Ho-166 부착풍선도자를 이용한 방사선 조사의 돼지 관상동맥 스텐트 재협착 예방 효과

김원 ( Kim Won ),정명호 ( Jeong Myeong Ho ),박옥영 ( Park Og Yeong ),정우곤 ( Jeong U Gon ),박우석 ( Park U Seog ),김주한 ( Kim Ju Han ),안영근 ( An Yeong Geun ),조정관 ( Jo Jeong Gwan ),박종춘 ( Park Jong Chun ),강정채 ( Kang Je 한국지질동맥경화학회 ( 구 한국지질학회 ) 2002 韓國脂質學會誌 Vol.12 No.1

배경 : 국내에서 개발된 방사선 동위원소 Holmium-166 (166Ho)은 주로 베타선을 방출하며, 166Ho을 부착한 풍선도자를 이용하여 돼지 관상동맥 재협착 모형에서 풍선확장술 후 신생내막 증식을 전신적 부작용 없이 안전하고 효과적으로 억제하였음을 보고한 바 있다. 본 연구에서는 돼지 관상동맥 스텐트 재협착 모형에서 스텐트 시술 후 신생내막 증식에 의한 재협착 병변을 166Ho 부착 풍선도자를 이용하여 치료하여 그 효과를 관찰하고자 하였다. 방법

원위 대퇴골의 고립성 골연골종에서 발생한 속발성 연골 육종 1례 보고

정필현,황장수,강석,김용민,오형호,채동주,김종필 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

연골육종은 비교적 서서히 자라며 늦게 전이하는 악성 연골 종양으로 알려져 있다. 골 연골종에서 발생한 속발성 연골육종은 발생빈도는 드물며 타부위로의 전이가 적고 악성도가 낮은 경우가 많아 적합한 수술적 치료로서 좋은 예후를 보이는 것으로 보고되고 있다. 본 동국대학교 정형외과학 교실에서는 우측 대퇴골 원위부 골간단부에 생긴 고립성 골 연골종에서 이차적으로 발생한 연골육종을 치험한 바 문헌고찰과 함께 보고하는 바이다. A case of Secondary Chondrosarcoma Arising from Solitary Osteochondroma of the Distal Femur Department of Orthopaedic Surgery, College of Medicine, DongGuk University Phil Hyun Chung M.D., Jung Su Hwang M.D., Suk Kang M.D., Yang Mln Kim M.D., Hyung Ho Oh M.D., Dong Ju Chae M.D., Jong Pil Kim M.D. Chondrpsarcoma is a malignant cartilage-forming tumor that grows slowly and metastasis of this tumor occurs in late stage. Secondary chondrosarcomas arising from a solitary osteocartilaginous exostosis are rare and those have a better prognosis than other chondrosarcomas, and they rarely metastasize. We present our experience with a case of secondary chondrpsarcoma arising in solitary osteochondroma of distal metaphysis of right femur with clinical details.

데이터 웨어하우징의 구축과 발전동향

주상호,이종호 公州大學校工科大學生産技術硏究所 1998 論文集 Vol.6 No.-

Data Warehousing is a data set of subject-orientation, integration, time variancy, nonvolatility to support decision making. Nowadays, information technology is changing past OLTP environment into OLAP environment. And DW is most suitable environment support decision-making for competitive advantages in management activities. So, to have a higher competitiveness advantages, in case of building DW, it is very important to look for the proper system building technique after the integrated review and analysis considering the purpose and the amount of data, etc.

발포폴리스티렌비드를 사용한 경량콘크리트의 역학적 특성에 관한 실험적 연구

주재금,이종찬,오세출,유택동,정광량,서치호 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

The purpose of this study is to obtain basic data on the properties of the lightweight concrete within expanded polystyrene beads for various applications in the field. Inquiring into the change of the properties as altering cement matrix mixture and the capacity mixture ratio of expanded polystyrene beads, the mixture plane of this study is set up as W/C is fixed 50%, expanded polystyrene beads is increased 10% from 0% to 80% per 1m³ and the ratio of cement:sand in the cement matrix is 1:0, 1:0.5, 1:1. The results of this study are as follow. The slump as changing the mixture ratio of expanded polystyrene beads decrease smoothly until mixture ratio 50% but decrease rapidly being in excess of 50%. The density decrease regularly as the mixture ratio of expanded polystyrene beads increase but the ratio of strength decrease. The difference of cement matrix. The strength of cement matrix having more sand mixture ratio relatively decrease rapidly as increasing the mixture ratio of expanded polystyrene beads. It is judged decreased strength phenomenon as the quantity of coherent material created in the mixture decrease rapidly.

