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韓國産 紅花子와 中國産 紅花子가 鎭痛 , 消炎 및 關節炎에 미치는 效果
서부일,이은숙,박지하,김상찬,변부형,최호영 대한본초학회 2001 大韓本草學會誌 Vol.16 No.1
This experimental study was done to compare the efficacy of Korean and Chinese Carthami Semen on analgesic effect and remedy of inflammation and arthritis. The results were as follows; 1. In analgesic action on the writhing syndrome in mice induced by 0.7% acetic acid, Korean and Chinese Carthami Semen extract group showed significant decrease in comparison with control group. And in analgesic action on the writhing syndrome in mice induced by Acetylcholine HC1, Korean and chinese Carthami Semen extract group showed significant decrease in comparison with control group. 2. In Anti-inflammatory effects, Chinese Carthami Semen extract group showed significant decrease at 150 and 180 minutes after inducing paw-edema in comparison with control group. 3. In the method of adjuvant arthritis, orally administered for 21 days, Korean Carthami Semen extract group showed significant inhibition of the hind paw edema after 1 day and 21 days. Whereas Chinese Carthami Semen extract group showed some reduction, but the results didn's show significant decrease. 4. In the level of leucocytes count, Korean and Chinese Carthami Semen extract group showed significant decrease in comparison with control group. And in the level of total protein. CRP and glucose, Korean and Chinese Carthami Semen extract group didn't showed significant change in comparison with control group.
최은석(Eun Suk Choi),정수룡(Su Ryong Jung),전무련(Mu Ryeun Jeun),이창구(Chang Goo Lee),최형경(Hyeong Kyeong Choi),조욱현(Woo Hyun Cho),이진관(Jin Kwan Lee),김용림(Yong Lim Kim),조동규(Dong Kyu Cho) 대한내과학회 1996 대한내과학회지 Vol.50 No.5
N/A Objectives: AFBN is a localized bacterial infection of the kidney presenting itself as an inflammatory mass without drainable pus. It is being increasingly recognized by current urographic imaging. It is important not to confuse AFBN with renal abscess or neoplasm as this might lead to inappropriate surgical therapy. This study was per- formed to find out clinical aspects of AFBN. Methods: From Jan. 1992 to Dec. 1993 in Dongkang hospital with a capacity of 600beds, 24cases thought to fulfill the sonographic criteria for AFBN were reviewed retrospectively. Results: 1) The overall male to female ratio was 4:20, and the age distribution ranged from 7 to 78years, and the mean age of overall patients was 35.7±15.9 years. 2) Underlying conditions could be identified in 13subjects(54.2%); pregnancy(N=5), diabetes mellitus (N=2), renal stone(N=2), previous urinary tract infection(N=2), etc. in order of frequency. 3) The duration of preadmission illness was 6.3±5.9 days(1-30). 4) Cardinal symptoms and signs were chills (100%), flank pain(83%), costovertebral angle tenderness(100%), fever(88%), pyuria(88%) and leukocytosis(79%). Urine culture revealed E. coli positive in 10out of 23patients tested: one patient had E. coli positive in blood culture. 5) In total 24 cases, There were two cases accompanying with intrarenal abscesses and one case progressing to intrarenal abscess. 6) All patients were admitted and treated with antibiotics. Fever and flank pain lasted 3.5±0.5 days and 4.1±2.2 days, respectively. No patient underwent surgical procedures. The duration of hospitalization was 8.9±4.4 days(2~20). Conclusion: AFBN is a focal variant of acute pyelonephritis with single area of suppuration. It is not an infrequent disease entity which has relatively good prognosis once diagnosed accurately in its early stage. With delayed treatment or inappropriate therapy, it probably progress to intrarenal abscess.
Medication Injection Safety Knowledge and Practices among Health Service Providers in Korea
Lee, Hyeong-Il,Choi, Ji-Eun,Choi, Sol-Ji,Ko, Eun-Bi Korean Society for Quality in Health Care 2019 한국의료질향상학회지 Vol.25 No.1
Purpose: Outbreaks resulting from medication injections have recently been on the rise in Korea despite various established guidelines. The objective of this study was to assess the degree to which healthcare professionals are aware of safe injection practice guidelines and to account for the adherence to and the deviation from safe injection guidelines formulated by healthcare providers. Methods: In November 2016, a cross-sectional anonymous questionnaire covering general characteristics of injections, patient safety culture, awareness of safe injection practices, and adherence to and barriers to safe injection guidelines was issued to healthcare providers who administer medication injections or manage and supervise these injections (N=550). Multivariate logistic regression analysis via enter method was performed to define the influencing factors of adherence of safe injection practices. Results: On average, respondents adhere to 17 of the 24 guidelines. Multivariate logistic regression found that those who were more likely to adhere to safe injection guidelines either underwent a patient safety training experience within the last year, provided care in a setting characterized by a highly developed patient safety culture, or were employed as physicians or nurses, as opposed to some other type of care provider. Barriers to safe injection guidelines were attributable to; thoughts of waste to discard leftover medicine, provisions that made adherence cumbersome, a weak culture of compliance, and insufficient amounts of injectable medicine, products, and education. Conclusions: The results of this study indicate that controllable factors like training experience of healthcare providers and patient safety culture were positively associated with adherence to safe injection practices. It was suggested that the training of healthcare providers on safe injection practices be a continuous process to promote patient safety. Additionally, there should be an increased focus on developing and implementing policies to improve patient safety culture from a prevention rather than post-management perspective.
