연구개의 이소성 뇌조직 - 1예 보고-

최현주,이연수,김영신,이교영,강창석,심상인 대한병리학회 1998 Journal of Pathology and Translational Medicine Vol.32 No.11

흰쥐 생체시료 중 5-플루오로우라실 및 테가푸르의 안정성

장지현,박종국,강진형,정석재,심창구,구효정 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.3

5-Fluorouracil (5-FU) is an antimetabolite anticancer agent active against many types of solid tumors. Tegafur (TF), a prodrug of 5-FU, is frequently used in combination with uracil as dihydropyrimidine dehydrogenase (DPD) inhibitory fluoropyrimidine. We studied the stability of 5-FU and TF in biological fluids of rats and determined their bioavailability (BA) and excretion into bile, and urine. The drug concentrations were analyzed by an HPLC method. At room temperature, there was a 14-30% decrease in the concentration of 5-FU and TF in bile, urine, and plasma specimen at 10 and 100 μg/ml over 240 min. No significant difference was noted among the sample types or between two different concentrations of 10 and 100 μg/ml. The decrease in drug concentration was significantly less in samples kept on ice (6-12%) for both drugs. These data indicate that biological fluid samples containing 5-FU or TF in plasma, urine, or bile should be placed on ice during the sample collection. Following these storage guidelines, samples were collected after administration 50 ㎎/㎏ of each drug via i.v. or oral route. BA was 1.5 folds greater for TF (60%) than that of 5-FU (42%). Approximately 0.52 and 3.3% of the i.v. doses of 5-FU and TF was excreted into bile, respectively. Renal clearance of 5-FU was about 16% of its total body clearance. These results suggest that instability of 5-FU and TF in biological fluids should be considered in pharmacokinetic or pharmacogenomic studies.

탄수화물에서 syn-과 anti-2, 3-디히드록시 알데히드의 합성 : L-Factor와 Muricatacin의 합성

강석구,조현성,심형수 성균관대학교 기초과학연구소 1993 論文集 Vol.44 No.1

천연물합성에 있어서 합성중간체로서 유용한 광학활성의 O-보호된 syn-과 anti-2, 3-디히드록시 알데히드의 네 가지 입체이성질체들을 쉽게 구할 수 있는 D-글루코스나 D-크실로스에서 유도된 푸라노스를 변형시켜 합성하였다. 예컨대 불포화 퓨라노스계의 이중결합에 수소화붕소 첨가반응-산화반응에 의해 입체선택적으로 히드록시퓨라노스를 얻고 이를 O-베질화후 탈아세톤화, 산화성절단반응에 의해 (2S, 3S)-3-포르옥시-2-벤질옥시알칸알을 얻었으며 그 외 (2S, 3R)-, (2R, 3S)-, (2R, 3R)-디히드록시알칸알을 얻었다. 이러한 중간체들을 이용하여 L-factor와 muricatacin을 합성하였다. Four stereosiomers of optically active O-protected syn- and anti-2, 3-dihydroxy aldehydes, chiral synthons for natutal product synthesis, were synthesized from readily avilable D-glucose and E-Xylose. (2S, 3S)-3-Formylosy-2-benzylxoy alkanals were synthesized by stereoselective hydroboration of the unsaturated furanoses followed by O-benzylation, deprotection, and oxidative cleavage. (2S, 3R)-, (2R, 3S)-, and (2R, 3R)-Dihydroxy alkanals were also synthesized. Using these chiral synthons, (4R, 5S)-(-)- and (4S, 5S)-(+)-L-factors, the proposed autoregulators from Strpiomyces griseus and muricatacin, a biologically active constituent from the seeds of Annona muricata L. were synthesized.

탄수화물에서 광학활성 중간체 O-보호된 (S)-와 (R)-3-히드록시 알데히드의 합성

강석구,조현성,심형수 성균관대학교 기초과학연구소 1993 論文集 Vol.44 No.1

탄수화물로부터 유도된 불포화 퓨라노스 고리계를 입체 선택적인 수소화 반응에 의해 chiral synthon인 광학활성의 (S)-3-포르밀옥시 알데히드를 합성하였고, 탄수화물에서 유도된 3-히드록시 퓨라노스를 Barton-McCombie의 deoxygenation반응에 의해 (R)-3-포르밀옥시 알데히드를 합성하였다. (S)-e-Formyloxyaldehydes, chiral synthons for natural products, were synthesized via highly stereoselective hydrogenation of the unsaturated furanose ring system derived from D-glucose or D-xylose. Alternatively, (R)-3-formyloxyaldehydes were prepared via deoxygenation of 3-hydroxyfuranoses.