과학 학습 부진아 지도로서의 중재반응모형(RTI)의 적용 효과

주혜련,박종호 이화여자대학교 사범대학 교과교육연구소 2013 교과교육학연구 Vol.17 No.4

This study attempted to demonstrate the effect of Response to Intervention(RTI) as a teaching methodology for underachievers in science. The participants were fifth-grade students, and the intervention program involved the science textbook section 'The speed of an object'. In the first stage of the intervention, the subject matter was taught generally over a period of three weeks. The researcher conducted subgroup teaching using the direct method of teaching in the second stage of the intervention for eight weeks. This study consisted of three stages: the first stage of the intervention involved selecting underachievers in science and determining their baseline(the bottom 15%), the second provided sixteen thirty-minute sessions, twice a week over eight weeks. In the first stage of the RTI program, the researcher selected eleven underachievers in a fifth-grade science class for an experimental group. In the second stage, interventions were provided to them based on the Direct Instruction(DI) method. During the interventions, three achievement tests and ten curriculum-based assessments were conducted. The major research findings were as follows: first, the interventions based on the DI approach had positive effects on the underachievers. The science underachievers showed a higher achievement level than the general students when a sincere attitude was indicated. Second, the RTI program had positive effects on some of the science underachievers; although three of the eleven participants in the second stage showed no significant change. Third, this study suggests that underachieving in mathematics and science is closely related; science underachievers in the second stage were all underachievers in mathematics, too. RTI has not been applied to mathematics classes; but, based on the results of this study. RTI in science classes should be actively carried out in the future; it could contribute to the relief and determination of science underachievers. 현대 과학교육은 ‘모든 이를 위한 과학’을 지향하고 있다. 과학적 인재를 양성하는데 주력하는 것이 아니라 모든 이에게 과학적 소양을 함양시킬 수 있는 과학교육에 집중하는 것이다. 초등교육은 더욱 그러하다. 이에 본 연구는 중재 반응(Response to Intervention, RTI)을 적용하여 과학 학습부진 아동을지도하여 구제하는 데 효과가 있는지 입증하기 위해 실시되었다. 초등학교 5학년 아동을 대상으로 하였으며 5학년 2학기 3단원 ‘물체의 속력’단원으로 중재 프로그램을 구성하였다. 중재 1단계에서는 3주에 걸쳐 과학 전담 교사가 일반 교수를 실시하였고, 중재 2단계는 8주간연구자가 직접 교수법을 활용한 소집단 교수를 실시하였다. 1단계에서 학업성취도 검사 2회, 교육과정 중심 평가는 4회를 실시하여 두 검사 점수의 합이 하위 15%를 나타내는 15명을 과학 학습부진 아동으로 선별하여 그중 본인의 동의를 얻은 11명을 2단계 연구를 실시하였고, 2단계에서는 총3회의 학업성취도 검사와 총 10회의 교육과정 중심 평가를 실시하여 중재 반응의 효과를 분석하였다. 그 결과 2단계 중재로 과학 학습부진 아동으로 선별된 11명의 아동 중 8명이 일반 아동을 뛰어넘은 점수를 획득하였다. 따라서 과학 학습부진 아동이라 할지라도 중재 반응의 2단계소집단 교수에 성실히 임한 부진 아동은 일반 아동과 같은 학업성취도를 보일 수 있음을 확인하였고, 구제되지 못한 나머지 3명의 아동은 동일한 시간 동안 동일한 중재를 적용했음에도 불구하고 반응하지 않았으므로 과학 학습부진 아동이라고 판별할 수 있었다. 또한 2단계에서 반응을 보이지 않아 과학 학습부진 아동으로 판별된 아동이 모두 수학기초 학습 부진이었던 것으로 나타나 수학기초 학습 부진과 과학 학습 부진은 관련성을 가지고 있음을 볼 수 있었다. 이러한 연구결과를 바탕으로 이제껏 수학에서만 다루어지던 틀을 깨고 앞으로는 과학에서도 중재 반응을 적용한 중재 프로그램을 통하여 과학 학습부진 아동의 구제와 판별에 기여할 것으로 보인다.

