Effect of reservoir properties on the heat extraction performance in multi-well production EGS

Liu Songze,Wei Jianguang,Liu Hongliang,Liu Xuemei,Yan Bingxu 한국자원공학회 2021 Geosystem engineering Vol.24 No.4

A multi-well production enhanced geothermal system (EGS) with discrete fracture network is designed for heat extraction in this study. A thermal-hydraulic numerical simulation model is established, and the effect of reservoir properties on heat extraction is investigated. The results show that the growth rate of heat extraction efficiency will decrease as the mining time increases. The initial reservoir temperature has a positive correlation with average production temperature which provides a broad space for the use of extracted thermal energy. The variation of initial reservoir pressure has little effect on the heat extraction performance. A higher matrix permeability leads to a higher average production temperature and heat extraction ratio which prompts more working fluid flow into the matrix, the heat transfer process is enhanced. Under the conditions of this study, the preferred initial reservoir temperature is 493.15 K, the matrix permeability is 10−14m2.

Isogeometric method based in-plane and out-of-plane free vibration analysis for Timoshenko curved beams

Hongliang Liu,Xuefeng Zhu,Dixiong Yang 국제구조공학회 2016 Structural Engineering and Mechanics, An Int'l Jou Vol.59 No.3

In-plane and out-of-plane free vibration analysis of Timoshenko curved beams is addressed based on the isogeometric method, and an effective scheme to avoid numerical locking in both of the two patterns is proposed in this paper. The isogeometric computational model takes into account the effects of shear deformation, rotary inertia and axis extensibility of curved beams, and is applicable for uniform circular beams, and more complicated variable curvature and cross-section beams as illustrated by numerical examples. Meanwhile, it is shown that, the Cp–1-continuous NURBS elements remarkably have higher accuracy than the finite elements with the same number of degrees of freedom. Nevertheless, for in-plane or out-of-plane vibration analysis of Timoshenko curved beams, the NURBS-based isogeometric method also exhibits locking effect to some extent. To eliminate numerical locking, the selective reduced one-point integration and B projection element based on stiffness ratio is devised to achieve locking free analysis for in-plane and out-of-plane models, respectively. The suggested integral schemes for moderately slender models obtain accurate results in both dominated and non-dominated regions of locking effect. Moreover, this strategy is effective for beam structures with different slenderness. Finally, the influence factors of structural parameters of curved beams on their natural frequency are scrutinized.

MoS2 Layers Decorated RGO Composite Prepared by a One-Step High-Temperature Solvothermal Method as Anode for Lithium-Ion Batteries

Xuehua Liu,Bingning Wang,Jine Liu,Zhen Kong,Binghui Xu,Yiqian Wang,Hongliang Li 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.11

A one-step high-temperature solvothermal approach to the synthesis of monolayer or bilayer MoS2 anchored onto reduced graphene oxide (RGO) sheet (denoted as MoS2/RGO) is described. It was found that single-layered or double-layered MoS2 were synthesized directly without an extra exfoliation step and well dispersed on the surface of crumpled RGO sheets with random orientation. The prepared MoS2/RGO composites delivered a high reversible capacity of 900 mAhg -1 after 200 cycles at a current density of 200 mAg -1 as well as good rate capability as anode active material for lithium ion batteries. This one-step high-temperature hydrothermal strategy provides a simple, cost-effective and eco-friendly way to the fabrication of exfoliated MoS2 layers deposited onto RGO sheets.

Targeting treatment of bladder cancer using PTK7 aptamer-gemcitabine conjugate

Xiang Wei,Peng Yongbo,Zeng Hongliang,Yu Chunping,Zhang Qun,Liu Biao,Liu Jiahao,Hu Xing,Wei Wensu,Deng Minhua,Wang Ning,Liu Xuewen,Xie Jianfei,Hou Weibin,Tang Jin,Long Zhi,Wang Long,Liu Jianye 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Gemcitabine (GEM) is one of the first-line chemotherapies for bladder cancer (BC), but the GEMs cannot recognize cancer cells and have a low long-term response rate and high recurrence rate with side effects during the treatment of BC. Targeted transport of GEMs to mediate cytotoxicity to tumor and avoid the systemic side effects remains a challenge in the treatment of BC.Based on a firstly confirmed biomarker in BC-protein tyrosine kinase 7 (PTK7), which is overexpressed on the cell membrane surface in BC cells, a novel targeting system protein tyrosine kinase 7 aptamer-Gemcitabine conjugate (PTK7-GEMs) was designed and synthesized using a specific PTK7 aptamer and GEM through auto-synthesis method to deliver GEM against BC. In addition, the antitumor effects and safety evaluation of PTK7-GEMs was assessed with a series of in vitro and in vivo assays.PTK7-GEMs can specifically bind and enter to BC cells dependent on the expression levels of PTK7 and via the macropinocytosis pathway, which induced cytotoxicity after GEM cleavage from PTK7-GEMs respond to the intracellular phosphatase. Moreover, PTK7-GEMs showed stronger anti-tumor efficacy and excellent biosafety in three types of tumor xenograft mice models.These results demonstrated that PTK7-GEMs is a successful targeted aptamer-drug conjugates strategy (APDCs) to treat BC, which will provide new directions for the precision treatment of BC in the field of biomarker-oriented tumor targeted therapy.

