유전학 연구실에 의뢰한 환자에 대한 염색체 연구

홍영범(YJ Hong),양재홍(JS Yang),정순오(SO Chung),곽현모(HM Kwak) 대한산부인과학회 1976 Obstetrics & Gynecology Science Vol.19 No.9

저자들은 1974년 1월부터 1975년 8월말까지 1년 8개월간 연세대학교 의과대학 부속 세브란 스병원에 입원하여 가료를 받았던 환자와 외래환자 중에서 유전적 질환이 의심되는 81예에 대하여 염색체 검사를 실시한 결과 39예의 이상을 얻었다. 그중 Down`s syndrome 13예 Turner`s syndrom 4예 Kleinefelter`s syndrome 2예, sex anomaly 가 19예로 나타났으며 전체 적으로 나타난 핵형의 종류는 다음과 같다. 1. Down`s syndrome은 primary 21 trisomy 와 mosaic type의 2가지가 보여졌다. 2. Turner`s syndrome은 45, X, 46, XX/45, X and 44, X, G/45, X의 3가지 핵형이 있었다. 3. Kleinefelter`s syndrome에서는 47, XXY 와 48, XXYY가 보여졌다. 4. Sex anomaly에는 XY female 와 XXmale 등이 보였다. The numerical and structural aberration of chromosomes were analysed from 81 patients who had been doubted as genetic disease in the genetics laboratory, Yonsei University Medical Center from Jan. 1. 1974 to Aug 31. 1975. Out of the 81 patients 39 had the abnormal karyotypes. 13 cases of Down`s syndrome, 4 cases of Turner`s syndrom , 2 cases of Kleinefelter`s syndrome and 19 cases of sex anomaly were found. All kinds of karyotypes observed were ; 1. Down`s syndrome ; primary 21 trisomy type and mosaic type 2. Turner`s syndrome ; 45, X, 46, XX/45, X and 44, X, G/45, X 3. Kleinefelter`s syndrome ; 47, XXY and 48, XXYY 4. Sex anomaly ; XY female and XXmale etc.

Electrical Polarization Characteristics and BSA Binding Capability of Hydrothermally Treated CaTiO₃ Powder

Hong SB,Seo YW,Jeong SH,Kim JW,Park YJ,Song HJ 대한치과재료학회 2011 대한치과기재학회 학술대회 Vol.2011 No.5

A humanized anti-4-1 BB monoclonal antibody suppresses antigen-induced humoral immune response in non-human primates

Hong HJ,Lee JW,Park SS,Kang YJ,Chang SY,Kim KM,Kim JO,Murthy KK,Payne JS,Yoon SK,Park MJ,Kim IC,Kim JG,Kang CY 대한약학회 2000 大韓藥學會 總會 및 學術大會 Vol.49 No.-

갱년기증후군 환자의 Hormone Replacement Treatment에 대한 혈중지질의 변화

이영진,홍민 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.10

This is the clinical data that evaluate the clinical effect of estrogen replacement therapy in postmenopausal women especially on cardiovascular effect by change of serum lipid profiles. Estrogen replacement therapy is known to reduce the incidence of cardiovascular disease in postmenopausal women, and its beneficial effect is thought to be mediated in part by the favoable changes in serum lipid profile. We treated 360 cases of postmenopausal patient who visitied Wonju christian hospital during the 24 months of period from March 1993 to May 1995. The result were as follows; 1. Total cholesterol was significantly decreased(-3.46% - -8.64%) during all period. 2. HDL cholesterol was significantly increased(+5.16% - +6.73%) during all period. 3. Total cholesterol/HDL ratio was significanlty decreased(3.19-2.73) during all period. So we concluded that the estrogen replacement therapy was effective on the prevention of cardiovascular disease.