전해 인프로세스 드레싱을 이용한 Optical glass계의 경면연삭에 관한 연구

조주현,원종호,박원규,이진오,김민수,김성수 한국공작기계학회 2003 한국공작기계학회 춘계학술대회논문집 Vol.2003 No.-

Electrolytic In-process Dressing (ELID) technique for metal bonded diamond grinding wheel has been developed for mirror surface grinding of hard and brittle materials. This study process optical glass in using Electrolytic In-process Dressing. In using to main variable wheel speed(400 rpm ~ 2000 rpm), feed rate(5 μm/min ~ 25 μm/min), depth of cut (3 μm - 15 μm), dressing and spray. we measured surface roughness by Form Talysurf series2. we finded optimum grinding condition to obtain confident surface roughness in representative brittle materials.

ERP 시스템 도입요인과 성과변수에 관한 연구

이종호,주상호 한국생산성학회 2002 生産性論集 Vol.16 No.2

According to the environmental change, organizational complexity, rapid information technology development, it is accelerated to introduce the ERP (Enterprise Resource Planning) system. Because of the rapid development of web and internet, the business structure is necessary to connect or integrate the ERP system with the old information system. Partly, the case studies between the influencing factors and performance analyses are prepared by the companies which introduced ERP system recently. But they are not sufficient on the ERP-introducing performance, especially, there are something yet to research between introducing factors in priority and their performance. In this paper, we examined the concept and introduction effect of ERP. We analysed some factors are influenced to the ERP. According to the result Environment factors divided into uncertainty and industrial competition factors, organization factors divided into scale, concentration of decision making, standardization of work, top management support. And information system take in IS/IT infra structure, integration of information technology. By the regression analysis with all 3 factors independent variables and with performance dependent one, the environmental factors and the organizational ones have positive significant level statistically. But because IS factors do not have affirmative, it is rejected. As a result, not IS factors but the environmental and the organizational ones have positive influence to the ERP performance. The organizational size(big or small and medium companies) has difference in the influence of the environmental, the organizational, IS factors. In this case, the influence in big firms is bigger than in small and medium ones. Also, industry kinds, namely manufacturing or non-manufacturing companies are the same as the organizational size. In case of manufacturing companies, the order of influence is first, organizational factors, second, environmental ones, last, IS ones, and in case of non-manufacturing companies, the order is first, organizational factors, second, IS ones, last, environmental ones. Regardless of the industry kinds, organizational factors are the biggest influence. Throughout this study, Enterprise which was introduced to the ERP enable to be provided for introduction judgment, guide of decision making, successfully adaptation, furthermore enlarged e-Business.

