Heme oxygenase-1 induced by desoxo-narchinol-A attenuated the severity of acute pancreatitis via blockade of neutrophil infiltration

Bae, Gi-Sang,Kim, Dong-Goo,Jo, Il-Joo,Choi, Sun-Bok,Kim, Myoung-Jin,Shin, Joon Yeon,Kim, Dong-Uk,Song, Ho-Joon,Joo, Myungsoo,Park, Sung-Joo ELSEVIER 2019 INTERNATIONAL IMMUNOPHARMACOLOGY Vol.69 No.-

<P><B>Abstract</B></P> <P>Heme oxygenase-1 (HO-1) has an anti-inflammatory action in acute pancreatitis (AP). However, its mechanism of action and natural compounds/drugs to induce HO-1 in pancreas are not well understood. In this study, we investigated the regulatory mechanisms of HO-1 during AP using desoxo-narchinol-A (DN), the natural compound inducing HO-1 in the pancreas. Female C57/BL6 Mice were intraperitoneally injected with supramaximal concentrations of cerulein (50 μg/kg) hourly for 6 h to induce AP. DMSO or DN was administered intraperitoneally, then mice were sacrificed 6 h after the final cerulein injection. Administration of DN increased pancreatic HO-1 expression through activation of activating protein-1, mediated by mitogen-activated protein kinases. Furthermore, DN treatment reduced the pancreatic weight-to-body weight ratio as well as production of digestive enzymes and pro-inflammatory cytokines. Inhibition of HO-1 by tin protoporphyrin IX abolished the protective effects of DN on pancreatic damage. Additionally, DN treatment inhibited neutrophil infiltration into the pancreas via regulation of chemokine (C-X-C motif) ligand 2 (CXCL2) by HO-1. Our results suggest that DN is an effective inducer of HO-1 in the pancreas, and that HO-1 regulates neutrophil infiltration in AP via CXCL2 inhibition.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Desoxo-narchinol-A (DN) is a natural compound of HO-1 inducer in pancreas. </LI> <LI> Mechanism of DN-induced HO-1 is mediated by MAPK/Activator Protein-1/HO-1 signaling. </LI> <LI> DN-induced HO-1 blocks neutrophil infiltration into pancreas via inhibition of CXCL2. </LI> <LI> DN inhibits cerulein-induced acute pancreatitis (AP) and AP-associated lung injury. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

玉垂 趙冕鎬의 <西事雜絶> 前後篇에 대하여 : 丙寅·辛未洋擾의 詩的 形象化

金明昊 韓國古典文學會 2001 古典文學硏究 Vol.20 No.-

Cho, Myun-Ho(趙冕鎬, 1804-1887), now almost forgotten, was one of the most famous poets of nineteenth century. He wrote over-five thousand Chinese poems, and work is now gather under the title of Collection of Oksu(玉垂集). This study Is the first work on Cho, Myun-Ho. It begins with the introduction of life of Cho, Myun-Ho and draws the outline of his world of poetry. Then on the foundation of the preparatory work it focuses and examines two masterpieces, Seosa-Chapjol(西事雜絶) and its sequel Hu-Seosa-Chapjol(後西事雜絶). Seosa-Chapjol deals with the "Foreign Disturbance of 1866(丙寅洋援)", the war between Korea and French ignited by Korea's suppression and execution of the French missionaries. This work has a characteristic of the 'linked-up form' composed of forty-seven parts, that is, each part consisted of four-line stanza and each stanza of seven characters. The poet shows very vivid depiction of the battle, as seen and heard by his own eye and ears. In this work, on the one hand, he expresses his strong hostility to the Western invaders and the Catholic, and on the other, severely criticizes the inert response of the government. Hu-Seosa-Chapjoi focuses on the "Foreign Disturbance of 1871(辛未洋握)", the war between Korea and America caused by the destruction of the General Sherman-an American merchant ship. This work has also all the same formal and structural characteristic of Seosa-Chapjol. In this work, the poet depicts the battle from various aspects and congratulates his countrymen for finally driving back the invaders. Seosa-Chapjol and Hu-Seosa-Chapjol are very rare works of art, dealing with the two clashes with the Western powers under the Taewongun government. Moreover, these works succeed in giving a live description of 'the historic accidents in a full scale in 'linked-up form.' Thus two poems could be described as one of the most outstanding 'historical poetry(詩史)' of nineteenth century Korea. And it could be said that through these poems Cho, Myun-Ho proved himself to be a poet of great abilities.

