논문 : 국립공원 탐방로 내 위험 급경사지 유지관리 방안 연구

김홍균 ( Hong Gyun Kim ),김태호 ( Tae Ho Kim ),김재학 ( Jae Hak Kim ),곽재환 ( Jae Hwan Kwak ),박성욱 ( Sung Wook Park ),최수원 ( Soo Won Choi ),송영갑 ( Young Karb Song ) 대한지질공학회 2016 지질공학 Vol.26 No.1

국립공원은 주로 산악 지형 내 조성되어 있으므로 산사태에 의한 피해 가능성을 항상 내포하고 있다. 본 연구는 산사태 연구의 일환으로 국립공원 탐방로 내 위험 급경사지를 체계적으로 유지관리하기 위한 방안을 마련하는데 목적이 있다. 국립공원에 특화된 자체 체크리스트를 제작하였으며, 전국 19개 국립공원 183개소 급경사지에 대한 실태조사가 이루어졌다. 실태조사의 최종 목적은 위험 급경사지에 대한 안정화 대책을 마련하는 것으로 현장조사와 안정해석의 과정을 거친다. 일부 급경사지에서는 위험성 판단을 위해 지상라이다 등 특수 장비를 이용한 조사를 시도하였다. 중장기 정비계획을 위한 투자우선순위 공식을 개발하였으며, 현장자료를 이용한 순위 및 위험등급을 산출하였다. 최종적으로 위험 급경사지의 향후 체계적인 관리를 위해 “국립공원 급경사지 유지관리시스템”을 개발하였으며, 모든 현장자료들은 시스템 내 DB화 되었다. National parks, which are located mainly in mountainous areas, are always at risk of damage by landslides. The goal of this study is to establish a method for systematically maintaining hazardous steep slopes along trails in national parks. We produced a checklist suitable for each of the 19 national parks nationwide and investigated 183 slopes. The aim of these investigations is to recommend appropriate slope-stability countermeasures, including field investigations and stability analysis. We made preliminary investigations at specific sites, evaluating the slope hazard using specialized equipment such as terrestrial LiDAR. An investment priority formula was developed, and ranking and hazardous grades were calculated as part of a long-term maintenance plan. Finally, to systematically manage dangerous slopes and to house all the field data within one system, we developed the “Slope Maintenance System in National Parks” based on web server that can show various information for slopes.

Platycodon grandiflorum root-derived saponins attenuate atopic dermatitis-like skin lesions via suppression of NF-kB and STAT1 and activation of Nrf2/ARE-mediated heme oxygenase-1

( Jae Ho Choi ),( Sun Woo Jin ),( Eun Hee Han ),( Bong Hwan Park ),( Hyung Gyun Kim ),( Tilak Khanal ),( Yong Pil Hwang ),( Minh Truong Do ),( Hyun Sun Lee ),( Young Chul Chung ),( Hee Suk Kim ),( Tae 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0

Purpose: The consequences of precipitously rising allergic skin inflammation rates worldwide have accelerated the risk of atopic dermatitis (AD). Natural product-based agents with good efficacy and low risk of side effects offer promising prevention and treatment strategies for inflammation-related diseases. We have already reported that Platycodon grandiflorum root-derived saponins (Changkil saponins, CKS) have many pharmacological effects, including anti-inflammatory and anti-allergic effects, but its influence on AD remains unclear. Therefore, we evaluated the inhibitory effect of CKS, mainly platycodin D, on AD-like skin symptoms in mice and the possible mechanisms in cells. Methods: Mice were sensitized and challenged with 2,4-dinitrochlorobenzene (DNCB). Four weeks after challenge, mice were treated with oral administration of CKS for 4 weeks. In addition, cells were used to evaluate the effect of CKS, mainly platycodin D, on the TARC expression regulated mechanism. Results: CKS attenuated DNCB-induced dermatitis severity, serum levels of IgE and TARC, and mRNA expression of TARC, TNF-α, IFN-γ, IL-4, IL-5, and IL-13 in mice. Histopathological examination showed reduced thickness of the epidermis/dermis and dermal infiltration of inflammatory cells and mast cells in the ears. Moreover, CKS and platycodin D inhibited TNF-α/IFN-γ-induced TARC expression through the suppression of NF-κB and STAT1 and induction of Nrf2/ARE-mediated hemeoxygenase-1 (HO-1) expression in cells. Conclusion: We suggest that CKS and platycodin D inhibited the development of AD-like skin symptoms by regulating cytokine mediators and may be an effective alternative therapy for AD-like skin symptoms.ⓒ2014 Elsevler Gmbh. All rights reserved.

Slide Session : OS-IFD-07 ; Infectious Disease : In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus

( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.

흉·요추부 압박골절에 대한 수술 전후의 3차원 영상진단상의 변화에 대한 비교 분석

박한준,김영태,서면,하호균 대한신경외과학회 1997 Journal of Korean neurosurgical society Vol.26 No.6

보일러 효율향상을 위한 초음파 발생장치의 개발

박정일,이석규,이호균,박준호 영남대학교 공업기술연구소 2000 工業技術硏究所論文集 Vol.28 No.1

This paper describes the development of ultrasonic generator to enhance the combustion efficiency of the domestic boiler based on the cavitation property of ultrasonic wave. The following procedure shows the proposed energy-saving-precess of the boiler. (1) vibrate the BLT(Bolted Langevin Transducer) type ultrasonic vibrator. (2) amplify the vibrating energy using resonance principle through the designed hem installed before the injection nozzle. The proposed ultrasonic device is designed to produce smaller fuel particles to be mixed homogeneously with air, which finally reduces the fuel consumption of the boiler.

