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Blood vessel remodeling in the cerebral cortex induced by binge alcohol intake in mice
Hasegawa Hiroshi,Tanaka Toshiya,Kondo Mari,Teramoto Koji,Nakayama Kei,Hwang Gi-Wook 한국독성학회 2023 Toxicological Research Vol.39 No.1
Ethanol is toxic to the brain and causes various neurological disorders. Although ethanol can directly exert toxicity on neurons, it also acts on other cell types in the central nervous system. Blood vessel endothelial cells interact with, and are affected by blood ethanol. However, the effects of ethanol on the vascular structures of the brain have not been well documented. In this study, we examined the effects of binge levels of ethanol on brain vasculature. Immunostaining analysis indicated structural alterations of blood vessels in the cerebral cortex, which became more tortuous than those in the control mice after ethanol administration. The interaction between the blood vessels and astrocytes decreased, especially in the upper layers of the cerebral cortex. Messenger RNA expression analysis revealed a unique downregulation of Vegfa mRNA encoding vascular endothelial growth factor (VEGF)-A among VEGF, angiopoietin, endothelin family angiogenic and blood vessel remodeling factors. The expression of three proteoglycan core proteins, glypican-5, neurocan, and serglycin, was also altered after ethanol administration. Thus, binge levels of ethanol affect the expression of VEGF-A and blood vessel-supporting proteoglycans, resulting in changes in the vascular structure of the cerebral cortex.
Efficacy and safety of cold forceps polypectomy utilizing the jumbo cup: a prospective study
( Hiroshi Hasegawa ),( Shigeki Bamba ),( Kenichiro Takahashi ),( Masaki Murata ),( Taketo Otsuka ),( Hiroshi Matsumoto ),( Takehide Fujimoto ),( Rie Osaki ),( Hirotsugu Imaeda ),( Atsushi Nishida ),( 대한장연구학회 2019 Intestinal Research Vol.17 No.2
Background/Aims: There are few prospective studies on cold forceps polypectomy (CFP) using jumbo cup forceps. Therefore, we examined patients with diminutive polyps (5 mm or smaller) treated with CFP using jumbo cup forceps to achieve an ade-noma-free colon and also assessed the safety of the procedure and the recurrence rate of missed or residual polyp after CFP by performing follow-up colo-noscopy 1 year later. Methods: We included patients with up to 5 adenomas removed at initial colonoscopy and analyzed data from a total of 361 patients with 573 adenomas. One-year follow-up colonoscopy was performed in 165 patients, at which 251 lesions were confirmed. Results: The one-bite resection rate with CFP was highest for lesions 3 mm or smaller and decreased significantly with increasing lesion size. Post-procedural hemorrhage was observed in 1 of 573 lesions (0.17%). No perforation was noted. The definite recurrence rate was 0.8% (2/251 lesions). The probable recurrence rate, which was defined as recurrence in the same colorectal segment, was 17%. Adenoma-free colon was achieved in 55% of patients at initial resection. Multivariate analysis revealed that achievement of an adenoma-free colon was significantly associated with number of adenomas and years of endoscopic experience. Conclusions: CFP using jumbo biopsy forceps was safe and showed a high one-bite resection rate for diminutive lesions of 3 mm or smaller. The low definite recurrence rate confirms the reliability of CFP using jumbo biopsy forceps. Number of adenomas and years of endoscopic experience were key factors in achieving an adenoma-free colon. (Intest Res 2019;17:265-272.)
Spatiotemporal Variations of Fine Particulate Organic and Elemental Carbons in Greater Tokyo
Hiroshi Hayami,Shinji Saito,Shuichi Hasegawa 한국대기환경학회 2019 Asian Journal of Atmospheric Environment (AJAE) Vol.13 No.3
Hourly concentrations of fine particulate OC and EC are monitored for more than one year by optical monitors at three sites in and out of Tokyo, Japan. Distances between the sites are 20 to 50 km. SOC concentrations are estimated from the OC and EC concentrations by an EC tracer method. Site A in an industrial site shows higher EC concentrations than site B in a residential area, but differences between the sites are much reduced for OC. Site C in a rural area, where measurements are available in colder months, shows pronounced seasonal variations with high peaks in October and December and characteristic diurnal variations in OC with the highest in the evening in October, due probably to open field burning. Photochemical formation of SOC is suggested but does not rise up so much OC concentrations in summer, which are quite lower than other seasons. A comparison between relative concentrations of EC among the sites and local emissions amounts indicates missing or considerable underestimation of EC emissions near the rural site C. Time lag correlations suggest transport of OC produced by open field burning around site C to site A. These findings would be useful for improving model performances in OC/EC predictions.
