Investigation of Transition Types of HPV DNA Test Results over Time in Korean Women

Ko, Kiwoong,Kwon, Min-Jung,Woo, Hee-Yeon,Park, Hyosoon Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8

Background: Understanding the history of human papilloma virus (HPV) infection is important for interpretation of a positive HPV DNA screening test, future work-up and treatment. We investigated the transition of HPV DNA test results in Korean women, and analyzed the association of cytology result with transition type. Materials and Methods: We retrospectively reviewed annual HPV DNA test results for 5,274 subjects between January 2005 and December 2012. Each subject had a minimum of five annual tests over the eight-year period. Based on the pattern of results, the transition type for each subject was assigned to one of the following: negative, persistent, latent, transient, and unclassifiable. Associations of cytology results with the HPV DNA transition types, number of positive results, and the durations of positive results were also analyzed. Results: The proportion of abnormal cytology findings decreased in the following order of transition patterns: persistent, latent, transient, and negative. Among transient patterns, a duration of three years or more significantly correlated with cytology results of non-high grade squamous intraepithelial lesion (HSIL; p<0.001). In the persistent group, duration of five years or more correlated with both non-HSIL and HSIL (p<0.001). Latent group showed no correlation with duration. Irrespective of patterns, having five or more positive results was significantly associated with HSIL (p<0.001). Conclusions: Our findings may contribute to better understanding of HPV infection, interpretation of HPV DNA screening results, and prediction of prognosis according to transition type.

CASE 프로그램에 의한 중학생들의 인지가속 효과

최병순,한효순,강성주,이상권,강순희,박종윤,남정희 한국과학교육학회 2002 한국과학교육학회지 Vol.22 No.4

학생들의 인지발달을 촉진시켜 학습효과를 높이려고 개발된 CASE 프로그램의 효과를 조사했다. 중학교 1학년(841명) 학생들이 연구에 참가하였으며, 같은 분량의 시간동안 실험반에서는 교육과정에 따른 과학 교과 수업과 '생각하는 과학' 활동을 병행하였고, 통제반에서는 과학교과 수업만을 수행하였다. 연구 초기에 논리적 사고력 검사(SRT II)를 이용하여 집단의 동질성을 비교하고, 2년 동안 실험반에 CASE프로그램을 처치한 후 이질동형겸사도구인 SRT VII을 이용하여 처치별, 성별, 인지수준별 인지가속에 대한 효과를 조사했다. CASE 프로그램에 의한 중학생들의 인지발달 가속효과는 중간검사에서는 보이지 않았으나, 사후검사에서 상당히 큰 것으로 확인되었다. 성별에 따라 CASE 프로그램의 효과를 비교한 결과 남??여 중학생들 모두에게 유의미한 인지가속이 이루어진 것으로 나타났다. 남학생들 보다 여학생들의 인지수준이 더 발달된 것으로 밝혀졌으며, 처치와 성별간 상호작용 효과는 나타나지 않았다. 학생들의 사전 인지수준에 따라 CASE 프로그램의 효과를 분석한 결과, 모든 인지수준에서 처치효과가 뚜렷하게 있었으나 특별한 경향성은 나타나지 않았다. 특히 초기 구체적 조작기(ES=1.1.)와 전조작기(ES=1.07), 그리고 구체적조작 후기(ES=1.01) 학생들에게 상당히 큰 효과가 있었다. 이상과 같은 CASE 프로그램의 성공적인 결과는 현행 우리나라 과학교육과정 개정과 교수방법 개선에 시사하는 바가 많다. In an attempt to accelerate the development of formal reasoning ability of students, 'Thinking Science' activities developed by the Cognitive Acceleration through Science Education(CASE) project were implemented to 841 students in 7th grade aged 12+ in six middle schools over a period of two years. Homogeneity between the CASE group and control group was tested with SRT Ⅱ, while the improvement of formal reasoning ability of the students was tested with SRT Ⅶ. The results were analyzed by treatment, gender, and cognitive levels of the students. Statistically significant gains were shown in the CASE group compared with those in the control group. Cognitive level of girls in the CASE group significantly increased as compared with the control group, while there was moderate effect in boys. These results implied that the thinking science activities were effective in cognitive acceleration of girls aged 12+. It was shown that much more CASE students in pre or concrete operational level shifted. to formal operational level as compared with the control group while there were significant effects in all levels (ES=0.31∼1.10) without showing any tendency.