경연대회를 통한 초·중고생의 창의력 현황에 관한 연구

육근철,이희복,류해일,김현섭,김희수,박달원,심규철,박종석,신영숙,박상태,변두원,김태균 공주대학교 과학교육연구소 2002 과학교육연구 Vol.33 No.-

21세기의 정보화 산업사회와 지식기반 사회에서 우리의 아이들이 자신의 목소리로 세계 속에서 살아가게 하기 위해서는 다른 사람과 다른 아이디어를 낼 수 있도록 교육의 틀을 바꾸지 않으면 안된다. 다라서 21세기의 미래 사회를 살아갈 학생들을 가르치는 교육의 현장 역시 창의적인 인간을 길러낼 수 있도록 변해야 한다. 즉, 미래 사회를 대비하기 위해서는 각 개인의 개성을 존중하는 분위기에서 창의적인 능력을 지닌 인간을 양성해야 한다는 것을 의미한다. 따라서, 학교 안에서의 교육뿐만이 아니라 학교 밖에서도 다양한 학습 경험을 통해서 교육 과정이 추구하는 인간상을 구현할 수 있도록 활동할 수 있는 기회가 학생들에게 제공되어야 한다. 창의력을 발휘하여 문제를 해결하는 능력을 기르기 위해서는 개별적이 아닌 여러 명의 동료가 주어진 과제를 해결할 수 있는 기회를 갖고 짧은 시간이 아닌 장시간 동안 고민하고 그 해결책을 찾는 활동을 가질 기회가 필요하다. In order to educate our students with their special talents for the informational and knowledge based age expected in the 21st century, we must improve our educational programs such that students are able to create their own fresh ideas. Hence the present educational environment should be changed such that they are willing to respect others' characters and personality with their own original ideas. Therefore, we must make them have the opportunity that they can acquire many experiences through the school education and the social education program, so that they may grow up to the person with the humanity and creativity. In this study we have suggested new educational program where students engage themselves in long term research projects with collaboration of the team and creativity of individuals.

Preventive Effect of Lactobacillus Fermentation Extract on Inflammation and Cytokine Production in Lipopolysaccharide-Induced Cystitis in Mice

Hyun Suk Yoon,Yong Tae Kim,Bong Suk Shim,Hana Yoon 대한요로생식기감염학회 2018 Urogenital Tract Infection Vol.13 No.3

Purpose: The effects of Lactobacillus fermentation extract (LFE) on cystitis induced by Escherichia coli lipopolysaccharide (LPS) in the mouse bladder were investigated by pathological analyses and measurement of the levels of tumor necrosis factor-alpha (TNF-) and interleukin-18 (IL-18).Materials and Methods: LFE was administered orally (5 g/L) to mice for 10 days after which the study group (n=12) received transurethral injection of 5 g/L LPS. The bladder tissue was then harvested after 24 hours and subjected to hematoxylin and eosin staining. A semi-quantitative score was used to evaluate inflammation (bladder inflammation index, BII). TNF- immunohistochemical staining and multiplex cytokine assays were also performed. TNF- and IL-18 levels were determined. The results were compared with those of the control group (n=12).Results: The BII in the control and study groups was 2.7±0.5 and 1.1±0.7, respectively, with the control group scores differing significantly from the study group scores (p<0.001). TNF- immunohistochemical staining results were similar. The TNF- levels determined by the multiplex cytokine assay were 2.82±1.35 pg/mg and 1.55±0.56 pg/mg for the control and study groups, respectively, and the difference between these groups was statistically significant (p=0.007).Conclusions: Oral administration of LFE appears to have a preventive effect against the inflammatory responses and TNF- expression induced by transurethral instillation of LPS in the mouse bladder. Further studies are required to determine the clinical application of this finding.