Treatment of bladder cancer by geoinspired synthetic chrysotile nanocarrier-delivered circPRMT5 siRNA

Chunping Yu,Yi Zhang,Ning Wang,Wensu Wei,Ke Cao,Qun Zhang,Peiying Ma,Dan Xie,Pei Wu,Biao Liu,Jiahao Liu,Wei Xiang,Xing Hu,Xuewen Liu,Jianfei Xie,Jin Tang,Zhi Long,Long Wang,Hongliang Zeng,Jianye Liu 한국생체재료학회 2022 생체재료학회지 Vol.26 No.1

Background: Circular RNAs (circRNAs) have important functions in many fields of cancer biology. In particular, we previously reported that the oncogenic circRNA, circPRMT5, has a major role in bladder cancer progression. Therapy based on circRNAs have good prospects as anticancer strategies. While anti-circRNAs are emerging as therapeutics, the specific in vivo delivery of anti-circRNAs into cancer cells has not been reported and remains challenging. Methods: Synthesized chrysotile nanotubes (SCNTs) with a relatively uniform length (~ 200 nm) have been designed to deliver an siRNA against the oncogenic circPRMT5 (si-circPRMT5) inhibit circPRMT5. In addition, the antitumor effects and safety evaluation of SCNTs/si-circPRMT5 was assessed with a series of in vitro and in vivo assays. Results: The results showed that SCNTs/si-circPRMT5 nanomaterials prolong si-circPRMT5’s half-life in circulation, enhance its specific uptake by tumor cells, and maximize the silencing efficiency of circPRMT5. In vitro, SCNTs encapsulating si-circPRMT5 could inhibit bladder cancer cell growth and progression. In vivo, SCNTs/si-circPRMT5 inhibited growth and metastasis in three bladder tumor models (a subcutaneous model, a tail vein injection lung metastatic model, and an in situ model) without obvious toxicities. Mechanistic study showed that SCNTs/sicircPRMT5 regulated the miR-30c/SNAIL1/E-adherin axis, inhibiting bladder cancer growth and progression. Conclusion: The results highlight the potential therapeutic utility of SCNTs/si-circPRMT5 to deliver si-circPRMT5 to treat bladder cancer.

Transcriptome analysis reveals genes connected to temperature adaptation in juvenile antarctic krill Euphausia superba

Liu Yongliang,Li Lingzhi,Yang Jialiang,Huang Hongliang,Song Wei 한국유전학회 2023 Genes & Genomics Vol.45 No.8

Background The Antarctic krill, Euphausia superba (E. superba), is a key organism in the Antarctic marine ecosystem and has been widely studied. However, there is a lack of transcriptome data focusing on temperature responses. Methods In this study, we performed transcriptome sequencing of E. superba samples exposed to three different temperatures: −1.19 °C (low temperature, LT), − 0.37 °C (medium temperature, MT), and 3 °C (high temperature, HT). Results Illumina sequencing generated 772,109,224 clean reads from the three temperature groups. In total, 1,623, 142, and 842 genes were differentially expressed in MT versus LT, HT versus LT, and HT versus MT, respectively. Moreover, Kyoto Encyclopedia of Genes and Genomes analysis revealed that these differentially expressed genes were mainly involved in the Hippo signaling pathway, MAPK signaling pathway, and Toll−like receptor signaling pathway. Quantitative reverse-transcription PCR revealed that ESG037073 expression was significantly upregulated in the MT group compared with the LT group, and ESG037998 expression was significantly higher in the HT group than in the LT group. Conclusions This is the first transcriptome analysis of E. superba exposed to three different temperatures. Our results provide valuable resources for further studies on the molecular mechanisms underlying temperature adaptation in E. superba.