못총에 의한 두부총상의 뇌정위적 수술 치험례 : 증례보고 Case Report

박한준,김영태,서면,하호균 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.9

The authous report a rare case of gunshot injury to the head by a nail-gun which was treated by stereotactic surgery. In the case a 23-year-old male patient, presented with semicomatose mentality and decerebrated rigidity. The large nail was located in the 3rd ventricular area in the mid-line with vertical stature. The entry point was identified 1㎝ anterior to the coronal suture line and just lateral to the sagittal suture line. The foreign body was removed stereotactically with the guidance of fluoroscope. But he died of initial severe brain damage.

복합레진의 중합 수축력과 수복물의 결합양상에 관한 연구 제 1 편 : 중합수축력

박남수,최대균,임호남,최부병,우이형 大韓齒科器材學會 1993 대한치과재료학회지 Vol.20 No.1

The polymerization contraction forces has a relationship with the contents of filler, and if forces surpass the bond strength between restoration and bonded surface, the failure of bond can be occured. This study was designed to evaluate the effects of filler contents on the polymerization contraction forces and to confirm whether the polymerization forces could induce the bond failure of composite resins to enamel or dentin. Low capacity load cell using strain gauge were prepared and used as a measurement system for polymerization contraction forces. Oxidized alloy surfaces, enamel surfaces and dentin surfaces were used as bonded surface. Measurements of the polymerization contraction forces were done for 1 hour, and a stress at 1 hour after was recorded as a polymerization contraction force. It was considered as a bond failure that the polymerization contraction forces increased and then decreased by the time. The following conclusions were drawn : 1. Polymerization contraction forces of composite resins were decreased by the increase of filler contents. 2. Polymerization contraction forces were increased at thickened resin specimens, but it was not significant at over two millimeter thickness. 3. Bond strength of composite resins to the acid etched enamel surfaces exceeded the polymerization contraction forces and the reduced polymerization contraction forces due to the bond failure were not confirmed. 4. Failure of bond and reduced polymerization contraction forces occured on dentin.

복합레진의 중합 수축력과 수복물의 결합양상에 관한 연구 제 2 편 결합강도

박남수,우이형,최부병,임호남,최대균 大韓齒科器材學會 1993 대한치과재료학회지 Vol.20 No.2

Failure of bond between resinous restorative materials and tooth can be occured by the polymerization contraction forces larger than bond strengths. This study was planned to confirmed that the bond strengths between composite resin and acid etched enamel will be influenced by the polymerization contraction forces altered with filler contents and diameter of attached resin specimens. Ten kinds of experimental composite resins were prepared and bonded to bovine tooth enamel which were acid-etched. The diameter of resin specimens attached were 4 mm and 6 mm. The following conclusions were drawn : 1. Shear bond strengths were increased and then decreased with rise of filler contents, maximum shear bond strength was obtained by the 40% filled composite resin. 2. Unit shear bond strengths of resin specimens bonded with large area were lower than that of narrow area bonding. It was concluded that shear bond strengths to acid etched enamel can be influenced by the polymerization contraction forces.

복합레진의 중합 수축력과 수복물의 결합양상에 관한 연구 제 3 편 변연누출과 틈새

박남수,최대균,임호남,최부병,우이형 大韓齒科器材學會 1993 대한치과재료학회지 Vol.20 No.2

This study was designed to confirm the influence of the polymerization contraction stress to the marginal leakage and gaps of resin restorations. Ten kinds of experimental composite resins were prepared with varing the filler contents to display the different polymerization contraction stress. A cavity with enamel and dentin margins were prepared on the cervical area of human tooth. Enamel margins were etched with 37% phosphoric acid for 1 minute. Experimental composite resins were filled into the cavities and immersed in water bath of 37±1℃ for 24 hours, and then immersed into dye solution. Tooth were cut through the restoration, and the infiltration of dye was observed. Marginal gaps were measured on the light microscope with 100 magnifications. The following conclusions were drawn : 1. Polymerization contraction stress and gaps showed the corelation between them, gaps were decreased by increase of filler contents. 2. There was not exist the relationships between polymerization contraction stress and marginal leakage. 3. Marginal leakage and gaps were larger at dentinal margins than enamel margins.

가상상태 및 Backstepping 기법을 이용한 슬라이딩 모드 제어기 설계

박승규,김성환,안호균,김민찬,김명현 國立 昌原大學校 產業技術硏究院 2004 産技硏論文集 Vol.18 No.-

This paper Backstepping design with Sliding Mode Control for AC Servo Systems. The robustness of sliding mode control can be used for backstepping technique to solve the uncertainty problem. A scalar design using Lyapunov function is developed for high-order systems. The result can be easily extended to non-linear system and used with many other sliding mode control results.