『燕巖集』 번역에 대하여

김명호(Kim Myoung-ho) 대동한문학회 2005 大東漢文學 Vol.23 No.-

연암 박지원의 문집으로 가장 널리 보급된 것은 1932년 박영철이 편찬한 활자본 『연암집』이다. 여기에는 『열하일기』와 『과농소초』를 제외하고, 연암의 한시 42수와 산문 237편이 수록되어 있다. 이러한 연암의 시문들에 대해 지금까지 이루어진 번역 성과들을 살펴보면, 전체 작품의 극히 일부만 대상으로 했을 뿐더러 텍스트 자체에 대한 서지적 검토를 소홀히 하고 작품의 이해와 감상에 필요한 주해를 충실히 베풀지 않은 한계를 지니고 있었다. 이와 같은 종래의 한계를 극복하려면 연암의 시문 전부를 완역할 뿐만 아니라, 역자 자신을 포함한 학계의 연암 연구 성과를 번역에 충분히 반영한 ‘전문적 학술번역’을 추구해야 할 것이다. 필자는 우전 신호열 선생이 생전에 구술하신 『연암집』 번역 원고를 가다듬고 여기에 원문 교감과 주해 작업을 하여, 연암의 전 시문에 대한 번역을 최근 완성하였다. 이러한 번역 작업을 하면서 필자는 전문적 학술번역을 성취하기 위해, 우선 『연암집』의 이본들을 널리 수집하고 검토하여 신뢰할 수 있는 교감본을 마련하고자 했다. 그리고 이와 아울러, 어귀 풀이에 그치지 않고, 창작 시기나 창작 배경, 난해하거나 심오한 의미를 지닌 대목들에 대한 해명 등 작품 감상에 긴요한 내용까지 충실히 주해하고자 했다. 본 논문에서는 『연암집』 원문 교감을 위해 참고한 많은 문헌들을 소개하고, 주해에서 특별히 힘쓴 점과 그에 해당하는 인상적인 사례들을 소개하였다. As a collection of Yeon-am, Park, Ji-won(1735~1805), 『Yeon-am-jip』, a printed book which was compiled by Park, Young-cheol in 1932, is most wide-spread. This book contains Yeon-am's 42 poems and 237 proses except 『Yeol-ha-il-gi』 and 『Gwa-nong-so-cho』. When I examine another translations of Yeon-am's literary works, including 『A selection of Park, Ji-won's works』(1960) by Hong, Gi-moon, I think they have some problems. They translated only a part of Yeon-am's works, not the whole. Besides they neglected bibliographical examination of the text and have no enough comments to understand and appreciate Yeon-am's works. In order to solve these problems, we have to make a complete translation of Yeon-am's works, and pursue a 'professional academic translation' showing the fruit of academic study on Yeon-am. I have finished a complete translation of Yeon-am's poems and proses recently. At first 『Yeon-am-jip』 was translated by Shin, Ho-yeol(1914~1993). I arranged his manuscript, revised the text and gave notes. While I translated this text, to accomplish a professional academic translation, I collected and examined many variants of 『Yeon-am-jip』, and tried to provide a nearly complete text. In addition I tried to give full comments upon the date of creation, the background of creation, and a difficult part of works, as well as an explanation of words and phrases. In this paper, I introduced various reference data for a revised edition of 『Yeon-am-jip』, a special effort in notes, and impressive cases in point.

편마비 환자의 총대퇴동맥에서 초음파를 이용한 혈류 동태 분석

김완호,고명환,서정환,김연희 大韓再活醫學會 1998 Annals of Rehabilitation Medicine Vol.22 No.3

시각장애의 감각보조를 위한 스테레오 카메라 캘리브레이션 방법

최명호 광주보건대학 2003 論文集 Vol.28 No.-

Stereoscopy is a technique for infering the position of objects from two or more simultaneously view of the scene. It is a reliable and effective way to extract range information from the environment for navigation with the Visually Impaired and Robot System. However, proper operation of the three dimensional stereo vision system, we must achieve the parameter for camera calibration. In response to this condition, we have investigated the three dimensional calibration technique that uses two-dimensional grid paper and a vanishing point concept. The proposed calibration method need not require information of the precise location in the calibration target compare with other calibration technique. We suggest the algorithm that the vanished estimation point using image process for accurate, reliable calibration of vision system.

