자원환경지질학회 2018 자원환경지질 Vol.51 No.1
1993년부터 2015년까지 관측된 제주도 지하수 장기모니터링 관측정(N = 4,835)에서 수집된 지하수 수질자료(N = 21,568)를 기반으로 질산성질소의 시공간적 변동 특성을 평가하였다. 제주도 지하수의 질산성질소 농도의 중앙값은 2.5 mg/L로서 다른 국가나 대륙의 조사 결과에 비해 다소 높거나 유사한 것으로 나타났다. 또한 지하수 용도, 행정구역 및 고도 별로 유의한 차이를 보였다. 특히, 산간 지역에 비해 저지대 해안가에 위치한 농업 및 주거지역에서 농도가 높음을 확인하였다. Mann-Kendall 및 Sen’s slope 분석을 활용한 질산성질소 농도의 추세 분석 결과, 하류 저지 대에 비해 중산간지역에서의 질산성질소 농도 증가 경향이 뚜렷하였다. 제주도 내 토지 피복의 시계열 변화 특성과 결부 지어 보면, 중산간지역의 오염 증가 추세는 농업지역의 확장 등 인위적 활동 증가에 기인한 결과로 판단된다. 반면,기지정된 지하수자원특별관리구역에서는 전반적으로 질산성질소 농도의 감소 경향이 나타났는데, 이는 지하수 관리 측면에서 수질관리를 위한 적극적인 정책이 유효함을 시사한다. 본 연구에서는 제주도 지하수의 질산성질소 오염관리를 위한 적정 방안을 제안한다. The spatio-temporal variations of nitrate concentrations in groundwater of Jeju Island were evaluated by an analysis of time series groundwater quality data (N = 21,568) that were collected from regional groundwater monitoring (number of wells = 4,835) for up to 20 years between 1993 and 2015. The median concentration of NO 3 -N is 2.5 mg/L, which is slightly higher than those reported from regional surveys in other countries. Nitrate concentrations of groundwater in wells tend to significantly vary according to different water usage (of the well), administrative districts, and topographic elevations: nitrate level is higher in low-lying agricultural and residential areas than those in high mountainous areas. The Mann-Kendall trend test and Sen’s slope analysis show that nitrate concentration in mid-mountainous areas tends to increase, possibly due to the expansion of agricultural areas toward highland. On the other hand, nitrate concentrations in the Specially Designated Groundwater Quality Protection Zones show the temporally decreasing trend, which implies the efficiency of groundwater management actions in Jeju. Proper measures for sustainable groundwater quality management are suggested in this study.
Sang-Ik Han,Ki Chang Jang,Woo Duck Seo,Ji-Eun Ra,Jun Young Kim,Seong-Hwan Oh,Kyung-Jin Choi,Min-Hee Nam 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07
Sorghum is the fifth most important cereal in the world as one of the staple food. For the use of natural dye, we have done some researches about sorghum red pigments extracted from stalk and leaves on its physiochemical properties, extracting methods and applications. The researches involved maximum extraction of sorghum pigment and analysis of its processing condition. Total polyphenol and tannin contents were measured by varieties and different plant parts. The stabilities of pigment by irradiation and heat treatment for processing were measured by colorimeter and thermal gravimetric analysis (TGA). In addition, hybrid nano-silica composites with sorghum pigment were made by combining with polyvinyl alcohol, polyvinyl acetate and sodium silicate. Water silica hybrids with sorghum pigment were performed by emulsion treatment. Nano-silica particles were identified and measured their size to be about 200 ~ 400 nm by SEM analysis.
Expression of barley HvCBF4 enhances tolerance to abiotic stress in transgenic rice
Oh, Se-Jun,Kwon, Chang-Woo,Choi, Dong-Woog,Song, Sang Ik,Kim, Ju-Kon BLACKWELL 2007 PLANT BIOTECHNOLOGY JOURNAL Vol.5 No.5
<P>Summary</P><P>C-repeat/dehydration-responsive element binding factors (CBF/DREBs) are a family of transcription factors that regulate freezing tolerance in <I>Arabidopsis</I>. As a step towards understanding the stress response of monocotyledonous plants, we isolated a barley gene <I>HvCBF4</I> whose expression is induced by low-temperature stress. Transgenic over-expression of <I>HvCBF4</I> in rice resulted in an increase in tolerance to drought, high-salinity and low-temperature stresses without stunting growth. Interestingly, under low-temperature conditions, the maximum photochemical efficiency of photosystem II in the dark-adapted state (<I>F</I><SUB>v</SUB>/<I>F</I><SUB>m</SUB>, where <I>F</I><SUB>v</SUB> is the variable fluorescence and <I>F</I><SUB>m</SUB> is the maximum fluorescence) in <I>HvCBF4</I> plants was higher by 20% and 10% than that in non-transgenic and <I>CBF3/DREB1A</I> plants, respectively. Using the 60K Rice Whole Genome microarray, 15 rice genes were identified that were activated by HvCBF4. When compared with 12 target rice genes of CBF3/DREB1A, five genes were common to both HvCBF4 and CBF3/DREB1A, and 10 and seven genes were specific to HvCBF4 and CBF3/DREB1A, respectively. Interestingly, HvCBF4 did not activate <I>Dip1</I> and <I>Lip5</I>, two important target genes of CBF3/DREB1A, in transgenic rice under normal growth conditions, but their expression was enhanced by HvCBF4 under low-temperature conditions. Our results suggest that <I>CBF/DREBs</I> of barley act differently from those of <I>Arabidopsis</I> in transgenic rice.</P>
