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Xuehua Liu,Mengmeng Li,Yuzhu Peng,Xiaoshan Hu,Jing Xu,Shasha Zhu,Zhangbin Yu,Shuping Han 생화학분자생물학회 2016 Experimental and molecular medicine Vol.48 No.-
MicroRNAs (miRNAs) are small, non-coding single-stranded RNAs that suppress protein expression by binding to the 3′ untranslated regions of their target genes. Many studies have shown that miRNAs have important roles in congenital heart diseases (CHDs) by regulating gene expression and signaling pathways. We previously found that miR-30c was highly expressed in the heart tissues of aborted embryos with ventricular septal defects. Therefore, this study aimed to explore the effects of miR-30c in CHDs. miR-30c was overexpressed or knocked down in P19 cells, a myocardial cell model that is widely used to study cardiogenesis. We found that miR-30c overexpression not only increased cell proliferation by promoting cell entry into S phase but also suppressed cell apoptosis. In addition, we found that miR-30c inhibited dimethyl sulfoxide-induced differentiation of P19 cells. miR-30c knockdown, in contrast, inhibited cell proliferation and increased apoptosis and differentiation. The Sonic hedgehog (Shh) signaling pathway is essential for normal embryonic development. Western blotting and luciferase assays revealed that Gli2, a transcriptional factor that has essential roles in the Shh signaling pathway, was a potential target gene of miR-30c. Ptch1, another important player in the Shh signaling pathway and a transcriptional target of Gli2, was downregulated by miR-30c overexpression and upregulated by miR-30c knockdown. Collectively, our study revealed that miR-30c suppressed P19 cell differentiation by inhibiting the Shh signaling pathway and altered the balance between cell proliferation and apoptosis, which may result in embryonic cardiac malfunctions.
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Xuehua Liu,Bingning Wang,Jine Liu,Zhen Kong,Binghui Xu,Yiqian Wang,Hongliang Li 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.11
A one-step high-temperature solvothermal approach to the synthesis of monolayer or bilayer MoS2 anchored onto reduced graphene oxide (RGO) sheet (denoted as MoS2/RGO) is described. It was found that single-layered or double-layered MoS2 were synthesized directly without an extra exfoliation step and well dispersed on the surface of crumpled RGO sheets with random orientation. The prepared MoS2/RGO composites delivered a high reversible capacity of 900 mAhg -1 after 200 cycles at a current density of 200 mAg -1 as well as good rate capability as anode active material for lithium ion batteries. This one-step high-temperature hydrothermal strategy provides a simple, cost-effective and eco-friendly way to the fabrication of exfoliated MoS2 layers deposited onto RGO sheets.
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Fuhao Liu,Hanjun Jiang,Shaona Liu,Xuehua Yu 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.12
A new analytical model of a spur gear system with sliding friction is presented. Unlike previous models, the excitation consists of two parts: the rotational driving speed of the pinion and the drag torque acting on the gear. The proposed model was validated with the finite element model. Using numerical method, the steady state resolutions was obtained to mainly demonstrate the nonlinear characteristics under both constant and variable excitations. The results obtained illustrate that sliding friction could introduce additional vibration. Moreover, the sliding friction even could decrease the dynamic transmission errors under proper operation condition. Further, the bifurcation diagram was plotted to show the influence of the rotational driving speed of the pinion on the dynamical characteristic of the gear system. Finally, the fluctuated excitation was used to exhibit their different effects on the gear system, which should form the basis of further analytical and experimental work in the gear dynamic area.
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A Hardware-in-the-loop Platform for Modular Multilevel Converter Simulations
Liu, Chongru,Tian, Pengfei,Wang, Yu,Guo, Qi,Lin, Xuehua,Wang, Jiayu The Korean Institute of Power Electronics 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.5
In this paper, a hardware-in-the-loop simulation platform for MMCs is established, which connects a real time digital simulator (RTDS) and a designed MMC controller with optical fiber. In this platform, the converter valves are simulated with a small time step of 2.5 microsecond in the RTDS, and multicore technology is implemented for the controller so that the parallel valve control is distributed between different cores. Therefore, the designed controller can satisfy the requirements of real-time control. The functions of the designed platform and the rationality for the designed controller are verified through experimental tests. The results show that different modulation modes and various control strategies can be implemented in the simulation platform and that each control objective can been tracked accurately and with a fast dynamic response.
