S-580 : Vitamin D and carotid subclinical atherosclerosis in SLE

( Chang Bum Bae ),( Ju Yang Jung ),( Bo Ram Go ),( Hyun Ah Kim ),( Chang Hee Suh ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Vitamin D and carotid subclinical atherosclerosis in SLE Chang-Bum Bae, Ju-Yang Jung, Bo-ram Go, Hyun-Ah Kim, Chang-Hee Suh Department of Rheumatology, Ajou University School of Medicine, Suwon, Korea Introduction Atherosclerosis develops earlier in systemic lupus erythematosus (SLE) and is the important cause of mortality. It has been suggested that vitamin D deficiency contributed cardiovascular disease and immune dysregulation in SLE. Methods One-hundred two female patients with SLE and 52 normal controls (NC) were recruited. The carotid artery intima-media thickness (cIMT) and plague were assessed by B-mode ultrasound at the carotid artery level. Vitamin 25(OH)D3 levels were checked by immunoradiometric assay using the Bio-Line 25(OH)D3-Ria CT kit (Bio-Line S.A., Belgium). Disease activity markers were checked at the time of enrollment. Results The cIMT of SLE is 0.41±0.08mm, which is higher than NC (0.37±0.11 mm, p=0.012). Also, carotid artery plague index (PI) of SLE is higher than NC (0.68±1.39 vs 0.26±0.87, p=0.026). The cIMT was correlated with age (r=0.442, p<0.001), body mass index (r=0.246, p=0.013), waist-hip ratio (r=0.245, p=0.013), SLE disease activity index (r=0.239, p=0.016), taking aspirin (r=0.244, p=0.013), and the carotid artery PI was correlated with renal involvement (r=0.224, p=0.023) in patients with SLE. Vitamin 25(OH)D3 was not showed correlation with cIMT and carotid artery PI. Also, it was not correlated with disease activity markers. Conclusion In patients with SLE, the risk of cardiovascular disease measured by cIMT and carotid artery plaque was higher than NC, which may be derived from systemic inflammation. However, vitamin D levels were not showed significant correlations with carotid subclinical atherosclerosis. It may be not suitable to assess vitamin D as marker of disease activity or subclinical atherosclerosis.

제왕절개 수술반흔에서 점액성 변화와 탈락막 변 화가 일어난 자궁내막증 2 예 및 조직면역학적연구

김주현(Ju Hyun Kim),한치동(Chi Dong Han),허창규(Chang Kyu Huh),조창호(Chang Ho Cho),고석봉(Suk Bong Koh) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.1

Decidualized cutaneous endometriosis infrequently arises in the absence of pelvic disease. It is described in which the histologic features included cytologic atypia, circumscription of endometrial epithelial cells with glandular or cystically dilated space, mononuclear cells within and around the endometrial nodules, and accompanied myxoid change. This histologic pseudomalignancy is not common and be misinterpreted as metastatic carcinoma or malignant tumors arising from soft tissue due to location of nodule and histologic feature. We have experienced two cases of myxoid change in decidualized cutaneous endometriosis in the abdominal scar following Cesarean section, which is presented with a brief review of the literature.

지역 언론의 구조적 악순환과 전략적 대안

강주현(Ju Hyun Kang),최창식(Chang shik Choi) 한국언론학회 2021 한국언론학보 Vol.65 No.1

As technology continues to develop and diffuse rapidly, drastic changes are taking place in various areas of our contemporary society, including the media environment and market. Local media, including local newspapers and local broadcasting stations are no exception to such change. In addition, as the traditional concept of locality, which is based on geographic space and boundary, evolves into a more multi-layered and complex concept of locality due to the development of transportation and communication technology, local media have been called on to newly establish the concept of locality in the changing media environment and required to seek their own way of survival and development. Beginning from this background, the current study conducted in-depth interviews with eight local newspaper reporters, including reporters from local newspapers and local correspondents of nation-wide newspapers. In the interviews with the reporters, the researchers asked several pivotal and probing questions, including those regarding the concept of locality they have in mind as local reporters, the meaning of the existence of local media, the current crisis and its causes surrounding their medium, and possible alternatives in their struggle for existence. After analysis, the researchers found that the interviewees from local newspapers are still sticking to the region-based traditional concept of locality and recognize themselves as chroniclers of local issues and history, advocates of the local people, and defenders of local interests against the central government. On the one hand, however, they confessed that the current local media crisis was caused not only by the external environment, such as increase of online news media, portal news, and breaking-news competition, but also internal problems, for example, the conservative atmosphere of their organization and internal resistance toward work environment changes. In addition, the interviewees suggested the necessity of crossover media production and deviations from existing practices. For example, newspaper companies need to have the ability to create and provide video content to their subscribers through different channels, such as YouTube, even though they have been known as newspaper companies through the decades in their respective regions. However, the researchers were not able to catch the recognition of neo-localism or hyper-localism, which have been suggested as new directions for the local media, from the interviewees. In summary, in order for the local media to overcome the current crisis and find a new way of survival and prosperity, it is recommended that they evolve their conception of locality into a multi-faceted one and become aware of new trends involving media localism.