WATER GAS SHIFT REACTION OVER CO-PRECIPITATED Cu−CeO₂, Cu−ZrO₂, AND Cu−Ce<SUB>(1−x)</SUB>Zr<SUB>(x)</SUB>O₂ CATALYSTS

Hyun-Suk NA,Dae-Woon JEONG,Jae-Oh SHIM,Won-Jun JANG,Hyun-Seog ROH,Un Ho JUNG,Wang Lai YOON 한국신재생에너지학회 2014 AFORE Vol.2014 No.-

Facile production of biofuel via solvent-free deoxygenation of oleic acid using a CoMo catalyst

Shim, Jae-Oh,Jeon, Kyung-Won,Jang, Won-Jun,Na, Hyun-Suk,Cho, Jae-Wan,Kim, Hak-Min,Lee, Yeol-Lim,Jeong, Dae-Woon,Roh, Hyun-Seog,Ko, Chang Hyun Elsevier 2018 Applied Catalysis B Vol.239 No.-

<P><B>Abstract</B></P> <P>Support- and sulfide-free cobalt molybdenum catalysts are prepared via different synthetic procedures for catalytic deoxygenation of oleic acid under inert (N<SUB>2</SUB>) and solvent-free conditions. Among the tested catalysts, the CoMo catalyst prepared via a sol-gel method achieves the highest catalytic performance, namely, 88.9% oleic acid conversion, with 48.1% C<SUB>9</SUB>–C<SUB>17</SUB> selectivity, and 69.6% oxygen removal rate, owing to its excellent physical properties. Additionally, oxygen vacancy is formed in CoMo catalyst during sol-gel synthesis process and it also effect on the catalytic activity. Examination of the deoxygenation reaction over pre-reduced catalysts reveals that the CoMoO<SUB>4</SUB> species is the active species in the CoMo catalysts. The fuel properties of the resultant products are affected strongly by the catalytic performances of the CoMo catalysts. The biofuel produced using the CoMo catalyst prepared via the sol-gel method showed the highest calorific value (10,119 cal/g) and the lowest viscosity (31.5 cP), and, consequently, this CoMo catalyst exhibits the highest catalytic activity and has significant potential for application in biofuel production.</P> <P><B>Highlights</B></P> <P> <UL> <LI> This study describes an efficient and accessible method for biofuel production. </LI> <LI> Deoxygenation of oleic was carried out under inert, solvent-free conditions. </LI> <LI> CoMo catalysts are prepared via different synthetic procedures. </LI> <LI> CoMo catalyst prepared via sol-gel method showed the highest catalytic performance. </LI> <LI> It also exhibits calorific value that is very similar to that of commercial diesel. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

HYDROGEN PRODUCTION FROM LOW-TEMPERATURE WGS REACTION ON CO-PRECIPITATED CU-CEO₂

Hyun-Suk NA,Dae-Woon JEONG,Jae-Oh SHIM,Won-Jun JANG,Hyun-Seog ROH,Un Ho JUNG,Wang Lai YOON 한국신재생에너지학회 2013 AFORE Vol.2013 No.-

Petroleum like biodiesel production by catalytic decarboxylation of oleic acid over Pd/Ce-ZrO₂ under solvent-free condition

Shim, Jae-Oh,Jang, Won-Jun,Jeon, Kyung-Won,Lee, Da-We,Na, Hyun-Suk,Kim, Hak-Min,Lee, Yeol-Lim,Yoo, Seong-Yeun,Jeon, Byong-Hun,Roh, Hyun-Seog,Ko, Chang Hyun Elsevier 2018 Applied Catalysis A Vol.563 No.-

<P><B>Abstract</B></P> <P>The Ce/Zr ratio of Pd/Ce-ZrO<SUB>2</SUB> catalysts was systematically changed in order to investigate the effect of oxygen vacancy concentration on their decarboxylation activityunder solvent-free conditions for potential sustainable petroleum like biodiesel production. Pd/Ce<SUB>0.5</SUB>Zr<SUB>0.5</SUB>O<SUB>2</SUB> exhibited the highest catalytic activity from all other tested catalysts because it contained the highest oxygen vacancy concentration and Pd dispersion, as shown by the X-ray photoelectron spectroscopy, Raman spectroscopy, and CO-chemisorption data. A catalyst deactivation study also showed that both the Pd dispersion and the oxygen vacancy concentration influences the catalytic activity.The catalyst deactivation was found to occur mainly due to Pd sintering, decreases in the BET surface area and Pd dispersion, and partially due to the loss of oxygen vacancies.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Varying the Ce/Zr ratio effectively tunes the concentration of oxygen vacancies. </LI> <LI> High Pd dispersion and oxygen vacancy concentrations lead to enhanced activity. </LI> <LI> The catalyst deactivation was mainly caused by Pd sintering. </LI> <LI> Decarboxylation was found to be the main pathway in this reaction. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>