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Antioxidative and Anticancer Activities of Korean Wild Edible Vegetables
Woo, Hye-Im;Hwang, Yu-Jin;Kim, Inhye;Park, Dong-Sik;Kim, Jaehyun;Om, Ae-Son;Hwang, Kyung-A 한양대학교 2011 韓國 生活 科學 硏究 Vol.31 No.2
The purpose of this study was performed to evaluated cytotoxicity of the water extract of five wild edible vegetables on five kinds of human cancer cells lines to provide as a fundamental data to be utilized for cancer chemopreventive agents. The total phenolics content of Ailanthus altissima, Patrinia saniculaefolia, Tetragonia tetragonoides, Aster yomena and Valeriana fauriei extracts were 73, 57, 32, 66, and 47 ㎎ GAE/g, respectively. In the α,α-diphenyl-β-picrylhydrazyl (DPPH) radical scavenging assay, Ailanthus altissima and Aster yomena the highest DPPH radical scavenging activity which were 45.1 and 45.8% at 100 ug/ml, respectively. The growth inhibitory activity of human cancer cells on HeLa, MKN-45 and NCI-H460 were 59, 66 and 60% in Patrinia saniculaefolia extract at 100 ㎍/㎖, respectively. In human colon cancer cell (HT29), Aster yomena extract showed 43.5% inhibitory activity at 100 ug/ml. The growth of human breast cancer cell (MCF-7) was inhibited 85.1% at 100 ug/ml by Ailanthus altissima extract.
Hye-Im Woo,Shin Hye Kwak,Yeojin Lee,Ji Hee Choi,Young Mi Cho,Ae-Son Om 대한암예방학회 2015 Journal of cancer prevention Vol.20 No.1
Background:This study evaluated the effect of vege-powder (VP), mainly consisted of chicory, broccoli, and whole grains, on bowel habit improvement and constipation alleviation. Methods:Using the Roman standard II, 96 male and female subjects in their twenties with constipation symptoms were divided into a control group or VP group. Subjects in a control group were supplied with rice flakes-powder (RFP) and subjects in the VP groupwere provided with 30 g of VP twice daily for 4 weeks. Constipation relief effectiveness was surveyed on 5-point Likert scales depending on stool hardness, amount of stool, sensation of incomplete evacuation, and straining to defecate at day 0, 14, and 28 of RFP or VP intake. Results:Repeated measures analysis of variance analysis revealed that VP intake caused significant temporal changes in stool hardness, amount, sensation of incomplete evacuation, and straining to defecate. In addition, significant differences between control andVP groups were found in stool hardness, amount, sensation of incomplete evacuation, and straining to defecate at day 14 and 28 of experimental diet consumption. VP supplement for 2 weeks significantly increased the evacuation frequency (1.04 ± 0.71), compared to controlgroup (0.41 ± 0.64) and this increase was maintained at 4 week of diet supplements. Conclusions:This result showed that constipated subjects who consumed VP, mainly consisting of chicory, broccoli, and whole grains, improved constipation symptoms at 2 and 4 weeks of consumption compared to those of control group who were provided with RFP.
Im, A-Rang,Kim, Young-Hwa,Uddin, Md. Romij,Lee, Hye Won,Chae, Seong Wook,Kim, Yun Hee,Jung, Woo Suk,Kang, Bong Ju,Mun, Chun Sun,Lee, Mi-Young Hindawi Publishing Corporation 2012 Evidence-based Complementary and Alternative Medic Vol.2012 No.-
<P>Antimycin A (AMA) damages mitochondria by inhibiting mitochondrial electron transport and can produce reactive oxygen species (ROS). ROS formation, aging, and reduction of mitochondrial biogenesis contribute to mitochondrial dysfunction. The present study sought to investigate extracts of <I>Scutellaria baicalensis</I> and its flavonoids (baicalin, baicalein, and wogonin), whether they could protect mitochondria against oxidative damage. The viability of L6 cells treated with AMA increased in the presence of flavonoids and extracts of <I>S. baicalensis</I>. ATP production decreased in the AMA treated group, but increased by 50% in cells treated with flavonoids (except wogonin) and extracts of <I>S. baicalensis</I> compared to AMA-treated group. AMA treatment caused a significant reduction (depolarized) in mitochondrial membrane potential (MMP), whereas flavonoid treatment induced a significant increase in MMP. Mitochondrial superoxide levels increased in AMA treated cells, whereas its levels decreased when cells were treated with flavonoids or extracts of <I>S. baicalensis</I>. L6 cells treated with flavonoids and extracts of <I>S. baicalensis</I> increased their levels of protein expression compared with AMA-treated cells, especially water extracts performed the highest levels of protein expression. These results suggest that the <I>S. baicalensis</I> extracts and flavonoids protect against AMA-induced mitochondrial dysfunction by increasing ATP production, upregulating MMP, and enhancing mitochondrial function.</P>