초기계태에서 valproic acid에 의한 신경관 기형 : 입체현미경적 관찰

김동호,조무연,정유남,최영주,이종선,민경수,이무섭 충북대학교 의학연구소 2000 忠北醫大學術誌 Vol.10 No.1

연구목적 ' 항경련제인 valproic acid가 초기계태의 신경관 형성에 영향을 주는 기형유발에 대해 입체현미경하에서 관찰하였다 연구재 료 및 방법 : 백색의 Leghorn의 신선한 수정란을 30-35시간 동안 배양하여 Hamburger & Hamilton 기 5-10기의 초기 계태를 천공 필터를 이용하여 분리하여 6-30시간 동안 CO2 세포 배양기에서 배양하였고 무작위로 대조군과 실험군을 분류하였다. 실험군은 valproic acid 의 RPMI culture media 의 농도에 따라 100 ㎍/㎖, 200 ㎍/㎖, 500 ㎍/㎖, 1000 ㎍/㎖ 네가지 군으로 분리하였다. 각각의 대조군과 valproic acid를 처치한 실험군에서 입체 현미경하에서 초기계태의 신경관 형성의 형태학적인 특징과 기형형성의 빈도를 비교하였다. 결과: valproic acid가 없는 RPMI media에서 배양된 대조군은 24개의 계태는 22(91.7%)개는 정상으로 자랐으며 2(8.3%)개는 비정상으로 자랐다 이에 반하여 valproic acid가 처치된 RPMI media에서 배양된 72개의 계태는 42(58.3%)개가 비정상으로 자랐다. 주로 확인된 이상 형태는 신경주름의 변형. 신경관 폐쇄부전, 체절의 장애 및 발육 정지 등 이었다. 계태의 기형 형성은 valproic acid의 농도에 비례하여 증가하였다. valproic acrid 의 농도가 100 ㎍/㎖인 경우 18개 계태 중 2(11.1%)개에서 경미한 신경관 기형이 나타났으며 200 ㎍/㎖인 경우 18개 계태 중 11(61,1%)개는 정상, 7(38.9%)개는 명백한 신경관 기형이 나타났으며 500 ㎍/㎖인 경우 18개의 계태 중 5(27.8%)개는 정상. 13(72.2%)개는 명백한 신경관 기형을 나타냈다. 1000 ㎍/㎖인 경우 18(100%)개 모두 심한 신경관 기형이 나타났다. 결론: valproic acid는 초기계태에서 신경관 기형을 유발 했는데 저농도에서는 일부 경미한 신경관 이상을 보였고 고농도에서는 대부분 심한 신경관 손상을 동반하고 성장 속도가 둔화되어 약 용량의 증가에 따라 기형이 증가되는 dose-dependent manner 로 그 영향이 나타났다. Purpose : The teratogeruc effects of valproic acid widely used as anticonvulsant on the neurulation of the explanted eraly chick embryos were observed by the stereoscope. Materials and Methods: Fresh fertilized white leghorn hen eggs were incubated for 30-35 hours in an e99 incubator. The Hamburger and Hamilton stage 5-10 chick embryos were explanted using the punched-out filter paper explantation technique and cultured in the CO2 cell culture incubator for 6-30 hours. They were randomly divided into a control group and an experimental group. The experimental group was divided into four subgroups according to the valproic acid concentrations of 100 ㎍/㎖, 200 ㎍/㎖, 500 ㎍/㎖, 1000 ㎍/㎖ with which the RPMI culture media were treated. The morphological characteristics and the incidences of teratogenic effects on the neurulation of early chick embryos in the control and experimental groups were compared with each other using the stereomicroscope. Results : Of the 24 chick embryos cultured in the RPMI media without valproic acrid, 22 embryos(91.7%) developed normally, and 2 embryos (8.3%) developed abnormally, in contrast, among 72 embryos cultured in the valproic acrid-treated media, 42 embryos(58.3%) developed abnormally. The frequent anomalous features were deformities of the neural folds, failure of neural tube closure, derangement of somites, and developmental arrest. Of 18 embryos cultured in the media treated each with 100㎍/㎖ of valproic acid, 2 embryos(11.1%) showed mild abnormality of neural tube defect on stereoscopic examination. Of 18 embryos cultured 7l the media treated each with 200㎍/㎖ of valproic acid, 11 embryos(61.1%) developed normally for 20 hours and 7 embryos (38.9%) showed definite neural tube defect. Of 18 embryos cultured in the media 7reated each with 500㎍/㎖ of vaIprolc acid, 5 embryos(27.8%) developed normally (or 20 hours and 13 embryos (72.2% ) showed definite neural tube defect. Of 18 embryos cultured in the media treated each with 1000㎍/㎖ of valproic acid, 1 embryo developed normally for 4 hours but all embryos (100%) showed severe neural tube defect on whole brain after 8 hours of culture. Conclusion : Valproic acid induced mild neural tube defects in low concentration and in high concentration of valproic acid, most chick embryos developed slowly and showed severe neral tube defects. The frequency and severity of abnormal embryos ulcreased in dose-dependent manner.