Association of Prostate Specific Antigen Concentration with Lifestyle Characteristics in Korean Men

Woo, Hee-Yeon,Park, Hyosoon,Kwon, Min-Jung,Chang, Yoosoo,Ryu, Seungho Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11

We investigated the relationships between demographics, lifestyle characteristics, and serum total prostate specific antigen (PSA) concentration and examined the population-based distribution of total PSA by age among 2,246 Korean men with a median age of 45 years. We obtained data about demographic and lifestyle characteristics based on self-reporting using a quetionnaire. We also performed physical examinations, anthropometric measurements, and biochemical measurements. The PSA concentration increased with age and there was a significant difference in total PSA concentration between the age groups of 21-60 years and >60 years. Age >60 years, height ${\geq}1.8$ m, a low frequency of alcohol consumption, and taking nutritional supplements showed a significantly increased odds ratio for increased PSA when 3.0 ng/mL was chosen as the PSA cut-off level. Smoking status, BMI, percent body fat, diabetes mellitus, fatty liver, herbal medicine use, vitamin use, and diet were not significantly associated with total PSA regardless of the cut-off level. When interpreting a single PSA test, height, alcohol consumption, and nutritional supplement use should be considered, in addition to age.

무선통신 시스템에서의 비례지연서비스를 위한 플로우 기반 WTP 스케쥴러

박효순,권은현,김태현,이재용,Park Hyosoon,Kwon Eunhyun,Kim Taehyoun,Lee Jaiyong 한국통신학회 2005 韓國通信學會論文誌 Vol.30 No.7B

본 논문에서는 무선 통신시스템에서 클래스간 비례지연 서비스를 위한 Flow Based Waiting Time Priority (FB-WTP) 스케쥴러를 제안한다. 기존의 스케쥴러는 클래스 단위로 동작하는 유선망의 구조를 그대로 사용하나, 제안된 FB-WTP 스제쥴러는 이와 달리 플로우 단위로 동작을 하며, 네트웍크 운영자가 입력한 클래스간 목표 큐잉 지연 비율은 기존 알고리즘과 같이 거의 동일하게 만족 시키면서도 클래스별 평균 큐잉 지연 성능은 월등히 향상 되었다. 이것은 각 플로우의 채널 환경이 동적으로 변화는 무선 환경에서 FB-WTP는 다중 플로우 다이버시티 효과를 최대한 이용 하기 때문이다. 또한 기존 알고리즘들에서 발생 할 수 있는 HOL 패킷 블록킹 문제가 발생하지 않는다. 성능평가를 위한 모의 실험에서 다중 채널 상태를 고려한 Look-ahead Waiting Time Priority (LWTP) 스케줄링 알고리즘과의 비교 분석으로 제안한 FB-WTP가 클래스간 목표 큐잉 지연 비율을 만족 시킬뿐만 아니라 LWTP에 비해 클래스별 평균 큐잉 지연 특성이 향상됨을 보였다. In this paper, we propose a Flow Based Waiting Time Priority (FB-WTP) scheduler that supports the proportional delay differentiated services between classes. Existing scheduling algorithms utilize the configuration of scheduler, which is operated as class unit, applied to wired network. However, FB-WTP scheduler is operated as flow unit and can take advantage of multi-flow diversity effect in time-varying channel state environment. As a result, FB-WTP improves the average queueing delay on each class as well as supporting the average queueing delay ratio between classes. It also solves the HOL packet blocking problem implicitly. Simulation results show that FB-WTP scheduler has better system queueing delay performance than Look-ahead Waiting Time Priority (LWTP) scheduler and supports the larger queueing delay ratio between classes that network operator set.