사내커뮤니케이션과 구성원 정서적, 자주적, 변화참여 열의와의 관계 연구

신호창(Shin, Ho-Chang),송주현(Song, Ju-Hyun) 한국정치정보학회 2015 정치정보연구 Vol.18 No.2

본 연구는 현대 경영에서 중요시되는 소통과 그 동안 커뮤니케이션학에서는 잘 다루어지지 않았던 열의(engagement)의 개념에 주목하여 사내커뮤니케이션과 구성원 열의와의 관계를 통합적으로 고찰하였다. 이를 위해 실무 종사자 약 300여 명을 표집하여 서베이 연구를 실시하였으며, 본 정량적 연구결과를 보강하고 변인간의 관계를 심층적으로 이해하고자 사내커뮤니케이션과 밀접한 직무를 수행하는 국내 유수 기업의 홍보, 인사, 기업 문화 담당 실무자 11명을 대상으로 심층인터뷰를 진행했다. 연구결과, 사내커뮤니케이션의 차원과 구성원 열의의 세부 변인 간에 밀접한 영향 관계가 나타났다. 기업의 가치관(경영이념)에 대한 구성원의 이해가 높을수록 구성원은 기업에 대한 소속감, 애착감이 높아지는 상관관계가 나타났으며, 업무상황에서 개인의 커뮤니케이션 능력과 구성원의 역할인지가 높을수록 업무에 대한 의미감과 자신감이 높게 나타나는 정(+)적인 관계를 발견할 수 있었다. 또한 조직 변화 시기에 구성원의 지지와 참여를 이끌어내기 위해서는 커뮤니케이션 캠페인 활동이 필수적이며, 이를 통해 성공적인 변화를 안착할 수 있음이 드러났다. 본 연구는 그동안 다양한 용어와 개념적 접근으로 혼재되었던 열의(engagement)를 종합적으로 고찰하여 한국형 구성원 열의를 설명하고자 시도했던 첫 연구라 할 수 있다. 특히 구성원 열의를 자발적이고 능동적인 개념에 주목하여 3가지 차원(정서적 열의, 자주적 열의, 변화참여 열의)을 도출하였다는 점에서 현대 조직 구성원의 특성을 반영하여 열의에 대한 새로운 논의를 이끌어냈다. 또한, 실무적으로도 사보제작 및 사내방송을 통한 일방향적인 커뮤니케이션 전술의 한계를 벗어나 구성원의 열의를 증진시키는 데 기여할 수 있는 커뮤니케이션 콘텐츠 및 전략을 논의하였다. The purpose of present study is to identify relations of internal communication (sharing the values, clearness of work communication, communication campaigns) and employee engagement(affective, independent, change-participation will in change situation). The major findings of the study are summarized as follows: First, there is a direct correlation between sharing the values and affective employee engagement. Especially, employees’ understanding of CEO’s philosophy is significantly associated with employees’ membership and organizational identification. Second, the clearness of work communication has positively related to independent employee engagement in work circumstance. In particular, through the open communication at work, personal communication ability and knowledge of working role are considerably associated with perception of work meaningfulness and job confidence. Third, communication campaign has positive effect on employee change-participation will in organizational change situation. This study has a significance owing to looking into the relations between communication and employee engagement in multiple levels. It focuses on not only the specific conditions related to employee’s job satisfaction or citizenship behaviors but also participation will in organizational changing situation. Also, this study strongly concludes that internal communication factors need to be considered in order to increase the level of employee engagement and improve the work effectiveness.