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Liu Ran,Han Xuehua,Gao Jing,Luo Min,Guo Dale,Wang Guangzhi 한국균학회 2023 Mycobiology Vol.51 No.3
Penicillium oxalicum strain can be isolated from the Bletilla striata (Thunb.) Reichb. f. tubers. Its solid-state fermentation products are concentrated by percolation extraction. Separation and purification have been conducted to the ethyl acetate extracts by preparative HPLC. Based on the use of spectrometry, we have determined 17 known compounds, 12,13-dihydroxy- fumitremorgin C (1), pseurotin A (2), tyrosol (3), cyclo-(L-Pro-L-Val) (4), cis-4-hydroxy-8- O-methylmellein (5), uracil (6), cyclo-(L-Pro-L-Ala) (7), 1,2,3,4-tetrahydro-4-hydroxy-4-quinolin carboxylic acid (8), cyclo-(Gly-L-Pro) (9), 2’-deoxyuridine (10), 1-(b-D-ribofuranosyl)thymine (11), cyclo-(L-Val-Gly) (12), 2’-deoxythymidine (13), cyclo-(Gly-D-Phe) (14), cyclo-L-(4-hydroxyprolinyl)- D-leucine (15), cyclo-(L)-4-hydroxy-Pro-(L)-Phe (16), uridine (17). Here, we report compounds 1–3, 5, 7–8, 11–12, 14–17 are first found and isolated from this endophyte.
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A Hardware-in-the-loop Platform for Modular Multilevel Converter Simulations
Chongru Liu,Pengfei Tian,Yu Wang,Qi Guo,Xuehua Lin,Jiayu Wang 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.5
In this paper, a hardware-in-the-loop simulation platform for MMCs is established, which connects a real time digital simulator (RTDS) and a designed MMC controller with optical fiber. In this platform, the converter valves are simulated with a small time step of 2.5 microsecond in the RTDS, and multicore technology is implemented for the controller so that the parallel valve control is distributed between different cores. Therefore, the designed controller can satisfy the requirements of real-time control. The functions of the designed platform and the rationality for the designed controller are verified through experimental tests. The results show that different modulation modes and various control strategies can be implemented in the simulation platform and that each control objective can been tracked accurately and with a fast dynamic response.
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Bingning Wang,Xuehua Liu,Binghui Xu,Yanhui Li,Dan Xiu,Peizhi Guo,Hongliang Li 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.3
Three-dimensional reduced graphene oxide (RGO) matrix decorated with nanoflowers of layered MoS2 (denoted as 3D MoS2/RGO) have been synthesized via a facile one-pot stepwise hydrothermal method. Graphene oxide (GO) is used as precursor of RGOand a 3D GOnetwork is formed in the first-step of hydrothermal treatment. At the second stage of hydrothermal treatment, nanoflowers of layered MoS2 formand anchor on the surface of previously formed 3D RGO network. In this preparation, thiourea not only induces the formation of the 3D architecture at a relatively low temperature, but also works as sulfur precursor of MoS2. The synthesized composites have been investigated with XRD, SEM, TEM, Raman spectra, TGA, N2 sorption technique and electrochemical measurements. In comparison with normal MoS2/RGO composites, the 3D MoS2/RGO composite shows improved electrochemical performance as anode material for lithium-ion batteries. A high reversible capacity of 930 mAh · g -1 after 130 cycles under a current density of 200 mA · g -1 as well as good rate capability and superior cyclic stability have been observed. The superior electrochemical performance of the 3D MoS2/RGO composite as anode active material for lithium-ion battery is ascribed to its robust 3D structures, enhanced surface area and the synergistic effect between graphene matrix and the MoS2 nanoflowers subunit.
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MiR-137 inhibits the proliferation, invasion and migration of glioma via targeting to regulate EZH2
Gu Jingshun,Wang Juntong,You Aiwu,Li Jun,Zhang Yuyan,Rao Guomin,Ge Xuehua,Zhang Kun,Liu Xuan,Wang Dongchun 한국유전학회 2021 Genes & Genomics Vol.43 No.10
Background Gliomas are common malignant tumors in the nervous system, known for poor prognosis and low survival rate. Objective This study aims to explore functions of miR-137 in glioma progression and identify messenger RNAs (mRNA) regulated by miR-137, which provides new ideas for further exploration of glioma therapeutic targets. Methods Gene expression data were downloaded from the Cancer Genome Atlas database, and abnormally expressed miRNAs and mRNAs in glioma were analyzed. The expression of genes in 20 pairs of clinical tissue samples and glioma cell lines were detected through qRT-PCR, and the expression of proteins was detected through Western blot. Changes in cell proliferative level after transfection were detected via CCK8 assay, and changes in cell migratory and invasive abilities were detected by Transwell assay. Besides, dual-luciferase reporter assay was employed to testify binding relationship between two genes. Results Our study found that miR-137 was signifcantly and lowly expressed in glioma tissue and cell lines, and the prognoses of glioma patients with highly expressed miR-137 were more optimistic. Overexpressed miR-137 could remarkably inhibit proliferative, invasive and migratory abilities of glioma cells U87, while transfection of miR-137 inhibitor presented an opposite efect. Additionally, EZH2 was a direct target of miR-137 and overexpressed EZH2 efectively reversed the efect of miR-137 on glioma proliferation and migration. Conclusions Our study found that miR-137 could suppress the proliferation, invasion and migration of glioma cells through regulating the expression of EZH2. So far, we have found a novel regulatory pair that infuences glioma progression, providing a basis for further development of new therapeutic strategies.
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