GOLF활동 참여 실태 조사연구 : 전북 T 컨트리클럽을 중심으로 Concentrating on T Country Club

임명재,이호성 圓光大學校附設 生活體育硏究所 2001 生活體育硏究 Vol.12 No.-

To accomplish the study concerning man's Golf-Life, After Carrying into effect the investigation of opinion and the study of records through a question acre of Jeon-buk residents-982. We could pet the conclusion as belows. 1. It was revealed respectively that the reason of playing Golf is a heolth control-589(60%), heister-128(l3%), the advance of physical force and becoming a excellent golfer-69(7%). 2. It Golf is benefit for men's stress, What is the reason? We pot the answer respectively-a natural sight-363(37%) striking a nice drive shot-324(33%) and succeeding my putting at distance place-197(20%). 3. It was revealed respectively to carry into effect man's Polt-life in the in the social effect side-courtesy-197(20%), independence-157(16%) cooperation-128(13%) and concentration-108(ll%). 4. It was shown respectively that the problem in group-association is deficiency of time-560(57%) an excess of cost-167(17%) and a deficiency in the scope of activity-128(13%). 5. It was shown secretary that the precondition of popularization in operating Golf-life is the construction of public-course-589(60%) a price cut-363(37%) and members-only close 30(3%). 6. What do you think about polt leader? The answer is shown like this average-47(27%), respect-265(27%) a little dissatisfaction and without knowing-99(10%).

2단 간헐폭기 시스템에서 aeration cycle이 질소 및 인 제거에 미치는 영향

정명선,이준호,서광범,김영관 江原大學校 附設 環境硏究所 2003 環境硏究 Vol.20 No.-

This bench-scale research investigated the aeration cycle(on/off) as the controlling factors for nitrogen and phosphorus removal in a 2-stage, intermittent aeration process. At this experiment, the aeration cycle time(air-on/air-offJ was 30min/30min, 60min/60min, 90min/90min. Organic matter removal was observed more than 90% regardless of the aeration cycle and phosphorus removal was relatively high when the aeration cycle time was 60min/GOmin. On the other hand, For all of the aeration cycle, TN removal was appeared less than 55%. This result was probably due to the limitation of the external substrate for heterotrophic nitrification and aerobic denitrification.

朴珪壽의 宮詞 「鳳韶餘響」에 대하여

金明昊 한국한문학회 2003 韓國漢文學硏究 Vol.0 No.31

이 논문은 환재 朴珪壽(1807~1877)의 『鳳韶餘響』에 대해 고찰한 것이다. 박규수는 燕巖 朴趾源의 손자로서 19세기 漢詩史에서도 주목해야 할 인물이다. 『봉소여향』은 7언 절구 100수로 된 宮詞로, 박규수의 초기 한시를 대표하는 力作이라 할 수 있다. 작품 전체에 대한 정밀한 독해 위해서, 창작배경을 이루는 박슈수의 삶과 시대 상황을 구체적으로 살피는 한편, 唐나라 王建이래 중국과 조선에서 창작되어온 궁사의 전통에 비추어 『봉소영향』의 예술성과 문학사적 의의를 밝히고자 했다. 박규수는 순조 29년(1829년) 국정을 대리하던 孝明世子의 하명에 따라 조선조 역대 임금들의 행적을 예찬한 『봉소여향』을 지었다. 이 작품은 왕조의 번영을 상징하는 ‘日出’이미지로써 작품의 서두와 결미가 상호 조응케 하여 짜임새를 갖추었으며, 절구 1수마다 문헌에 근거하여 자상한 주를 붙이고 있는 점이 한 특생이다. 주제 면에서 『봉소여향』은 임금의 修身上의 덕목을 예찬한 시와 治國上의 업적을 예찬한 시로 나누어 볼 수 있다. 또한 ‘萬家’와 ‘萬川’위에 비추이는 ‘明月’의 이미지로써 강력한 왕권을 상징하였다. 이렇게 볼 때 박규수는 외척 세도를 견제하고 왕권을 강화하고자한 효명세자의 염원에 호응하여, 국정을 주도하면서 신민들에게 덕정을 베푸는 모범적인 군주상을 제시하고자 했음을 알 수 있다 한편 『봉소여향』에는 尊明批情主義와 性理學 사상이 강하게 드러나 있어 당시 박규수의 사상적 지향을 알 수 있다. 『봉소여향』은 다채로운 소재와 화려한 수사법을 구사하여 왕정을 태평성세로 찬양하고 있는 점에서 궁사다운 특생을 공유하고 있다. 그러나 종래의 궁사들이 이를 통해 궁중의 향락을 표현하는 데 주력했음에 반해, 이 작품은 그같은 소재와 수법을 어디까지나 주제와 사상 전달을 위한 수단으로 활용한다. 그리하여 교훈적인 주제와 사상성을 생경하게 노출하는 대신 궁사의 특징을 살려 시로서의 예술성을 획득하고 있다. 문학사적으로 볼 때 『봉소여향』은 향락적 작품을 止揚하고자 했던 허균의 「궁사」를 계승하면서 예술적으로도 빼어난 성과를 거둔 작품이라 하겠다. This is the paper on Bongsoyeohyang by Park, Gyou-su(l807-1877). Bongsoyeohyang is the Goongsa(poems written based on circumstances within the Royal Court) composed of one hundred poem of a quatrain with seven-word lines, and is one of Park's most important works. Following the order of the Prince Hyornyoung(Ik-jong), in 1829 Park wrote Bongsoyeohyang praising contributions of successive kings of the Chosun dynasty. In the aspect of theme, Bongsoyeohyang is composed of several kinds of poems: one praised moral training of king and the other praised achievements in governing the country. It also represented the great power of the king by the symbol of a bright m n shining on 'every house' and 'every stream'. From this viewpoint, we can see that Park responded to the wish of the Prince Hyomyoung who would restrain the power of maternal relatives and strengthen the power of the lang; that he wanted to bring up the image of a model king leading political &airs and well governing the people. Bongsoyeohyang has much color of Goongsa in that it praised the kingly rule through various materials and flourishing rhetoric. While usual Goongsa concentrated on representing the pleasures within the Royal court, this work used these materials and techniques to deliver themes and thoughts. Therefore, evading crude exposure of instructive themes and thoughts, it obtained artistic achievements by the best use of the form of Goongsa. In the history of Korean literature, Bongsoyeohyang succeeded to Goongsa of Huh, Kyun which denied the literary style of pleasure-seeking and it was also crowned with outstanding artistic success.