Adaptive Complex Interpolator for Channel Estimation in Pilot-Aided OFDM System

Liu, Guanghui,Zeng, Liaoyuan,Li, Hongliang,Xu, Linfeng,Wang, Zhengning The Korea Institute of Information and Commucation 2013 Journal of communications and networks Vol.15 No.5

In an orthogonal frequency division multiplexing system, conventional interpolation techniques cannot correctly balance performance and overhead when estimating dynamic long-delay channels in single frequency networks (SFNs). In this study, classical filter analysis and design methods are employed to derive a complex interpolator for maximizing the resistible echo delay in a channel estimator on the basis of the correlation between frequency domain interpolating and time domain windowing. The coefficient computation of the complex interpolator requires a key parameter, i.e., channel length, which is obtained in the frequency domain with a tentative estimation scheme having low implementation complexity. The proposed complex adaptive interpolator is verified in a simulated digital video broadcasting for terrestrial/handheld receiver. The simulation results indicate that the designed channel estimator can not only handle SFN echoes with more than $200{\mu}s$ delay but also achieve a bit-error rate performance close to the optimum minimum mean square error method, which significantly outperforms conventional channel estimation methods, while preserving a low implementation cost in a short-delay channel.

Influences of Pump Spot Radius and Depth of Focus on the Thermal Effect of Tm:YAP Crystal

Hongliang Zhang,Ya Wen,Lin Zhang,Zhen Fan,Jinge Liu,Chunting Wu 한국광학회 2019 Current Optics and Photonics Vol.3 No.5

The thermal effect and the light output of a laser crystal under different pumping depths were reported., Based on the thermal model of a single-ended pumped Tm:YAP crystal, the thermal stress coupled model used Comsol to theoretically calculate the effect of changing the pump spot size and pump depth on crystal heat distribution and stress distribution. The experimental results showed that the laser output power first increased and then decreased with increasing pump spot size. As the depth of focus increased, the laser output power first increased and then decreased. The experimental results were consistent with the theoretical simulation results. The theory of pump spot radius and depth of focus in this paper provided an effective simulation method for mitigating thermal effects, and provided theoretical supports for laser crystals to obtain higher laser output power.

Evaluation of Solar Temperature Field under Different Wind Speeds for Shanghai 65 m Radio Telescope

Hongliang Qian,Deshen Chen,Feng Fan,Ye Liu,Shi-zhao Shen 한국강구조학회 2016 International Journal of Steel Structures Vol.16 No.2

The Shanghai 65 m radio telescope is currently the largest full range rotatable radio telescope in Asia. Gravity, wind and temperature are the three main factors which may have a bad effect on the reflector’s surface precision. To study the effect of the thermal deformation caused by daily non-uniform temperature fields on the surface precision of the main reflector, both the temperature field and its effect were studied in detail for two typical days (January 15th and July 15th). The method to simulate temperature fields was studied initially, considering heat conduction, solar radiation, shadowing, air convection, sky radiation and ground radiation. Then, an integral parametric thermal finite element model (FEM) of the telescope was established using the ANSYS thermal analysis module. Finally, the effect of non-uniform temperature fields on the surface precision of the main reflector was estimated in terms of the Root Mean Square (RMS) deformation based on temperature transient analysis. The proposed methods and conclusions drawn can provide valuable information for thermal design, thermal monitoring and thermal control of the Shanghai 65 m radio telescope and other similar giant antenna structures.

Robust CFO Acquisition in PN-Padded OFDM Systems

Guanghui Liu,Liaoyuan Zeng,Hongliang Li,Linfeng Xu,ZhengningWang 한국전자통신연구원 2013 ETRI Journal Vol.35 No.4

As an alternative to the traditional pilot-aided orthogonal frequency division multiplexing (OFDM), the time-domain pseudonoise (PN)-padded OFDM provides a higher spectral efficiency. However, the carrier frequency offset (CFO) attenuates peaks of the conventional PN correlation output, which limits the CFO estimation range of the OFDM synchronizer. An improved correlation is proposed in this letter to remove the CFO-induced amplitude attenuation of correlation peaks. For a synchronizer adopting the designed correlator, a larger range of CFO acquisition is obtained through using wider correlation windows with a smaller interval between them. The proposed method of CFO acquisition is verified in a digital terrestrial multimedia broadcast receiver, in which the synchronizer is able to acquire CFOs up to ±320 kHz in the DVB-T F1 channel. Furthermore, the acquisition range can be expanded in more favorable channels.