Dangyuja (Citrus grandis Osbeck) Peel Improves Lipid Profiles and Alleviates Hypertension in Rats Fed a High-Fat Diet

Hyun Ju Hong,Ju Youn Jin,Heekyoung Yang,Won Young Kang,Dong Geon Kim,Sunyi Lee,Younghun Choi,Jae Hoon Kim,Chang Hoon Han,Young Jae Lee 한국실험동물학회 2010 Laboratory Animal Research Vol.26 No.4

Obesity is a major public health problem and significant risk factor for many serious diseases including coronary artery disease, cancer, and diabetes. This study was performed to investigate the hypolipidemic effects and anti-hypertensive effect of Dangyuja (Citrus grandis Osbeck) peel, which is bred on Jeju island, in rats fed a high-fat diet. This study was conducted on 4 equal rat groups which were fed as follows; normal diet group (ND), high fat diet group (HFD), high fat diet supplemented with powdered peel of Dangyuja (1%, wt/wt) group (HFD+Dangyuja), and high fat diet treated with sibutramine simultaneously at a dose of 10 ㎎/㎏ group (HFD+Sibutramine). After feeding the high fat diet, body weight gain and relative weight of adipose tissues and liver significantly increased in HFD group, but Dangyuja peel supplementation protected these HFD-induced changes. The levels of serum triglyceride, total cholesterol, low-density lipoprotein (LDL)-cholesterol, and the atherogenic index significantly decreased in the HFD+Dangyuja peel group compared with the HFD group. The systolic blood pressure was significantly increased by feeding the high fat diet, whereas the supplementation of Dangyuja peel effectively prevented the elevation of blood pressure. Therefore, these results suggest that Dangyuja exerts a beneficial effect on obesity by improving lipid metabolism and alleviating obesity-related hypertension.

안구적출에 따른 위둔덕의 Calbindin D-28k과 c-fos의 변화에 관한 연구

김명,김기훈,김주영,하현철,안명수,김장민,조향훈,정명섭,장인엽 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Changes of Calbindin D-28k- and c-fos-immunoreactivities in the superior collicuclus after Eye Enucleation. Objective and methods: Calcium-binding proteins (CBPs) play an important role in the protection, differentiation and reorganization of the central nervous system. The effects of neonatal retinal deafferentation on a CBPs, calbindin D-28k were examined immunohistochemically in the superficial layer of the rat superior colliculus. Also early gene familly c-fos was examined to evaluate the neuronal characteristics in the superior colliculus after monocular enucleation. Results: On the experimental side of superior colliculus, the number of calbindin D-28k-immunoreactive (IR) cells was reduced (77.4% compared to control), but not fibers. Appearance of c-fos-like immunoreactivity was represented much more in the ipsilateral superior colliculus than contralateral side within 24h after eye enucleation. Conclusion: These results suggest that the changes of retinotectal projection may alter the expressional pattern of calbindin D-28k and c-fos expression.

자동차 칵핏 모듈용 플라스틱 소재의 열화 동특성 평가

우창수(Chang Su Woo),박현성(Hyun Sung Park),조진호(Jin Ho Jo),김지훈(Ji Hoon Kim),최주호(Ju Ho Choi),김영국(Yeoung Kuk Kim) 대한기계학회 2012 大韓機械學會論文集A Vol.36 No.12

플라스틱 소재는 온도, 습도 및 자외선 등 다양한 환경의 영향으로 인해 기계적 물성변화가 심하기 때문에 체결부의 견고함이 느슨해지고 형태의 변형에 의해 부품간의 마찰 등을 유발하여 잡음이 발생하게 된다. 따라서, 본 논문에서는 자동차 칵핏 모듈에 사용되는 다양한 플라스틱 소재에 대해 온도변화에 따른 동 특성시험을 통해 유리전이온도, 저장탄성계수, 손실계수 등을 측정하여 상온 및 열화조건에 따른 물성변화를 파악하였다. 시험결과, 온도가 높을수록 저장탄성계수는 감소하고 손실계수는 증가하는 경향을 나타내었다. Engineering plastics are used in instrument panels, interior trim, and other vehicle applications, and the thermomechanical behaviors of plastic materials are strongly influenced by many environmental factors such as temperature, sunlight, and rain. As the material properties change, the mechanical parts create unexpected noise. In this study, the dynamic mechanical property changes of plastics used in automobiles are measured to investigate the temperature effects. Viscoelastic properties such as the glass transition temperature and storage modulus and loss factor under temperature and frequency sweeps were measured. The data were compared with the original ones before aging to analyze the behavior changes. It was found that as the temperature increased, the storage modulus decreased and the loss factor increased slightly.