An Assessment Protocol on Accessibility of Smart-Home Environment for People with Disability

( Jeonghyun Kim ),( Jongbae Kim ),( Myoungjun Lim ),( Hyosoon Kwon ),( Heesuk Lee ),( Kyungsun Pyo ) 한국감성과학회 2014 춘계학술대회 Vol.2014 No.-

A Quality of Life Technology (QoLT) research team at NRRI design and build a QoLT testbed for assessing QoLT products, i.e., highly advanced assistive devices, and prescribing appropriate living environment for the individuals with disability. The QoLT testbed is possible by Focus Group`s participation in user needs analysis, design, and building of the testbed. To design effective and efficient method of prescription and delivery of appropriate independent living environment for the individuals with disability, the QoLT team at NRRI designs a tentative assessment protocol focused on performance and satisfaction, parts of accessibility and usability, and evaluate the tentative protocol for seven months. The tentative assessment protocol for accessibility and usability of assistive devices in testbed environment for independent living of individuals with disability including Spinal Cord Injury (SCI) is designed and verified with outcomes of 15 cases. The tentative assessment protocol is designed by referring Canadian Occupational Performance Measurement (COPM) with ten scale-based scoring and performed by an Occupational Therapist. The 15 subjects are 10 individuals with SCI - seven cervical spinal cord injury, two thoracic spinal cord injury, one lumbar spinal cord injury - and five individuals with stroke - three individuals with left hemiplegia and two individuals with right hemiplegia. 15 subjects are taken surveys before and after living in the testbed from one week up to four weeks, which is a part of the tentative assessment protocol.

An Assessment Protocol on Accessibility of Smart-Home Environment for People with Disability

Jeonghyun Kim,Jongbae Kim,Myoungjun Lim,Hyosoon Kwon,Heesuk Lee,Kyungsun Pyo 대한인간공학회 2014 대한인간공학회 학술대회논문집 Vol.2014 No.5

Comparison of the efficacy of disinfectants in automated endoscope reprocessors for colonoscopes: tertiary amine compound (Sencron2®) versus ortho-phthalaldehyde (Cidex®OPA)

( Hyun Il Seo ),( Dae Sung Lee ),( Eun Mi Yoon ),( Min Jung Kwon ),( Hyosoon Park ),( Yoon Suk Jung ),( Jung Ho Park ),( Chong Il Sohn ),( Dong Il Park ) 대한장연구학회 2016 Intestinal Research Vol.14 No.2

Background/Aims: To prevent the transmission of pathogens by endoscopes, following established reprocessing guidelines is critical. An ideal reprocessing step is simple, fast, and inexpensive. Here, we evaluated and compared the efficacy and safety of two disinfectants, a tertiary amine compound (TAC) and ortho-phthalaldehyde (OPA). Methods: A total of 100 colonoscopes were randomly reprocessed using two same automated endoscope reprocessors, according to disinfectant. The exposure time was 10 minutes for 0.55% OPA (Cidex® OPA, Johnson & Johnson) and 5 minutes for 4% TAC (Sencron2®, Bab Gencel Pharma & Chemical Ind. Co.). Three culture samples were obtained from each colonoscope after reprocessing. Results: A total of nine samples were positive among the 300 culture samples. The positive culture rate was not statistically different between the two groups (4% for OPA and 2% for TAC, P =0.501). There were no incidents related to safety during the study period. Conclusions: TAC was non-inferior in terms of reprocessing efficacy to OPA and was safe to use. Therefore, TAC seems to be a good alternative disinfectant with a relatively short exposure time and is also less expensive than OPA. (Intest Res 2016;14:178-182)

Late Diagnosis of Wilson Disease, Initially Presenting as Cerebellar Atrophy Mimicking Spinocerebellar Ataxia, by Multigene Panel Testing

Min-Kyeong Kim,Kyunghoon Lee,Hee-Yeon Woo,Hyosoon Park,Suho Ro,Won Tae Yoon,Min-Jung Kwon 대한진단검사의학회 2020 Annals of Laboratory Medicine Vol.40 No.6