지방식이가 Rat 간 Epoxide Hydrolase 활성에 미치는 영향

김은주,손기호,최종원 慶星大學校 環境問題硏究所 1991 環境硏報 Vol.1 No.1

간 microsomal epoxide hydrolase 활성과 bromobenzene에 의해 유도된 간 독성에 미치는 지방식이의 영향에 대한 실험을 통하여 다음과 같은 결과를 얻었다. 간 microsomal cytochrome p-450 및 aniline hydroxylase 활성에 지방식이 (20%)를 섭취케 한 군에서는 본 효소의 활성이 다소 증가되었으나 bromobenzene을 동시에 투여함으로 두 효소의 활성이 유의성 있게 증가되었다. Bromobenzene 단독 투여에서는 두 효소의 활성에 별다른 영향이 없었다. Epoxide hydrolase 활성에서는 bromobenzene 투여로서 감소 되었으며 지방식이를 섭취게 하고 bromobenzene을 투여함으로 bromobenzene 단독 투여보다 약 25% 현저하게 감소하였다. 지방식이를 섭취게 하고 bromobenzene을 투여한 군에서의 간 손상의 지표를 생화학적 측면(s-AST,sALT) 및 간 조직의 과산화 지질 함량에 미치는 영향에서 bromobenzene 단독 투여보다 지방식이를 섭취케 하고 bromobenzene을 투여함으로 현저하게 증가되었다. We have the mecdied the mechanism by examining the effect of fat diet on the epoxide hydrolase activity and bromobenzene-induced hepatotoxicity. Activities of anivities of aniline hydroxylase and cytochrome p-450 as epoxide generating enzymes were singificantly increased by the treatment with fat diet and bromobenzene treatment with fat diet and bromobenzene decreased show any changes on the activities of the epoxide scavenging enzyme such as epoxide hydrolase Furthermore, fat diet elevated against bromobenzene-inducible hepatotoxicity in rats as evidenced by the increased formation of lipid peroxidation, highered serum alanine and aspartate aminotrnsferase activities. Therfore, it can be concluded that the mechanism for the observed elevative effect of fat diet against bromobenzene-induced hepatotoxicity was due to the inhibition of epoxide hydrolase which related with metabolism of these materials.

VDT작업별 정신사회적 스트레스와 근골격계 장애에 관한 연구

백남종,강종두,주영수,배인근,권호장,박종만,조수헌,김돈규,김재용,최홍렬 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.4

It has been hypothesized that jobs that have both high psychological demands and low decision latitude("job strain") can lead to musculoskeletal disorder. The objective of this study was to test whether job strain was correlated with the presence of work-related musculoskeletal disorder, especially myofascial pain syndrome(MPS). Information on demographic factors, confounders such as household load and taking care of children or not, and scores for decision latitude, job demand, and social support was obtained by self-administered questionnaire, which had been developed in Korean language, by adopting NIOSH instrument and Extended Karasek Model(16 items). All subjects were also examined by rehabilitation medicine specialists for musculoskeletal disorders. Subjects(n=370) could be categorized into 4 groups, these were, housewives(n=89), shipyard CAD workers(n=89), general female workers(n=79; nurses, insurance counselors, public officials, clerks, etc), and telephone directory assistance operators(n=113). Results from univariate analyses indicated that all demographic factors, all confounders, scores for decision latitude and social support were not associated with the risk of musculoskeletal disorder. However, score for job demand was higher in musculoskeletal disorder cases than others. In subgroup analysis, this association was convinced again, in telephone directory assistance operators. Job strain model showed that the group of telephone directory assistance operators was high-stain group, and OR of musculo skeletal disorder was 2.446(95% C. I. : 1.174, 5.096), when comparing this with the low strain group. In conclusion, job strain is a risk factor for work-related musculoskeletal disorder.