Protective effect of chorioamnionitis on the development of bronchopulmonary dysplasia triggered by postnatal systemic inflammation in neonatal rats

Choi, Chang Won,Lee, Juyoung,Oh, Joo Youn,Lee, Seung Hyun,Lee, Hyun Ju,Kim, Beyong Il Nature Publishing Group 2016 Pediatric research Vol.79 No.2

<P><B>Background:</B></P><P>Prenatal or postnatal systemic inflammation can contribute to the development of bronchopulmonary dysplasia (BPD). We investigated whether prenatal intra-amniotic (i.a.) inflammation or early postnatal systemic inflammation can induce BPD in a rat model.</P><P><B>Methods:</B></P><P>One microgram of lipopolysaccharide (LPS) or vehicle was injected into the amniotic sacs 2 d before delivery (E20). After birth, 0.25 mg/kg of LPS or vehicle was injected into the peritoneum of pups on postnatal day (P)1, P3, and P5. On P7 and P14, peripheral blood (PB), bronchoalveolar lavage fluid (BALF), and lung tissue were obtained and analyzed.</P><P><B>Results:</B></P><P>Postnatal i.p. injections of LPS significantly increased neutrophil counts in PB and BALF on P7 and P14. Similarly, proinflammatory cytokine and angiogenic factor transcript levels were increased in the lung by i.p. LPS on P7. Alveolar and pulmonary vascular development was markedly disrupted by i.p. LPS on P14. However, pretreatment with i.a. LPS significantly negated the detrimental effects of postnatal i.p. LPS on PB and BALF neutrophil counts and on lung proinflammatory cytokine expression and histopathological changes.</P><P><B>Conclusion:</B></P><P>Exposure to early postnatal systemic LPS induces BPD, an arrest in alveolarization, in neonatal rats. Preceding exposure to i.a. LPS protects the lungs against BPD triggered by postnatal systemic inflammation.</P>

자동차 칵핏 모듈용 플라스틱 소재의 열화 동특성 평가

우창수(Chang Su Woo),박현성(Hyun Sung Park),조진호(Jin Ho Jo),김지훈(Ji Hoon Kim),최주호(Ju Ho Choi),김영국(Yeoung Kuk Kim) 대한기계학회 2012 대한기계학회 춘추학술대회 Vol.2012 No.5-2

플라스틱 소재는 온도, 습도 및 자외선 등 다양한 환경의 영향으로 인해 기계적 물성변화가 심하기 때문에 체결부의 견고함이 느슨해지고 형태의 변형에 의해 부품간의 마찰 등을 유발하여 잡음이 발생하게 된다. 따라서, 본 논문에서는 자동차 칵핏 모듈에 사용되는 다양한 플라스틱 소재에 대해 온도변화에 따른 동 특성시험을 통해 유리전이온도, 저장탄성계수, 손실계수 등을 측정하여 상온 및 열화조건에 따른 물성변화를 파악하였다. 시험결과, 온도가 높을수록 저장탄성계수는 감소하고 손실계수는 증가하는 경향을 나타내었다. Engineering plastics are used in instrument panels, interior trim, and other vehicle applications, and the thermo-mechanical behaviors of plastic materials are strongly influenced by many environmental factors such as temperature, sun light, and rain. As the properties change, the mechanical parts creating unexpected noise. In this paper, the dynamic mechanical property changes of plastics for automobiles are measured to investigate the temperature effects. Visco-elastic properties such as the glass transition temperature and storage modulus and loss factor under temperature and frequency sweeps were measured. The data were compared with the original ones before the aging to analyze the behavior changes. As results, the temperature was increased, the storage modulus was decreased on the other hand, loss factor is slightly increases.

Real-Time External Compensation of Threshold Voltage Shift Using Double-Gate Oxide TFTs in a Gate Driving System

You, Bong-Hyun,Lee, Soo-Yeon,Hong, Seok-Ha,Lee, Jae-Hoon,Kim, Hyun-Chang,Ju, Ha-Ram,Choi, Moon-Chul,Jeong, Deog-Kyoon IEEE 2016 Journal of display technology Vol.12 No.9

<P>In order to suppress the malfunction caused by the shift of the threshold voltage (V-TH) of oxide thin film transistors (TFTs) to a negative value, double-gate TFTs are used in the shift register of the gate driving system to control V-TH by adjusting the top gate bias. The proposed circuit detects the current consumption of the shift register and adjusts V-TH so that the current consumption of the shift register is regulated within the desired value. The system includes a compensation algorithm, which can search for an optimized top gate bias in various circumstances such as process fluctuations and ambient temperature change. The proposed system provides a stable operation compared with a conventional structure especially at high temperature. Experimental results show that, in the conventional system without compensation, the output voltage of the shift register deteriorates at 80 degrees C and above, and the power consumption increases from 1.15 to 2.14 mW after 21600 s of continuous operation at 60 degrees C. On the other hand, the proposed system provides a stable gate output up to 100 degrees C and keeps the power consumption below 1.10 mW by adjusting the top gate bias responding to environment changes.</P>