새만금 주변해역의 동수역학적 변동 특성

박영진(YJ.Park),송현구(H.G.Song),김용관(Y.KKim),홍도응(D.U.Hong),김종규(J.KKim) 한국해양환경·에너지학회 2012 한국해양환경공학회 학술대회논문집 Vol.2012 No.5

새만금 방조제 주변해역의 동수역학적 특성을 파악하기 위하여 방조제 주변인 호내와 외측에서 수위(조위)와 유동관측 및 EFDC모델을 이용한 수치실험을 수행하였다. 수치실험의 수위(조위) 및 유동 검증결과는 정도 및 재현성에 있어서 양호한 결과를 제시하였으며, 만경강 및 동진강의 하천 유출수량과 조석 및 조류에 의한 유량의 변동 특성을 잘 반영하고 있음을 확인할 수 있었다. 따라서, 이들 결과들은 향후 새만금방조제 수문개폐 등의 효율적 수위관리를 위한 기초자료로 활용될 수 있을 것으로 판단된다. The hydraulic characteristics around the Saemangeum seadike was observed flow and water(tide) level in the inside and outside of Seamangeum seadike. As a results, the flow is greatly affected by sluice gate at the Shinsi and Galuck, and the change of water level is affected by river outflow and open the sluice gate.

외상성 내경동맥 거대 가성동맥류 1례의 혈관내 치료

이명섭,김영주,김명순,박정미,홍순기,황 금 대한신경외과학회 2002 Journal of Korean neurosurgical society Vol.31 No.4

제왕절개술후 복벽반흔에 발생한 자궁내막증의 임상적 고찰

서영욱,박윤정,박정엽,홍성률,이태엽,공두식,조창호 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.4

배경: 외과적 수술후 반흔부위에 발생하는 자궁내막증은 비교적 드문 질환으로 주로 제왕절개술이나 자궁절개술이후에 발생하는 것으로 알려져 있다. 최근 이질환이 증가하는 경향을 보이나 그 임상적 중요성에 대해서는 잘 알려져 있지 않다. 이에 저자들은 지금까지 경험한 제왕절개술후 수술반흔부위에 발생한 자궁내막증 환자들의 임상적 결과를 분석하고 월경력 및 수술후 수술부위에 자궁내막증이 발생하기까지의 기간을 비교함으로써 수술후 반흔부위에 발생한 자궁내막증의 진단에 도움이 되고자 하였다. 방법: 1981년부터 1997년까지 포항 선린병원, 마산 삼성병원, 마산 파티마병원, 대구 파티마병원에서 제왕절개술을 시행받은 환자중 술후 복벽반흔에 자궁내막증이 발생된 11명과 국내문헌에 보고된 12명을 대상으로 하였다. 이들의 임상적 자료, 수술소견, 조직학적 소견을 분석하였으며 월경력 및 수술후 수술부위에 자궁내막증이 발생하기까지의 기간을 비교하였다. 결과 : 1] 23명 전례[100%]에서 종물감 촉지 및 국소적 동통이 있었으며 5명[21.7%]에서 월경통이 동반되었다. 2] 23명 전례[100%]에서 종물은 단단하게 만져졌으며 19명[92.3%]에서 불규칙적인 종물의 경계를 보였다. 3] 2명[8.7%]에서 피하조직, 복직근 및 복막까지의 침범소견을 보였으며 2명[8.7%]에서 각각 자궁후벽과 우측난소 침범소견을 보였다. 4] 초경과 월경주기, 수술후 수술부위에 자궁내막증이 발생하기까지의 기간은 술후 반흔부위에 발생한 자궁내막증의 빈도에 큰영향을 주지 못했으나[p$gt;0.05] 월경주기가 규칙적인 경우가 불규칙적인 경우에 비해 의미있게 많았으며 월경기간이 정상적인 경우가 긴경우에 비해 의미있게 많은 소견을 보였다[p$lt;0.05]. 결론: 제왕절개술을 시행받은후 복벽반흔에 자궁내막증으로 진단받은 환자에서 초경, 수술후 수술부위에 자궁내막증이 발생하기까지의 기간은 임상적으로 중요한 의미를 나타내지 않을것으로 생각되며 월경주기의 규칙성 및 월경기간은 임상적으로 중요한 인자가 될것으로 보이며 향후 더많은 연구가 필요할것으로 생각된다. Objective Endometriosis in the abdominal scar following cesarean section is very rare condition among the extrapelvic endometriosis. Recently, patients with endometriosis in the abdominal scar were increased but its clinical significances were not well-known. The purpose of this study is to evaluate clinical significant factor of endometriosis in the abdominal scar following cesarean section. Methods We retrospectively studied 19 patients who were histologically confirmed endometriosis in the abdominal scar following cesarean section. We reviewed physical findings, operative findings, histologic findings and analyzed menstrual history[menarche, menstrual cycle, menstrual duration] and interval between cesarean section and endometriosis. Results 1] All patients[100%] complained mass palpation, local pain at operation site and 5 patients[21.7%] complained menorrhalgia. 2] All patients[100%] had firm mass, 19 patients[92.3%] had irregular mass margin. 3] Two patients[8.7%] had peritoneal invasion, one patient[4.4%] was involved posterior wall of uterus and one patient[4.4%] was involved right ovary. 4] According to menarche, menstrual duration and interval between cesarean section and endometriosis, the incidence of endometriosis was not different[p$gt;0.05]. But patients with regular menstrual cycle were more common than patients with irregular menstrual cycle and patients with mormal menstrual duration[2-6 days] were more common than patients with longer menstrual duration[$gt;7 days][p$lt;0.05]. Conclusion We probably suggested that menarche and interval between cesarean section and endometriosis may be not significant factor but menstrual cycle and menstrual duration may be significant factor in patients with endometriosis in the abdominal scar following cesarean section.