Clinical Significance of F-18 FP-CIT Dual Time Point PET Imaging in Idiopathic Parkinson's Disease
Oh, Jin-Kyoung,Yoo, Ik-Dong,Seo, Ye-Young,Chung, Yong-An,Yoo, Ie-Ryung,Kim, Sung-Hoon,Song, In-Uk The Korea Society of Nuclear Medicine 2011 핵의학 분자영상 Vol.45 No.4
Purpose The purpose of this study was to investigate the diagnostic value of dual time point F-18 FP-CIT PET imaging in idiopathic Parkinson's disease (PD). Materials and Methods Twenty-four patients with PD (mean age 69.6) and 18 healthy people (mean age 70.26) underwent two sequential PET/CT scans (dual time point imaging) at 90 and 210 min after F-18 FPCIT injection. Tracer activity of region of interest was measured in the caudate, putamen and a reference region in the brain from both time points. The outcome parameter was the striatooccipital ratio (SOR). Normal SOR values were obtained in the control group. The percent change in tracer activity between 90- and 210- min images was calculated. The SOR values and the percent change in tracer activity were compared between the patients and healthy control group. Results The SOR values for the caudate, anterior and posterior putamen at both 90- and 210-min images were significantly reduced in the patients with PD. The lowest P value was obtained for the anterior and posterior putamen (p<0.001) at both time points. There were significant differences of the percent change in tracer activity for the anterior and posterior putamen in the two groups (p=0.01). Conclusions F-18 FP-CIT PET scans at 90 and 210 min after injection are both able to diagnose PD. Therefore, the 90-min image by itself is sufficient for diagnosing PD.
( Ik Sung Choi ),( Kil Jong Yu ),( Dae Hyeon Cho ),( Ji Enu Oh ),( Chang Wook Jeong ),( Kwang Min Kim ),( Hyoun Soo Lee ),( Jung Won Lee ),( Dong Kyu Lee ),( Byung Soo Kwan ),( Sang Goon Shim ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: A direct-acting antiviral (DAA) drug is in the spotlight for the treatment of patients with chronic hepatitis C. The combination of sofosbuvir and ribavirin is more effective than the peg IFN and ribavirin in patients with genotype 2 HCV. The aim of this study was to evaluate the treatment efficacy and safety for GT2 HCV patients treated with sofosbuvir and ribavirin in a single center. Methods: The study was performed retrograde from May 2016 to December 2017 in GT2 HCV patients treated with sofosbuvir (400mg) plus ribavirin (800-1200mg; based on body weight) treatment. The primary endpoint was sustained virologic response at 12 weeks (SVR12). The secondary endpoint was the occurrence of side effects during treatment. Results: A total of 95 patients with GT2 HCV infection were enrolled, of which 92 were genotype 2a (96.8%) and 3 were 2b (3.2%). 2 patients were follow up loss, 1 patient discontinued treatment voluntarily. SVR12 was confirmed in 91 of 92 patients (98.91%). 1 patient with failed treatment were combined LC and HCC, HCV RNA was not detected at 4 weeks and 8 weeks after initiation of treatment, but HCV RNA detected at 12 weeks. Liver cirrhosis was diagnosed on the imaging studies or clinical manifestations and 24 patients were included (CTP-A; n=23, C; n=1). SVR12 with cirrhotic patients was 95.83%. The average HCR RNA titer was 2.46x10<sup>6</sup> IU/ml. Hemoglobin decrease (Mean ± SD; 2.95±1.19 g/dl) occurred in 21 patients during treatment and ribavirin dose reduction was required. Conclusions: This study was performed on a small group of patients compared with other studies, but showed that treatment with sofosbuvir and ribavirin was highly effective in patients with GT2 HCV infection. In aspect of safety, there was no serious side effects about treatment although hemoglobin decrease.
Sang-Ik Oh,Ha-Young Kim,Jae-Won Byun,Myungju Chae,Jong Ho Kim,Yu-Ran Lee,Bun Seung Jo,Ji-Sun Yoon,Jong Wan Kim 한국예방수의학회(구 한국수의공중보건학회) 2017 예방수의학회지 Vol.42 No.1
The seroprevalence of major infectious abortion agents was investigated in native Korean goats from Jeonnam province using ELISA. A total of 98 blood samples were collected from goats. Overall, 48 (49.0%), 11 (11.2%), and 1 (1.0%) serum samples tested positive for C. burnetii, T. gondii, and C. abortus, respectively, while none of the samples were positive for B. abortus or N. caninum. Moreover, a PCR assay conducted to detect C. burnetii antigens in goats with a history of abortion revealed 18 (38.3%) of 47 goats were C. burnetii positive by both the ELISA and PCR assay.