WTO/GATS하에서 자유무역협정(FTA)을 위한 서비스산업 경쟁력 강화방안

김명호,김환규 朝鮮大學校 經營經濟硏究所 2007 經營經濟硏究 = Management and economics research Vol.30 No.2

접착제 미 사용시 치면열구전색제로서의 유동성 복합레진 평가

권호범,김명진,신철환,김지연,박기태 大韓小兒齒科學會 2006 大韓小兒齒科學會誌 Vol.33 No.2

본 연구의 목적은 유동성 복합레진을 치면열구전색제로 사용할 수 있는지 여부를 평가하는 것이다. 세 종류의 유동성 복합레진(Filtek Flow, Tetric Flow, Charmfil Flow)과 한 종류의 filled sealant(Ultraseal XT plus)가 사용되었다. 주사전자 현미경을 이용하여 세 종류의 유동성 복합레진 및 filled sealant의 resin tag 형성 양상을 비교하였다. 미세누출 평가를 위해 발거된 사람의 소구치 54개를 각각 18개씩 무작위로 세 군으로 배분하였다. 각 군마다 통상의 filled sealant 와 한 가지씩의 유동성 복합레진을 교합면 열구에 도포하였다. 치아들은 thermocycling(5˚ ± 2℃와 55˚ ± 2℃ 사이에서 30초씩 1200회 시행) 후 48시간 동안 1% methylene blue 용액에 보관하였다. 각각의 치아를 절단하여 미세누출 정도를 관찰하였다. 세 종류의 유동성 복합레진 및 filled sealant는 유사한 resin tag 형성양상을 보였다. 세 종류의 유동성 복합레진은 각각 filled sealant보다 현저히 더 많은 미세누출을 보였다. 세 종류의 유동성 복합레진 간의 미세누출 정도는 유사하였다. 유동성 복합레진은 통상의 filled sealant와 비교해볼 때 보다 많은 미세누출을 야기할 수 있으므로 치면열구전색제로 적절하지 않다. The aims of this study were to determine if flowable composites can be used as pit and fissure sealants without bonding agents. Three flowable composites(Filtek Flow, Tetric Flow, Charmfil Flow) and a filled sealant (Ultraseal XT plus) were used. The pattern of resin tag formation in the four sealant meterials were compared using SEM. For the microleakage assessment, 54 extracted human premolar teeth were randomly divided into 3 groups containing 18 premolars each. In each group, a conventional filled sealant and one of the three flowable composites were applied to occlusal fissures. The teeth were thermocycled(1200 cycles between 5˚± 2℃ and 55˚± 2℃ with a dwell time of 30 seconds) and immersed in a 1% methylene blue solution for 48 hours. Each tooth was sectioned and examined to determine the extent of dye penetration. Three flowable composites and a filled sealant showed a similar resin tag formation pattern. The three flowable composites showed significantly more microleakage in each group than the filled sealant. The level of microleakage was similar in the three flowable composites. Flowable composites are not recommended as pit and fissure sealants because more microleakage can occur even when occlural fissures are mechanically widened.