Noboru Hasegawa,Akira Sasaki,Hiroshi Yamatani,Maki Kishimoto,Momoko Tanaka,Yoshihiro Ochi,Masaharu Nishikino,Yuichi Kunieda,,Hitoki Yoneda,Atsushi Iwamae 한국광학회 2009 Current Optics and Photonics Vol.13 No.1
We attempted the first measurement of the spectral width of the nickel-like molybdenum x-ray laser ( = 18.895 nm) by use of a high-resolution spectrometer in order to determine the strength of the magnetic field required for the generation of a circularly polarized x-ray laser. The spectral width was measured to be = 18 mÅ under the substantial lasing condition. The magnetic field required for the generation of a circularly polarized x-ray laser was 40 T. The splitting of the x-ray laser line was clearly obtained under 15 T external magnetic field. The strength of the magnetic field estimated from the splitting of the x-ray laser line was large compared with the external magnetic field. It implies that there might be an alternative mechanism for enhancement of the magnetic field in the gain medium plasma.
Rino Hasegawa,Kenshi Yao,Shoutomi Ihara,Masaki Miyaoka,Takao Kanemitsu,Kenta Chuman,Go Ikezono,Akikazu Hirano,Toshiharu Ueki,Hiroshi Tanabe,Atsuko Ota,Seiji Haraoka,Akinori Iwashita 대한소화기내시경학회 2018 Clinical Endoscopy Vol.51 No.6
Background/Aims: While the occurrence of multiple whitish flat elevated lesions (MWFL) was first reported in 2007, no studieson MWFL have been published to date. The present retrospective observational study aimed to clarify the endoscopic findings andclinicopathological features of MWFL. Methods: Subjects were consecutive patients who underwent upper gastrointestinal endoscopy as part of routine screening betweenApril 2014 and March 2015. The conventional white-light, non-magnifying and magnifying narrow-band images were reviewed. Clinical features were compared between patients with and without MWFL. Results: The conventional endoscopic findings of MWFL include multiple whitish, flat, and slightly elevated lesions of various sizes,mainly located in the gastric body and fundus. Narrow-band imaging enhanced the contrast of MWFL and background mucosa,and magnifying narrow-band imaging depicted a uniformly long, narrow, and elliptical marginal crypt epithelium with an unclearmicrovascular pattern. Histopathological findings revealed hyperplastic changes of the foveolar epithelium, and parietal cell protrusionsand oxyntic gland dilatations were observed in the fundic glands, without any intestinal metaplasia. The rate of acid-reducing drug usewas significantly higher in patients with MWFL than in those without (100% [13/13] vs. 53.7% [88/164], p<0.001). Conclusions: The present study indicated a relationship between the presence and endoscopic features of MWFL and history of acidreducingdrug use.
Imamura, Hiroshi,Hasegawa, Yutaka,Murata, Junsuke,Chihara, Sho,Takezaki, Daisuke,Kamiya, Naotsugu Korean Society for Fluid machinery 2009 International journal of fluid machinery and syste Vol.2 No.3
Since large-scale commercial wind turbine generator systems such as MW-class wind turbines are becoming widely operated, the vibration and distortion of the blade are becoming larger and larger. Therefore the soft structure design instead of the solid-design is one of the important concepts to reduce the structural load and the cost of the wind turbine rotors. The objectives of the study are development of the fluid-structure coupled analysis code and evaluation of soft rotor-blade design to reduce the unsteady structural blade load. In this paper, fluid-structure coupled analysis for the HAWT rotor blade is performed by free wake panel method coupled with hinge-spring blade model for the flapwise blade motion. In the model, the continuous deflection of the rotor blade is represented by flapping angle of the hinge with one degree of freedom. The calculation results are evaluated by comparison with the database of the NREL unsteady aerodynamic experiment. In the analysis the unsteady flapwise moments in yawed inflow conditions are compared for the blades with different flapwise eigen frequencies.