Effects of myeloid sirtuin 1 deficiency on hypothalamic neurogranin in mice fed a high-fat diet
Kim, Kyung Eun,Jeong, Eun Ae,Shin, Hyun Joo,Lee, Jong Youl,Choi, Eun Bee,An, Hyeong Seok,Park, Kyung-Ah,Jin, Zhen,Lee, Dong Kun,Horvath, Tamas L.,Roh, Gu Seob Elsevier 2019 Biochemical and biophysical research communication Vol.508 No.1
<P><B>Abstract</B></P> <P>Hypothalamic inflammation has been known as a contributor to high-fat diet (HFD)-induced insulin resistance and obesity. Myeloid-specific sirtuin 1 (SIRT1) deletion aggravates insulin resistance and hypothalamic inflammation in HFD-fed mice. Neurogranin, a calmodulin-binding protein, is expressed in the hypothalamus. However, the effects of myeloid SIRT1 deletion on hypothalamic neurogranin has not been fully clarified. To investigate the effect of myeloid SIRT1 deletion on food intake and hypothalamic neurogranin expression, mice were fed a HFD for 20 weeks. Myeloid SIRT1 knockout (KO) mice exhibited higher food intake, weight gain, and lower expression of anorexigenic proopiomelanocortin in the arcuate nucleus than WT mice. In particular, KO mice had lower ventromedial hypothalamus (VMH)-specific neurogranin expression. However, SIRT1 deletion reduced HFD-induced hypothalamic neurogranin. Furthermore, hypothalamic phosphorylated AMPK and parvalbumin protein levels were also lower in HFD-fed KO mice than in HFD-fed WT mice. Thus, these findings suggest that myeloid SIRT1 deletion affects food intake through VMH-specific neurogranin-mediated AMPK signaling and hypothalamic inflammation in mice fed a HFD.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Myeloid surtuin1 deficiency increases food intake and body weight in normal diet (ND)-fed mice. </LI> <LI> Myeloid surtuin1 deficiency decreases hypothalamic POMC and neurogranin in ND-fed mice. </LI> <LI> High-fat diet (HFD) increases hypothalamic neurogranin in mice. </LI> <LI> Myeloid surtuin1 deficiency reduces HFD-induced neurogranin, p-AMPK, and parvalbumin in the hypothalamus. </LI> </UL> </P>
원적외선 온열요법이 혈액투석 환자의 혈관통로 기능에 미치는 효과
최향미 ( Hyang Mi Choi ),최은덕 ( Eun Duck Choi ),장소형 ( So Hyeong Jang ),김은희 ( Eun Hee Kim ),최미정 ( Mi Jung Choi ),백송이 ( Song Yi Back ),한복희 ( Bok Hee Han ) 병원간호사회 2015 임상간호연구 Vol.21 No.2
Purpose: For hemodialysis, a vascular access which can maintain a certain speed for a long time is required. The prevention of the vascular access dysfunction is very important to decrease morbidity and to improvethe quality of life of patients receiving hemodialysis It is reported that far infrared heat increases the blood flow by expanding capillaries and micro-arteriovenouses. This study aimed to evaluate the effect of far infrared heat therapy as a new nursing intervention for maintaining vascular access function and improving the blood flow of patients receiving hemodialysis. Methods: The quasi-experimental research of nonequivalent control group pre-post test design was carried out for 59 patients receiving hemodialysis 3 times per week at K medical center. A far infrared heat was applied to the experimental group for 3 months. Results: The arteriovenous fistula blood flow of the experimental group (far infrared heat therapy group) increased significantly when compared to the control group (p=.047). However, static intra-access pressure ratio(SIAPR)was not different statistically (p=.101). Conclusion: The far infrared therapy could be considered as nursing intervention of choice as it demonstrated increase in the arteriovenous fistula blood flow in the patients receiving hemodialysis.