Prostaglandin F2a의 양막외주입에 의한 중기임신중절

정순오(SO Chung),홍영범(YJ Hong),곽현모(HM Kwak) 대한산부인과학회 1976 Obstetrics & Gynecology Science Vol.19 No.10

Prostagladin F2a was injected extra-amniotically through foley catheter in 26 patients between 15 and 31 weeks gestation in the dosage schedule. Mid-trimester abortion was successfully induced in 26 patients by administration of extra-amniotic PgF2a The mean abortion time for the successful induction was 19.65 hrs. Abortion was successfully induced in 77% of patients within 24 hrs and in 100% within 48 hrs. Multiparous patients aborted somewhat faster than nulliparous patients, but the difference was not sighnificant . Among the 26 successful inductions 20 patients aborted in 24 hrs. the most frequently encountered side effect of extra-amniotic PgF2a administration was a gastriontestinal disturbances-nausea, vomitting and diarrhea. A temperature elevation was also common, which returned to normal within a few hours of last dose of the drug. These side effects were in general well tolerated by the patients and never required therapy or termination. In a single patients surgical intervention was required to remove the placenta. In one patients the placenta was removed by sponge forceps and in one patients the placenta was removed mannually . There was an estimated blood loss exceeding 250ml in one patients but transfusion was not required. Indication of extraamniotic PgF2a administration was intrauterine fetal death in 8 patients and psychosocial problem in 8 patients. the mean pitocin augmentation time for the successful induction was 3.78hours. Multiparous patients aborted somewhat faster than nulliparous patients in pitocin augmentation time but the difference was not sighnificantly. The mean total dosage of PgF2a was 5529ug. The mid-trimester abortion with extra-amniotic administration of PgF2a appears to offer a valid alternative to the presently available techniques, with a rapid abortion time high success rate, low incidence of side effects and complications.

관동맥 스텐트 시술후 발생하는 재협착의 형태와 미만성 재협착의 예측인자

박종선,석준호,홍그루,신동구,김영조,심봉섭 대한순환기학회 2001 Korean Circulation Journal Vol.31 No.11

악성 Brenner 종양 1 예

한치동,김용진,김미숙,박영길,지청수,홍성연,박미옥 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.7

저자들은 매우 드문 것으로 알려진 악성 Brenner 종양 1예를 경험하였기에 간단한 문헌 고찰과 함께 보고하는 바이다. The Brenner tumor is a relative rare ovarian neoplasia and the malignant Brenner tumor is very rare. We present a postmenopausal patient with a huge pelvic mass with vaginal spotting. Computed tomography scanning showed suspicious ovarian malignancy and tumor marker studies showed slightly elevated CEA and CA 125. Total abdominal hysterectomy and bilateral salpingooophorectomy with omentectomy was done. Histologic diagnosis was a malignant Brenner tumor, FIGO stage Ia. We applied postoperative chemotherapy (cyclophosphamide and cisplatin) six times. And then we report a case of malignant Brenner tumor.